what is the paul pirtea publication on the transfer of euploid embryos

what is the paul pirtea publication on the transfer of euploid embryos for achieving a new born with a propbability higher than 90%?

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Pirtea et al. (2021) - Euploid Embryo Transfers & >90% Live Birth Rate

Title: Rate of true recurrent implantation failure is low: results of three successive frozen euploid single embryo transfers

Authors: Paul Pirtea, Dominique De Ziegler, Xin Tao, Li Sun, Yiping Zhan, Jean Marc Ayoubi

Journal: Fertility and Sterility, 2021

DOI: 10.1016/j.fertnstert.2020.07.002

PMID: 33077239

Key Findings

Study design: Retrospective cohort of 4,429 women with an anatomically normal uterus who underwent up to three consecutive frozen euploid single embryo transfers (FE-SETs), excluding donor egg and gestational carrier cycles.
Mean patient age: 35.4 years.
Per-transfer live birth rates: 64.8% (1st transfer), 54.4% (2nd), 54.1% (3rd).
Cumulative live birth rate after up to 3 FE-SETs: 92.6% - this is the figure exceeding 90%.
Cumulative sustained implantation rate after 3 transfers: 95.2%.
Conclusion: True recurrent implantation failure is rare. Fewer than 5% of patients with the capacity to produce euploid blastocysts will fail to achieve a clinical pregnancy across three transfers - and this small residual failure rate likely reflects statistical probability rather than a truly refractory uterus.

This study was conducted at Reproductive Medicine Associates (RMA) in Basking Ridge, New Jersey, and is the landmark paper demonstrating that the probability of achieving a live birth exceeds 90% when up to three euploid embryos are available for transfer.

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