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Addiomiq crisis

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An Addisonian crisis (acute adrenal insufficiency) is a life-threatening emergency caused by a sudden, severe drop in cortisol (and often aldosterone). It requires immediate treatment.
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"adrenal crisis" AND management

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Here is a comprehensive overview of Addisonian Crisis (Acute Adrenal Insufficiency):

Addisonian Crisis (Acute Adrenal Insufficiency)

Definition

An Addisonian crisis is a life-threatening medical emergency caused by critically insufficient cortisol levels. It typically occurs in patients with pre-existing adrenal insufficiency who are exposed to an acute physiological stressor, or from sudden, complete destruction of adrenal function. - Tintinalli's Emergency Medicine, p. 230; Sabiston Textbook of Surgery

Causes & Precipitants

  • Underlying primary adrenal insufficiency (Addison's disease) unmasked by stress
  • Secondary/tertiary adrenal insufficiency (pituitary/hypothalamic disease)
  • Waterhouse-Friderichsen syndrome - bilateral adrenal hemorrhage from severe sepsis (classically meningococcal)
  • Sudden cessation of chronic glucocorticoid therapy
  • Acute stressors in patients with marginal adrenal reserve:
    • Infection (most common; especially GI infections)
    • Surgery or trauma
    • Extreme physical activity
    • Acute burns
  • Hypercoagulable states causing adrenal infarction
  • Bailey and Love's Surgery 28e; Tintinalli's Emergency Medicine

Clinical Features

Symptoms are non-specific, making diagnosis challenging. Classic features include:
FeatureDetails
HypotensionSevere, refractory to vasopressors - hallmark sign
Abdominal painSevere; mimics acute abdomen (commonly misdiagnosed as surgical emergency)
GI symptomsNausea, vomiting, diarrhea
FeverCommon; may suggest underlying infection as precipitant
CNS changesConfusion, disorientation, lethargy, coma
HypoglycemiaDue to cortisol deficiency
Electrolyte disturbanceHyponatremia + hyperkalemia (primary); variable in secondary

Primary vs. Secondary: Key Differences

FeaturePrimary (Addison's)Secondary (Pituitary)
Volume depletionMarkedLess severe
Serum K+HyperkalemiaHypokalemia
Skin pigmentationPresent (high ACTH)Absent
AldosteroneDeficientPresent
ACTHHighLow/normal
  • Tintinalli's Emergency Medicine, Table 230-3

Diagnosis

Do not delay treatment while awaiting results.
Initial labs:
  • Serum cortisol, plasma ACTH
  • Electrolytes (Na+, K+, Ca2+), glucose, CBC
  • Plasma renin, aldosterone
  • ECG (potassium-related changes)
Key thresholds:
  • Morning serum cortisol >18 mcg/dL - effectively rules out adrenal insufficiency
  • Morning serum cortisol <15 mcg/dL (or salivary <5.8 ng/mL) - adrenal insufficiency possible
Confirmatory test - ACTH Stimulation (Synacthen/Cosyntropin Test):
  • Give 250 mcg cosyntropin IV
  • Measure cortisol at baseline and 30-60 min post
  • Post-cortisol <18 mcg/dL = strongly suggestive of adrenal insufficiency
  • Note: If steroids must be given urgently before the test, use dexamethasone (no cross-reactivity with cortisol assays)
Algorithm:
Adrenal Insufficiency Diagnosis Algorithm
- Sabiston Textbook of Surgery, Fig. 75.7

Treatment (Emergency Protocol)

Treatment must start IMMEDIATELY - do not wait for lab results. - Bailey and Love's Surgery 28e

1. IV Fluids

  • Normal saline (0.9%): 2-3 L in the first 6 hours
  • Use D5/NS (dextrose-saline) if hypoglycemic

2. Steroids (Drug of Choice: Hydrocortisone)

  • Hydrocortisone 100 mg IV bolus (first-line - provides both glucocorticoid AND mineralocorticoid effects)
  • Followed by 50 mg IV q6h (or 200 mg/24h infusion)
  • If no IV access: 100 mg IM
  • Alternative: Dexamethasone 4 mg IV (preferred if ACTH stimulation test is planned - no cortisol cross-reactivity); must add fludrocortisone 100 mcg/day as dexamethasone has no mineralocorticoid activity

3. Supportive Care

  • Airway, breathing, circulation
  • Correct electrolytes (Na+, K+, Ca2+)
  • Treat underlying precipitant (antibiotics for infection)

4. Vasopressors (if needed)

  • Only after steroid therapy, in patients unresponsive to fluids
  • Norepinephrine, dopamine, or phenylephrine

5. Mineralocorticoid Replacement (NOT urgent initially)

  • Fludrocortisone effects take days to manifest; saline infusion covers early needs
  • Begin once patient is stabilized and tolerating oral medications
  • Tintinalli's Emergency Medicine, Table 230-4; Bailey and Love's Surgery 28e; Sabiston Textbook of Surgery

Prevention / Patient Education

Patients with known chronic adrenal insufficiency must:
  • Take lifelong glucocorticoid replacement (hydrocortisone 15-25 mg/day PO in 2-3 divided doses)
  • Double the dose during illness or stress ("sick day rules")
  • Take fludrocortisone 0.05-0.2 mg each morning (for primary insufficiency)
  • Carry a steroid emergency card and injectable hydrocortisone for self-injection
  • Bailey and Love's Surgery 28e

Recent Evidence Note

A 2025 systematic review and meta-analysis (PMID: 40966723) confirmed increased all-cause mortality in primary adrenal insufficiency, underscoring the importance of early recognition and aggressive treatment of adrenal crisis.
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