Dose of platelet and FFP in pediatrics
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platelet transfusion pediatrics
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plasma transfusion pediatrics
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pediatric transfusion platelet dose 10-15 mL/kg FFP dose 10-15 mL/kg guideline
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https://www.lifeblood.com.au/health-professionals/clinical-p…
Typical pediatric transfusion doses
| Component | Usual dose | Practical note |
|---|---|---|
| Platelets | 10 mL/kg of platelet concentrate | Common range is 5-10 mL/kg in children ≤30 kg. Apheresis platelets are generally dosed at about 10 mL/kg. |
| FFP | 10-15 mL/kg | Many protocols use 15 mL/kg initially. Some pediatric guidance permits 10-20 mL/kg, guided by bleeding and coagulation results. |
Use FFP only when there is clinically relevant coagulopathy, such as active bleeding with prolonged PT/aPTT, DIC, massive hemorrhage, or before an urgent invasive procedure in a bleeding-risk coagulopathy. Do not give it solely for a mildly abnormal INR in a non-bleeding child.
Platelets: dose depends on product platelet content and clinical indication. In ITP, platelets are generally reserved for severe or life-threatening bleeding, because transfused platelets are rapidly destroyed.
Check local blood-bank policy for product-specific volumes, ABO compatibility, irradiation/CMV-negative requirements in neonates or immunocompromised children, and reassess platelet count or coagulation tests after transfusion.
References: Miller’s Anesthesia, 10th ed., table on transfusion therapy lists random-donor platelets at 5-10 mL/kg and apheresis platelets at >10 mL/kg; the Australian Lifeblood FFP guidance lists 10-20 mL/kg for pediatric patients under 30 kg.
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