How many ml of duphalec should be given in an adult
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Duphalac lactulose adult dose ml constipation hepatic encephalopathy
Duphalac is a brand of lactulose solution (3.335 g/5 mL). The adult dose depends on the indication:
Duphalac (Lactulose) — Adult Dosing
Constipation
| Source | Dose |
|---|---|
| BNF (NICE) | 15 mL twice daily initially, adjusted to response |
| NHS | 15–30 mL per day (may be split into doses) |
The dose is titrated up or down depending on stool frequency. The goal is 1–3 soft stools per day.
Hepatic Encephalopathy (Portal-Systemic Encephalopathy)
| Source | Dose |
|---|---|
| BNF (NICE) | 30–50 mL three times daily |
| NHS | 30–50 mL three times daily |
| StatPearls (NIH) | 15–30 mL two to four times daily |
| MIMS | 30–45 mL three to four times daily, adjusted to achieve 2–3 soft stools/day |
For hepatic encephalopathy, dosing is guided by stool output — the target is 2–3 semi-soft stools per day.
Rectal (Enema) — Hepatic Encephalopathy (if unable to take orally)
- 300 mL lactulose in 700 mL water or normal saline, retained for 30–60 minutes every 4–6 hours.
Key point: The dose is always titrated to effect. Start at the lower end and adjust based on the patient's response and stool frequency.
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