const pptxgen = require("pptxgenjs");

const pres = new pptxgen();
// Academic conference poster — use LAYOUT_WIDE (13.3" x 7.5") rotated to portrait-like wide format
// We'll use LAYOUT_WIDE as a landscape poster (common conference format)
pres.layout = "LAYOUT_WIDE";

// Color palette — deep navy dominates, teal accent, gold highlights
const C = {
  navy:    "0D2B45",   // dominant bg for header/footer
  teal:    "0F7173",   // section headers
  gold:    "F4A523",   // accent/icon color
  white:   "FFFFFF",
  light:   "EAF4F4",   // section bg
  midBg:   "D6EAF8",   // alternate section
  darkText:"1A1A2E",
  mutedText:"3D5A80",
  border:  "0F7173",
};

const slide = pres.addSlide();

// ── BACKGROUND ──────────────────────────────────────────────
slide.addShape(pres.ShapeType.rect, {
  x: 0, y: 0, w: 13.3, h: 7.5,
  fill: { color: C.white },
  line: { color: C.white },
});

// ── HEADER BAND ─────────────────────────────────────────────
slide.addShape(pres.ShapeType.rect, {
  x: 0, y: 0, w: 13.3, h: 1.2,
  fill: { color: C.navy },
  line: { color: C.navy },
});

// Gold accent bar
slide.addShape(pres.ShapeType.rect, {
  x: 0, y: 1.2, w: 13.3, h: 0.07,
  fill: { color: C.gold },
  line: { color: C.gold },
});

// Title
slide.addText("YOUNG SYNDROME", {
  x: 0.35, y: 0.05, w: 12.6, h: 0.6,
  fontSize: 36, bold: true, color: C.white,
  fontFace: "Calibri", align: "center",
  charSpacing: 4,
});

// Subtitle
slide.addText("Sinusitis-Infertility Syndrome  |  A Rare Inherited Triad", {
  x: 0.35, y: 0.66, w: 12.6, h: 0.38,
  fontSize: 14, bold: false, color: C.gold,
  fontFace: "Calibri", align: "center",
  italic: true,
});

// ── AUTHORS / INSTITUTION LINE ──────────────────────────────
slide.addText("Academic Poster Presentation  •  Department of Respiratory Medicine & Urology  •  2026", {
  x: 0.35, y: 1.25, w: 12.6, h: 0.22,
  fontSize: 9, color: C.mutedText, fontFace: "Calibri", align: "center",
  italic: true,
});

// ── COLUMN LAYOUT ───────────────────────────────────────────
// Three columns: col1 x=0.15 w=3.8 | col2 x=4.15 w=5.0 | col3 x=9.3 w=3.85
// All sections from y=1.55 to y=7.35

// Helper: section header
function sectionHeader(slide, pres, x, y, w, title, color) {
  slide.addShape(pres.ShapeType.rect, {
    x, y, w, h: 0.32,
    fill: { color: color || C.teal },
    line: { color: color || C.teal },
    rectRadius: 0.04,
  });
  slide.addText(title, {
    x: x + 0.08, y: y + 0.03, w: w - 0.16, h: 0.26,
    fontSize: 10.5, bold: true, color: C.white,
    fontFace: "Calibri", align: "left", margin: 0,
  });
}

// Helper: content box
function contentBox(slide, pres, x, y, w, h, bgColor) {
  slide.addShape(pres.ShapeType.rect, {
    x, y, w, h,
    fill: { color: bgColor || C.light },
    line: { color: "CBD5E0", size: 0.5 },
    rectRadius: 0.04,
  });
}

// ══════════════════════════════════════════════════════
// COLUMN 1 — Left  (x=0.15, w=3.9)
// ══════════════════════════════════════════════════════
const C1X = 0.15, C1W = 3.9;

// 1. INTRODUCTION
sectionHeader(slide, pres, C1X, 1.55, C1W, "📋  INTRODUCTION", C.navy);
contentBox(slide, pres, C1X, 1.88, C1W, 1.25, C.light);
slide.addText([
  { text: "Young Syndrome", options: { bold: true } },
  { text: " (also called ", options: {} },
  { text: "sinusitis-infertility syndrome", options: { italic: true } },
  { text: ") is a rare inherited condition first described in 1970 by D.A. Young. It is characterized by a classic triad:", options: {} },
], {
  x: C1X + 0.12, y: 1.9, w: C1W - 0.24, h: 0.38,
  fontSize: 9.5, fontFace: "Calibri", color: C.darkText,
});

// Triad boxes
const triadY = 2.3;
const boxes = [
  { label: "Bronchiectasis", sub: "Lower lobe predominant", icon: "🫁" },
  { label: "Sinusitis", sub: "Chronic / recurrent", icon: "👃" },
  { label: "Azoospermia", sub: "Obstructive type", icon: "♂" },
];
boxes.forEach((b, i) => {
  const bx = C1X + 0.1 + i * 1.26;
  slide.addShape(pres.ShapeType.rect, {
    x: bx, y: triadY, w: 1.2, h: 0.72,
    fill: { color: C.teal }, line: { color: C.teal }, rectRadius: 0.06,
  });
  slide.addText(b.icon, {
    x: bx, y: triadY + 0.02, w: 1.2, h: 0.28,
    fontSize: 14, align: "center", fontFace: "Calibri",
  });
  slide.addText(b.label, {
    x: bx, y: triadY + 0.28, w: 1.2, h: 0.2,
    fontSize: 8, bold: true, color: C.white,
    align: "center", fontFace: "Calibri",
  });
  slide.addText(b.sub, {
    x: bx, y: triadY + 0.48, w: 1.2, h: 0.18,
    fontSize: 7, color: C.gold,
    align: "center", fontFace: "Calibri",
  });
});

// 2. EPIDEMIOLOGY
sectionHeader(slide, pres, C1X, 3.15, C1W, "🌍  EPIDEMIOLOGY & ETIOLOGY", C.teal);
contentBox(slide, pres, C1X, 3.48, C1W, 1.2, "F0FFF4");
slide.addText([
  { text: "• ", options: {} }, { text: "Rare", options: { bold: true } }, { text: ": Primarily affects males; presents in 2nd–4th decade\n", options: {} },
  { text: "• ", options: {} }, { text: "Genetic basis", options: { bold: true } }, { text: ": Exact gene unknown; autosomal inheritance suspected\n", options: {} },
  { text: "• ", options: {} }, { text: "Mercury hypothesis", options: { bold: true } }, { text: ": Incidence declined after mercury (calomel) restrictions in teething powders in 1950s–60s\n", options: {} },
  { text: "• ", options: {} }, { text: "Prevalence", options: { bold: true } }, { text: ": Less common now vs. mid-20th century", options: {} },
], {
  x: C1X + 0.1, y: 3.5, w: C1W - 0.2, h: 1.14,
  fontSize: 9, fontFace: "Calibri", color: C.darkText, lineSpacingMultiple: 1.2,
});

// 3. PATHOPHYSIOLOGY
sectionHeader(slide, pres, C1X, 4.72, C1W, "⚙️  PATHOPHYSIOLOGY", C.teal);
contentBox(slide, pres, C1X, 5.05, C1W, 1.1, C.light);
slide.addText([
  { text: "• Not fully elucidated\n", options: {} },
  { text: "• ", options: {} }, { text: "Abnormal mucus viscosity", options: { bold: true } }, { text: " → impaired mucociliary clearance\n", options: {} },
  { text: "• Lungs are structurally normal at birth; thick viscous secretions cause damage over time\n", options: {} },
  { text: "• Ciliary ultrastructure is ", options: {} }, { text: "normal", options: { bold: true } }, { text: " (unlike Kartagener/PCD)\n", options: {} },
  { text: "• Epididymal obstruction by inspissated secretions → obstructive azoospermia", options: {} },
], {
  x: C1X + 0.1, y: 5.07, w: C1W - 0.2, h: 1.05,
  fontSize: 9, fontFace: "Calibri", color: C.darkText, lineSpacingMultiple: 1.2,
});

// 4. PROGNOSIS
sectionHeader(slide, pres, C1X, 6.19, C1W, "📈  PROGNOSIS", C.navy);
contentBox(slide, pres, C1X, 6.52, C1W, 0.74, "FFF8E7");
slide.addText([
  { text: "• Normal life expectancy in most cases\n", options: {} },
  { text: "• Lung function decline is ", options: {} }, { text: "slower than CF", options: { bold: true, color: "27AE60" } }, { text: "\n", options: {} },
  { text: "• Repeated sinopulmonary infections reduce quality of life\n", options: {} },
  { text: "• Lung function variation is independent of age at diagnosis", options: {} },
], {
  x: C1X + 0.1, y: 6.54, w: C1W - 0.2, h: 0.68,
  fontSize: 9, fontFace: "Calibri", color: C.darkText, lineSpacingMultiple: 1.2,
});


// ══════════════════════════════════════════════════════
// COLUMN 2 — Centre  (x=4.2, w=4.95)
// ══════════════════════════════════════════════════════
const C2X = 4.2, C2W = 4.95;

// 5. CLINICAL FEATURES
sectionHeader(slide, pres, C2X, 1.55, C2W, "🩺  CLINICAL FEATURES", C.navy);
contentBox(slide, pres, C2X, 1.88, C2W, 2.0, C.light);

// Sub-headers inside clinical features
const clinSections = [
  {
    title: "Respiratory",
    color: "1A6B8A",
    items: ["Chronic productive cough", "Recurrent lower respiratory infections", "Bronchiectasis (lower lobe predominant)", "Mild obstructive airways disease on PFTs", "Hyperinflated lungs on CXR"],
  },
  {
    title: "ENT",
    color: "8E44AD",
    items: ["Chronic rhinosinusitis", "Nasal polyps", "Recurrent sinusitis; frontal & maxillary sinus opacification"],
  },
  {
    title: "Reproductive",
    color: C.teal,
    items: ["Obstructive azoospermia", "Palpable epididymis & vas deferens (present)", "Normal testicular size & spermatogenesis", "Male infertility — primary presenting complaint in young adults"],
  },
];

let clinY = 1.9;
clinSections.forEach(sec => {
  slide.addText(sec.title.toUpperCase(), {
    x: C2X + 0.1, y: clinY, w: 0.8, h: 0.18,
    fontSize: 7.5, bold: true, color: sec.color, fontFace: "Calibri",
  });
  clinY += 0.18;
  sec.items.forEach(item => {
    slide.addText("▸  " + item, {
      x: C2X + 0.18, y: clinY, w: C2W - 0.3, h: 0.17,
      fontSize: 8.5, fontFace: "Calibri", color: C.darkText,
    });
    clinY += 0.17;
  });
  clinY += 0.04;
});

// 6. DIAGNOSIS
sectionHeader(slide, pres, C2X, 3.93, C2W, "🔬  DIAGNOSIS", C.teal);
contentBox(slide, pres, C2X, 4.26, C2W, 1.52, "EBF5FB");

// Diagnostic criteria table-like
const diagRows = [
  { test: "Clinical Triad", detail: "Bronchiectasis + Chronic sinusitis + Obstructive azoospermia" },
  { test: "Sweat Chloride Test", detail: "NEGATIVE — rules out cystic fibrosis (CF)" },
  { test: "Ciliary Function", detail: "NORMAL — rules out PCD / Kartagener syndrome" },
  { test: "Semen Analysis", detail: "Azoospermia with normal FSH & normal testicular size" },
  { test: "CT Chest", detail: "Cystic bronchiectasis; lower lobe predominance" },
  { test: "Sinus X-ray / CT", detail: "Central opacification of maxillary & frontal sinuses" },
  { test: "Genetic Testing", detail: "Homozygosity / compound heterozygosity (if available)" },
];

diagRows.forEach((row, i) => {
  const rowY = 4.28 + i * 0.2;
  const rowBg = i % 2 === 0 ? "D6EAF8" : "EBF5FB";
  slide.addShape(pres.ShapeType.rect, {
    x: C2X + 0.08, y: rowY, w: C2W - 0.16, h: 0.19,
    fill: { color: rowBg }, line: { color: "BDC3C7", size: 0.3 },
  });
  slide.addText(row.test, {
    x: C2X + 0.1, y: rowY + 0.01, w: 1.45, h: 0.17,
    fontSize: 8, bold: true, fontFace: "Calibri", color: C.navy,
  });
  slide.addText(row.detail, {
    x: C2X + 1.58, y: rowY + 0.01, w: C2W - 1.7, h: 0.17,
    fontSize: 8, fontFace: "Calibri", color: C.darkText,
  });
});

// 7. DIFFERENTIAL DIAGNOSIS
sectionHeader(slide, pres, C2X, 5.82, C2W, "⚖️  DIFFERENTIAL DIAGNOSIS", C.teal);
contentBox(slide, pres, C2X, 6.15, C2W, 1.12, "FFF0F0");

const diffDx = [
  { dx: "Cystic Fibrosis", diff: "Normal sweat chloride; no pancreatic insufficiency in Young Syndrome" },
  { dx: "PCD / Kartagener Syndrome", diff: "Ciliary ultrastructure is NORMAL in Young Syndrome; situs inversus absent" },
  { dx: "Idiopathic Bronchiectasis", diff: "No epididymal obstruction / azoospermia" },
];
diffDx.forEach((d, i) => {
  slide.addText([
    { text: "◆ " + d.dx + ": ", options: { bold: true, color: "C0392B" } },
    { text: d.diff, options: { color: C.darkText } },
  ], {
    x: C2X + 0.1, y: 6.17 + i * 0.34, w: C2W - 0.2, h: 0.3,
    fontSize: 8.5, fontFace: "Calibri",
  });
});


// ══════════════════════════════════════════════════════
// COLUMN 3 — Right  (x=9.3, w=3.85)
// ══════════════════════════════════════════════════════
const C3X = 9.3, C3W = 3.85;

// 8. MANAGEMENT
sectionHeader(slide, pres, C3X, 1.55, C3W, "💊  MANAGEMENT", C.navy);
contentBox(slide, pres, C3X, 1.88, C3W, 2.6, C.light);

const mgmtSections = [
  {
    title: "Pulmonary",
    color: "1A6B8A",
    items: [
      "Antibiotics for bacterial exacerbations",
      "Inhaled albuterol (bronchodilation)",
      "Hypertonic saline (airway clearance)",
      "Chest physiotherapy & postural drainage",
      "Smoking cessation (paramount)",
      "Influenza & pneumococcal vaccination",
    ],
  },
  {
    title: "Sinus",
    color: "8E44AD",
    items: [
      "Nasal saline irrigation",
      "Intranasal corticosteroids",
      "Functional endoscopic sinus surgery (FESS) if severe",
    ],
  },
  {
    title: "Fertility",
    color: C.teal,
    items: [
      "Epididymal sperm aspiration (PESA/MESA)",
      "Assisted reproductive techniques (ART/ICSI)",
      "Genetic counselling before fertility treatment",
      "Sperm retrieved from epididymis — normal morphology",
    ],
  },
];

let mgmtY = 1.9;
mgmtSections.forEach(sec => {
  slide.addText(sec.title.toUpperCase(), {
    x: C3X + 0.1, y: mgmtY, w: 3.5, h: 0.18,
    fontSize: 7.5, bold: true, color: sec.color, fontFace: "Calibri",
  });
  mgmtY += 0.18;
  sec.items.forEach(item => {
    slide.addText("▸  " + item, {
      x: C3X + 0.18, y: mgmtY, w: C3W - 0.3, h: 0.17,
      fontSize: 8.5, fontFace: "Calibri", color: C.darkText,
    });
    mgmtY += 0.17;
  });
  mgmtY += 0.05;
});

// 9. KEY COMPARISONS TABLE
sectionHeader(slide, pres, C3X, 4.52, C3W, "📊  COMPARISON WITH MIMICS", C.teal);
contentBox(slide, pres, C3X, 4.85, C3W, 1.42, "EBF5FB");

// Table header
const tblHdrY = 4.87;
const cols = [
  { label: "Feature", x: C3X + 0.08, w: 1.1 },
  { label: "Young", x: C3X + 1.2, w: 0.8 },
  { label: "CF", x: C3X + 2.02, w: 0.7 },
  { label: "PCD", x: C3X + 2.74, w: 0.9 },
];
cols.forEach(c => {
  slide.addShape(pres.ShapeType.rect, {
    x: c.x, y: tblHdrY, w: c.w, h: 0.2,
    fill: { color: C.navy }, line: { color: C.navy },
  });
  slide.addText(c.label, {
    x: c.x + 0.02, y: tblHdrY + 0.01, w: c.w - 0.04, h: 0.18,
    fontSize: 7.5, bold: true, color: C.white, fontFace: "Calibri", align: "center",
  });
});

const tblRows = [
  ["Sweat Cl⁻",     "Normal", "High",   "Normal"],
  ["Cilia",         "Normal", "Normal", "Abnormal"],
  ["Situs inversus","Absent",  "Absent", "50% present"],
  ["Male fertility","Infertile","Infertile","Infertile"],
  ["GI symptoms",   "Absent",  "Present","Absent"],
  ["Pancreas",      "Normal",  "Affected","Normal"],
];
tblRows.forEach((row, ri) => {
  const ry = tblHdrY + 0.21 + ri * 0.19;
  const bg = ri % 2 === 0 ? "D6EAF8" : "EBF5FB";
  cols.forEach((c, ci) => {
    slide.addShape(pres.ShapeType.rect, {
      x: c.x, y: ry, w: c.w, h: 0.18,
      fill: { color: bg }, line: { color: "BDC3C7", size: 0.3 },
    });
    const val = row[ci];
    const isYoungNormal = ci === 1 && val === "Normal";
    slide.addText(val, {
      x: c.x + 0.02, y: ry + 0.01, w: c.w - 0.04, h: 0.16,
      fontSize: 7.5, fontFace: "Calibri", align: "center",
      color: isYoungNormal ? "27AE60" : (ci === 0 ? C.navy : C.darkText),
      bold: ci === 0,
    });
  });
});

// 10. KEY PEARLS
sectionHeader(slide, pres, C3X, 6.31, C3W, "💡  CLINICAL PEARLS", C.gold.replace("#",""));
// Fix: use gold as bg properly
slide.addShape(pres.ShapeType.rect, {
  x: C3X, y: 6.31, w: C3W, h: 0.32,
  fill: { color: C.gold }, line: { color: C.gold }, rectRadius: 0.04,
});
slide.addText("💡  CLINICAL PEARLS", {
  x: C3X + 0.08, y: 6.34, w: C3W - 0.16, h: 0.26,
  fontSize: 10.5, bold: true, color: C.navy, fontFace: "Calibri", align: "left", margin: 0,
});
contentBox(slide, pres, C3X, 6.64, C3W, 0.7, "FFFACD");
slide.addText([
  { text: "★ ", options: { color: C.gold, bold: true } },
  { text: "No cure — management mirrors CF protocols\n", options: {} },
  { text: "★ ", options: { color: C.gold, bold: true } },
  { text: "Diagnosis often delayed by years — high index of suspicion in young men with infertility + chest symptoms\n", options: {} },
  { text: "★ ", options: { color: C.gold, bold: true } },
  { text: "Sperm retrieval is feasible — reproductive prognosis is not hopeless", options: {} },
], {
  x: C3X + 0.1, y: 6.66, w: C3W - 0.2, h: 0.64,
  fontSize: 8.5, fontFace: "Calibri", color: C.darkText, lineSpacingMultiple: 1.25,
});


// ── FOOTER ──────────────────────────────────────────────────
slide.addShape(pres.ShapeType.rect, {
  x: 0, y: 7.28, w: 13.3, h: 0.22,
  fill: { color: C.navy }, line: { color: C.navy },
});
slide.addText(
  "References: StatPearls (Mohammed & Jan, 2023) • Cihanbeylerden & Kurt, Eur Rev Med Pharmacol Sci 2022 • Murray & Nadel Respiratory Medicine • Smith & Tanagho General Urology",
  {
    x: 0.2, y: 7.29, w: 13.0, h: 0.19,
    fontSize: 6.5, color: "AABBC8", fontFace: "Calibri", align: "center",
  }
);

// Save
pres.writeFile({ fileName: "/home/daytona/workspace/young-syndrome-poster/Young_Syndrome_Poster.pptx" })
  .then(() => console.log("✅ Poster saved successfully."))
  .catch(err => console.error("❌ Error:", err));