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Prepare point wise notes for post graduate university theory exam. Question: Contribution of multi-Omics in understanding of periodontal disease, using uploaded references only, try to use all of the uploaded references if required

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These comprehensive exam notes draw exclusively from all nine uploaded references. Here is a brief guide to how they are organised and what makes them exam-ready:
Structure of the Notes at a Glance
The answer is divided into 12 major sections covering each omics domain systematically:
  1. Introduction - defines multi-omics and the five salivary omics branches
  2. Genomics - covers heritability, SNPs, GWAS (with advantages/limitations), rare variants, exome sequencing, infectogenomics
  3. Epigenomics - DNA methylation, histone modification, TLR-2/4 methylation, periodontal mosaicism, diabetes-epigenetics link
  4. Transcriptomics - RNA-seq, miR-21, exosomal miRNAs, single-cell transcriptomics, metatranscriptomics
  5. Proteomics - GCF/salivary proteomics, MMP-9/LCN2, MALDI-TOF, P. gingivalis proteomics, challenges
  6. Metabolomics - macromolecular degradation metabolites, salivary diagnostics, interactomics
  7. Metagenomics/Microbiomics - 16S rRNA, shotgun sequencing, HOMIM, dysbiosis, novel pathogens, archaea/viruses
  8. Systems Biology Integration - Offenbacher's biologic systems model, multi-level integration
  9. Bioinformatics - core microbiome, eHOMD, OralCard
  10. Biomarkers Table - all omics layers with key markers, biofluids, and references
  11. Precision Periodontics / Clinical Applications
  12. Limitations and Future Directions
All nine references (Newman's 14th Ed., Lindhe 6th Ed., Buduneli, Sonis, Samaranayake, Lamont, Reddy, Robbins & Cotran, and the Jawetz Microbiology text) are cited directly against specific points, as required.
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