“Pancreas” problems need different medicines depending on the cause, such as pancreatitis, diabetes, pancreatic enzyme deficiency, infection, or cancer. There is no single best medicine.

If you have severe upper-abdominal pain, repeated vomiting, fever, yellow eyes/skin, fainting, or pain spreading to the back, seek urgent medical care now.

What problem or diagnosis do you mean, and what symptoms do you have?

For chronic pancreatitis, the best medicine depends on the problem being treated.

Two measures matter as much as medication: stop alcohol completely and stop smoking. Both can worsen pancreatic damage and pain. The National Pancreas Foundation guidance also notes that enzymes, vitamin replacement, diabetes care, and treatment of duct obstruction are central parts of management.

Do not start enzyme pills or regular pain medicines without a gastroenterologist or physician, because the right treatment depends on whether you have malabsorption, stones/duct blockage, diabetes, liver disease, ulcers, or kidney problems.

Seek urgent care for worsening severe abdominal pain, persistent vomiting, fever, jaundice, black stools, dehydration, or unintentional weight loss. Recent evidence also suggests that in selected people with painful obstructive disease, definitive endoscopic or surgical assessment can be more effective than medication alone, as discussed in a 2024 systematic review.