I now have all the information needed for a thorough interpretation. Here is a complete breakdown of this report:
Spirometry (PFT) Report Interpretation
Patient: Kanteshiya Chimanbhai Lakhmanbhai | 59 years, Male | Weight 57 kg, Height 157 cm | Non-smoker
Performed at: U N Mehta Hospital, Ahmedabad | Date: 08-Aug-2026
Ordered by: Dr. Keyuri H Patel | Performed by: Dr. Jil B Chokshi
Key Values at a Glance
| Parameter | Predicted | Measured | % of Predicted | Interpretation |
|---|
| FVC (Forced Vital Capacity) | 2.53 L | 2.60 L | 103% | Normal |
| FEV1 (Forced Exp. Vol. in 1 sec) | 1.91 L | 2.13 L | 112% | Normal |
| FEV1/FVC % | 75.49% | 81.92% | 109% | Normal |
| FEF 25-75% (Mid-expiratory flow) | 2.84 L/s | 2.20 L/s | 77% | Mildly reduced |
| PEFR (Peak Expiratory Flow Rate) | 7.26 L/s | 4.64 L/s | 64% | Reduced |
| FEF 25% | 7.04 L/s | 4.07 L/s | 58% | Reduced |
| FEF 50% | 4.71 L/s | 3.09 L/s | 66% | Reduced |
| FEF 75% | 1.76 L/s | 0.83 L/s | 47% | Reduced |
| Lung Age | 59 years | 52 years | 88% | Better than chronological age |
Overall Conclusion
The machine itself reports two findings:
- Spirometry within normal limits - FEV1/FVC %Pred is >95% and FVC %Pred is >80%, meaning there is no obstructive or restrictive ventilatory defect by standard criteria.
- Early Small Airway Obstruction - because FEF 25-75 %Pred (77%) and PEFR %Pred (64%) are both below 70%.
What This Means - Plain Language
The Big Airways Are Fine
The classic markers of airflow obstruction (FEV1/FVC ratio and FVC) are completely normal - in fact, slightly above predicted. This rules out typical COPD, asthma, or a restrictive lung disease (like pulmonary fibrosis) at this point in time.
The Small Airways Show Early Changes
The FEF 25-75% (also called the mid-expiratory flow or MMEF) reflects airflow through the smaller, peripheral airways (bronchioles). At 77% of predicted, it falls just below the 80% threshold. Combined with:
- FEF 25% at only 58% of predicted
- FEF 50% at 66% of predicted
- FEF 75% at 47% of predicted
...this creates a consistent picture of early/mild small airway dysfunction. This is the earliest detectable stage of airway disease - the large airways compensate and mask it until later stages.
PEFR is Low (64%)
The Peak Expiratory Flow Rate being at 64% may also reflect effort variability (PEFR is effort-dependent) and/or early airway narrowing. It should be interpreted alongside clinical symptoms.
Lung Age is 52 (Actual Age 59)
The calculated lung age is 7 years younger than his chronological age, suggesting his lung function is preserved relative to his age - a reassuring finding despite the small airway changes.
Clinical Significance
- This pattern of isolated small airway obstruction with normal FEV1/FVC is seen in the earliest stage of smoking-related lung disease, occupational exposures, or as an incidental finding. Notably, this patient is listed as a non-smoker, so other causes (indoor air pollution, biomass fuel exposure, occupational dust, recurrent infections) should be considered if clinically relevant.
- This finding alone does not constitute COPD or asthma - it is a preclinical or early warning signal.
- The COPD severity grid on the report (which plots FEV1% vs FEV1/FVC%) shows the patient falls within the normal range, not in the moderate/severe/very severe COPD zones.
- As Dr. Jil notes: "KINDLY CORRELATE CLINICALLY" - this result should be interpreted in the context of symptoms (cough, breathlessness, wheeze), exposure history, and physical examination.
Recommended Next Steps (to be discussed with the treating doctor)
- Clinical correlation - Does the patient have any cough, wheeze, or breathlessness? The report is most meaningful when matched against symptoms.
- Bronchodilator reversibility test (if not already done) - Only pre-bronchodilator values were recorded (Post columns are blank). A post-bronchodilator test would help identify if the small airway changes are reversible (suggesting asthma-type physiology).
- Follow-up spirometry in 6-12 months to track progression.
- Exposure history review - Check for occupational or indoor exposures that could explain early small airway changes in a non-smoker.
Source: Murray & Nadel's Textbook of Respiratory Medicine - interpretation framework for PFT patterns. This is a general educational interpretation and does not replace clinical judgment by the treating physician.