A 67-year-old patient with chronic HFrEF is started on an ACE inhibitor. After several weeks, his symptoms improve and echocardiography shows reduced progression of LV remodeling. Which neurohormonal effect is primarily responsible for this beneficial outcome? Increased angiotensin II-mediated vasoconstriction Increased aldosterone-mediated sodium retention Reduced angiotensin II and aldosterone activity Increased sympathetic stimulation of the myocardium Increased ventricular wall stress

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