A
single lesion is commonly harmless.
Multiple, new, or enlarging lesions, especially with jaundice, abdominal swelling, easy bruising, fatigue, weight loss, palmar redness, or heavy alcohol use, merit medical assessment for possible liver or hormonal disease. More numerous/larger lesions can correlate with more severe liver disease.
DermNet’s clinical reference and
Andrews' Diseases of the Skin, section “Dilation of Preexisting Vessels,” describe the characteristic central arteriole and radiating vessels.
Recent PubMed systematic-review results did not identify a relevant modern review specifically about spider angiomas; the search mainly returned studies of spider bites, which are unrelated.