make a detailed ppt for md medicine level for pathological diseases in pregnancy including liver disease, thyroid disorders and heart diseases
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Pathological Diseases in Pregnancy
Presentation · PPTX
What's inside (16 slides, MD Medicine level)
Design: Navy/teal/gold color scheme, wide 16:9 format, two-column layouts, color-coded by section, comparison tables.
SECTION 1 — Liver Disease in Pregnancy (5 slides)
| Slide | Content |
|---|---|
| Liver Physiology | Biochemical changes table (↑ ALP, ↓ albumin, ↓ GGT, ↑ AFP), 3-category classification |
| ICP | Pathophysiology (ABCB4/ABCB11), Swansea bile acid thresholds, UDCA management, fetal surveillance |
| HELLP | Tennessee/Mississippi classification, microangiopathy, DIC/rupture complications, MgSO₄ + delivery |
| AFLP | LCHAD deficiency link, Swansea criteria (6 of 11), ICU management, perimortem delivery |
| Chronic Liver Disease | AIH (azathioprine safe), PBC, Hep B/C/E (HepE 20–25% mortality), cirrhosis/varices |
SECTION 2 — Thyroid Disorders in Pregnancy (4 slides)
| Slide | Content |
|---|---|
| Thyroid Physiology | TBG changes, hCG as TSH agonist, trimester-specific TSH reference intervals (ATA 2017) |
| Hypothyroidism | Hashimoto's, SCH 2–3%, LT4 targets, dose titration schedule, TPOAb risks |
| Hyperthyroidism/Graves | PTU in 1st trimester → switch to MMI, neonatal risk via TRAb, radioiodine contraindicated |
| Postpartum Thyroiditis | Biphasic pattern (thyrotoxic → hypothyroid), GTT vs Graves differentiation, screening debate |
SECTION 3 — Heart Disease in Pregnancy (5 slides)
| Slide | Content |
|---|---|
| CV Physiology | ↑50% plasma volume, ↑30–50% CO, peak at 28–30 wks; NYHA classification |
| WHO Risk Classification (table) | Class I–IV conditions, risk level, management intensity |
| Valvular Disease | MS (PMC preferred), AS (fixed obstruction = high risk), mechanical valves (warfarin dilemma), endocarditis prophylaxis |
| CHD + PPCM | Eisenmenger (contraindicated), Marfan aortic thresholds, PPCM (prolactin 16 kDa), bromocriptine |
| Delivery Management | Vaginal vs C-section trade-offs, obstetric drug hemodynamic effects, perimortem CS within 5 min |
Plus:
- Differential diagnosis comparison table (ICP vs HELLP vs AFLP vs Preeclampsia)
- Key take-home summary slide for all 3 systems
Sources: Yamada's Gastroenterology, Creasy & Resnik's Maternal-Fetal Medicine, Tietz Laboratory Medicine, Goldman-Cecil Medicine
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Pathological Diseases in Pregnancy
Presentation · PPTX
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Pathological Diseases in Pregnancy
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