In which part of the cell are steroid hormone receptors located: - In

In which part of the cell are steroid hormone receptors located: - In the membrane - in the core - in mitochondria - in the cytoplasm

Steroid hormone receptors are located in the cytoplasm (and nucleus). They are intracellular receptors - when unbound, they reside in the cytoplasm complexed with heat shock proteins. Upon binding their lipophilic steroid hormone (which crosses the membrane freely), the receptor undergoes a conformational change, dissociates from heat shock proteins, and translocates to the nucleus to act as a transcription factor.

So the answer is: in the cytoplasm (option 4).

Note: Some sources describe certain steroid receptors as predominantly nuclear even in the unbound state (e.g., thyroid hormone receptors, though those are technically not steroid receptors). For classical steroid receptors (glucocorticoids, mineralocorticoids, sex steroids), the cytoplasm is the correct answer.

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