Cervical cancer
Reading File
Finding Sources
Searching PubMed
"cervical cancer"[MeSH Terms] AND ("screening" OR "treatment" OR "prevention")
Searching the Web
cervical cancer 2025 2026 guidelines screening treatment updates
Reading File
Finding Sources
Reading File
Reading File
Reading File
Reading File
Finding Sources
Finding Sources
Reading File
Cervical cancer in detail point wise manner
Reading File
Finding Sources
Searching PubMed
"cervical cancer"[MeSH Terms] AND ("immunotherapy" OR "pembrolizumab" OR "bevacizumab")
Searching the Web
cervical cancer FIGO 2018 staging treatment guidelines 2025
Reading File
Reading File
Finding Sources
Reading File
Finding Sources
Reading File
Reading File
Reading File
Reading File
Reading File
Reading File
Reading File
This is a fully detailed, point-wise breakdown of cervical cancer covering all major domains. Here is a quick navigation summary:
| Section | Key Highlights |
|---|---|
| Epidemiology | 3rd most common gynecologic cancer; >99% HPV-associated; median age 48 |
| Etiology & Risk | HPV 16/18 = 70% of cases; smoking, HIV, OCP use, multiparity |
| Pathobiology | E6 degrades p53; E7 degrades pRB; persistent infection required for malignancy |
| Precursor Lesions | CIN I/II/III (LSIL/HSIL); HSIL 30% regress, 10% → invasive carcinoma |
| Histology | SCC 80%, adenocarcinoma 15%, neuroendocrine <5% |
| Spread | Local → vagina/parametria/bladder; lymphatic → pelvic/para-aortic nodes |
| Symptoms | Postcoital bleeding, discharge, pelvic pain (early stages often silent) |
| FIGO 2018 Staging | IA1 → IVB; now includes lymph node metastasis in Stage IIIC |
| Treatment | Early: radical hysterectomy (open); advanced: cisplatin + EBRT + brachytherapy; metastatic: chemo + bevacizumab ± pembrolizumab |
| 5-yr Survival | Stage I ~90%, Stage IV <20% |
| Screening (2025-26) | Self-collected hrHPV now endorsed; primary HPV testing q5 years preferred for ages 30-65 |
| Prevention | 9-valent HPV vaccine (ages 9-26); WHO 90-70-90 elimination strategy |
This is a shared conversation. Sign in to Orris to start your own chat.