Dose rate of milbimycin in dogs in case of ancylostoma caninum
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milbemycin oxime dose rate dogs Ancylostoma caninum hookworm
Here is a clear summary of the dose rate:
Milbemycin Oxime - Dose Rate in Dogs for Ancylostoma caninum
Standard Dose
0.5 mg/kg body weight, orally, once monthly
This is the established and well-validated dose. Multiple studies confirm its efficacy:
- At 500 micrograms/kg (0.5 mg/kg) PO, a single treatment achieves ~96.5% controlled efficacy against adult A. caninum, and two treatments (day 0 and day 30) achieve ~99.5% efficacy (PMID: 1429184).
- In naturally infected dogs, 0.5 mg/kg reduced adult worm burden from a mean of 56 worms to 1.3 worms - a 97.8% efficacy (PMID: 2316928).
Available Tablet Strengths (Interceptor/Milbemax)
| Tablet | Body weight range |
|---|---|
| 2.3 mg | 2-10 lb (approx 1-4.5 kg) |
| 5.75 mg | 11-25 lb (approx 5-11 kg) |
| 11.5 mg | 26-50 lb (approx 12-22 kg) |
| 23 mg | 51-100 lb (approx 23-45 kg) |
Key Points
- Route: Oral
- Frequency: Once monthly (for prevention and control)
- Minimum age: 4 weeks and minimum weight: 2 lbs (0.9 kg)
- Milbemycin oxime is approved for A. caninum treatment; note it lacks efficacy against Uncinaria stenocephala (the northern hookworm)
- Resistance of A. caninum to macrocyclic lactones (including milbemycin) has been reported in parts of Australia and more recently in the southeastern US - this is an emerging concern per Merck Veterinary Manual
- Common brand names: Interceptor, Milbemax, Trifexis, Sentinel, Sentinel Spectrum, Interceptor Plus
Off-label Higher Doses
For demodectic mange, milbemycin is used at much higher doses (1-2 mg/kg daily), but this is not relevant for hookworm treatment.
Summary: The dose rate of milbemycin oxime in dogs for Ancylostoma caninum is 0.5 mg/kg PO, given once monthly.
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