I'll start with a quick overview while I consult the medical library for detailed information.

Quick Answer: Sacubitril/valsartan (Entresto) is an angiotensin receptor-neprilysin inhibitor (ARNI) used primarily for heart failure with reduced ejection fraction (HFrEF). Sacubitril inhibits neprilysin (preventing breakdown of natriuretic peptides), while valsartan blocks AT1 receptors. Together they reduce cardiac preload/afterload and have proven mortality benefit over ACE inhibitors in the landmark PARADIGM-HF trial.

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