Here is a structured guide to learning ECG interpretation, built around the systematic approach described in Harrison's Principles of Internal Medicine (22nd Edition).
How to Learn ECG Interpretation
Step 1 - Understand What an ECG Records
An ECG (electrocardiogram) records the electrical activity of the heart from 12 different "camera angles" (leads). Each lead sees the same heart events from a different spatial direction.
The 12 leads split into:
- 6 limb leads (I, II, III, aVR, aVL, aVF) - look at the heart in the frontal plane
- 6 precordial leads (V1-V6) - look at the heart in the horizontal plane
Step 2 - Learn the Waveforms First
Every heartbeat produces a repeating pattern of waves. Memorize what each wave represents before anything else:
| Wave/Segment | What it Represents |
|---|
| P wave | Atrial depolarization (atria contracting) |
| PR interval | Time from atrial to ventricular activation (includes AV node delay) |
| QRS complex | Ventricular depolarization (ventricles contracting) |
| ST segment | Early ventricular repolarization (key area for ischemia) |
| T wave | Ventricular repolarization |
| U wave | Sometimes seen; may relate to repolarization of Purkinje fibers |
| QT interval | Total ventricular depolarization + repolarization time |
Step 3 - Learn the Normal Values
Commit these numbers to memory early:
| Measurement | Normal Range |
|---|
| Heart rate | 60-100 bpm |
| PR interval | 120-200 ms (3-5 small squares) |
| QRS duration | < 100-110 ms (< 2.5 small squares) |
| QTc | < 450 ms (men), < 460 ms (women) |
| P wave duration | 60-120 ms |
Grid reminder: Each small square = 40 ms (horizontal), 0.1 mV (vertical). Each large square = 200 ms / 0.5 mV.
Step 4 - Use a Systematic 14-Step Approach Every Time
According to Harrison's, every ECG must be assessed for these 14 parameters in order - never skip steps:
- Standardization/calibration - Is the paper speed 25 mm/s? Is gain set to 1 mV = 10 mm?
- Rhythm - Sinus or not? Regular or irregular?
- Heart rate - Count R-R intervals (300 ÷ large squares between R waves)
- PR interval - Normal, short (pre-excitation), or prolonged (AV block)?
- QRS duration - Narrow or wide? Wide = bundle branch block or ventricular origin
- QT/QTc interval - Prolonged = arrhythmia risk
- Mean QRS electrical axis - Normal, left axis deviation, or right axis deviation?
- P waves - Present? Morphology normal? One before each QRS?
- QRS voltages - Low voltage or high voltage (LVH/RVH)?
- Precordial R-wave progression - R wave should grow from V1 to V5/V6
- Abnormal Q waves - Pathological Q waves = old infarction
- ST segments - Elevated or depressed? Pattern of leads affected?
- T waves - Inverted, peaked, or flat?
- U waves - Prominent U waves (hypokalemia, bradycardia)?
"Many mistakes in ECG interpretation are errors of omission. Therefore, a systematic approach is essential." - Harrison's Principles of Internal Medicine, 22E
Step 5 - Learn Axis Determination (Quick Method)
Look at leads I and aVF:
| Lead I | Lead aVF | Axis |
|---|
| Positive (up) | Positive (up) | Normal (0° to +90°) |
| Positive (up) | Negative (down) | Left axis deviation |
| Negative (down) | Positive (up) | Right axis deviation |
| Negative (down) | Negative (down) | Extreme/indeterminate axis |
Step 6 - Learn the Major Patterns (in Order of Importance)
Start with the most clinically urgent patterns:
1. STEMI (ST elevation myocardial infarction)
- ST elevation in two or more contiguous leads
- Location tells you which artery: anterior (V1-V4 = LAD), inferior (II, III, aVF = RCA), lateral (I, aVL, V5-V6 = circumflex)
2. Arrhythmias
- Atrial fibrillation: irregularly irregular rhythm, no P waves, fibrillatory baseline
- Atrial flutter: sawtooth P waves at ~300 bpm, 2:1 or 4:1 block
- VT: wide complex tachycardia, rate > 100
3. Heart blocks
- 1st degree: PR > 200 ms, every P conducts
- 2nd degree Mobitz I (Wenckebach): PR progressively lengthens then drops a beat
- 2nd degree Mobitz II: PR fixed, random dropped beats
- 3rd degree (complete): no relationship between P waves and QRS
4. Bundle branch blocks
- RBBB: "RSR prime" (rabbit ears) in V1, wide S in V6. Mnemonic: WiRRoW (Wide R in Right, Wide S left in RBBB... use MaRRoW for RBBB, WiLLiaM for LBBB)
- LBBB: broad notched R in V5-V6, no septal Q waves
5. LVH and RVH
- LVH: S in V1 + R in V5 or V6 > 35 mm (Sokolow-Lyon criteria)
Step 7 - Practice Strategy
The single biggest factor in ECG competence is volume of practice. Here is a proven approach:
- Learn waveforms and normal values first (1-2 days)
- Read a focused textbook - Goldberger's Clinical Electrocardiography: A Simplified Approach is the gold standard reference (cited directly in Harrison's)
- Use free online cases - ECG Wave-Maven (Harvard/BIDMC) is a free self-assessment program with hundreds of real ECGs
- Read at least 1-2 ECGs daily - consistent daily exposure beats cramming
- Always read the clinical context - the patient's age, symptoms, and history shape interpretation
- Review your errors - keep a log of ECGs you misread and revisit them
Quick Reference: What to Say When Presenting an ECG
"This ECG shows a [rate] bpm, [regular/irregular] rhythm with [normal sinus/atrial fibrillation/etc.] rhythm. The PR interval is [normal/prolonged/short]. The QRS is [narrow/wide]. The axis is [normal/LAD/RAD]. There [are/are no] ST changes. There [are/are no] pathological Q waves. The T waves are [normal/inverted]. Overall impression: [diagnosis]."
This habit of presenting in a fixed order forces you to check everything and prevents errors of omission.
Sources: Harrison's Principles of Internal Medicine, 22E (2025); Goldberger's Clinical Electrocardiography, 10th Ed.