Explain each and every line with reasons with details like you are giving a lecture. Also explain complicated terms that are written here explain as explain to non medico
| Type | Consciousness | Duration | Key Feature |
|---|---|---|---|
| Focal aware | INTACT | Variable | Jerking/sensory one side |
| Focal impaired | IMPAIRED | Variable | Automatisms (lip smacking) |
| Absence (petit mal) | Brief lapse | ~10 sec | Blank stare, 3Hz EEG, no postictal |
| Myoclonic | INTACT | Seconds | Quick jerks bilaterally |
| Tonic-clonic (grand mal) | LOST | 1-5 min | Stiffening → shaking, tongue bite, incontinence |
| Tonic | LOST | Seconds | Only stiffening, falls |
| Atonic | LOST | Seconds | Drop attacks, mistaken for fainting |
| Type | Location | Duration | Key Feature | Acute Treatment |
|---|---|---|---|---|
| Tension | Bilateral | 4-6 hrs | Bandlike, no nausea | NSAIDs |
| Migraine | Unilateral | 4-72 hrs | POUND mnemonic, aura | Triptans, NSAIDs |
| Cluster | Unilateral (eye) | 15min-3hr | Excruciating + autonomic + Horner | O₂, sumatriptan |
| Trigeminal neuralgia | Face (V2/V3) | Seconds | Lightning, triggered by touch | Carbamazepine |
| Disorder | Movement Type | Location of Lesion |
|---|---|---|
| Chorea | Rapid, dance-like | Basal ganglia |
| Athetosis | Slow, writhing | Basal ganglia |
| Hemiballismus | Wild flailing, one side | Contralateral subthalamic nucleus |
| Essential tremor | Action/postural | Cerebellar circuits |
| Resting tremor | Pill-rolling at rest | Substantia nigra (Parkinson's) |
| Intention tremor | Worsens near target | Cerebellum |
| Dystonia | Sustained posture | Basal ganglia |
| Disease | Key Features | Pathology |
|---|---|---|
| Alzheimer's | Memory first, gradual | Amyloid plaques + tau tangles |
| Parkinson's | TRAP symptoms | Lewy bodies (α-synuclein) |
| Huntington's | CAG repeat, age 30-50, chorea + psych | Loss of GABAergic neurons in caudate |
| Lewy Body | haLEWYcinations, fluctuating, REM sleep disorder | Cortical Lewy bodies |
| Frontotemporal | Personality first, language | Pick bodies / TDP-43 |
| Vascular | Step-wise decline | Multiple infarcts |
| CJD | Rapid (weeks), myoclonus | Prions, spongiform brain |
| Disease | Chromosome | Skin Sign | Brain Sign |
|---|---|---|---|
| Sturge-Weber | GNAQ (somatic) | Port-wine stain (face) | Leptomeningeal angioma, seizures |
| Tuberous Sclerosis | 9 (TSC1) or 16 (TSC2) | Ash-leaf spots, angiofibromas | Cortical tubers, seizures |
| NF1 | 17 | Café-au-lait, neurofibromas | Lisch nodules, optic glioma |
| NF2 | 22 | Minimal skin | Bilateral acoustic neuromas |
| VHL | 3 | None typical | Hemangioblastomas + RCC + pheo |