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Mebemin C

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Mebemin C tablet composition uses

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"mebeverine" AND "irritable bowel syndrome"

Mebemin-C is not a vitamin, despite the "C". It is an Indian brand tablet that combines two drugs. Brand listings (1mg, PlatinumRx) give the composition as:
  • Mebeverine 135 mg, an antispasmodic.
  • Chlordiazepoxide 5 mg, a benzodiazepine (anxiolytic).
Use: It is prescribed for irritable bowel syndrome (IBS) with abdominal cramps, bloating, and altered bowel habit. This is especially so when anxiety or stress seems to drive the symptoms.
How each component works
  • Mebeverine acts directly on gut smooth muscle. It appears to block K⁺, Na⁺ and Ca²⁺ channels and is used outside the US for IBS. - Goodman & Gilman's The Pharmacological Basis of Therapeutics, "Other Drugs". It has no anticholinergic cognitive effects. - The Maudsley Prescribing Guidelines in Psychiatry, 15th ed, "Antispasmodics".
  • Chlordiazepoxide is a benzodiazepine. It reduces anxiety and is also sold in fixed combinations for GI conditions such as IBS and spastic colitis. - Kaplan and Sadock's Synopsis of Psychiatry, "Combination of Drugs".
Evidence and caveats
  • Gastroenterology texts say smooth muscle relaxants such as mebeverine may help some patients with IBS, but controlled trials are lacking. - Yamada's Textbook of Gastroenterology, 7th ed. In head-to-head trials, mebeverine performed about the same as otilonium and ramosetron, and was inferior to alosetron. - Yamada's Textbook of Gastroenterology, "Antispasmodics".
  • Mebeverine alone is the usual antispasmodic choice. The benzodiazepine adds a risk of sedation, dependence and withdrawal, and is generally not recommended for long-term IBS management. This point comes from general pharmacology and not from the library results above.
  • A recent network meta-analysis (PMID 42470701, 2026) compares antispasmodics and antidepressants in IBS. I only saw its title, not the abstract. Check it if you want current comparative evidence, because antidepressants are the usual choice when psychological symptoms are prominent.
Safety points (from the brand listings, not verified against a formal label)
  • Drowsiness, dizziness and impaired driving or machinery use.
  • Avoid alcohol and other sedatives, including opioids.
  • Use caution in the elderly, in liver or kidney disease, and in pregnancy and breastfeeding.
  • Avoid in myasthenia gravis, severe respiratory insufficiency, sleep apnoea, and a history of benzodiazepine dependence.
  • Don't stop it abruptly after prolonged use.
I can't give a dose for your situation. Dosing and suitability should come from your prescriber or pharmacist. If you meant a different product (for example a vitamin C or B12 supplement), tell me the manufacturer or the ingredients on the strip.

Spenzo

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Spenzo tablet composition uses

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"flupentixol" AND "schizophrenia"

Spenzo is an Indian brand of flupentixol (also spelled flupenthixol), an antipsychotic. The 0.5 mg tablet is made by Intas Pharmaceuticals, and a 3 mg strength is also listed (1mg, Carex24). It is prescription-only.
Drug class
  • Flupentixol is a thioxanthene, a typical (first-generation) antipsychotic. Its clinical characteristics resemble those of the phenothiazines. - Kaplan & Sadock's Comprehensive Textbook of Psychiatry, "Thioxanthenes".
  • It blocks dopamine receptors and also acts on serotonin receptors. - Kaplan & Sadock's, "Dopamine-Serotonin Antagonists".
Uses (from the brand listings)
  • Schizophrenia and other psychoses, to control delusions, hallucinations and disordered thinking.
  • Low doses (the 0.5 mg tablet) are also used for depression, often with anxiety, in some regions. The 1mg listing says it may be used for depression and bipolar disorder.
  • The long-acting decanoate injection is used for maintenance treatment. In bipolar disorder, an open study of 85 patients suggested flupentixol decanoate 20 mg every 2 to 3 weeks reduced elevated mood episodes. The one RCT of flupentixol LAI showed no effect. - The Maudsley Prescribing Guidelines in Psychiatry, 15th ed, "Antipsychotic long-acting injections in bipolar disorder".
  • The oral drug is not widely prescribed in the US. Kaplan & Sadock's notes that the long-acting form is the main exception, and it is not available in the US.
Adverse effects (general class knowledge, not found in the library search)
  • Extrapyramidal effects: parkinsonism, akathisia, dystonia, and tardive dyskinesia with long-term use.
  • Raised prolactin, sedation or activation, weight gain, and QT prolongation.
  • Mild anticholinergic burden. The Maudsley anticholinergic table scores flupentixol as 1 (low). - The Maudsley Prescribing Guidelines, "Anticholinergic drugs".
  • Rarely, neuroleptic malignant syndrome.
Cautions
  • It is generally avoided in acute agitation or excitable, overactive states, because it can worsen them.
  • Use caution with Parkinson's disease, QT-prolonging drugs, and liver or kidney disease. Be careful in the elderly and with dementia, where antipsychotics raise mortality.
  • It causes drowsiness, so avoid driving until you know how it affects you. Avoid alcohol.
  • Don't stop it abruptly. Relapse and withdrawal effects can occur.
Recent evidence check: A PubMed search of the last two years found no systematic review specifically on oral flupentixol that changes this picture. The closest hit was a Cochrane review (PMID 42781843, 2026) on zuclopenthixol acetate, a related thioxanthene, which is not the same drug.
I'm not giving a dose. The dose depends on the indication, and flupentixol for depression is dosed very differently from flupentixol for psychosis. Take it exactly as prescribed. If you want comparisons with other antipsychotics, side-effect management or a switch, tell me what you need.
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