const {
  Document, Packer, Paragraph, TextRun, Table, TableRow, TableCell,
  AlignmentType, HeadingLevel, BorderStyle, WidthType, ShadingType,
  VerticalAlign, PageBreak, PageOrientation, convertInchesToTwip,
  Header, Footer, PageNumber, NumberFormat
} = require('docx');
const fs = require('fs');

// Color palette
const COLORS = {
  paracetamol:  { header: 'F6C026', light: 'FFF8E1', accent: 'E65100' },
  aspirin:      { header: 'E55A2B', light: 'FBE9E7', accent: 'BF360C' },
  tca:          { header: '3F6BB5', light: 'E3F0FF', accent: '1A237E' },
  digoxin:      { header: '2E8B57', light: 'E8F5E9', accent: '1B5E20' },
  lithium:      { header: '7C4DBA', light: 'F3E5F5', accent: '4A148C' },
  benzo:        { header: '0097A7', light: 'E0F7FA', accent: '006064' },
  opioid:       { header: '8D4E4E', light: 'FDECEA', accent: '4E342E' },
};

const WHITE = 'FFFFFF';
const DARK  = '212121';
const SUBHEAD_BG = 'ECEFF1';

function border(color = '000000', size = 6) {
  return { style: BorderStyle.SINGLE, size, color };
}
function noBorder() {
  return { style: BorderStyle.NONE, size: 0, color: 'FFFFFF' };
}

// ─── Helper: big colored title cell ───────────────────────────────────────────
function titleCell(text, emoji, bgColor, colspan = 2) {
  return new TableCell({
    columnSpan: colspan,
    shading: { type: ShadingType.SOLID, color: bgColor },
    borders: { top: noBorder(), bottom: border(DARK,8), left: noBorder(), right: noBorder() },
    verticalAlign: VerticalAlign.CENTER,
    margins: { top: 120, bottom: 120, left: 200, right: 200 },
    children: [
      new Paragraph({
        alignment: AlignmentType.CENTER,
        children: [
          new TextRun({ text: emoji + '  ' + text, bold: true, size: 36, color: WHITE, font: 'Calibri' })
        ]
      })
    ]
  });
}

// ─── Helper: section sub-header ───────────────────────────────────────────────
function sectionHeader(text, bgColor, colspan = 2) {
  return new TableRow({
    children: [
      new TableCell({
        columnSpan: colspan,
        shading: { type: ShadingType.SOLID, color: bgColor },
        borders: { top: border(bgColor,4), bottom: border(bgColor,4), left: noBorder(), right: noBorder() },
        margins: { top: 60, bottom: 60, left: 160, right: 100 },
        children: [
          new Paragraph({
            children: [
              new TextRun({ text: '  ' + text, bold: true, size: 20, color: WHITE, font: 'Calibri' })
            ]
          })
        ]
      })
    ]
  });
}

// ─── Helper: label + value row ────────────────────────────────────────────────
function kvRow(label, value, lightBg, idx = 0) {
  const bg = idx % 2 === 0 ? lightBg : WHITE;
  return new TableRow({
    children: [
      new TableCell({
        width: { size: 2800, type: WidthType.DXA },
        shading: { type: ShadingType.SOLID, color: bg },
        borders: { top: border('DDDDDD',3), bottom: border('DDDDDD',3), left: noBorder(), right: border('CCCCCC',4) },
        margins: { top: 50, bottom: 50, left: 160, right: 80 },
        children: [new Paragraph({ children: [new TextRun({ text: label, bold: true, size: 18, color: DARK, font: 'Calibri' })] })]
      }),
      new TableCell({
        shading: { type: ShadingType.SOLID, color: bg },
        borders: { top: border('DDDDDD',3), bottom: border('DDDDDD',3), left: noBorder(), right: noBorder() },
        margins: { top: 50, bottom: 50, left: 120, right: 100 },
        children: [new Paragraph({ children: [new TextRun({ text: value, size: 18, color: DARK, font: 'Calibri' })] })]
      })
    ]
  });
}

// ─── Helper: build a mini-table ────────────────────────────────────────────────
function miniTable(headers, rows, accentColor, lightBg) {
  const headerRow = new TableRow({
    tableHeader: true,
    children: headers.map((h, i) => new TableCell({
      shading: { type: ShadingType.SOLID, color: accentColor },
      borders: { top: noBorder(), bottom: border(DARK,4), left: noBorder(), right: i < headers.length-1 ? border(WHITE,3) : noBorder() },
      margins: { top: 50, bottom: 50, left: 100, right: 100 },
      children: [new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: h, bold: true, size: 17, color: WHITE, font: 'Calibri' })] })]
    }))
  });
  const dataRows = rows.map((row, ri) => new TableRow({
    children: row.map((cell, ci) => new TableCell({
      shading: { type: ShadingType.SOLID, color: ri % 2 === 0 ? lightBg : WHITE },
      borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: ci < row.length-1 ? border('CCCCCC',3) : noBorder() },
      margins: { top: 40, bottom: 40, left: 100, right: 100 },
      children: [new Paragraph({ children: [new TextRun({ text: cell, size: 17, color: DARK, font: 'Calibri' })] })]
    }))
  }));
  return new Table({
    width: { size: 100, type: WidthType.PERCENTAGE },
    borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder(), insideH: noBorder(), insideV: noBorder() },
    rows: [headerRow, ...dataRows]
  });
}

// ─── Helper: bullet paragraph ─────────────────────────────────────────────────
function bullet(text, color = DARK, bold = false) {
  return new Paragraph({
    indent: { left: 200, hanging: 200 },
    children: [
      new TextRun({ text: '• ', bold: true, size: 18, color, font: 'Calibri' }),
      new TextRun({ text, size: 18, color: DARK, bold, font: 'Calibri' })
    ]
  });
}
function subbullet(text) {
  return new Paragraph({
    indent: { left: 420, hanging: 200 },
    children: [
      new TextRun({ text: '◦ ', size: 17, color: '888888', font: 'Calibri' }),
      new TextRun({ text, size: 17, color: DARK, font: 'Calibri' })
    ]
  });
}
function plain(text, bold = false, size = 18, color = DARK) {
  return new Paragraph({ children: [new TextRun({ text, bold, size, color, font: 'Calibri' })] });
}
function spacer() { return new Paragraph({ children: [new TextRun({ text: '' })] }); }

// ─── Helper: warning box ──────────────────────────────────────────────────────
function warningBox(lines, bgColor = 'FFF3CD', borderColor = 'F9A825') {
  return new Table({
    width: { size: 100, type: WidthType.PERCENTAGE },
    borders: { top: border(borderColor,8), bottom: border(borderColor,8), left: border(borderColor,10), right: border(borderColor,8), insideH: noBorder(), insideV: noBorder() },
    rows: [new TableRow({
      children: [new TableCell({
        shading: { type: ShadingType.SOLID, color: bgColor },
        margins: { top: 60, bottom: 60, left: 160, right: 100 },
        children: lines.map(l => new Paragraph({ children: [new TextRun({ text: l, size: 18, color: DARK, font: 'Calibri', bold: l.startsWith('⚠') || l.startsWith('✅') })] }))
      })]
    })]
  });
}

// ─── Build a full cheat-sheet section ─────────────────────────────────────────
function buildSheet(drug) {
  switch(drug) {

    // ════════════════════════════════════════════════════════════════════════
    case 'paracetamol': {
      const c = COLORS.paracetamol;
      return [
        new Table({
          width: { size: 100, type: WidthType.PERCENTAGE },
          borders: { top: border(c.header,8), bottom: border(c.header,8), left: border(c.header,8), right: border(c.header,8), insideH: noBorder(), insideV: noBorder() },
          rows: [
            new TableRow({ children: [titleCell('PARACETAMOL POISONING', '🟡', c.header)] }),
            sectionHeader('TOXIC DOSE', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Category','Adults','Children'],
                [
                  ['Therapeutic','500–1000 mg/dose (max 4 g/day)','10–15 mg/kg/dose'],
                  ['Toxic','≥ 150 mg/kg single dose','150–200 mg/kg'],
                  ['Lethal','> 350 mg/kg','> 250–350 mg/kg'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('MECHANISM', c.accent),
            ...['Normal: 90% → glucuronide/sulfate conjugation (SAFE)', '10% via CYP2E1 → NAPQI (reactive toxic metabolite)', 'NAPQI + Glutathione → safe excretion (mercapturic acid)', 'OVERDOSE: Glutathione depleted → NAPQI accumulates → centrilobular hepatocyte necrosis', 'CYP2E1 INDUCERS worsen toxicity: alcohol, INH, rifampicin, phenytoin, carbamazepine'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('CLINICAL STAGES (Rumack-Matthew)', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Stage','Time','Features'],
                [
                  ['I','0–24 hrs','Nausea, vomiting, malaise, pallor — may be asymptomatic'],
                  ['II','24–72 hrs','RUQ pain, ↑ LFTs, ↑ PT, ↑ creatinine'],
                  ['III','72–96 hrs','Peak toxicity: jaundice, coagulopathy, encephalopathy, renal failure, hypoglycaemia'],
                  ['IV','4 days–2 wks','Recovery OR fulminant hepatic failure'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('MANAGEMENT', c.accent),
            ...['Decontamination: Activated charcoal 1 g/kg within 1–2 hrs of ingestion', 'Antidote: IV N-Acetylcysteine (NAC) — 3-bag regimen:', '  Bag 1: 150 mg/kg in 200 mL D5W over 60 min (loading dose)', '  Bag 2: 50 mg/kg in 500 mL D5W over 4 hrs', '  Bag 3: 100 mg/kg in 1000 mL D5W over 16 hrs', 'Oral NAC: 140 mg/kg load, then 70 mg/kg q4h × 17 doses', 'Start NAC if level plots ABOVE treatment line on nomogram', 'Start empirically if > 8 hrs post-ingestion (do not wait for level)'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: l.startsWith('  ') ? '    ↳ '+l.trim() : '• '+l, size: 18, color: DARK, font: 'Calibri', bold: l.includes('NAC') || l.includes('Antidote') })] })]
            })] })),
            sectionHeader("KING'S COLLEGE CRITERIA (Liver Transplant)", c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'FFF8E1' },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,8), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                new Paragraph({ children: [new TextRun({ text: 'Arterial pH < 7.3 after resuscitation   OR   ALL THREE of:', bold: true, size: 18, color: c.accent, font: 'Calibri' })] }),
                new Paragraph({ children: [new TextRun({ text: '  • PT > 100 sec   +   Creatinine > 300 µmol/L   +   Grade III–IV encephalopathy', size: 18, color: DARK, font: 'Calibri' })] }),
              ]
            })] }),
          ]
        }),
        new Paragraph({ children: [new PageBreak()] })
      ];
    }

    // ════════════════════════════════════════════════════════════════════════
    case 'aspirin': {
      const c = COLORS.aspirin;
      return [
        new Table({
          width: { size: 100, type: WidthType.PERCENTAGE },
          borders: { top: border(c.header,8), bottom: border(c.header,8), left: border(c.header,8), right: border(c.header,8), insideH: noBorder(), insideV: noBorder() },
          rows: [
            new TableRow({ children: [titleCell('ASPIRIN (SALICYLATE) POISONING', '🟠', c.header)] }),
            sectionHeader('TOXIC DOSE & KINETICS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Preparation','Fatal Dose'],
                [['Aspirin / Sodium salicylate','15–20 g'],['Methyl salicylate (oil of wintergreen)','5–15 mL (≈ 1 tsp)']],
                c.accent, c.light
              )]
            })] }),
            ...['Elimination t½: Therapeutic = 2–3 hrs | Toxic overdose > 20 hrs (zero-order kinetics)','Volume of distribution: increases in acidaemia (more drug enters CNS)'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('MECHANISM', c.accent),
            ...['Directly stimulates medullary respiratory centre → hyperventilation → Respiratory ALKALOSIS (EARLY)', 'Uncouples oxidative phosphorylation → ↑ organic acids + ↑ O₂ consumption → Metabolic ACIDOSIS (LATE)', 'Inhibits Krebs cycle enzymes → lactic acidosis', 'Each 300 mg tablet contributes 1.7 mEq acid'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('ABG EVOLUTION', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Stage','ABG Pattern'],
                [['Early','Respiratory alkalosis (hyperventilation)'],['Middle','Mixed: Resp alkalosis + Metabolic acidosis'],['Late','Pure Metabolic acidosis (dominant in children)']],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('CLINICAL FEATURES BY SEVERITY', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Severity','Level (mg/L)','Features'],
                [
                  ['Mild','< 300','Nausea, vomiting, TINNITUS, vertigo, hearing loss, lethargy'],
                  ['Moderate','300–700','Dehydration, restlessness, tachypnoea, diaphoresis, warm extremities'],
                  ['Severe','> 700','Pulmonary oedema, cerebral oedema, seizures, coma, renal failure, hyperpyrexia, arrhythmias'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('MANAGEMENT', c.accent),
            ...['Activated charcoal 1 g/kg within 2–4 hrs (repeat doses for enteric-coated tabs)','IV rehydration: D5W + NaHCO₃ — correct hypokalaemia first (essential for urine alkalinisation)','Urinary Alkalinisation (mainstay for moderate–severe): NaHCO₃ IV → target urine pH 7.5–8.5 → ion trapping → ↑ renal clearance 10–20x','Target serum pH 7.45–7.50','DO NOT use acetazolamide (acidifies blood) or NSAIDs'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri', bold: l.startsWith('DO') })] })]
            })] })),
            sectionHeader('HAEMODIALYSIS INDICATIONS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'FBE9E7' },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,8), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('Level > 700 mg/L (severe)  |  Renal failure  |  Pulmonary / cerebral oedema', true, 18, c.accent),
                plain('Persistent acidosis despite NaHCO₃  |  Level > 500 mg/L in elderly/impaired', false, 18, DARK),
              ]
            })] }),
          ]
        }),
        new Paragraph({ children: [new PageBreak()] })
      ];
    }

    // ════════════════════════════════════════════════════════════════════════
    case 'tca': {
      const c = COLORS.tca;
      return [
        new Table({
          width: { size: 100, type: WidthType.PERCENTAGE },
          borders: { top: border(c.header,8), bottom: border(c.header,8), left: border(c.header,8), right: border(c.header,8), insideH: noBorder(), insideV: noBorder() },
          rows: [
            new TableRow({ children: [titleCell('TRICYCLIC ANTIDEPRESSANT (TCA) POISONING', '🔵', c.header)] }),
            sectionHeader('COMMON AGENTS & TOXIC DOSE', c.accent),
            ...['Agents: Amitriptyline (most toxic), Imipramine, Clomipramine, Nortriptyline, Doxepin','Toxic: > 10 mg/kg | Potentially fatal: > 20 mg/kg | Amitriptyline: as little as 500 mg can be fatal in adults'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('MULTI-CHANNEL BLOCKADE (MECHANISM)', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Receptor/Channel','Effect'],
                [
                  ['Na+ channel block (fast INa)','Broad QRS, myocardial depression, arrhythmias ⚡'],
                  ['Muscarinic (M1) block','Anticholinergic syndrome'],
                  ['K+ channel block','QTc prolongation'],
                  ['α1-adrenoceptor block','Vasodilation, hypotension'],
                  ['GABA-A block','Seizures'],
                  ['H1 block','Sedation / coma'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('CLINICAL FEATURES — "SOAP" TOXIDROME', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: c.light },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,10), right: noBorder() },
              margins: { top: 70, bottom: 70, left: 160, right: 100 },
              children: [
                new Paragraph({ children: [new TextRun({ text: 'S  Seizures  |  O  QRS widening  |  A  Anticholinergic syndrome  |  P  Pressure ↓ (hypotension)', bold: true, size: 20, color: c.accent, font: 'Calibri' })] }),
                spacer(),
                new Paragraph({ children: [new TextRun({ text: 'Anticholinergic: "Dry as bone, blind as bat, red as beet, hot as hare, mad as hatter, full as flask"', size: 18, color: DARK, font: 'Calibri', italics: true })] }),
                new Paragraph({ children: [new TextRun({ text: '→ Dry mouth, urinary retention, mydriasis, flushing, hyperthermia, tachycardia, ileus, delirium', size: 18, color: DARK, font: 'Calibri' })] }),
              ]
            })] }),
            sectionHeader('CARDIAC DANGER SIGNS (ECG)', c.accent),
            ...['QRS > 100 ms → risk of arrhythmia; QRS > 160 ms → VT/VF imminent 💀','R wave in aVR > 3 mm  OR  R:S ratio in aVR > 0.7 → predictor of seizures & arrhythmias','Sinus tachycardia (most common early finding)','Brugada pattern may be unmasked'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri', bold: l.includes('💀') })] })]
            })] })),
            sectionHeader('MANAGEMENT', c.accent),
            ...['Activated charcoal within 1–2 hrs (NOT gastric lavage unless intubated)','Early intubation if GCS < 8, seizures, or haemodynamic instability','NaHCO₃ 50–100 mEq IV BOLUS for: QRS > 100 ms, hypotension, arrhythmias  →  Target pH 7.45–7.55','Mechanism of NaHCO₃: (1) Na+ loading overcomes Na-channel block; (2) Alkalosis ↑ protein binding of TCA','Seizures: Benzodiazepines (1st line) — AVOID phenytoin (also Na-channel blocker)','Hypotension: IV fluids → Noradrenaline (α-agonist preferred) — AVOID dopamine (β-effects)','Arrhythmias: NaHCO₃ 1st → Lidocaine 2nd — AVOID Class Ia/Ic, Amiodarone'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: l.includes('AVOID') ? c.accent : DARK, font: 'Calibri', bold: l.includes('AVOID') || l.includes('NaHCO') })] })]
            })] })),
            sectionHeader('⚠ CRITICAL CONTRAINDICATIONS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'FFF3E0' },
              borders: { top: noBorder(), bottom: noBorder(), left: border('E65100',10), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('Flumazenil — CONTRAINDICATED (precipitates seizures)', true, 18, 'C62828'),
                plain('Physostigmine — CONTRAINDICATED (asystole risk)', true, 18, 'C62828'),
                plain('Phenytoin — AVOID for seizures (worsens QRS widening)', true, 18, 'E65100'),
                plain('Haemodialysis — NOT useful (large Vd 10–20 L/kg, high protein binding)', true, 18, '37474F'),
              ]
            })] }),
          ]
        }),
        new Paragraph({ children: [new PageBreak()] })
      ];
    }

    // ════════════════════════════════════════════════════════════════════════
    case 'digoxin': {
      const c = COLORS.digoxin;
      return [
        new Table({
          width: { size: 100, type: WidthType.PERCENTAGE },
          borders: { top: border(c.header,8), bottom: border(c.header,8), left: border(c.header,8), right: border(c.header,8), insideH: noBorder(), insideV: noBorder() },
          rows: [
            new TableRow({ children: [titleCell('DIGOXIN POISONING', '🟢', c.header)] }),
            sectionHeader('DRUG LEVELS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Level','Value (ng/mL)'],
                [['Therapeutic','0.8 – 2.0'],['Toxic','> 2.0 (lower with hypokalaemia)'],['Acute OD — Life-threatening','> 10']],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('MECHANISM', c.accent),
            ...['Inhibits Na+/K+-ATPase → ↑ intracellular Na+ → ↑ intracellular Ca²⁺ (via Na+/Ca²⁺ exchanger)','Therapeutic: ↑ myocardial contractility + ↓ AV conduction (vagotonic)','Toxic: Triggered activity (delayed afterdepolarisations) → ↑ automaticity → arrhythmias','Acute OD → HYPERKALEMIA (ATPase inhibition); Chronic → HYPOKALAEMIA (diuretics) worsens toxicity'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('CLINICAL FEATURES', c.accent),
            ...['GI (EARLY, most common): Nausea, vomiting, anorexia, abdominal pain, diarrhoea','Neuro: Yellow-green halos (xanthopsia), blurred vision, confusion, fatigue','Cardiac: ANY arrhythmia possible — "regularise the irregular, irregularise the regular"','Pathognomonic: PAT with 2:1 AV block | Junctional tachycardia with AV block | Ventricular bigeminy','Acute OD: More AV block; Chronic: More ventricular ectopy'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: l.includes('Pathognomonic') ? c.accent : DARK, font: 'Calibri', bold: l.includes('Pathognomonic') })] })]
            })] })),
            sectionHeader('ECG SIGNS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: c.light },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,8), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('"Salvador Dalí moustache" = Reverse tick / Scoop sign (downsloping ST depression)', true, 18, c.accent),
                plain('Shortened QTc  |  T-wave inversion  |  U waves  |  Prolonged PR interval', false, 18, DARK),
              ]
            })] }),
            sectionHeader('MANAGEMENT', c.accent),
            ...['Activated charcoal if within 2 hrs (repeat doses for ongoing absorption)','Correct hypokalaemia aggressively with IV KCl (K+ < 3.5 mmol/L)','Correct hypomagnesaemia | AVOID calcium in acute OD (may cause stone heart)','Atropine 0.5–1 mg IV for symptomatic bradycardia (temporary measure)','MgSO₄ 1–2 g IV over 20 min for ventricular arrhythmias','Temporary pacing for refractory bradycardia/AV block'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: l.includes('AVOID') ? 'C62828' : DARK, font: 'Calibri', bold: l.includes('AVOID') })] })]
            })] })),
            sectionHeader('✅ ANTIDOTE — DIGOXIN-SPECIFIC Fab FRAGMENTS (Digibind / DigiFab)', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'E8F5E9' },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,10), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('INDICATIONS: Life-threatening arrhythmias | Haemodynamic instability', true, 18, c.accent),
                plain('Acute ingestion > 10 mg adults / > 4 mg children | K+ > 5.5 mmol/L (acute)', false, 18, DARK),
                spacer(),
                plain('DOSE: No. of vials = (serum digoxin ng/mL × weight kg) ÷ 100', true, 18, c.accent),
                plain('OR from known dose: mg ingested × 0.8 ÷ 0.5', false, 18, DARK),
                spacer(),
                plain('NOTE: Serum digoxin levels RISE post-Fab (measures bound + free) — do NOT recheck to guide re-dosing', false, 18, '37474F'),
                plain('Haemodialysis: NOT effective (large Vd, protein bound)', false, 18, '37474F'),
              ]
            })] }),
          ]
        }),
        new Paragraph({ children: [new PageBreak()] })
      ];
    }

    // ════════════════════════════════════════════════════════════════════════
    case 'lithium': {
      const c = COLORS.lithium;
      return [
        new Table({
          width: { size: 100, type: WidthType.PERCENTAGE },
          borders: { top: border(c.header,8), bottom: border(c.header,8), left: border(c.header,8), right: border(c.header,8), insideH: noBorder(), insideV: noBorder() },
          rows: [
            new TableRow({ children: [titleCell('LITHIUM TOXICITY', '🟣', c.header)] }),
            sectionHeader('THERAPEUTIC RANGE: 0.6 – 1.2 mmol/L', c.accent),
            sectionHeader('TYPES OF TOXICITY', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Type','Cause','Severity'],
                [
                  ['Acute','OD in non-user (naive)','GI symptoms prominent'],
                  ['Chronic','Accumulation in long-term user','Neurological features dominate'],
                  ['Acute-on-chronic','OD in established user','MOST SEVERE — mixed features'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('PRECIPITATING FACTORS (in therapeutic users)', c.accent),
            ...['Dehydration, Na⁺ restriction, diarrhoea, vomiting','NSAIDs — ↓ renal clearance of Li⁺','ACE inhibitors / ARBs — ↑ tubular reabsorption','Thiazide diuretics — Na⁺ depletion → compensatory Li⁺ retention','Renal failure'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('CLINICAL FEATURES BY SEVERITY', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Level (mmol/L)','Severity','Features'],
                [
                  ['1.5 – 2.0','Mild','Nausea, vomiting, diarrhoea, coarse tremor, polyuria/polydipsia'],
                  ['2.0 – 2.5','Moderate','Confusion, agitation, ataxia, drowsiness, dysarthria, myoclonus'],
                  ['> 2.5','Severe','Seizures, coma, hypotension, arrhythmias, renal failure'],
                  ['> 4.0','Life-threatening','Irreversible neurological damage, respiratory failure, death'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('SILENT SYNDROME', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'F3E5F5' },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,10), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('SILENT = Syndrome of Irreversible Lithium-Effectuated Neurotoxicity', true, 18, c.accent),
                plain('Cerebellar dysfunction | Dementia | Brainstem signs — PERSISTS even after normalization of serum levels', false, 18, DARK),
              ]
            })] }),
            sectionHeader('MANAGEMENT', c.accent),
            ...['Stop lithium immediately','Activated charcoal — NOT useful (Li⁺ is a small ionic molecule, not adsorbed)','Gastric lavage within 1 hr of acute ingestion','Whole Bowel Irrigation (PEG) for sustained-release preparations','IV 0.9% NaCl aggressively — Li+ clearance follows Na+ → volume expands → ↑ excretion','Avoid NSAIDs, ACEi/ARBs, thiazides'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: l.includes('NOT') || l.includes('Avoid') ? 'C62828' : DARK, font: 'Calibri', bold: l.includes('NOT') || l.includes('Avoid') })] })]
            })] })),
            sectionHeader('✅ HAEMODIALYSIS — KEY TREATMENT (EXTRIP Guidelines)', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'F3E5F5' },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,10), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('Indications:', true, 18, c.accent),
                plain('• Severe neurological features (seizures, coma, altered consciousness)', false, 18, DARK),
                plain('• Li+ ≥ 5.0 mmol/L regardless of symptoms', false, 18, DARK),
                plain('• Li+ ≥ 4.0 mmol/L with renal failure', false, 18, DARK),
                plain('• Li+ ≥ 2.5 mmol/L with severe neurological symptoms', false, 18, DARK),
                spacer(),
                plain('⚠ POST-HD REBOUND: Recheck levels 6–12 hrs post-session (tissue redistribution). Continue HD until Li+ < 1 mmol/L post-rebound.', true, 18, 'E65100'),
              ]
            })] }),
          ]
        }),
        new Paragraph({ children: [new PageBreak()] })
      ];
    }

    // ════════════════════════════════════════════════════════════════════════
    case 'benzo': {
      const c = COLORS.benzo;
      return [
        new Table({
          width: { size: 100, type: WidthType.PERCENTAGE },
          borders: { top: border(c.header,8), bottom: border(c.header,8), left: border(c.header,8), right: border(c.header,8), insideH: noBorder(), insideV: noBorder() },
          rows: [
            new TableRow({ children: [titleCell('BENZODIAZEPINE POISONING', '🔵', c.header)] }),
            sectionHeader('COMMON AGENTS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Class','Agents'],
                [
                  ['Short-acting (most toxic in OD)','Alprazolam, Triazolam, Temazepam'],
                  ['Long-acting','Diazepam, Chlordiazepoxide, Clonazepam'],
                  ['IV agents','Midazolam, Lorazepam'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('MECHANISM', c.accent),
            ...['Positive allosteric modulator of GABA-A receptor → ↑ frequency of Cl⁻ channel opening → CNS depression','Does NOT cause Na-channel blockade (unlike TCAs) → no QRS widening on ECG','Alprazolam is relatively more toxic than other BZDs in overdose'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('CLINICAL FEATURES', c.accent),
            ...['CNS: Drowsiness → slurred speech → ataxia → confusion → coma (rarely deep in isolated OD)','Respiratory depression: MILD in isolation — SEVERE when combined with opioids/alcohol 💀','Cardiovascular: Mild hypotension, mild bradycardia — NO QRS/QTc changes','Paradoxical reactions (rare, elderly/children): Agitation, aggression, disinhibition, hallucinations'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: l.includes('💀') ? 'C62828' : DARK, font: 'Calibri', bold: l.includes('💀') })] })]
            })] })),
            sectionHeader('MANAGEMENT', c.accent),
            ...['Airway: First priority — supportive ventilation if respiratory failure','Activated charcoal within 1 hr if airway is protected','Supportive: Monitor resp status, O₂ saturation, treat hypotension with IV fluids','Haemodialysis: NOT effective (high protein binding, large Vd)','Key principle: Isolated BZD OD rarely fatal — most recover with supportive care alone'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: DARK, font: 'Calibri' })] })]
            })] })),
            sectionHeader('✅ ANTIDOTE — FLUMAZENIL', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'E0F7FA' },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,10), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('Competitive BZD receptor antagonist', true, 18, c.accent),
                plain('Dose: 0.2 mg IV over 30 sec → repeat 0.1–0.2 mg q1 min → max 1–2 mg', false, 18, DARK),
                plain('Onset: 2 min | Duration: 30–60 min ⚠ RESEDATION RISK (shorter than BZDs)', false, 18, DARK),
              ]
            })] }),
            sectionHeader('⚠ FLUMAZENIL CONTRAINDICATIONS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'FFF3E0' },
              borders: { top: noBorder(), bottom: noBorder(), left: border('E65100',10), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('BZD-dependent patients → precipitates acute WITHDRAWAL / SEIZURES', true, 18, 'C62828'),
                plain('Co-ingestion with TCAs → precipitates SEIZURES (DO NOT USE)', true, 18, 'C62828'),
                plain('Raised ICP | History of epilepsy | Chronic BZD use', false, 18, 'E65100'),
              ]
            })] }),
          ]
        }),
        new Paragraph({ children: [new PageBreak()] })
      ];
    }

    // ════════════════════════════════════════════════════════════════════════
    case 'opioid': {
      const c = COLORS.opioid;
      return [
        new Table({
          width: { size: 100, type: WidthType.PERCENTAGE },
          borders: { top: border(c.header,8), bottom: border(c.header,8), left: border(c.header,8), right: border(c.header,8), insideH: noBorder(), insideV: noBorder() },
          rows: [
            new TableRow({ children: [titleCell('OPIOID POISONING', '🟤', c.header)] }),
            sectionHeader('COMMON AGENTS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Class','Agents','Special Notes'],
                [
                  ['Natural','Morphine, Codeine','Baseline agents'],
                  ['Semi-synthetic','Heroin, Oxycodone, Buprenorphine','Heroin: non-cardiogenic pulmonary oedema'],
                  ['Synthetic','Fentanyl (100x morphine), Methadone, Tramadol','Methadone: long t½ 24–36 hrs; Tramadol: seizures'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('MECHANISM', c.accent),
            ...['Agonists at μ (mu), κ (kappa), δ (delta) opioid receptors (GPCRs)','μ-receptor: analgesia, euphoria, respiratory depression, miosis, GI effects','↓ cAMP → hyperpolarisation → ↓ neuronal excitability','RESPIRATORY DEPRESSION = primary cause of death (brainstem respiratory centre)'].map((l,i) => new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: i%2===0 ? c.light : WHITE },
              borders: { top: border('DDDDDD',2), bottom: border('DDDDDD',2), left: noBorder(), right: noBorder() },
              margins: { top: 45, bottom: 45, left: 160, right: 100 },
              children: [new Paragraph({ children: [new TextRun({ text: '• '+l, size: 18, color: l.includes('RESPIRATORY') ? 'C62828' : DARK, font: 'Calibri', bold: l.includes('RESPIRATORY') })] })]
            })] })),
            sectionHeader('CLASSIC TRIAD (OPIOID TOXIDROME)', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: c.light },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,10), right: noBorder() },
              margins: { top: 70, bottom: 70, left: 160, right: 100 },
              children: [
                new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: '🔴  MIOSIS  +  RESPIRATORY DEPRESSION  +  CNS DEPRESSION (Coma)', bold: true, size: 24, color: c.accent, font: 'Calibri' })] }),
              ]
            })] }),
            sectionHeader('CLINICAL FEATURES', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Feature','Detail'],
                [
                  ['Pinpoint pupils (miosis)','Bilateral — even in hypoxia (key sign)'],
                  ['Respiratory depression','↓ RR < 12/min, shallow → apnoea'],
                  ['CNS depression','Drowsiness → stupor → coma'],
                  ['Hypothermia','Common'],
                  ['Bradycardia / Hypotension','Present'],
                  ['Pulmonary oedema (non-cardiac)','Especially heroin, methadone'],
                  ['Seizures','Tramadol, pethidine (norpethidine), propoxyphene'],
                  ['Muscle rigidity','High-dose fentanyl ("wooden chest")'],
                ],
                c.accent, c.light
              )]
            })] }),
            sectionHeader('✅ ANTIDOTE — NALOXONE (Narcan)', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: 'FDECEA' },
              borders: { top: noBorder(), bottom: noBorder(), left: border(c.accent,10), right: noBorder() },
              margins: { top: 60, bottom: 60, left: 160, right: 100 },
              children: [
                plain('Competitive μ-receptor antagonist', true, 18, c.accent),
                plain('IV: 0.4–2 mg bolus q2–3 min | IM/SC: 0.4–0.8 mg | Intranasal: 2–4 mg (pre-hospital)', false, 18, DARK),
                plain('Onset: IV 1–2 min | IM 5 min | Duration: 30–90 min', false, 18, DARK),
                spacer(),
                plain('⚠ RESEDATION RISK: Naloxone SHORTER-acting than most opioids', true, 18, 'E65100'),
                plain('Infusion: 2/3 of effective bolus per hour — especially for methadone, fentanyl, SR opioids', false, 18, DARK),
                plain('Titrate to ADEQUATE RESPIRATORY EFFORT (not full reversal — precipitates withdrawal)', false, 18, DARK),
                plain('Max dose: 10 mg — if no response, re-assess diagnosis', false, 18, '37474F'),
              ]
            })] }),
            sectionHeader('SPECIAL AGENT CONSIDERATIONS', c.accent),
            new TableRow({ children: [new TableCell({
              columnSpan: 2,
              shading: { type: ShadingType.SOLID, color: WHITE },
              borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
              margins: { top: 60, bottom: 40, left: 100, right: 100 },
              children: [miniTable(
                ['Agent','Special Consideration'],
                [
                  ['Methadone','Long t½ 24–36 hrs → admit 24 hrs, naloxone infusion needed, QTc prolongation'],
                  ['Tramadol','Seizures → treat with BZDs; partial response to naloxone'],
                  ['Buprenorphine','High receptor affinity → requires high-dose naloxone; RD less severe'],
                  ['Illicit fentanyl','Ultra-potent → multiple naloxone doses needed'],
                ],
                c.accent, c.light
              )]
            })] }),
          ]
        }),
        new Paragraph({ children: [new PageBreak()] })
      ];
    }

    default: return [];
  }
}

// ─── Title / Cover Page ───────────────────────────────────────────────────────
function coverPage() {
  return [
    new Table({
      width: { size: 100, type: WidthType.PERCENTAGE },
      borders: { top: border('2C3E50',10), bottom: border('2C3E50',10), left: border('2C3E50',10), right: border('2C3E50',10), insideH: noBorder(), insideV: noBorder() },
      rows: [
        new TableRow({ children: [new TableCell({
          shading: { type: ShadingType.SOLID, color: '2C3E50' },
          borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
          margins: { top: 300, bottom: 80, left: 300, right: 300 },
          children: [
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: '💊', size: 72, font: 'Segoe UI Emoji' })] }),
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: 'TOXICOLOGY', bold: true, size: 64, color: 'F39C12', font: 'Calibri' })] }),
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: 'CHEAT SHEETS', bold: true, size: 56, color: WHITE, font: 'Calibri' })] }),
          ]
        })] }),
        new TableRow({ children: [new TableCell({
          shading: { type: ShadingType.SOLID, color: '34495E' },
          borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
          margins: { top: 100, bottom: 100, left: 300, right: 300 },
          children: [
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: 'Drug Poisoning & Overdose Management', size: 32, color: 'ECF0F1', font: 'Calibri' })] }),
          ]
        })] }),
        new TableRow({ children: [new TableCell({
          shading: { type: ShadingType.SOLID, color: '2C3E50' },
          borders: { top: border('F39C12',4), bottom: noBorder(), left: noBorder(), right: noBorder() },
          margins: { top: 80, bottom: 80, left: 300, right: 300 },
          children: [
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: '📚  Davidson  ·  Harrison  ·  Archith Baloor', size: 26, color: 'F39C12', font: 'Calibri', bold: true })] }),
          ]
        })] }),
        new TableRow({ children: [new TableCell({
          shading: { type: ShadingType.SOLID, color: '2C3E50' },
          borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
          margins: { top: 60, bottom: 300, left: 300, right: 300 },
          children: [
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: '1. Paracetamol    2. Aspirin    3. TCA    4. Digoxin', size: 22, color: 'BDC3C7', font: 'Calibri' })] }),
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: '5. Lithium    6. Benzodiazepines    7. Opioids', size: 22, color: 'BDC3C7', font: 'Calibri' })] }),
          ]
        })] }),
      ]
    }),
    new Paragraph({ children: [new PageBreak()] })
  ];
}

// ─── Quick Reference Antidote Summary ────────────────────────────────────────
function antidotePage() {
  return [
    new Table({
      width: { size: 100, type: WidthType.PERCENTAGE },
      borders: { top: border('2C3E50',8), bottom: border('2C3E50',8), left: border('2C3E50',8), right: border('2C3E50',8), insideH: noBorder(), insideV: noBorder() },
      rows: [
        new TableRow({ children: [new TableCell({
          columnSpan: 1,
          shading: { type: ShadingType.SOLID, color: '2C3E50' },
          borders: { top: noBorder(), bottom: border('F39C12',6), left: noBorder(), right: noBorder() },
          margins: { top: 120, bottom: 120, left: 200, right: 200 },
          children: [new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: '⚡  QUICK REFERENCE — ANTIDOTES & KEY FACTS', bold: true, size: 32, color: 'F39C12', font: 'Calibri' })] })]
        })] }),
        new TableRow({ children: [new TableCell({
          shading: { type: ShadingType.SOLID, color: WHITE },
          borders: { top: noBorder(), bottom: noBorder(), left: noBorder(), right: noBorder() },
          margins: { top: 80, bottom: 80, left: 100, right: 100 },
          children: [miniTable(
            ['Drug','Antidote','Dose / Route','Key Pitfall'],
            [
              ['Paracetamol','N-Acetylcysteine (NAC)','IV 3-bag regimen OR oral 17-dose','Start if >8 hrs even before level returns'],
              ['Aspirin','NaHCO₃ + HD if severe','Urine pH 7.5–8.5 target','AVOID acetazolamide — acidifies blood'],
              ['TCA','Sodium Bicarbonate','50–100 mEq IV bolus','AVOID flumazenil, phenytoin, amiodarone'],
              ['Digoxin','Digoxin Fab (Digibind)','Vials = (level × wt) ÷ 100','AVOID calcium in acute OD'],
              ['Lithium','Haemodialysis','Serial sessions, target < 1 mmol/L','Charcoal useless; check rebound at 6–12 hrs'],
              ['Benzodiazepines','Flumazenil (with caution)','0.2 mg IV → max 2 mg','CI: TCA co-ingestion, BZD dependence'],
              ['Opioids','Naloxone ± infusion','0.4–2 mg IV; 2/3 bolus/hr infusion','Resedation risk; titrate gently'],
            ],
            '2C3E50', 'F8F9FA'
          )]
        })] }),
        new TableRow({ children: [new TableCell({
          shading: { type: ShadingType.SOLID, color: 'FFF8E1' },
          borders: { top: border('F39C12',4), bottom: noBorder(), left: noBorder(), right: noBorder() },
          margins: { top: 80, bottom: 80, left: 200, right: 200 },
          children: [
            new Paragraph({ alignment: AlignmentType.CENTER, children: [new TextRun({ text: '📚  References: Archith Baloor — Essentials of Forensic Medicine & Toxicology (36th Ed. 2026)  |  Harrison\'s Principles of Internal Medicine 22E (2025)  |  Davidson\'s Principles & Practice of Medicine', size: 16, color: '666666', font: 'Calibri', italics: true })] }),
          ]
        })] }),
      ]
    })
  ];
}

// ─── ASSEMBLE DOCUMENT ────────────────────────────────────────────────────────
const sections = [
  ...coverPage(),
  ...buildSheet('paracetamol'),
  ...buildSheet('aspirin'),
  ...buildSheet('tca'),
  ...buildSheet('digoxin'),
  ...buildSheet('lithium'),
  ...buildSheet('benzo'),
  ...buildSheet('opioid'),
  ...antidotePage(),
];

const doc = new Document({
  styles: {
    default: {
      document: {
        run: { font: 'Calibri', size: 18 }
      }
    }
  },
  sections: [{
    properties: {
      page: {
        margin: { top: convertInchesToTwip(0.5), bottom: convertInchesToTwip(0.5), left: convertInchesToTwip(0.6), right: convertInchesToTwip(0.6) }
      }
    },
    children: sections
  }]
});

Packer.toBuffer(doc).then(buf => {
  fs.writeFileSync('/home/daytona/workspace/toxicology-cheatsheets/Toxicology_Cheatsheets.docx', buf);
  console.log('Done!');
}).catch(e => { console.error(e); process.exit(1); });