CAD/CAM milled occlusal splints demonstrated maximum flexural strength among all groups.  Conventional occlusal splints showed minimum flexural strength but lowest surface roughness.  3D printed splints exhibited intermediate mechanical and surface properties.  Both flexural strength and surface roughness were significantly affected by fabrication technique. CONCLUSION Within the limitations of this in-vitro study, it can be concluded that: 1. CAD/CAM milling produces occlusal splints with superior flexural strength, making them suitable for patients requiring higher fracture resistance. 2. 3D printed occlusal splints offer a balance between strength and surface characteristics and may serve as a viable alternative in clinical practice. 3. Conventional heat-cured splints, while exhibiting lower strength, demonstrate smoother surfaces and remain clinically acceptable when cost and accessibility are considerations. The choice of fabrication technique should be guided by clinical requirements, functional load, and patient-specific factors