Usually, metoprolol succinate should not be stopped suddenly, particularly if it has been taken regularly for more than a few days or if the patient has angina, coronary artery disease, prior heart attack, or heart failure.
Abrupt withdrawal can cause rebound sympathetic activity:
rapid pulse, raised blood pressure, return or worsening of palpitations/angina, and rarely myocardial infarction. Product labeling advises reducing it
gradually over about 1 to 2 weeks when possible. The
official prescribing information specifically warns about abrupt cessation.
Exception: if the prescriber told the patient to stop immediately because of a serious problem such as very low pulse, fainting, marked low blood pressure, worsening heart block, severe wheeze, or an acute adverse effect, follow that prescriber’s explicit instruction and contact them promptly to confirm the plan.
For this patient with frequent PVCs/bigeminy, do not assume that stopping metoprolol is automatically appropriate. Metoprolol often suppresses palpitations/PVCs, though it may be stopped for another reason such as bradycardia or intolerance. Ask the prescribing clinician today for a specific tapering schedule based on the current dose, duration of treatment, reason it was prescribed, pulse, and blood pressure.
Seek urgent care if chest pain, fainting, severe shortness of breath, sustained fast heartbeat, or severe dizziness occurs.