const pptxgen = require("pptxgenjs");

const pres = new pptxgen();
pres.layout = "LAYOUT_WIDE"; // 13.3" x 7.5"
pres.title = "Evidence-Based Ayurvedic Medicines for Clinical Practice";
pres.author = "Orris Medical";

// ─── Color Palette ───────────────────────────────────────────────
const C = {
  darkGreen:  "1A3C2E",  // dominant dark background
  midGreen:   "2D6A4F",  // accent panels
  leafGreen:  "40916C",  // secondary accent
  gold:       "D4A853",  // highlight / evidence badges
  cream:      "F5F0E8",  // light text / card BG
  white:      "FFFFFF",
  orange:     "E07B39",  // warning / caution
  teal:       "52B788",  // data highlight
  lightGray:  "EAF4EE",  // table rows
};

// ─── Helpers ─────────────────────────────────────────────────────
function slideBg(slide, color) {
  slide.background = { color };
}

function headerBar(slide, title, subtitle, bgColor, textColor) {
  bgColor = bgColor || C.darkGreen;
  textColor = textColor || C.gold;
  // full-width top bar
  slide.addShape(pres.ShapeType.rect, {
    x: 0, y: 0, w: "100%", h: 1.05,
    fill: { color: bgColor }, line: { type: "none" }
  });
  slide.addText(title, {
    x: 0.3, y: 0.08, w: 12.5, h: 0.55,
    fontSize: 22, bold: true, color: textColor,
    fontFace: "Calibri", margin: 0
  });
  if (subtitle) {
    slide.addText(subtitle, {
      x: 0.3, y: 0.62, w: 12.5, h: 0.38,
      fontSize: 12, color: C.cream, fontFace: "Calibri", margin: 0
    });
  }
}

function evidenceBadge(slide, tier, x, y) {
  const label = tier === 1 ? "Meta-Analysis" : "RCT";
  const col   = tier === 1 ? C.gold : C.teal;
  slide.addShape(pres.ShapeType.roundRect, {
    x, y, w: 1.45, h: 0.28,
    fill: { color: col },
    line: { type: "none" },
    rectRadius: 0.06
  });
  slide.addText(label, {
    x, y, w: 1.45, h: 0.28,
    fontSize: 9, bold: true, color: C.darkGreen,
    align: "center", valign: "middle", fontFace: "Calibri", margin: 0
  });
}

function pmidTag(slide, pmid, x, y) {
  slide.addText("PMID: " + pmid, {
    x, y, w: 2.2, h: 0.22,
    fontSize: 8, color: C.teal, italic: true, fontFace: "Calibri", margin: 0
  });
}

function footerLine(slide) {
  slide.addShape(pres.ShapeType.line, {
    x: 0.3, y: 7.2, w: 12.7, h: 0,
    line: { color: C.midGreen, width: 0.5 }
  });
  slide.addText("Evidence-Based Ayurvedic Medicine | Clinical Reference 2024-2026 | Sources: PubMed Indexed Journals", {
    x: 0.3, y: 7.26, w: 12.7, h: 0.22,
    fontSize: 7.5, color: C.leafGreen, fontFace: "Calibri", margin: 0
  });
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.darkGreen);

  // Large decorative leaf shape (circle)
  s.addShape(pres.ShapeType.ellipse, {
    x: 9.8, y: -1.2, w: 5.5, h: 5.5,
    fill: { color: C.midGreen }, line: { type: "none" }
  });
  s.addShape(pres.ShapeType.ellipse, {
    x: 10.5, y: 4.5, w: 3.5, h: 3.5,
    fill: { color: "1F4D35" }, line: { type: "none" }
  });

  // Gold accent bar
  s.addShape(pres.ShapeType.rect, {
    x: 0.5, y: 2.2, w: 0.08, h: 3.1,
    fill: { color: C.gold }, line: { type: "none" }
  });

  s.addText("Evidence-Based", {
    x: 0.8, y: 2.2, w: 9, h: 0.75,
    fontSize: 42, bold: true, color: C.gold,
    fontFace: "Calibri", margin: 0
  });
  s.addText("Ayurvedic Medicines", {
    x: 0.8, y: 2.9, w: 9, h: 0.8,
    fontSize: 42, bold: true, color: C.white,
    fontFace: "Calibri", margin: 0
  });
  s.addText("for Clinical Practice", {
    x: 0.8, y: 3.65, w: 9, h: 0.7,
    fontSize: 36, bold: false, color: C.cream,
    fontFace: "Calibri", margin: 0
  });

  s.addText("Peer-Reviewed Evidence from PubMed | Meta-Analyses & RCTs", {
    x: 0.8, y: 4.5, w: 9, h: 0.4,
    fontSize: 14, color: C.teal, fontFace: "Calibri", margin: 0
  });

  s.addText([
    { text: "Compiled: June 2026  ", options: { bold: false } },
    { text: "  Sources: PubMed MEDLINE", options: { bold: false } }
  ], {
    x: 0.8, y: 5.0, w: 9, h: 0.35,
    fontSize: 11, color: "7BAE9A", fontFace: "Calibri", margin: 0
  });
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 2 — OVERVIEW / WHY EVIDENCE MATTERS
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.cream);
  headerBar(s, "Why Evidence-Based Ayurveda Matters", "Bridging Traditional Wisdom with Modern Clinical Standards");

  // 4 stat boxes
  const boxes = [
    { n: "5,000+", label: "Years of\nAyurvedic\nPractice", col: C.darkGreen },
    { n: "103+",   label: "RCTs on\nCurcumin\nAlone",       col: C.midGreen },
    { n: "45+",    label: "RCTs on\nAshwagandha",            col: C.leafGreen },
    { n: "2026",   label: "Latest\nMeta-Analyses\nIndexed",  col: C.gold },
  ];

  boxes.forEach((b, i) => {
    const x = 0.5 + i * 3.1;
    s.addShape(pres.ShapeType.roundRect, {
      x, y: 1.3, w: 2.8, h: 2.3,
      fill: { color: b.col }, line: { type: "none" }, rectRadius: 0.15
    });
    s.addText(b.n, {
      x, y: 1.4, w: 2.8, h: 0.9,
      fontSize: 36, bold: true, color: C.white,
      align: "center", fontFace: "Calibri", margin: 0
    });
    s.addText(b.label, {
      x, y: 2.25, w: 2.8, h: 1.2,
      fontSize: 13, color: i === 3 ? C.darkGreen : C.cream,
      align: "center", valign: "top", fontFace: "Calibri", margin: 8
    });
  });

  s.addText([
    { text: "Key principle: ", options: { bold: true, color: C.darkGreen } },
    { text: "The strongest herbs have Level 1 (Meta-Analysis) evidence — comparable to pharmaceutical trials.", options: { color: C.darkGreen } }
  ], {
    x: 0.5, y: 3.9, w: 12.3, h: 0.5,
    fontSize: 14, fontFace: "Calibri", margin: 0
  });

  const points = [
    "Ashwagandha & Curcumin: multiple independent Meta-Analyses confirm efficacy",
    "Shatavari: 4 double-blind RCTs published in 2024-2026 alone",
    "Bacopa monnieri: 2026 Network Meta-Analysis vs. Ginkgo biloba — favours Bacopa for working memory",
    "Terminalia arjuna: 2026 Systematic Review in BMC Cardiovascular Disorders"
  ];

  s.addText(points.map((p, i) => ({
    text: (i < points.length - 1 ? p : p),
    options: { bullet: { type: "bullet", indent: 15 }, breakLine: i < points.length - 1, color: C.darkGreen }
  })), {
    x: 0.5, y: 4.5, w: 12.3, h: 2.4,
    fontSize: 12.5, fontFace: "Calibri", margin: 5
  });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 3 — ASHWAGANDHA (Withania somnifera)
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.darkGreen);
  headerBar(s, "Ashwagandha  (Withania somnifera)", "Adaptogen | CNS | Endocrine | Musculoskeletal");

  // left panel
  s.addShape(pres.ShapeType.rect, {
    x: 0, y: 1.05, w: 4.5, h: 6.45,
    fill: { color: C.midGreen }, line: { type: "none" }
  });

  s.addText("Clinical Profile", {
    x: 0.2, y: 1.15, w: 4.1, h: 0.4,
    fontSize: 14, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
  });

  const profile = [
    ["Sanskrit", "Ashwagandha"],
    ["Latin",    "Withania somnifera"],
    ["Part used","Root extract"],
    ["Dose",     "300–600 mg/day"],
    ["Duration", "8–12 weeks"],
    ["Safety",   "Generally safe; avoid in pregnancy"],
  ];
  profile.forEach(([k, v], i) => {
    s.addText(k + ":", {
      x: 0.25, y: 1.65 + i * 0.52, w: 1.3, h: 0.42,
      fontSize: 10, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
    });
    s.addText(v, {
      x: 1.55, y: 1.65 + i * 0.52, w: 2.7, h: 0.42,
      fontSize: 10, color: C.cream, fontFace: "Calibri", margin: 0
    });
  });

  s.addText("Mechanisms", {
    x: 0.2, y: 4.9, w: 4.1, h: 0.35,
    fontSize: 13, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
  });
  s.addText([
    { text: "• Withanolides — cortisol modulation\n", options: {} },
    { text: "• HPA axis regulation\n", options: {} },
    { text: "• GABA-mimetic anxiolytic\n", options: {} },
    { text: "• Anti-inflammatory (NF-κB inhibition)", options: {} }
  ], {
    x: 0.2, y: 5.25, w: 4.1, h: 1.9,
    fontSize: 10, color: C.cream, fontFace: "Calibri", margin: 2
  });

  // right side - evidence cards
  const cards = [
    {
      tier: 1, pmid: "39348746", year: "2024",
      journal: "Explore (NY)",
      title: "Meta-Analysis: Stress & Anxiety",
      findings: [
        "Cortisol reduced by 21-32%",
        "GAD anxiety score significantly improved",
        "Perceived Stress Scale (PSS) reduced"
      ]
    },
    {
      tier: 1, pmid: "34559859", year: "2021",
      journal: "PLoS ONE",
      title: "Meta-Analysis: Sleep Quality",
      findings: [
        "Sleep onset latency reduced",
        "Total sleep time increased",
        "Morning alertness improved"
      ]
    },
    {
      tier: 3, pmid: "38732539", year: "2024",
      journal: "Nutrients",
      title: "RCT: Chronically Stressed Adults",
      findings: [
        "Double-blind, placebo-controlled",
        "Cortisol, fatigue, sleep all improved",
        "No serious adverse events"
      ]
    },
  ];

  cards.forEach((c, i) => {
    const y = 1.15 + i * 2.05;
    s.addShape(pres.ShapeType.roundRect, {
      x: 4.8, y, w: 8.2, h: 1.9,
      fill: { color: "1F4D35" }, line: { color: C.leafGreen, width: 0.5 }, rectRadius: 0.1
    });
    evidenceBadge(s, c.tier, 4.95, y + 0.08);
    s.addText(c.year + "  |  " + c.journal, {
      x: 6.55, y: y + 0.08, w: 4, h: 0.26,
      fontSize: 9, color: C.teal, fontFace: "Calibri", margin: 0
    });
    s.addText(c.title, {
      x: 4.95, y: y + 0.42, w: 8, h: 0.35,
      fontSize: 13, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
    });
    c.findings.forEach((f, j) => {
      s.addText("✓  " + f, {
        x: 4.95, y: y + 0.82 + j * 0.3, w: 7.9, h: 0.28,
        fontSize: 10.5, color: C.cream, fontFace: "Calibri", margin: 0
      });
    });
    pmidTag(s, c.pmid, 10.8, y + 1.6);
  });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 4 — CURCUMIN / HARIDRA
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, "2A1F0A");
  headerBar(s, "Curcumin  (Curcuma longa / Haridra)", "Anti-Inflammatory | Antioxidant | Metabolic | Joint Health", "2A1F0A", C.gold);

  // left panel - golden
  s.addShape(pres.ShapeType.rect, {
    x: 0, y: 1.05, w: 4.5, h: 6.45,
    fill: { color: "3D2B0F" }, line: { type: "none" }
  });

  s.addText("Clinical Profile", {
    x: 0.2, y: 1.15, w: 4.1, h: 0.4,
    fontSize: 14, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
  });

  const profile = [
    ["Sanskrit",  "Haridra"],
    ["Latin",     "Curcuma longa"],
    ["Active",    "Curcumin (3-5%)"],
    ["Dose",      "500–1000 mg/day"],
    ["Duration",  "8–12 weeks"],
    ["Note",      "Use with piperine for bioavailability"],
  ];
  profile.forEach(([k, v], i) => {
    s.addText(k + ":", {
      x: 0.25, y: 1.65 + i * 0.52, w: 1.3, h: 0.42,
      fontSize: 10, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
    });
    s.addText(v, {
      x: 1.55, y: 1.65 + i * 0.52, w: 2.7, h: 0.42,
      fontSize: 10, color: C.cream, fontFace: "Calibri", margin: 0
    });
  });

  s.addText("103 RCTs Analysed", {
    x: 0.2, y: 4.9, w: 4.1, h: 0.35,
    fontSize: 13, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
  });
  s.addText([
    { text: "• NF-κB inhibition\n", options: {} },
    { text: "• COX-2 inhibition\n", options: {} },
    { text: "• TNF-α & IL-6 reduction\n", options: {} },
    { text: "• Nrf2 pathway activation", options: {} }
  ], {
    x: 0.2, y: 5.25, w: 4.1, h: 1.9,
    fontSize: 10, color: C.cream, fontFace: "Calibri", margin: 2
  });

  const cards = [
    {
      tier: 1, pmid: "39478418", year: "2024",
      journal: "Phytotherapy Research",
      title: "Meta-Analysis: 103 RCTs — Comprehensive Review",
      findings: [
        "Diabetes, inflammation, obesity, cholesterol — all improved",
        "Largest curcumin meta-analysis to date",
        "High safety profile across all studies"
      ]
    },
    {
      tier: 1, pmid: "35935936", year: "2022",
      journal: "Frontiers in Immunology",
      title: "Meta-Analysis: Arthritis (RA & OA)",
      findings: [
        "VAS pain score significantly reduced",
        "WOMAC score improved (joint function)",
        "Comparable to NSAIDs — fewer side effects"
      ]
    },
    {
      tier: 1, pmid: "36804260", year: "2023",
      journal: "Cytokine",
      title: "GRADE Meta-Analysis: Anti-Inflammatory",
      findings: [
        "CRP reduced by 19%",
        "IL-6 & TNF-α significantly reduced",
        "Dose-response relationship confirmed"
      ]
    },
  ];

  cards.forEach((c, i) => {
    const y = 1.15 + i * 2.05;
    s.addShape(pres.ShapeType.roundRect, {
      x: 4.8, y, w: 8.2, h: 1.9,
      fill: { color: "3D2B0F" }, line: { color: C.gold, width: 0.5 }, rectRadius: 0.1
    });
    evidenceBadge(s, c.tier, 4.95, y + 0.08);
    s.addText(c.year + "  |  " + c.journal, {
      x: 6.55, y: y + 0.08, w: 5, h: 0.26,
      fontSize: 9, color: C.teal, fontFace: "Calibri", margin: 0
    });
    s.addText(c.title, {
      x: 4.95, y: y + 0.42, w: 8, h: 0.35,
      fontSize: 13, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
    });
    c.findings.forEach((f, j) => {
      s.addText("✓  " + f, {
        x: 4.95, y: y + 0.82 + j * 0.3, w: 7.9, h: 0.28,
        fontSize: 10.5, color: C.cream, fontFace: "Calibri", margin: 0
      });
    });
    pmidTag(s, c.pmid, 10.8, y + 1.6);
  });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 5 — SHATAVARI & GUDUCHI
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.cream);
  headerBar(s, "Shatavari & Guduchi — Women's Health & Immunity");

  // ── Shatavari (left half) ──
  s.addShape(pres.ShapeType.roundRect, {
    x: 0.3, y: 1.15, w: 5.9, h: 5.85,
    fill: { color: C.darkGreen }, line: { type: "none" }, rectRadius: 0.15
  });
  s.addText("Shatavari", {
    x: 0.5, y: 1.25, w: 5.5, h: 0.45,
    fontSize: 20, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
  });
  s.addText("Asparagus racemosus | Women's Tonic", {
    x: 0.5, y: 1.68, w: 5.5, h: 0.28,
    fontSize: 10, color: C.teal, fontFace: "Calibri", margin: 0
  });

  const shatRCTs = [
    { pmid: "41816216", year: "2026", title: "PCOS — Hormonal balance improved\nFSH/LH ratio corrected\nDouble-blind RCT" },
    { pmid: "41055223", year: "2025", title: "Lactation — Prolactin levels raised\nPostpartum milk production improved\nDouble-blind RCT" },
    { pmid: "40434025", year: "2025", title: "Menopause — Vasomotor symptoms reduced\nHormonal balance restored\nDouble-blind RCT" },
  ];
  shatRCTs.forEach((r, i) => {
    const y = 2.08 + i * 1.55;
    s.addShape(pres.ShapeType.roundRect, {
      x: 0.5, y, w: 5.5, h: 1.38,
      fill: { color: C.midGreen }, line: { type: "none" }, rectRadius: 0.1
    });
    evidenceBadge(s, 3, 0.65, y + 0.08);
    s.addText(r.year, { x: 2.25, y: y + 0.08, w: 1, h: 0.26, fontSize: 9, color: C.teal, fontFace: "Calibri", margin: 0 });
    s.addText(r.title, {
      x: 0.65, y: y + 0.42, w: 5.2, h: 0.85,
      fontSize: 10.5, color: C.cream, fontFace: "Calibri", margin: 2
    });
    pmidTag(s, r.pmid, 3.9, y + 1.1);
  });

  // ── Guduchi (right half) ──
  s.addShape(pres.ShapeType.roundRect, {
    x: 6.9, y: 1.15, w: 6.1, h: 5.85,
    fill: { color: C.darkGreen }, line: { type: "none" }, rectRadius: 0.15
  });
  s.addText("Guduchi (Giloy)", {
    x: 7.1, y: 1.25, w: 5.7, h: 0.45,
    fontSize: 20, bold: true, color: C.gold, fontFace: "Calibri", margin: 0
  });
  s.addText("Tinospora cordifolia | Immunomodulator", {
    x: 7.1, y: 1.68, w: 5.7, h: 0.28,
    fontSize: 10, color: C.teal, fontFace: "Calibri", margin: 0
  });

  const gudInfo = [
    { pmid: "38422192", year: "2024", tier: 1, title: "AYUSH Prophylaxis Meta-Analysis\nCOVID-19 — Fever duration reduced\nInflammatory markers improved" },
    { pmid: "38049897", year: "2023", tier: 3, title: "RCT: Mild COVID-19\nCRP & LDH levels reduced\nFaster clinical recovery" },
    { pmid: "34132429", year: "2021", tier: 1, title: "Systematic Review: Antiviral Properties\nImmunomodulatory actions confirmed\nAntioxidant capacity documented" },
  ];

  gudInfo.forEach((r, i) => {
    const y = 2.08 + i * 1.55;
    s.addShape(pres.ShapeType.roundRect, {
      x: 7.1, y, w: 5.7, h: 1.38,
      fill: { color: C.midGreen }, line: { type: "none" }, rectRadius: 0.1
    });
    evidenceBadge(s, r.tier, 7.25, y + 0.08);
    s.addText(r.year, { x: 8.85, y: y + 0.08, w: 1, h: 0.26, fontSize: 9, color: C.teal, fontFace: "Calibri", margin: 0 });
    s.addText(r.title, {
      x: 7.25, y: y + 0.42, w: 5.4, h: 0.85,
      fontSize: 10.5, color: C.cream, fontFace: "Calibri", margin: 2
    });
    pmidTag(s, r.pmid, 10.5, y + 1.1);
  });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 6 — BRAHMI & ARJUNA
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, "0E1F3A");
  headerBar(s, "Brahmi & Arjuna — Brain & Heart", "Neurocognitive Enhancement | Cardiovascular Support", "0E1F3A", C.teal);

  // Brahmi
  s.addShape(pres.ShapeType.roundRect, {
    x: 0.3, y: 1.15, w: 5.9, h: 5.85,
    fill: { color: "142840" }, line: { color: C.teal, width: 0.5 }, rectRadius: 0.15
  });
  s.addText("Brahmi", { x: 0.5, y: 1.25, w: 5.5, h: 0.45, fontSize: 20, bold: true, color: C.teal, fontFace: "Calibri", margin: 0 });
  s.addText("Bacopa monnieri | Medhya Rasayana (Brain Tonic)", { x: 0.5, y: 1.68, w: 5.5, h: 0.28, fontSize: 10, color: C.cream, fontFace: "Calibri", margin: 0 });

  const brahmCards = [
    { pmid: "41678913", year: "2026", tier: 1, journal: "Phytomedicine", title: "Network Meta-Analysis vs Ginkgo biloba", body: "Working memory: Brahmi > Ginkgo\nAttention & processing speed improved\n300-450 mg/day | 12 weeks" },
    { pmid: "42102930", year: "2026", tier: 3, journal: "Neurochem Int", title: "H1-MRS Brain Imaging RCT", body: "MRI Spectroscopy — direct brain changes\nNAA & Choline metabolites improved\nFirst neuroimaging RCT of Bacopa" },
  ];
  brahmCards.forEach((c, i) => {
    const y = 2.08 + i * 2.3;
    s.addShape(pres.ShapeType.roundRect, {
      x: 0.5, y, w: 5.5, h: 2.1,
      fill: { color: "1A3658" }, line: { type: "none" }, rectRadius: 0.1
    });
    evidenceBadge(s, c.tier, 0.65, y + 0.1);
    s.addText(c.year + " | " + c.journal, { x: 2.25, y: y + 0.1, w: 3.6, h: 0.26, fontSize: 9, color: C.teal, fontFace: "Calibri", margin: 0 });
    s.addText(c.title, { x: 0.65, y: y + 0.45, w: 5.2, h: 0.38, fontSize: 12, bold: true, color: C.white, fontFace: "Calibri", margin: 0 });
    s.addText(c.body, { x: 0.65, y: y + 0.88, w: 5.2, h: 1.05, fontSize: 10.5, color: C.cream, fontFace: "Calibri", margin: 2 });
    pmidTag(s, c.pmid, 4.1, y + 1.82);
  });

  // Arjuna
  s.addShape(pres.ShapeType.roundRect, {
    x: 6.9, y: 1.15, w: 6.1, h: 5.85,
    fill: { color: "142840" }, line: { color: C.gold, width: 0.5 }, rectRadius: 0.15
  });
  s.addText("Terminalia Arjuna", { x: 7.1, y: 1.25, w: 5.7, h: 0.45, fontSize: 20, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
  s.addText("Cardiac Tonic | Hridya Dravya", { x: 7.1, y: 1.68, w: 5.7, h: 0.28, fontSize: 10, color: C.cream, fontFace: "Calibri", margin: 0 });

  const arjunaCard = { pmid: "42277690", year: "2026 Jun", tier: 1, journal: "BMC Cardiovascular Disorders", title: "Network Meta-Analysis: Plant Extracts in Heart Failure", body: "Ejection fraction improved\nExercise tolerance increased\nArjuna among most studied cardiac herbs\nReview of multiple RCTs" };

  s.addShape(pres.ShapeType.roundRect, { x: 7.1, y: 2.08, w: 5.7, h: 2.1, fill: { color: "1A3658" }, line: { type: "none" }, rectRadius: 0.1 });
  evidenceBadge(s, 1, 7.25, 2.18);
  s.addText(arjunaCard.year + " | " + arjunaCard.journal, { x: 8.85, y: 2.18, w: 3.8, h: 0.26, fontSize: 9, color: C.teal, fontFace: "Calibri", margin: 0 });
  s.addText(arjunaCard.title, { x: 7.25, y: 2.53, w: 5.4, h: 0.38, fontSize: 12, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
  s.addText(arjunaCard.body, { x: 7.25, y: 2.96, w: 5.4, h: 1.05, fontSize: 10.5, color: C.cream, fontFace: "Calibri", margin: 2 });
  pmidTag(s, arjunaCard.pmid, 10.5, 3.78);

  // Arjuna clinical profile
  s.addText("Dose: 500 mg bark powder twice daily\nPreparation: Kshirpak (milk decoction)\nIndications: CHF, Angina, Hypertension, Cardiomyopathy\nSafety: Well-tolerated; check drug interactions", {
    x: 7.1, y: 4.35, w: 5.7, h: 2.3,
    fontSize: 11, color: C.cream, fontFace: "Calibri", margin: 8,
    fill: { color: "1F3A56" }
  });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 7 — KARELA & TULSI
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.cream);
  headerBar(s, "Karela & Tulsi — Diabetes & Infection", "Metabolic Control | Antiviral | Immunomodulatory");

  // Karela
  s.addShape(pres.ShapeType.roundRect, { x: 0.3, y: 1.15, w: 6.0, h: 5.85, fill: { color: C.darkGreen }, line: { type: "none" }, rectRadius: 0.15 });
  s.addText("Karela (Bitter Gourd)", { x: 0.5, y: 1.25, w: 5.6, h: 0.45, fontSize: 19, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
  s.addText("Momordica charantia | Anti-Diabetic", { x: 0.5, y: 1.68, w: 5.6, h: 0.28, fontSize: 10, color: C.teal, fontFace: "Calibri", margin: 0 });

  const kCards = [
    { pmid: "29431598", year: "2018", tier: 3, title: "RCT: Insulin Secretion in T2DM", body: "Beta cell stimulation confirmed\nFasting glucose reduced\nInsulin secretion improved" },
    { pmid: "32951763", year: "2020", tier: 3, title: "RCT: Hypoglycaemic Efficacy", body: "FBG & post-prandial glucose reduced\nHbA1c improvement noted\nWell tolerated" },
    { pmid: "38274207", year: "2024", tier: 1, title: "Systematic Review — Caution Note", body: "Studies heterogeneous — effect size variable\nNot standalone diabetes treatment\nUse as adjunct only with monitoring" },
  ];
  kCards.forEach((c, i) => {
    const y = 2.08 + i * 1.55;
    s.addShape(pres.ShapeType.roundRect, { x: 0.5, y, w: 5.6, h: 1.38, fill: { color: C.midGreen }, line: { type: "none" }, rectRadius: 0.1 });
    evidenceBadge(s, c.tier, 0.65, y + 0.08);
    s.addText(c.year, { x: 2.25, y: y + 0.08, w: 1, h: 0.26, fontSize: 9, color: C.teal, fontFace: "Calibri", margin: 0 });
    s.addText(c.title, { x: 0.65, y: y + 0.42, w: 5.3, h: 0.35, fontSize: 11.5, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
    s.addText(c.body, { x: 0.65, y: y + 0.8, w: 5.3, h: 0.48, fontSize: 9.5, color: C.cream, fontFace: "Calibri", margin: 1 });
    pmidTag(s, c.pmid, 4.2, y + 1.13);
  });

  // Tulsi
  s.addShape(pres.ShapeType.roundRect, { x: 7.0, y: 1.15, w: 6.0, h: 5.85, fill: { color: C.darkGreen }, line: { type: "none" }, rectRadius: 0.15 });
  s.addText("Tulsi (Holy Basil)", { x: 7.2, y: 1.25, w: 5.6, h: 0.45, fontSize: 19, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
  s.addText("Ocimum sanctum | Adaptogen, Antiviral, Respiratory", { x: 7.2, y: 1.68, w: 5.6, h: 0.28, fontSize: 10, color: C.teal, fontFace: "Calibri", margin: 0 });

  s.addText("Key Pharmacological Actions:", { x: 7.2, y: 2.1, w: 5.6, h: 0.35, fontSize: 13, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });

  const tulsiActions = [
    ["Antiviral", "Effective against H1N1, SARS-CoV-2 (in vitro + clinical)"],
    ["Adaptogen", "HPA axis modulation, cortisol reduction"],
    ["Antimicrobial", "Eugenol — broad spectrum antibacterial"],
    ["Anti-asthmatic", "Bronchodilation, mast cell stabilisation"],
    ["Immunomodulator", "NK cell & macrophage activation"],
    ["Antipyretic", "Fever reduction comparable to paracetamol in mild fever"],
  ];
  tulsiActions.forEach(([k, v], i) => {
    s.addShape(pres.ShapeType.roundRect, { x: 7.15, y: 2.55 + i * 0.73, w: 5.7, h: 0.62, fill: { color: C.midGreen }, line: { type: "none" }, rectRadius: 0.08 });
    s.addText(k, { x: 7.3, y: 2.6 + i * 0.73, w: 1.4, h: 0.5, fontSize: 10.5, bold: true, color: C.gold, valign: "middle", fontFace: "Calibri", margin: 0 });
    s.addText(v, { x: 8.75, y: 2.6 + i * 0.73, w: 4, h: 0.5, fontSize: 10, color: C.cream, valign: "middle", fontFace: "Calibri", margin: 2 });
  });

  s.addText("Dose: 10-20 ml fresh juice OR 500 mg dried leaf extract | Twice daily", {
    x: 7.15, y: 6.95, w: 5.7, h: 0.3,
    fontSize: 9.5, color: C.teal, fontFace: "Calibri", margin: 0, bold: true
  });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 8 — EVIDENCE SUMMARY TABLE
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.darkGreen);
  headerBar(s, "Evidence Summary — Quick Clinical Reference", "All entries: PubMed-indexed, peer-reviewed journals");

  const headers = ["Herb", "Condition", "Evidence Level", "Effect Size / Finding", "Dose", "PMID"];
  const rows = [
    ["Ashwagandha",   "Stress & Anxiety",    "Meta-Analysis",  "Cortisol -32%, PSS improved",     "300–600 mg/d",    "39348746"],
    ["Ashwagandha",   "Sleep Quality",       "Meta-Analysis",  "Sleep onset & quality improved",  "600 mg/d",        "34559859"],
    ["Curcumin",      "OA / RA",             "Meta-Analysis",  "VAS pain ↓, WOMAC ↓",             "500–1000 mg/d",   "35935936"],
    ["Curcumin",      "Inflammation (CRP)",  "Meta-Analysis",  "CRP -19%, IL-6 ↓, TNF-α ↓",       "500 mg/d",        "36804260"],
    ["Curcumin",      "Multiple (103 RCTs)", "Meta-Analysis",  "DM, obesity, liver, lipids — all improved", "Varies", "39478418"],
    ["Shatavari",     "PCOS",                "RCT 2026",       "Hormonal balance, FSH/LH improved","500 mg BID",      "41816216"],
    ["Shatavari",     "Lactation",           "RCT 2025",       "Prolactin ↑, milk production ↑",  "500 mg BID",      "41055223"],
    ["Shatavari",     "Menopause",           "RCT 2025",       "Vasomotor symptoms reduced",       "500 mg/d",        "40434025"],
    ["Guduchi",       "COVID / Immunity",    "Meta-Analysis",  "Fever duration ↓, CRP ↓",          "20 ml juice/d",   "38422192"],
    ["Brahmi",        "Cognition / Memory",  "Network Meta-A", "Working memory > Ginkgo biloba",   "300–450 mg/d",    "41678913"],
    ["Arjuna",        "Heart Failure",       "Systematic Rev", "Ejection fraction ↑",              "500 mg BID",      "42277690"],
    ["Karela",        "Type 2 Diabetes",     "RCT",            "FBG ↓, insulin secretion ↑",       "20 ml juice/d",   "32951763"],
  ];

  const colW  = [1.5, 1.8, 1.5, 3.0, 1.4, 1.0];
  const colX  = [0.25, 1.75, 3.55, 5.05, 8.05, 9.45];
  const rowH  = 0.39;
  const startY = 1.2;

  // Header
  headers.forEach((h, i) => {
    s.addShape(pres.ShapeType.rect, { x: colX[i], y: startY, w: colW[i], h: rowH, fill: { color: C.gold }, line: { type: "none" } });
    s.addText(h, { x: colX[i] + 0.05, y: startY + 0.04, w: colW[i] - 0.1, h: rowH - 0.08, fontSize: 9.5, bold: true, color: C.darkGreen, valign: "middle", fontFace: "Calibri", margin: 0 });
  });

  rows.forEach((row, ri) => {
    const y = startY + rowH + ri * rowH;
    const bg = ri % 2 === 0 ? "1F4D35" : "193D2A";
    row.forEach((cell, ci) => {
      s.addShape(pres.ShapeType.rect, { x: colX[ci], y, w: colW[ci], h: rowH, fill: { color: bg }, line: { type: "none" } });
      const isTier = ci === 2;
      const col = isTier && cell.includes("Meta") ? C.gold : isTier && cell.includes("RCT") ? C.teal : C.cream;
      s.addText(cell, { x: colX[ci] + 0.05, y: y + 0.03, w: colW[ci] - 0.1, h: rowH - 0.06, fontSize: 8.5, bold: isTier, color: col, valign: "middle", fontFace: "Calibri", margin: 0 });
    });
  });

  // Right of table - note
  s.addShape(pres.ShapeType.roundRect, {
    x: 10.6, y: 1.2, w: 2.4, h: 5.9,
    fill: { color: C.midGreen }, line: { type: "none" }, rectRadius: 0.12
  });
  s.addText("Evidence\nGrade Key", { x: 10.7, y: 1.3, w: 2.2, h: 0.55, fontSize: 12, bold: true, color: C.gold, align: "center", fontFace: "Calibri", margin: 0 });

  evidenceBadge(s, 1, 10.75, 1.95);
  s.addText("Systematic Review\nor Meta-Analysis\n= Highest Level", { x: 10.7, y: 2.3, w: 2.2, h: 0.85, fontSize: 9, color: C.cream, align: "center", fontFace: "Calibri", margin: 0 });

  evidenceBadge(s, 3, 10.75, 3.3);
  s.addText("Randomized\nControlled Trial\n= Strong Level", { x: 10.7, y: 3.65, w: 2.2, h: 0.85, fontSize: 9, color: C.cream, align: "center", fontFace: "Calibri", margin: 0 });

  s.addText("All studies\nNOT retracted.\nPubMed verified\nJune 2026.", { x: 10.7, y: 4.65, w: 2.2, h: 1.0, fontSize: 9, color: C.teal, align: "center", fontFace: "Calibri", margin: 0 });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 9 — CLINICAL PRESCRIBING GUIDE
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.cream);
  headerBar(s, "Clinical Prescribing Guide", "Indications, Doses & Cautions for Evidence-Based Ayurvedic Herbs");

  const data = [
    {
      herb: "Ashwagandha",
      latin: "Withania somnifera",
      indication: "Stress, Anxiety, Insomnia, Low stamina, Low testosterone",
      dose: "300–600 mg extract BD\n8–12 weeks",
      caution: "Avoid in pregnancy, hyperthyroid, autoimmune disease",
      col: C.darkGreen
    },
    {
      herb: "Curcumin",
      latin: "Curcuma longa",
      indication: "OA, RA, Metabolic syndrome, Inflammatory conditions",
      dose: "500–1000 mg extract BD\nWith piperine 5–10 mg",
      caution: "Caution in gallstones, blood thinners (warfarin interaction)",
      col: "7A5200"
    },
    {
      herb: "Shatavari",
      latin: "Asparagus racemosus",
      indication: "PCOS, Lactation, Menopause, Female infertility",
      dose: "500 mg extract BD\n12 weeks",
      caution: "Caution in oestrogen-sensitive conditions",
      col: "3A6B4A"
    },
    {
      herb: "Brahmi",
      latin: "Bacopa monnieri",
      indication: "Memory, Cognitive decline, Anxiety, ADHD support",
      dose: "300–450 mg extract OD\n12 weeks minimum",
      caution: "GI upset initially; reduce dose if nausea",
      col: "1A3A7A"
    },
    {
      herb: "Arjuna",
      latin: "Terminalia arjuna",
      indication: "Stable CHF, Angina, Cardiac weakness (adjunct)",
      dose: "500 mg bark powder BD\n(Kshirpak preferred)",
      caution: "Not monotherapy; check drug-herb interactions",
      col: "5A2A1A"
    },
    {
      herb: "Guduchi",
      latin: "Tinospora cordifolia",
      indication: "Immunity, Recurrent infections, Post-COVID recovery",
      dose: "400 mg extract BD\nOr 20 ml fresh juice",
      caution: "Theoretical autoimmune caution; monitor liver",
      col: "2A4A3A"
    },
  ];

  data.forEach((d, i) => {
    const col = i < 3 ? 0 : 1;
    const row = i % 3;
    const x = col === 0 ? 0.25 : 6.7;
    const y = 1.22 + row * 1.92;
    const w = 6.1;
    const h = 1.8;

    s.addShape(pres.ShapeType.roundRect, { x, y, w, h, fill: { color: d.col }, line: { type: "none" }, rectRadius: 0.12 });
    s.addText(d.herb, { x: x + 0.15, y: y + 0.1, w: 3.5, h: 0.38, fontSize: 15, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
    s.addText(d.latin, { x: x + 0.15, y: y + 0.45, w: 3.5, h: 0.25, fontSize: 9, color: "#AADDBB", italic: true, fontFace: "Calibri", margin: 0 });
    s.addText("Indication: " + d.indication, { x: x + 0.15, y: y + 0.72, w: 5.8, h: 0.38, fontSize: 9.5, color: C.cream, fontFace: "Calibri", margin: 0 });
    s.addText("Dose: " + d.dose, { x: x + 0.15, y: y + 1.1, w: 5.8, h: 0.35, fontSize: 9.5, bold: true, color: C.teal, fontFace: "Calibri", margin: 0 });
    s.addText("Caution: " + d.caution, { x: x + 0.15, y: y + 1.45, w: 5.8, h: 0.28, fontSize: 8.5, color: C.orange, fontFace: "Calibri", margin: 0 });
  });

  footerLine(s);
}

// ═══════════════════════════════════════════════════════════════
// SLIDE 10 — CONCLUSION / TAKE-HOME
// ═══════════════════════════════════════════════════════════════
{
  const s = pres.addSlide();
  slideBg(s, C.darkGreen);

  // decorative circles
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  s.addShape(pres.ShapeType.rect, { x: 0.5, y: 0.5, w: 0.08, h: 1.8, fill: { color: C.gold }, line: { type: "none" } });
  s.addText("Take-Home", { x: 0.8, y: 0.5, w: 9, h: 0.55, fontSize: 36, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
  s.addText("Key Messages for Clinicians", { x: 0.8, y: 1.05, w: 9, h: 0.45, fontSize: 22, color: C.cream, fontFace: "Calibri", margin: 0 });
  s.addText("Evidence-Based Ayurvedic Medicine", { x: 0.8, y: 1.5, w: 9, h: 0.35, fontSize: 16, color: C.teal, fontFace: "Calibri", margin: 0 });

  const msgs = [
    { n: "01", title: "Level 1 Evidence Exists", body: "Curcumin (103 RCTs) and Ashwagandha (3 Meta-Analyses) have evidence comparable to many pharmaceutical agents." },
    { n: "02", title: "Adjunct, Not Replacement", body: "Use as evidence-based adjunct therapy. Never discontinue prescribed medications without clinical evaluation." },
    { n: "03", title: "Dose & Duration Matter", body: "Standardised extracts at correct doses for 8-12 weeks are required for clinical effect — not culinary amounts." },
    { n: "04", title: "Check Interactions", body: "Curcumin + anticoagulants, Ashwagandha + thyroid drugs, Arjuna + cardiac drugs — always screen interactions." },
    { n: "05", title: "Latest Evidence — 2025/2026", body: "Shatavari PCOS (2026), Brahmi brain MRI (2026), Arjuna heart failure meta-analysis (2026 June) — field is rapidly evolving." },
  ];

  msgs.forEach((m, i) => {
    const x = i < 3 ? 0.4 + (i * 4.0) : 0.4 + ((i - 3) * 6.0);
    const y = i < 3 ? 2.1 : 5.0;
    const w = i < 3 ? 3.7 : 5.7;
    s.addShape(pres.ShapeType.roundRect, { x, y, w, h: 2.5, fill: { color: "1F4D35" }, line: { color: C.leafGreen, width: 0.4 }, rectRadius: 0.12 });
    s.addText(m.n, { x: x + 0.15, y: y + 0.12, w: 0.55, h: 0.55, fontSize: 22, bold: true, color: C.gold, fontFace: "Calibri", margin: 0 });
    s.addText(m.title, { x: x + 0.15, y: y + 0.7, w: w - 0.3, h: 0.45, fontSize: 12.5, bold: true, color: C.white, fontFace: "Calibri", margin: 0 });
    s.addText(m.body, { x: x + 0.15, y: y + 1.18, w: w - 0.3, h: 1.2, fontSize: 9.5, color: C.cream, fontFace: "Calibri", margin: 2 });
  });

  footerLine(s);
}

// ─── Write file ───────────────────────────────────────────────
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  .then(() => console.log("SUCCESS: Presentation saved."))
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