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SMT NHL MUNICIPAL COLLEGE - PEDIATRICS INTERNAL EXAM
SECTION 1
QUESTION 1 (10 marks) - Write ANY ONE in detail
Option 1: Respiratory Distress in Newborn + RDS in Preterm
Causes of Respiratory Distress in Newborn:
- Pulmonary: RDS (Hyaline Membrane Disease), Transient Tachypnea of Newborn (TTN), Meconium Aspiration Syndrome (MAS), Pneumonia, Pneumothorax, Congenital lung malformations
- Cardiac: Cyanotic CHD, cardiac failure
- Others: Metabolic acidosis, hypothermia, polycythemia, CNS depression, diaphragmatic hernia
RDS in Preterm - Aetiology:
- Deficiency of surfactant (produced by Type II pneumocytes after 34 weeks)
- More common in <34 weeks gestation, LBW, maternal diabetes, male sex, C-section without labor, perinatal asphyxia
Pathophysiology:
- Surfactant deficiency → increased alveolar surface tension → alveolar collapse (atelectasis) → V/Q mismatch → hypoxia + hypercapnia → acidosis → pulmonary vasoconstriction → protein-rich fluid leaks into alveoli forming hyaline membranes → worsening hypoxia (vicious cycle)
Clinical Features:
- Onset within 4-6 hours of birth
- Tachypnea (>60/min), grunting, nasal flaring, subcostal/intercostal retractions, cyanosis
- Chest X-ray: Ground-glass appearance, air bronchograms, reduced lung volume, "white-out" in severe cases
Management:
- Antenatal: Betamethasone/Dexamethasone to mother (34 weeks), accelerates surfactant production
- Oxygen: Warmed humidified O2; target SpO2 91-95%
- CPAP: First-line respiratory support (nasal CPAP 5-7 cm H2O)
- Surfactant therapy: Natural surfactant (Poractant alfa/Beractant) via ET tube - within 2 hours of birth (INSURE technique: Intubate-Surfactant-Extubate to CPAP)
- Mechanical ventilation: If CPAP fails
- Supportive: Thermoregulation, IV fluids, antibiotics (Ampicillin + Gentamicin), correct acidosis, maintain glucose
Option 2: Neonatal Jaundice (10 marks)
Causes of Neonatal Jaundice:
Physiological: Normal; appears day 2-3, peaks day 4-5, resolves by day 7 (term) or day 14 (preterm)
Pathological causes:
- Increased production: Hemolytic disease (Rh/ABO incompatibility), G6PD deficiency, hereditary spherocytosis, polycythemia
- Decreased conjugation: Crigler-Najjar syndrome, Gilbert syndrome, hypothyroidism
- Increased enterohepatic circulation: Pyloric stenosis, intestinal obstruction
- Infection: Sepsis, TORCH infections
- Cholestasis: Biliary atresia, neonatal hepatitis (conjugated hyperbilirubinemia)
- Breast milk jaundice (prolonged, after day 5)
Pathophysiology of Physiological Jaundice:
- Neonates have higher RBC mass with shorter RBC lifespan (70-90 days vs 120 days) → more bilirubin produced
- Immature liver with low UDP-glucuronosyltransferase activity → poor conjugation
- Increased enterohepatic circulation (beta-glucuronidase in gut deconjugates bilirubin)
- Low albumin binding capacity
- Result: Unconjugated (indirect) hyperbilirubinemia - peaks then resolves as enzyme activity matures
Treatment Modalities:
| Method | Indication | Details |
|---|
| Phototherapy | TSB >15 mg/dL (term), lower threshold for preterm | Blue-green light (450-490 nm wavelength) converts bilirubin to water-soluble lumirubin; expose maximum skin area |
| Exchange Transfusion | TSB >25 mg/dL or rising >0.5 mg/dL/hr despite phototherapy; signs of acute bilirubin encephalopathy | Double volume (160-200 mL/kg); removes sensitized RBCs + antibodies in hemolytic disease |
| IVIG | Rh/ABO incompatibility | Reduces need for exchange transfusion |
| Treat underlying cause | Sepsis → antibiotics; hypothyroidism → thyroxine | - |
| Adequate feeding | Reduces enterohepatic circulation | Encourage breastfeeding 8-12 times/day |
QUESTION 2 (12 marks) - Write ANY TWO short notes (6 marks each)
Q2.1: 3-year-old with bow legs and wrist widening - Rickets
Radiological Features on X-ray:
- Widening, fraying, cupping, and splaying of metaphysis (especially distal radius/ulna and distal femur/proximal tibia)
- Indistinct zone of provisional calcification
- Widened epiphyseal growth plate
- Osteoporosis / reduced bone density
- Looser zones (pseudofractures) in severe cases
- Bow legs (genu varum) in toddlers
Treatment:
- Nutritional Rickets (Vit D deficiency - most common):
- Vitamin D: 1,000-5,000 IU/day orally for 3 months OR single stoss therapy (600,000 IU once)
- Calcium: 500-1000 mg/day (milk, calcium supplements)
- Sun exposure: 30 min/day
- Maintenance: 400 IU/day thereafter
- Dietary advice: Dairy products, eggs, fortified foods
- Orthopedic: Bracing for severe deformity; surgery (corrective osteotomy) only after metabolic correction
Q2.2: 10-year-old with fever, vomiting, jaundice for 5 days
Most Likely Diagnosis: Hepatitis A (Acute viral hepatitis A)
Investigations:
- Confirmatory: Anti-HAV IgM antibody (positive in acute infection)
- LFT: Elevated ALT/AST (>10x normal), elevated bilirubin (predominantly conjugated/direct)
- CBC: Leukopenia with relative lymphocytosis
- USG abdomen: Hepatomegaly, periportal edema
- PT/INR (assess severity/fulminant hepatitis)
- Urine: Bile salts and pigments positive
Management:
- No specific antiviral therapy
- Rest, adequate nutrition, high carbohydrate diet
- IV fluids if vomiting prevents oral intake
- Avoid hepatotoxic drugs (paracetamol high doses, NSAIDs)
- Monitor for fulminant hepatic failure (encephalopathy, coagulopathy)
- Isolation precautions: Enteric precautions, hand hygiene
- Indications for hospitalization: Encephalopathy, INR >1.5, severe vomiting, dehydration
- Prognosis: Excellent; self-limiting in 4-8 weeks; no chronicity
Q2.3: Vitamin A Deficiency - WHO Staging + National Control Programme
WHO Staging (Xerophthalmia Classification):
| Stage | Features |
|---|
| XN | Night blindness |
| X1A | Conjunctival xerosis |
| X1B | Bitot's spots |
| X2 | Corneal xerosis |
| X3A | Corneal ulceration <1/3 cornea |
| X3B | Keratomalacia (ulceration >1/3 cornea) |
| XS | Corneal scar |
| XF | Xerophthalmic fundus |
X1B and beyond = active VAD requiring treatment
National Control Programme (for 11-month-old child):
Under National Programme for Prevention of Nutritional Blindness (NPPNB):
- 9 months: Vitamin A 1 lakh IU (100,000 IU) with measles vaccine
- 16-18 months: 2 lakh IU (200,000 IU) with DPT booster
- Every 6 months thereafter up to 5 years: 2 lakh IU
- For an 11-month-old: Give 1st dose of 1 lakh IU now if not given at 9 months
- Dietary diversification: Green leafy vegetables, yellow fruits, eggs, dairy
- ICDS, ANM, ASHA-based delivery of supplements
QUESTION 3 (18 marks) - Write ANY THREE short notes (6 marks each)
Q3.1: Neonatal Hypoglycemia - Causes and Management
Definition: Blood glucose <45 mg/dL (2.5 mmol/L) in neonates
Causes:
- Inadequate substrate: LBW/SGA/prematurity, poor feeding, delayed feeding
- Hyperinsulinism: IDM (Infant of Diabetic Mother), Rh hemolytic disease, Beckwith-Wiedemann syndrome, nesidioblastosis
- Increased utilization: Perinatal asphyxia, hypothermia, sepsis, polycythemia, respiratory distress
- Endocrine: Congenital hypopituitarism, cortisol deficiency, growth hormone deficiency
- Inborn errors of metabolism: Galactosemia, MSUD, fatty acid oxidation defects
Management:
Asymptomatic:
- Blood glucose 25-45 mg/dL: Oral/NGT feeds; recheck in 1 hour
- If not responding: IV Dextrose 10% at 5-8 mg/kg/min GIR (Glucose Infusion Rate)
Symptomatic (jitteriness, seizures, apnea, lethargy):
- IV Dextrose 10% bolus: 2 mL/kg over 5-10 minutes
- Followed by continuous infusion at 6-8 mg/kg/min
- Recheck every 30-60 min; titrate infusion
Refractory:
- Hydrocortisone 5 mg/kg/day (decreases glucose utilization)
- Glucagon 0.3 mg/kg IM (useful in IDM)
- Diazoxide (persistent hyperinsulinism)
Goals: Maintain glucose >45 mg/dL; avoid hyperosmolar solutions; screen at-risk babies
Q3.2: Breastfeeding Counselling - Antenatal and Post-Natal
Antenatal Counselling:
- Explain benefits of breastfeeding: Best nutrition, immune protection (IgA), reduces infections (diarrhea, ARI), bonding, reduces SIDS, maternal benefits (uterine involution, ovulation suppression, reduced breast cancer risk)
- Initiation within 30-60 minutes of birth (early initiation)
- Reassure about milk sufficiency; address myths
- Breast examination - inverted nipples: Can be corrected by Hoffman technique or nipple shield
- Importance of colostrum (first milk - yellow, thick, rich in antibodies and Vitamin A)
- Counsel about exclusive breastfeeding for 6 months
Post-Natal Counselling:
- Positioning and attachment: Cradle hold; baby's mouth covers most of areola, not just nipple; chin touching breast
- Feed on demand - 8-12 times/day; both breasts each feed
- Signs of adequate feeding: 6-8 wet diapers/day, satisfactory weight gain (25-30 g/day)
- Exclusive breastfeeding for 6 months, then continue with complementary foods up to 2 years
- Manage common problems: Engorgement (frequent feeding, warm compress), sore nipples (correct latch, leave breast milk on nipple to dry), mastitis (continue feeding, antibiotics)
- Working mothers: Expression and storage of breast milk (refrigerator 72 hrs, freezer 3 months)
Q3.3: Adolescence - Definition and Health Problems
Definition:
Adolescence is the transitional period between childhood and adulthood, defined by WHO as 10-19 years of age. Early adolescence: 10-13 yrs; Middle: 14-16 yrs; Late: 17-19 yrs.
General Health Problems in Adolescence:
-
Nutritional problems: Iron deficiency anemia (especially girls - menstruation), obesity, eating disorders (anorexia nervosa, bulimia), undernutrition
-
Reproductive health: Menstrual disorders (dysmenorrhea, irregular cycles), early pregnancy, STIs, PCOD
-
Mental health: Depression, anxiety, stress, suicidal ideation, body image issues, eating disorders
-
Substance abuse: Tobacco, alcohol, drugs (gateway: peer pressure)
-
Injuries and violence: Road traffic accidents (highest cause of death in adolescents globally), physical/sexual abuse
-
Skin problems: Acne vulgaris (androgen-driven, sebaceous gland hypertrophy)
-
Musculoskeletal: Osgood-Schlatter disease, scoliosis
-
Behavioral issues: Risk-taking behavior, school dropout, delinquency
-
PCOD, thyroid disorders, type 2 diabetes (rising due to obesity)
National Programme: RKSK (Rashtriya Kishor Swasthya Karyakram) - addresses nutrition, sexual/reproductive health, mental health, substance abuse, injuries, NCDs
Q3.4: Tanner Staging in Females
Tanner stages describe pubertal development. In females, assessed by breast development and pubic hair.
Breast Development (B):
| Stage | Features | Age (approx) |
|---|
| B1 | Pre-pubertal; no glandular tissue | <8 yrs |
| B2 | Breast bud; elevation of breast and papilla | 8-13 yrs (thelarche) |
| B3 | Further enlargement; breast and areola form single mound | 10-14 yrs |
| B4 | Areola and papilla project above breast contour (double mound) | 11-15 yrs |
| B5 | Adult breast; areola recedes to level of breast | 12-18 yrs |
Pubic Hair (PH):
| Stage | Features |
|---|
| PH1 | Pre-pubertal; no pubic hair |
| PH2 | Sparse, slightly pigmented hair along labia |
| PH3 | Darker, coarser, curly hair over pubis |
| PH4 | Adult type but not spread to medial thigh |
| PH5 | Adult distribution including medial thighs |
Sequence in girls: Thelarche (B2) → Pubarche → Peak height velocity → Menarche (average B3-B4, ~12.5 yrs)
- Entire process: 2-5 years
- Adrenarche (axillary hair, body odor) occurs around PH2-PH3
QUESTION 4 (10 marks) - ANY FIVE in 2-3 sentences each (2 marks each)
Q4.1: Microcephaly and its Causes
Microcephaly is defined as head circumference >2 SD below the mean for age and sex (some define >3 SD as severe). It reflects reduced brain growth and is associated with intellectual disability.
Causes:
- Primary (genetic): Autosomal recessive microcephaly (MCPH genes), chromosomal abnormalities (Down syndrome, trisomy 13/18), Angelman syndrome
- Secondary (acquired): TORCH infections (CMV most common, Zika virus, rubella, toxoplasmosis), perinatal hypoxia-ischemia, meningitis/encephalitis, metabolic (PKU, untreated hypothyroidism), craniosynostosis (secondary), fetal alcohol syndrome, radiation exposure
Q4.2: Components of Moro's Reflex
Moro (startle) reflex is elicited by sudden head extension or a loud noise, present from birth to 4-5 months. It has three components:
- Abduction and extension of arms with opening of hands (spreading of fingers)
- Adduction of arms (embracing movement, arms come together)
- Cry (may or may not be present)
Absence = neuromuscular disease or birth injury; asymmetric = brachial plexus palsy or fractured clavicle.
Q4.3: 4 Red Flag Signs in Child Development
Red flags indicate developmental delay and warrant urgent evaluation:
- No social smile by 3 months
- No babbling / monosyllables by 12 months (or loss of language at any age)
- Not walking independently by 18 months
- Not using 2-word meaningful phrases by 24 months
Additional flags: hand dominance before 18 months, regression of milestones at any age.
Q4.4: Rotavirus Vaccine
Rotavirus is the most common cause of severe dehydrating diarrhea in children under 5 years. Two vaccines are available in India:
- Rotavac (116E strain): Indigenous Indian vaccine; 3 doses at 6, 10, 14 weeks (oral); included in UIP India
- Rotarix (RV1): 2 doses at 6 and 14 weeks; RotaTeq (RV5): 3 doses at 2, 4, 6 months
Both are oral live attenuated vaccines. Contraindication: SCID, history of intussusception.
Q4.5: Age-Independent Anthropometric Parameters
These measurements are independent of age and are used to assess nutritional status when age is unknown:
- MUAC (Mid-Upper Arm Circumference): <11.5 cm = SAM; 11.5-12.5 cm = MAM; >12.5 cm = normal (for children 6 months - 5 years)
- Triceps Skinfold Thickness
- Subscapular Skinfold Thickness
- Weight-for-Height (WHZ score)
MUAC is the most practical field tool and is age-independent from 6 months to 5 years.
Q4.6: 4 Causes of High Anion Gap Metabolic Acidosis
Anion Gap = Na - (Cl + HCO3); normal = 8-12 mEq/L. High AG = unmeasured anions accumulating.
Mnemonic - MUDPILES:
- M - Methanol poisoning
- U - Uremia (renal failure)
- D - Diabetic ketoacidosis (DKA)
- P - Paracetamol / Propylene glycol
- L - Lactic acidosis (sepsis, tissue hypoxia)
- I - Isoniazid / Iron poisoning
- S - Salicylate poisoning
SECTION 2
QUESTION 5 (10 marks) - Write ANY ONE in detail
Option 1: Principles of Development and Milestones up to 2 years
Principles of Development:
- Development is continuous but not uniform (spurts occur)
- Proceeds in a cephalocaudal direction (head → foot)
- Proceeds in a proximodistal direction (trunk → periphery)
- From general to specific movements
- Sequential and predictable order
- Differentiation before integration
- Each child follows the same sequence but at their own pace
- Earlier development influences later development
- Critical/sensitive periods exist for certain functions (language, vision)
- Genetic, environmental (nutrition, stimulation, SES) and biological factors interact
Developmental Milestones up to 2 years:
| Age | Gross Motor | Fine Motor | Language | Social/Adaptive |
|---|
| 1 month | Raises chin prone | Follows to midline | Startles to sound | Regards face |
| 3 months | Head steady; lifts chest prone | Holds rattle briefly | Cooing | Social smile |
| 6 months | Sits with support; rolls over | Palmar grasp; transfers hand to hand | Babbling (ba, ma) | Recognizes mother; stranger anxiety begins |
| 9 months | Sits without support; crawls | Pincer grasp (immature) | "Mama/Dada" (non-specific) | Waves bye-bye; object permanence |
| 12 months | Stands alone; walks with support | Mature pincer grasp | 1-2 words with meaning | Imitates; gives objects |
| 15 months | Walks alone | Scribbles | 4-6 words | Shows wants by pointing |
| 18 months | Runs; climbs stairs (both feet/step) | Tower of 3-4 cubes; turns pages | 10+ words; jargon | Domestic mimicry; spoon feeding |
| 24 months | Runs well; up/down stairs | Tower of 6 cubes; vertical stroke | 2-3 word phrases; 50+ words | Parallel play; pulls on clothing |
Memory aid: At 3-6-9-12: Head steady / Sits with support / Stands with support / Walks with support
Option 2: SAM/PEM - Definition, Classification, Management, Prevention
Definition of SAM:
SAM = Severe Acute Malnutrition. Any one of:
- WHZ (Weight-for-Height Z-score) < -3 SD (WHO standards)
- MUAC < 11.5 cm (6 months - 5 years)
- Bilateral pitting pedal edema (nutritional = Kwashiorkor)
- WFA (Weight-for-Age) < -3 SD (used in field settings)
Classification of PEM (Protein Energy Malnutrition):
Clinical Classification (Wellcome Trust):
| Weight-for-Age | No Edema | With Edema |
|---|
| 60-80% | Underweight | Kwashiorkor |
| <60% | Marasmus | Marasmic-Kwashiorkor |
WHO Z-score Classification:
- Moderate Acute Malnutrition (MAM): WHZ -3 to -2 SD or MUAC 11.5-12.5 cm
- SAM: WHZ <-3 SD or MUAC <11.5 cm or edema
Clinical Features:
- Marasmus: Severe wasting, skin over bones appearance, "old man face," loss of buccal fat pad (Bichat's fat pad), irritable, alert, no edema, ravenous appetite
- Kwashiorkor: Edema (starts feet → legs → face), moon face, sparse reddish discoloured hair (flag sign), "flaky paint" dermatosis, hepatomegaly (fatty liver), apathetic, no appetite
WHO 10-Step Management of SAM:
Phase 1 (Stabilization - Days 1-7): Treat/prevent complications
- Treat/prevent HYPOGLYCEMIA (10% glucose NGT or D10% IV if unconscious)
- Treat/prevent HYPOTHERMIA (warm environment, skin-to-skin, warm feeds)
- Treat/prevent DEHYDRATION (ReSoMal solution - not standard ORS)
- Correct ELECTROLYTE imbalance (K, Mg supplementation; avoid Na)
- Treat/prevent INFECTION (Amoxicillin for all SAM children; add Gentamicin if severely ill)
- Correct MICRONUTRIENT deficiencies (Vit A, Zinc, Folic acid, multivitamins; IRON only in rehabilitation phase)
- Start CAUTIOUS FEEDING (F-75 formula: 75 kcal/100 mL; 130 mL/kg/day)
- Achieve CATCH-UP GROWTH
- Provide SENSORY STIMULATION (play, activities)
- Prepare for FOLLOW-UP
Phase 2 (Rehabilitation - Weeks 2-6):
- Transition from F-75 to F-100 (100 kcal/100 mL)
- Increase gradually to 150-220 kcal/kg/day
- RUTF (Ready-to-Use Therapeutic Food = Plumpy'Nut): 500 kcal/day
- Iron supplementation started here
- Sensory stimulation, play therapy, mother education
Preventive Measures:
- Promote exclusive breastfeeding for 6 months + timely complementary feeding
- ICDS (Integrated Child Development Services): Supplementary nutrition, growth monitoring
- Vitamin A supplementation program
- Immunization (prevents infections leading to malnutrition)
- POSHAN Abhiyan (National Nutrition Mission)
- Growth monitoring with Road-to-Health chart (weight faltering detection)
- MAM management with RUTF in community (CMAM - Community-based Management)
- Sanitation, safe water (WASH programs)
- Mother literacy and education
QUESTION 6 (12 marks) - Write ANY TWO short notes (6 marks each)
Q6.1: Dehydration Classification + Fluid Management (WHO)
Clinical Scenario: 1-year-old child with profuse diarrhea - lethargic and unable to drink
Classification:
Based on WHO IMCI guidelines:
| Feature | No Dehydration | Some Dehydration | Severe Dehydration |
|---|
| General | Well, alert | Restless, irritable | Lethargic/unconscious |
| Eyes | Normal | Sunken | Very sunken |
| Drinking | Normal | Drinks eagerly | Unable to drink |
| Skin pinch | Normal | Goes back slowly | Goes back very slowly |
This child = SEVERE DEHYDRATION (lethargic + unable to drink)
WHO Fluid Management:
Plan C (Severe Dehydration):
- If can drink: ORS 20 mL/kg/hr orally/NGT for 4-6 hours
- IV fluids preferred: Ringer's Lactate (or normal saline):
- <12 months: 30 mL/kg IV over 1 hour, then 70 mL/kg over 5 hours
- >12 months: 30 mL/kg IV over 30 min, then 70 mL/kg over 2.5 hours
- Reassess every 15-30 min
- Once alert/can drink: Start ORS
- Continue feeding (breastfeeding throughout)
- Zinc supplementation: 10 mg/day (<6 months) or 20 mg/day (>6 months) for 14 days
Q6.2: Malaria - Differential Diagnosis, Investigations, Treatment
Differential Diagnoses for Fever + Chills + Splenomegaly:
- Malaria (most likely)
- Typhoid fever (enteric fever)
- Viral hepatitis
- Infective endocarditis
- Kala-azar (visceral leishmaniasis - prolonged fever, massive splenomegaly)
- Hemolytic anemia (sickle cell, thalassemia)
- Lymphoma / leukemia
- Brucellosis
Investigations for Malaria:
- Peripheral blood smear (thick and thin film): Gold standard; identifies species and parasite density
- Rapid Diagnostic Test (RDT): HRP-2 antigen (P. falciparum), pLDH antigen (P. vivax) - quick bedside test
- CBC: Anemia, thrombocytopenia, leukopenia
- LFT, RFT (assess organ involvement)
- Blood sugar (hypoglycemia in P. falciparum)
- Blood culture (rule out typhoid/bacteremia)
Treatment:
-
Uncomplicated P. vivax:
- Chloroquine 25 mg/kg over 3 days (10 + 10 + 5 mg/kg) + Primaquine 0.25 mg/kg/day × 14 days (after G6PD test)
-
Uncomplicated P. falciparum (per NVBDCP India):
- Artemisinin-based Combination Therapy (ACT): Artesunate + Lumefantrine OR Arterakine (AS + SP) × 3 days
- Primaquine single dose (0.75 mg/kg) to clear gametocytes
-
Severe/Complicated Malaria (P. falciparum):
- IV Artesunate 2.4 mg/kg at 0, 12, 24 hrs, then daily
- If not available: IV Quinine (loading dose 20 mg/kg in dextrose saline over 4 hrs, then 10 mg/kg 8-hourly)
- Treat complications: IV dextrose (hypoglycemia), transfusion (severe anemia Hb <5), anticonvulsants (cerebral malaria), dialysis (renal failure)
Q6.3: Catch-up Immunization for 9-month-old + AEFI
Scheduled vaccines missed: 6 weeks and 10 weeks
Vaccines due at 6 weeks: DTwP1, IPV1, HepB2 (if given at birth and 6wks), Hib1, PCV1, Rotavirus1
Vaccines due at 10 weeks: DTwP2, IPV2, Hib2, PCV2, Rotavirus2
Catch-up at 9 months (along with due vaccines: MR/MMR, Vit A, JE if applicable):
Principle: Minimum intervals must be maintained
- DTwP/IPV/Hib/PCV: Minimum interval = 4 weeks between doses
- At 9 months: Give DTwP1 + IPV1 + Hib1 + PCV1 + Rotavirus1 NOW
- 4 weeks later (10 months): DTwP2 + IPV2 + Hib2 + PCV2 + Rotavirus2
- 4 weeks later (11 months): DTwP3 + IPV3 + Hib3 + PCV3
- At 9 months: Also give MR/MMR (scheduled dose), Vitamin A 1 lakh IU, JE 1 (if endemic area)
- Never restart a series; count valid prior doses and continue from where left off
AEFI (Adverse Events Following Immunization):
AEFI = Any untoward medical event that occurs after immunization and may or may not be causally related.
Types:
- Vaccine reaction: Programmatic error (abscess, injection site infection), vaccine-induced (fever, anaphylaxis, febrile seizures post-DTP, intussusception post-Rotavirus - rare)
- Coincidental: Would have occurred regardless of vaccine
- Injection reaction: Fainting, pain at site
Common AEFIs:
- Fever, local redness/swelling (most common - within 48 hrs, self-limiting)
- BCG: Local ulcer → scar (expected); abscess (programmatic error)
- DTwP: Persistent screaming, hypotonic-hyporesponsive episode (HHE)
- MMR: Rash, fever at day 5-12 (vaccine-strain viremia)
- Anaphylaxis: Rare but most serious; treat with Adrenaline 0.01 mg/kg IM
Management of AEFI: Report to Medical Officer → District Immunization Officer → AEFI committee review → State/national reporting (under AEFI surveillance program)
QUESTION 7 (18 marks) - Write ANY THREE short notes (6 marks each)
Q7.1: Measles - Clinical Features and Complications
Clinical Features:
Incubation period: 10-14 days
Prodromal stage (3-5 days):
- High fever (39-40°C), cough, coryza (3 C's), conjunctivitis
- Koplik's spots: Pathognomonic - bluish-white spots on red base on buccal mucosa (opposite lower molars); appear 1-2 days before rash
Eruptive stage (rash):
- Maculopapular rash appears day 3-4 of fever
- Starts behind ears/hairline → spreads downward: Face → neck → trunk → extremities (cephalocaudal spread)
- Rash lasts 4-6 days, then fades in order of appearance (leaving brownish discolouration = desquamation)
- Fever highest when rash appears on face
Fading stage:
- Rash fades with branny desquamation
- "Koplik's + cough + conjunctivitis + cephalocaudal rash" = clinical diagnosis
Complications (use 3Rs + others):
| System | Complication |
|---|
| Respiratory | Pneumonia (leading cause of death - bacterial superinfection), croup, bronchiolitis |
| CNS | Post-infectious encephalomyelitis (1:1000), SSPE (Subacute Sclerosing Panencephalitis - 7-10 yrs later), febrile seizures |
| GIT | Diarrhea, stomatitis, cancrum oris (noma) |
| Eye | Corneal ulceration (especially with Vit A deficiency) → blindness |
| Ear | Otitis media |
| Nutritional | Rapid precipitation of malnutrition, Vitamin A deficiency |
| Immunological | Immune amnesia (transient immunosuppression for weeks) |
Treatment:
- Vit A: 2 lakh IU at diagnosis and next day (reduces mortality)
- Supportive: antipyretics, fluids, nutrition
- Antibiotics for bacterial superinfection
Q7.2: Dengue - Clinical Phases, Warning Signs, Severe Dengue, Management of DSS
Clinical Phases:
1. Febrile Phase (Days 1-3):
- Sudden high fever (39-40°C), "breakbone fever" (severe myalgia, arthralgia, retroorbital pain)
- Flushed face, headache, nausea, vomiting
- Early rash (macular), thrombocytopenia begins
- Positive tourniquet test
2. Critical Phase (Days 3-6):
- Fever may defervese (misleading improvement)
- Plasma leakage → pleural effusion, ascites, hemoconcentration (HCT rises >20%)
- Thrombocytopenia <100,000 → platelet <20,000 in severe
- Bleeding manifestations: petechiae, epistaxis, gum bleeding, melena
- WARNING SIGNS occur here
3. Recovery Phase (Days 6-7):
- Reabsorption of leaked plasma → fluid overload risk
- Bradycardia, dilutional thrombocytopenia
- "Convalescent rash" - isles of white in sea of red
Warning Signs (WHO):
- Abdominal pain or tenderness
- Persistent vomiting
- Clinical fluid accumulation (ascites, pleural effusion)
- Mucosal bleeding
- Lethargy/restlessness
- Liver enlargement >2 cm
- Rapid rise in HCT with rapid fall in platelet
Severe Dengue:
- Severe plasma leakage → Dengue Shock Syndrome (DSS) or fluid accumulation with respiratory distress
- Severe bleeding (clinically significant)
- Severe organ involvement: liver (AST/ALT >1000), CNS (encephalitis), heart (myocarditis), renal failure
Management of DSS:
Fluid resuscitation is cornerstone:
- Compensated shock (BP maintained): Isotonic crystalloid (NS or RL) 10 mL/kg over 1 hour; reassess; repeat if improving, reduce gradually (10→5→3 mL/kg/hr)
- Hypotensive shock: Crystalloid 20 mL/kg over 15-30 min bolus; if HCT rises = use colloid (Dextran 70 or 6% HES 10 mL/kg)
- Monitor: Vital signs every 15-30 min, urine output (target >1 mL/kg/hr), HCT, BP
- Avoid: Excessive IV fluids (cause pulmonary edema in recovery phase)
- Platelet transfusion only if <10,000 or active significant bleeding
- Blood transfusion if severe hemorrhage
- Monitor for fluid overload in recovery phase (diuretics if needed)
Q7.3: Behavioural Problems in Toddlers + PICA
Behavioural Problems in Toddler Age Group (1-3 years):
- Temper tantrums: Most common; child throws self on floor, screams when wishes thwarted; peaks 18-36 months; management: ignore, consistent limit-setting, positive reinforcement, avoid giving in
- Breath-holding spells: Provoked by frustration/pain; child holds breath → cyanosis/pallor → may faint; benign; management: reassure parents, no medication needed
- Night terrors and nightmares: Night terrors (NREM, inconsolable, no memory); management: reassurance, regular sleep schedule
- Thumb sucking: Normal up to 4 years; dental problems if persists; ignore until 4 years
- Head banging/rocking: Self-stimulatory; often at bedtime; usually benign; padding of crib
- Feeding problems: Food refusal, food jags (eating same food repeatedly); normal autonomy-related
- Sleep problems: Resistance to bedtime, night waking
- Aggression/biting: Normal toddler behavior related to autonomy development
PICA:
- Definition: Persistent eating of non-nutritive, non-food substances for >1 month, inappropriate for developmental level (age > 18 months to diagnose)
- Substances: Soil/mud (geophagia - most common), paint chips (lead poisoning risk), hair (trichophagia), ice (pagophagia - suggests iron deficiency), paper, chalk, clay
Causes/Associations:
- Iron deficiency anemia (most common association)
- Zinc deficiency
- Autism spectrum disorder, intellectual disability
- Neglect, psychosocial deprivation
- Cultural practices (e.g., geophagia in some communities)
Complications:
- Lead poisoning (paint chips)
- Intestinal obstruction (trichobezoar from hair)
- Parasitic infections (soil eating)
- Dental injury, constipation
Management:
- Treat underlying deficiency (Iron, Zinc supplementation)
- Behavioral therapy (positive reinforcement, redirection)
- Environmental safety (remove access to substances)
- Psychosocial support
- Address autism/ID if present
Q7.4: Childhood Tuberculosis - Clinical Features and Diagnostic Approach
Clinical Features:
Pulmonary TB (most common form):
- Constitutional: Fever (low-grade, persistent >2 weeks), night sweats, weight loss/failure to thrive, fatigue, loss of appetite
- Respiratory: Chronic cough >2 weeks, rarely hemoptysis in children
- Lymphadenopathy (hilar, paratracheal on CXR - most common finding)
- Primary complex: Ghon's focus + lymphangitis + hilar lymphadenopathy
Extrapulmonary TB:
- TB Lymphadenitis: Most common extrapulmonary; cervical nodes; cold abscess (non-tender, matted), "collar stud abscess"
- TB Meningitis: Fever + headache + altered sensorium + meningismus; high mortality; CSF - lymphocytic pleocytosis, high protein, low glucose, cobweb clot
- Miliary TB: Hematogenous dissemination; diffuse micronodular "millet seed" shadows on CXR; choroid tubercles on fundus examination
- Skeletal TB: Pott's spine (gibbus deformity), cold abscess
- Abdominal TB: Doughy abdomen, ascites, tabes mesenterica
Diagnostic Approach:
-
History: Contact with adult TB case (most important in children), BCG status, previous treatment
-
Mantoux (TST): Intradermal PPD 2 TU; read at 48-72 hrs
- ≥10 mm = positive (≥5 mm if immunocompromised/malnutritioned/HIV)
- Negative TST does NOT rule out TB in children
-
IGRA (Interferon-Gamma Release Assay): Quantiferon TB Gold / T-SPOT; preferred in BCG-vaccinated
-
Chest X-ray: Primary complex, hilar lymphadenopathy, miliary pattern, cavities (uncommon in children), pleural effusion
-
Microbiological: Gastric lavage (young children can't expectorate) × 3 days; sputum AFB smear + culture (Lowenstein-Jensen); GeneXpert MTB/RIF (rapid, detects rifampicin resistance)
-
Scoring System (Stegen-Toledo / Indian Pediatric TB Score): Used when bacteriology unavailable - scores symptoms, contact, TST, CXR, malnutrition, response to antibiotics
-
Other: CSF analysis (TBM), tissue biopsy (lymph node), ADA (ascitic fluid), CT chest/abdomen
Treatment (RNTCP/NTEP guidelines):
- Intensive phase: 2 months HRZE (or HRZ for non-severe)
- Continuation phase: 4 months HR
- Total: 6 months (extrapulmonary/miliary/TBM: 9-12 months)
QUESTION 8 (10 marks) - ANY FIVE in 2-3 sentences (2 marks each)
Q8.1: Clinical Features of Zinc Deficiency
Zinc deficiency presents with the triad of acrodermatitis enteropathica (perioral, perineal, and acral skin rash), alopecia (hair loss), and diarrhea. Other features include growth retardation/stunting, hypogonadism (in adolescents), poor wound healing, loss of taste (hypogeusia) and smell, immune deficiency (recurrent infections), and night blindness. In neonates, the inherited form (acrodermatitis enteropathica) presents after weaning from breast milk.
Q8.2: Difference between Caput Succedaneum and Cephalohematoma
| Feature | Caput Succedaneum | Cephalohematoma |
|---|
| Nature | Edema/serosanguineous fluid | Subperiosteal blood collection |
| Extent | Crosses suture lines | Does NOT cross suture lines |
| Onset | Present at birth | Appears hours after birth |
| Resolution | Within 24-48 hours | Weeks to months (may calcify) |
| Complication | Rare | Jaundice, anemia; rarely infection |
| Cause | Pressure of birth canal/scalp electrode | Birth trauma, vacuum extraction |
Q8.3: Entitlements under JSSK (Janani Shishu Suraksha Karyakram)
JSSK is a government scheme (launched 2011) entitling pregnant women and sick newborns to absolutely free services at public health facilities with zero out-of-pocket expenditure. Entitlements for newborns (up to 30 days) include: free treatment, free drugs and consumables, free diagnostics, free blood, free diet, free transport from home to facility, between facilities, and drop back home, and exemption from all user charges. For pregnant women: free antenatal care, delivery (normal and C-section), postnatal care, drugs, diagnostics, blood, diet, and transport.
Q8.4: Hyperkalaemia - Definition and ECG Changes
Hyperkalemia is defined as serum potassium >5.5 mEq/L (severe >7 mEq/L). Causes include renal failure, acidosis, hemolysis, Addison's disease, and drugs (ACE inhibitors, K-sparing diuretics).
ECG changes (in sequence with rising K):
- Tall, peaked (tented) T waves (earliest change, K ~5.5-6.5)
- Prolonged PR interval
- Widened QRS complex
- Sine wave pattern
- Ventricular fibrillation / asystole (K >8-9)
Q8.5: BMI (Body Mass Index)
BMI = Weight (kg) / Height² (m²); a measure of adiposity using weight and height. In children, BMI is age- and sex-specific, plotted on CDC/WHO growth charts as BMI-for-age percentiles: <5th %ile = underweight; 5th-84th = normal; 85th-94th = overweight; ≥95th = obese. Limitations: does not differentiate fat from muscle mass; may underestimate central adiposity; must always be interpreted with growth charts in children.
Q8.6: Neonatal Mortality Rate (NMR)
NMR is defined as the number of deaths occurring in the first 28 days of life per 1000 live births in a given year. It is divided into early neonatal mortality (0-7 days) and late neonatal mortality (7-28 days). India's NMR as per recent data is approximately 20/1000 live births; leading causes are preterm birth complications, birth asphyxia, and sepsis. Reduction in NMR is a key target of the India Newborn Action Plan (INAP) with goal of <10 by 2030.
Exam Tip Summary by Weightage:
- Q1, Q5 (10 marks each) = Full detailed long answers with all subparts
- Q2, Q6 (12 marks = 6 each) = Moderate structured answers with tables/points
- Q3, Q7 (18 marks = 6 each) = Focused short essays with key headings
- Q4, Q8 (10 marks = 2 each) = Exactly 2-3 sentences per topic