from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm
from reportlab.platypus import (SimpleDocTemplate, Table, TableStyle,
                                 Paragraph, Spacer, HRFlowable)
from reportlab.lib.enums import TA_CENTER, TA_LEFT

doc_path = "/home/daytona/workspace/neet-pg/Pharma_DOC_QuickRef_NEETPG.pdf"
doc = SimpleDocTemplate(doc_path, pagesize=A4,
                        topMargin=1.2*cm, bottomMargin=1.2*cm,
                        leftMargin=1.5*cm, rightMargin=1.5*cm)

styles = getSampleStyleSheet()

# Custom styles
title_style = ParagraphStyle('Title', parent=styles['Normal'],
    fontSize=16, fontName='Helvetica-Bold', alignment=TA_CENTER,
    textColor=colors.HexColor('#1a237e'), spaceAfter=4)
subtitle_style = ParagraphStyle('Subtitle', parent=styles['Normal'],
    fontSize=9, fontName='Helvetica', alignment=TA_CENTER,
    textColor=colors.HexColor('#555555'), spaceAfter=10)
section_style = ParagraphStyle('Section', parent=styles['Normal'],
    fontSize=10, fontName='Helvetica-Bold', alignment=TA_LEFT,
    textColor=colors.white, spaceAfter=2)
cell_style = ParagraphStyle('Cell', parent=styles['Normal'],
    fontSize=8, fontName='Helvetica', leading=10)
bold_cell_style = ParagraphStyle('BoldCell', parent=styles['Normal'],
    fontSize=8, fontName='Helvetica-Bold', leading=10)
note_style = ParagraphStyle('Note', parent=styles['Normal'],
    fontSize=7, fontName='Helvetica-Oblique', textColor=colors.HexColor('#b71c1c'))

# Color palette
HDR = colors.HexColor('#1a237e')       # deep navy
SEC1 = colors.HexColor('#283593')      # infections
SEC2 = colors.HexColor('#1565c0')      # CVS
SEC3 = colors.HexColor('#0277bd')      # CNS / Neuro
SEC4 = colors.HexColor('#00695c')      # respiratory
SEC5 = colors.HexColor('#2e7d32')      # GI
SEC6 = colors.HexColor('#4527a0')      # psychiatry
SEC7 = colors.HexColor('#ad1457')      # obs/gynae
SEC8 = colors.HexColor('#e65100')      # misc / special
ROW_EVEN = colors.HexColor('#e8eaf6')
ROW_ODD  = colors.white
HIGHLIGHT = colors.HexColor('#fff9c4')  # yellow for "remember" rows

def make_section_header(text, color):
    return Paragraph(f'<font color="white"><b>{text}</b></font>', section_style)

def make_table(headers, data_rows, col_widths, section_color):
    """Build a styled table."""
    table_data = [headers] + data_rows
    t = Table(table_data, colWidths=col_widths, repeatRows=1)
    style = [
        # Header
        ('BACKGROUND', (0,0), (-1,0), section_color),
        ('TEXTCOLOR', (0,0), (-1,0), colors.white),
        ('FONTNAME', (0,0), (-1,0), 'Helvetica-Bold'),
        ('FONTSIZE', (0,0), (-1,0), 8),
        ('BOTTOMPADDING', (0,0), (-1,0), 5),
        ('TOPPADDING', (0,0), (-1,0), 5),
        # Body
        ('FONTNAME', (0,1), (-1,-1), 'Helvetica'),
        ('FONTSIZE', (0,1), (-1,-1), 7.5),
        ('TOPPADDING', (0,1), (-1,-1), 3),
        ('BOTTOMPADDING', (0,1), (-1,-1), 3),
        ('GRID', (0,0), (-1,-1), 0.3, colors.HexColor('#9fa8da')),
        ('VALIGN', (0,0), (-1,-1), 'MIDDLE'),
    ]
    for i, row in enumerate(data_rows):
        bg = ROW_EVEN if i % 2 == 0 else ROW_ODD
        style.append(('BACKGROUND', (0, i+1), (-1, i+1), bg))
    t.setStyle(TableStyle(style))
    return t

story = []

# ── TITLE ────────────────────────────────────────────────────────────────────
story.append(Paragraph("PHARMACOLOGY — DRUG OF CHOICE (DOC)", title_style))
story.append(Paragraph("NEET PG Quick Reference Sheet  •  All exam-relevant DOCs in one place", subtitle_style))
story.append(HRFlowable(width="100%", thickness=1.5, color=HDR, spaceAfter=8))

# ══════════════════════════════════════════════════════════════════════════════
# 1. INFECTIOUS DISEASES
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("1. INFECTIOUS DISEASES", SEC1)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC1),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

inf_headers = ["Condition / Organism", "Drug of Choice (DOC)", "Alternative / Notes"]
inf_rows = [
    ["Syphilis (all stages)", "Benzathine Penicillin G", "Doxycycline if penicillin allergy"],
    ["Syphilis in pregnancy", "Penicillin G (desensitize if allergic)", "No safe alternative — must desensitize"],
    ["Gonorrhea (uncomplicated)", "Ceftriaxone (IM) + Azithromycin", ""],
    ["Chlamydia", "Azithromycin (single dose) / Doxycycline", ""],
    ["Cholera", "Doxycycline (adults)", "Tetracycline; TMP-SMX; Erythromycin"],
    ["Typhoid fever", "Fluoroquinolone (Ciprofloxacin)", "Ceftriaxone (3rd gen); Azithromycin"],
    ["Shigella dysentery", "Ciprofloxacin", "Ampicillin (resistance common)"],
    ["Plague (Bubonic)", "Streptomycin / Gentamicin", "Doxycycline (oral); Quinolones"],
    ["Plague Meningitis", "Chloramphenicol", "High CSF penetration needed"],
    ["Brucellosis", "Doxycycline + Rifampicin (6 wks)", "Doxy + Gentamicin (acute)"],
    ["Q Fever (Coxiella burnetti)", "Doxycycline", "Chronic: Doxy + Hydroxychloroquine"],
    ["Rickettsial infections / RMSF", "Doxycycline", "Chloramphenicol (pregnancy)"],
    ["Scrub Typhus", "Doxycycline", "Azithromycin in pregnancy"],
    ["Leptospirosis", "Penicillin G / Doxycycline", "Ceftriaxone (severe)"],
    ["Anthrax (inhalation)", "Ciprofloxacin + Clindamycin", "60-day course post-exposure"],
    ["Leprosy — Paucibacillary", "Dapsone + Rifampicin (6 months)", "WHO MDT regimen"],
    ["Leprosy — Multibacillary", "Dapsone + Rifampicin + Clofazimine (12 mo)", "WHO MDT regimen"],
    ["Tuberculosis (new case)", "HRZE × 2 months → HR × 4 months", "RNTCP/WHO DOTS regimen"],
    ["MDR-TB", "Bedaquiline-based regimen", "Longer course 18–24 months"],
    ["Malaria — P. vivax / P. ovale", "Chloroquine + Primaquine (radical cure)", "Primaquine clears liver hypnozoites"],
    ["Malaria — P. falciparum (uncomplicated)", "Artemisinin-based Combo (ACT)", "Artemether-Lumefantrine, ASPY"],
    ["Malaria — Severe / Complicated", "IV Artesunate", "WHO drug of choice for severe malaria"],
    ["Leishmaniasis (Kala-azar)", "Liposomal Amphotericin B", "Miltefosine (oral); Sodium Stibogluconate"],
    ["Sleeping Sickness — Blood stage", "Suramin (T. rhodesiense) / Pentamidine (T. gambiense)", ""],
    ["Sleeping Sickness — CNS stage", "Melarsoprol", "Eflornithine (T. gambiense CNS)"],
    ["Trichomoniasis", "Metronidazole (single 2g dose)", "Tinidazole"],
    ["Amoebiasis (Intestinal & hepatic)", "Metronidazole → Diloxanide furoate (luminal)", ""],
    ["Giardiasis", "Metronidazole / Tinidazole", ""],
    ["Cysticercosis", "Praziquantel / Albendazole", "Surgery for ocular/cerebral"],
    ["Neurocysticercosis", "Albendazole + Dexamethasone", ""],
    ["Toxoplasmosis", "Pyrimethamine + Sulfadiazine + Folinic acid", "TMP-SMX (prophylaxis)"],
    ["Meningitis — N. meningitidis", "Penicillin G / Ceftriaxone", "Rifampicin (prophylaxis for contacts)"],
    ["Meningitis — H. influenzae", "Ceftriaxone / Cefotaxime", "Rifampicin (prophylaxis)"],
    ["Meningitis — Listeria", "Ampicillin (± Gentamicin)", "TMP-SMX if penicillin allergy"],
    ["Meningitis — Cryptococcal", "Liposomal Amphotericin B + Flucytosine", "Fluconazole (maintenance)"],
    ["Pneumonia — Community acquired (CAP)", "Amoxicillin / Amoxicillin-Clavulanate", "Atypical: Azithromycin/Doxycycline"],
    ["Pneumonia — Atypical (Mycoplasma)", "Azithromycin / Doxycycline", "Fluoroquinolone"],
    ["Pneumocystis jirovecii (PCP)", "TMP-SMX (high dose)", "Pentamidine (if intolerant)"],
    ["Candida (systemic)", "Fluconazole / Echinocandin (Caspofungin)", "Amphotericin B (severe)"],
    ["Aspergillosis (invasive)", "Voriconazole", "Amphotericin B"],
    ["Histoplasmosis (severe/disseminated)", "Amphotericin B → Itraconazole (step-down)", ""],
    ["HIV (initial ART)", "TDF + 3TC + DTG (dolutegravir)", "Current WHO preferred regimen"],
    ["CMV Retinitis (HIV patient)", "Ganciclovir / Valganciclovir", "Foscarnet (resistance)"],
    ["Herpes Simplex (genital / oral)", "Acyclovir / Valacyclovir", ""],
    ["Herpes Zoster", "Acyclovir / Famciclovir / Valacyclovir", "Start within 72 hrs of rash"],
    ["Influenza (treatment)", "Oseltamivir (Tamiflu)", "Zanamivir (inhaled)"],
]
story.append(make_table(inf_headers, inf_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC1))
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 2. CARDIOVASCULAR
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("2. CARDIOVASCULAR", SEC2)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC2),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

cvs_rows = [
    ["Hypertensive Emergency — CNS disorder", "Sodium Nitroprusside", "Labetalol (alternative)"],
    ["Hypertensive Emergency — Intracranial hemorrhage", "Sodium Nitroprusside", "Labetalol"],
    ["Hypertensive Emergency — Acute LV failure", "Enalaprilat (IV)", "Labetalol CONTRAINDICATED"],
    ["Hypertensive Emergency — Acute coronary ischemia / Unstable angina", "Nitroglycerin (IV)", "Labetalol / Nitroprusside"],
    ["Hypertensive Emergency — Aortic Dissection", "Esmolol (IV)", "Nitroprusside + Propranolol; Hydralazine CI"],
    ["Hypertensive Emergency — Eclampsia", "Magnesium Sulphate", "Hydralazine (BP control)"],
    ["Hypertensive Emergency — Pheochromocytoma", "Phentolamine (alpha-blocker)", "Beta-blockers CONTRAINDICATED initially"],
    ["Stable Angina", "Beta-blocker (1st line)", "Nitrates; CCB"],
    ["Acute MI (STEMI) — Reperfusion", "Primary PCI (within 90 min)", "Thrombolysis if PCI not available"],
    ["Acute MI — Adjunct drug", "Aspirin + Heparin + Beta-blocker", "ACE inhibitor (post-MI LV dysfunction)"],
    ["Heart Failure with reduced EF (HFrEF)", "ACE inhibitor + Beta-blocker + Spironolactone", "ARNi (Sacubitril-Valsartan) superior"],
    ["Atrial Fibrillation — Rate control", "Beta-blocker / Digoxin / Diltiazem", ""],
    ["Atrial Fibrillation — Rhythm control", "Amiodarone / DC cardioversion", ""],
    ["SVT (AVNRT) — Acute", "Adenosine (IV)", "Verapamil; Vagal maneuvers first"],
    ["Ventricular Fibrillation / Pulseless VT", "Defibrillation (unsynchronized shock)", "Amiodarone (adjunct)"],
    ["Torsades de Pointes", "Magnesium Sulphate (IV)", "Stop offending drug; pace if bradycardia"],
    ["Digoxin toxicity (life-threatening)", "Digoxin-specific antibody fragments (Fab)", ""],
    ["Cardiogenic Shock", "Dobutamine (inotrope)", "Noradrenaline (vasopressor if hypotensive)"],
]
story.append(make_table(inf_headers, cvs_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC2))
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 3. CNS / NEUROLOGY
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("3. CNS / NEUROLOGY & EPILEPSY", SEC3)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC3),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

neuro_rows = [
    ["Status Epilepticus — 1st line", "Lorazepam / Diazepam (IV benzodiazepine)", "Midazolam (buccal/IM if no IV access)"],
    ["Status Epilepticus — 2nd line", "Phenytoin / Fosphenytoin IV", "Valproate IV; Levetiracetam IV"],
    ["Absence (Petit mal) Seizures", "Ethosuximide", "Valproate (if mixed seizure types)"],
    ["Juvenile Myoclonic Epilepsy (JME)", "Valproate", "Levetiracetam (women of childbearing age)"],
    ["Tonic-Clonic Seizures", "Valproate / Levetiracetam", "Phenytoin; Carbamazepine"],
    ["Partial / Focal Seizures", "Carbamazepine / Oxcarbazepine", "Levetiracetam; Lamotrigine"],
    ["Febrile Seizures (prophylaxis)", "Oral / Rectal Diazepam", "Only if high-risk recurrence"],
    ["Trigeminal Neuralgia", "Carbamazepine", "Oxcarbazepine; Gabapentin"],
    ["Parkinson's Disease — Early", "Levodopa + Carbidopa (gold standard)", "Dopamine agonist (younger patients)"],
    ["Parkinson's (drug-induced psychosis)", "Quetiapine / Clozapine", "Most antipsychotics worsen PD"],
    ["Alzheimer's Disease — Mild to moderate", "Donepezil / Rivastigmine (AChE inhibitors)", "Galantamine"],
    ["Alzheimer's Disease — Moderate to severe", "Memantine ± AChE inhibitor", ""],
    ["Migraine — Acute attack", "Triptans (Sumatriptan)", "NSAIDs; Ergotamine"],
    ["Migraine — Prophylaxis", "Propranolol / Valproate / Topiramate", "Amitriptyline; CCB"],
    ["Myasthenia Gravis — Symptomatic", "Pyridostigmine (AChE inhibitor)", ""],
    ["Myasthenia Gravis — Immunosuppression", "Prednisolone → Azathioprine", ""],
    ["Myasthenic Crisis", "IV Immunoglobulin / Plasmapheresis", "Avoid aminoglycosides"],
    ["Multiple Sclerosis — Relapse", "High-dose IV Methylprednisolone", ""],
    ["Guillain-Barré Syndrome", "IV Immunoglobulin / Plasmapheresis", "Steroids NOT effective"],
    ["Bacterial Meningitis (empirical adult)", "Ceftriaxone + Dexamethasone", "Add Ampicillin if Listeria suspected"],
    ["Raised ICP / Cerebral edema", "Mannitol (osmotic diuretic)", "Hypertonic saline; Dexamethasone (tumor)"],
    ["Wilson's Disease", "D-Penicillamine", "Trientine (if intolerant); Zinc (maintenance)"],
]
story.append(make_table(inf_headers, neuro_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC3))
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 4. RESPIRATORY
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("4. RESPIRATORY", SEC4)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC4),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

resp_rows = [
    ["Asthma — Acute severe", "Salbutamol (SABA) + IV Hydrocortisone", "Add Ipratropium; IV Magnesium sulphate (life-threatening)"],
    ["Asthma — Chronic (Step 2+)", "Inhaled Corticosteroid (ICS) + SABA PRN", "LABA added at Step 3"],
    ["COPD — Stable (Step 1)", "SAMA (Ipratropium) or SABA PRN", ""],
    ["COPD — Stable (Step 2+)", "LAMA (Tiotropium) ± LABA", "ICS only if frequent exacerbations"],
    ["COPD Exacerbation", "Salbutamol + Ipratropium nebulization + Steroids + Abx", ""],
    ["Pulmonary Arterial Hypertension", "Sildenafil / Bosentan / Epoprostenol", "Based on WHO functional class"],
    ["Allergic Bronchopulmonary Aspergillosis", "Prednisolone + Itraconazole", ""],
    ["Cystic Fibrosis (CFTR modulator, F508del)", "Elexacaftor-Tezacaftor-Ivacaftor (ETI)", "Current standard of care"],
]
story.append(make_table(inf_headers, resp_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC4))
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 5. GI & LIVER
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("5. GI, LIVER & METABOLIC", SEC5)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC5),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

gi_rows = [
    ["H. pylori Eradication (Triple therapy)", "PPI + Clarithromycin + Amoxicillin (7–14 days)", "Quad therapy if clarithromycin resistance"],
    ["GERD — Acute", "PPI (Omeprazole/Pantoprazole)", "H2 blocker (less effective)"],
    ["Peptic Ulcer Disease", "PPI + H. pylori eradication if positive", ""],
    ["C. difficile — Mild/moderate", "Oral Vancomycin / Fidaxomicin", "Metronidazole (1st-line historically, now 2nd)"],
    ["C. difficile — Severe/recurrent", "Oral Vancomycin + Fidaxomicin / FMT", ""],
    ["IBD — Crohn's (induction)", "Corticosteroids / Infliximab (biologics)", "Azathioprine (maintenance)"],
    ["IBD — Ulcerative Colitis (mild-mod)", "Mesalazine (5-ASA)", "Topical 5-ASA (proctitis)"],
    ["Hepatic Encephalopathy", "Lactulose + Rifaximin", "Low protein diet (outdated concept)"],
    ["Type 1 DM", "Insulin (basal-bolus regimen)", ""],
    ["Type 2 DM — 1st line", "Metformin", "SGLT2i or GLP-1 RA if CVD/CKD"],
    ["Diabetic Ketoacidosis (DKA)", "IV Insulin + IV Fluids + K+ replacement", "Treat precipitating cause"],
    ["Hyperosmolar Hyperglycemic State", "IV Fluids (0.9% NaCl) + Low-dose Insulin", "Avoid rapid fluid shifts"],
    ["Hypoglycemia (conscious)", "Oral glucose / Glucagon IM", "IV Dextrose 25% if unconscious"],
    ["Thyrotoxic Crisis / Storm", "PTU + Beta-blocker + Iodine (Lugol's) + Steroids", "PTU preferred over MMI in crisis"],
    ["Hypothyroidism", "Levothyroxine (T4)", ""],
    ["Addisonian Crisis", "IV Hydrocortisone + IV Fluids + Glucose", ""],
    ["Cushing's Disease (pituitary)", "Trans-sphenoidal surgery", "Metyrapone / Ketoconazole (medical)"],
    ["Gout — Acute attack", "Colchicine / NSAIDs / Corticosteroids", "NOT allopurinol during acute attack"],
    ["Gout — Prophylaxis", "Allopurinol (xanthine oxidase inhibitor)", "Febuxostat; Uricosurics"],
    ["Paget's Disease of bone", "Bisphosphonates (Zoledronate)", "Calcitonin (2nd line)"],
]
story.append(make_table(inf_headers, gi_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC5))
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 6. PSYCHIATRY
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("6. PSYCHIATRY", SEC6)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC6),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

psych_rows = [
    ["Depression — 1st line", "SSRI (Escitalopram / Sertraline)", "SNRIs; Mirtazapine; Bupropion"],
    ["Treatment-Resistant Depression", "Venlafaxine + add-on Lithium / Atypical antipsychotic", "ECT"],
    ["OCD", "SSRI (Fluvoxamine / Fluoxetine) + CBT", "Clomipramine (TCA)"],
    ["Panic Disorder / Anxiety", "SSRI (1st choice) + CBT", "Benzodiazepines (short-term only)"],
    ["PTSD", "SSRI (Sertraline / Paroxetine)", "Prazosin (nightmares)"],
    ["Schizophrenia — 1st episode", "Atypical antipsychotic (Risperidone / Olanzapine)", "Clozapine (treatment-resistant)"],
    ["Bipolar Disorder — Manic episode", "Lithium / Valproate / Atypical antipsychotic", ""],
    ["Bipolar Disorder — Maintenance", "Lithium (gold standard)", "Valproate; Lamotrigine (depressive phase)"],
    ["ADHD (children)", "Methylphenidate (stimulant)", "Atomoxetine (non-stimulant)"],
    ["Alcohol withdrawal / Delirium Tremens", "Chlordiazepoxide / Diazepam (BZD)", "Lorazepam (if liver disease)"],
    ["Alcohol dependence (relapse prevention)", "Naltrexone / Acamprosate", "Disulfiram (aversion therapy)"],
    ["Opioid dependence (maintenance)", "Buprenorphine / Methadone", "Naltrexone (after detox)"],
    ["Opioid overdose", "Naloxone (IV/IM/intranasal)", "Repeat dosing may be needed"],
    ["Benzodiazepine overdose", "Flumazenil", "Short-acting; re-sedation possible"],
    ["Neuroleptic Malignant Syndrome (NMS)", "Stop antipsychotic + Dantrolene / Bromocriptine", "Supportive care"],
    ["Serotonin Syndrome", "Stop offending drug + Cyproheptadine", "Benzodiazepines (agitation); ICU"],
]
story.append(make_table(inf_headers, psych_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC6))
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 7. OBG / GYNAECOLOGY
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("7. OBSTETRICS & GYNAECOLOGY", SEC7)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC7),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

obg_rows = [
    ["Eclampsia / Pre-eclampsia seizure", "Magnesium Sulphate (Pritchard regimen)", "Diazepam (2nd line)"],
    ["PPH (Uterine atony) — 1st line", "Oxytocin (IV/IM)", "Misoprostol; Ergometrine; Carboprost"],
    ["PPH — Carboprost (15-methyl PGF2α)", "Intramyometrial injection", "Asthma is a CONTRAINDICATION"],
    ["Gestational Diabetes", "Metformin / Insulin", "Insulin preferred if Metformin inadequate"],
    ["Ectopic Pregnancy (unruptured, small)", "Methotrexate (IM)", "Surgery if ruptured or large"],
    ["Cervical Ripening / Labour Induction", "Misoprostol (PGE1) / Dinoprostone", ""],
    ["Preterm Labour (tocolysis)", "Nifedipine (CCB) / Atosiban", "Ritodrine (beta-2 agonist)"],
    ["Fetal Lung Maturity (< 34 wks)", "Betamethasone / Dexamethasone (antenatal corticosteroids)", "Single course; repeat controversial"],
    ["Endometriosis", "Progestogens / GnRH agonists / COC pill", "Surgery for severe cases"],
    ["PCOS — Menstrual regulation", "Combined OCP", ""],
    ["PCOS — Insulin resistance / Fertility", "Metformin / Clomiphene / Letrozole", ""],
    ["Hyperprolactinemia / Prolactinoma", "Cabergoline / Bromocriptine (dopamine agonists)", "Surgery (macroadenoma if no response)"],
    ["Emergency Contraception", "Levonorgestrel (within 72 hrs) / Ulipristal (72–120 hrs)", "Cu-IUD (most effective, up to 5 days)"],
    ["Menopausal symptoms", "HRT (Estrogen ± Progesterone)", "Tibolone; SSRIs (vasomotor)"],
    ["Vulvovaginal Candidiasis", "Fluconazole (oral) / Clotrimazole (topical)", ""],
    ["Bacterial Vaginosis", "Metronidazole (oral or gel)", "Clindamycin"],
]
story.append(make_table(inf_headers, obg_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC7))
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 8. MISCELLANEOUS HIGH-YIELD
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[make_section_header("8. MISCELLANEOUS HIGH-YIELD DOCs", SEC8)]],
    colWidths=[17.5*cm],
    style=[('BACKGROUND',(0,0),(-1,-1),SEC8),('TOPPADDING',(0,0),(-1,-1),4),
           ('BOTTOMPADDING',(0,0),(-1,-1),4),('LEFTPADDING',(0,0),(-1,-1),6)]))
story.append(Spacer(1, 4))

misc_rows = [
    ["Anaphylaxis", "Adrenaline (Epinephrine) IM", "Thigh, anterolateral; then antihistamine + steroid"],
    ["Iron Deficiency Anemia", "Oral Ferrous Sulphate", "IV iron if severe/intolerant"],
    ["Megaloblastic Anemia — B12 deficiency", "Cyanocobalamin / Hydroxocobalamin (IM)", ""],
    ["Megaloblastic Anemia — Folate deficiency", "Folic Acid (oral)", ""],
    ["Aplastic Anemia — Young (matched donor)", "Allogeneic BMT", "ATG + Cyclosporine if no donor"],
    ["Sickle Cell Crisis (vaso-occlusive)", "Hydroxyurea (disease-modifying)", "Analgesics + Hydration for crisis"],
    ["Hemophilia A", "Factor VIII concentrate / DDAVP (mild)", ""],
    ["Hemophilia B", "Factor IX concentrate", ""],
    ["ITP — 1st line", "Prednisolone / IVIG", "Anti-D; Splenectomy; TPO agonists"],
    ["Rheumatoid Arthritis — 1st DMARD", "Methotrexate", "Hydroxychloroquine; Leflunomide"],
    ["SLE — Mild", "Hydroxychloroquine + NSAIDs", "Low-dose steroids"],
    ["SLE — Severe (nephritis)", "High-dose Steroids + Cyclophosphamide / Mycophenolate", "Belimumab (biologic)"],
    ["Vasculitis (ANCA-associated)", "Cyclophosphamide + Prednisolone", "Rituximab (alternative induction)"],
    ["Acute Graft Rejection", "High-dose IV Methylprednisolone", "Antithymocyte globulin (steroid-resistant)"],
    ["Benign Prostatic Hyperplasia (BPH)", "Alpha-1 blocker (Tamsulosin) ± 5-ARI (Finasteride)", ""],
    ["Overactive Bladder", "Solifenacin / Oxybutynin (antimuscarinic)", "Mirabegron (beta-3 agonist)"],
    ["Osteoporosis (postmenopausal)", "Bisphosphonate (Alendronate / Zoledronate)", "Denosumab; Romosozumab; HRT"],
    ["Paracetamol / Acetaminophen toxicity", "N-Acetylcysteine (NAC)", "Within 8–10 hrs most effective"],
    ["Organophosphate poisoning", "Atropine (large doses) + Pralidoxime (2-PAM)", "Atropine first, then 2-PAM"],
    ["Heparin overdose", "Protamine Sulphate", "1 mg per 100 units heparin"],
    ["Warfarin overdose", "Vitamin K (phytomenadione) + FFP / 4-factor PCC", "PCC faster than FFP"],
    ["Benzodiazepine overdose", "Flumazenil", "Short half-life; re-sedation possible"],
    ["Methanol / Ethylene glycol poisoning", "Fomepizole / Ethanol + Haemodialysis", "Fomepizole preferred"],
    ["Cyanide poisoning", "Hydroxocobalamin / Sodium thiosulphate + Amyl nitrite", ""],
    ["CO poisoning", "100% Oxygen (hyperbaric if severe)", ""],
    ["Lead poisoning (high BLL / symptomatic)", "DMSA (Succimer) oral / EDTA + BAL (IV, encephalopathy)", ""],
    ["Arsenic / Mercury poisoning", "BAL (British Anti-Lewisite / Dimercaprol)", "DMSA for Hg; DMPS for As"],
    ["Iron poisoning (acute)", "Desferrioxamine (IV chelation)", ""],
    ["Age-related Macular Degeneration (wet)", "Anti-VEGF (Ranibizumab / Bevacizumab)", ""],
    ["Glaucoma (open angle)", "Prostaglandin analogue (Latanoprost)", "Beta-blocker (Timolol); CAI"],
    ["Acute Angle-Closure Glaucoma", "IV Acetazolamide + Pilocarpine (miotic)", "Laser iridotomy (definitive)"],
    ["Otitis Media (acute)", "Amoxicillin", "Amoxicillin-Clavulanate (recurrent)"],
    ["Peritonsillar Abscess", "I&D + IV Penicillin / Amoxicillin-Clavulanate", ""],
    ["Scurvy (Vit C deficiency)", "Ascorbic Acid (Vitamin C)", ""],
    ["Rickets / Osteomalacia", "Vitamin D3 (Cholecalciferol) + Calcium", ""],
]
story.append(make_table(inf_headers, misc_rows, [5.8*cm, 6.2*cm, 5.5*cm], SEC8))
story.append(Spacer(1, 10))

# Footer note
story.append(HRFlowable(width="100%", thickness=0.5, color=colors.HexColor('#9fa8da'), spaceAfter=4))
story.append(Paragraph(
    "⚠  Always verify against current guidelines. DOCs can vary by institution, patient population, local resistance patterns & drug availability. "
    "Sources: Goodman & Gilman's Pharmacology, Katzung's Basic & Clinical Pharmacology, Harrison's Medicine, Swanson's Family Medicine, Park's PSM, Kaplan Psychiatry.",
    note_style))

doc.build(story)
print(f"PDF saved to: {doc_path}")