Ligamentum arteriosum

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ligamentum arteriosum ductus arteriosus anatomy diagram

This composite of contrast-enhanced computed tomography angiography (CTA) images of the thoracic aorta illustrates a ductus arteriosus diverticulum (DAD) and an associated pseudoaneurysm. Panel A, an axial image, shows the DAD (arrow) as a contrast-filled outpouching from the aorta, connecting to a larger, more peripheral pseudoaneurysm (arrowhead) that displays heterogeneous density, indicating a mix of opacified blood and potential thrombus. Panel B is a two-dimensional sagittal reformatted image showing the DAD (arrow) and pseudoaneurysm (arrowhead) arising from the inferior aspect of the aortic arch, near the site of the ligamentum arteriosum. Panel C presents a three-dimensional volume-rendered reconstruction, providing a spatial overview of the aortic arch anatomy for surgical planning. The reconstruction clearly delineates the wide neck of the DAD (arrow) and the orientation of the pseudoaneurysm sac (arrowhead) toward the pulmonary artery. These images demonstrate key diagnostic features used to differentiate a benign ductus diverticulum from a complex vascular pathology requiring intervention.

This composite of contrast-enhanced computed tomography angiography (CTA) images of the thoracic aorta illustrates a ductus arteriosus diverticulum (DAD) and an associated pseudoaneurysm. Panel A, an axial image, shows the DAD (arrow) as a contrast-filled outpouching from the aorta, connecting to a larger, more peripheral pseudoaneurysm (arrowhead) that displays heterogeneous density, indicating a mix of opacified blood and potential thrombus. Panel B is a two-dimensional sagittal reformatted image showing the DAD (arrow) and pseudoaneurysm (arrowhead) arising from the inferior aspect of the aortic arch, near the site of the ligamentum arteriosum. Panel C presents a three-dimensional volume-rendered reconstruction, providing a spatial overview of the aortic arch anatomy for surgical planning. The reconstruction clearly delineates the wide neck of the DAD (arrow) and the orientation of the pseudoaneurysm sac (arrowhead) toward the pulmonary artery. These images demonstrate key diagnostic features used to differentiate a benign ductus diverticulum from a complex vascular pathology requiring intervention.

This diagnostic image consists of two axial chest CT scans—contrast-enhanced (A) and non-contrast (B)—demonstrating a calcified ligamentum arteriosum in a 32-year-old female. Both images show a small, well-defined, hyperdense focal point (indicated by white arrows) located at the level of the tracheal bifurcation. This calcification is positioned within the aortopulmonary window, specifically near the 12 o'clock position relative to the descending thoracic aorta. Anatomical landmarks include the descending thoracic aorta posteriorly, the bifurcation of the trachea (carina) centrally, and the pulmonary artery adjacent to the aorta. The primary educational focus is to distinguish this benign, physiological calcification of the ligamentum arteriosum from a small patent ductus arteriosus (PDA). On enhanced CT (A), the high density of the calcification can mimic vascular enhancement; however, the non-contrast image (B) confirms the pre-existing high density characteristic of calcification rather than contrast-filled lumen. This distinction is critical for radiologists to avoid misdiagnosing a congenital vascular shunt.

This diagnostic image consists of two axial chest CT scans—contrast-enhanced (A) and non-contrast (B)—demonstrating a calcified ligamentum arteriosum in a 32-year-old female. Both images show a small, well-defined, hyperdense focal point (indicated by white arrows) located at the level of the tracheal bifurcation. This calcification is positioned within the aortopulmonary window, specifically near the 12 o'clock position relative to the descending thoracic aorta. Anatomical landmarks include the descending thoracic aorta posteriorly, the bifurcation of the trachea (carina) centrally, and the pulmonary artery adjacent to the aorta. The primary educational focus is to distinguish this benign, physiological calcification of the ligamentum arteriosum from a small patent ductus arteriosus (PDA). On enhanced CT (A), the high density of the calcification can mimic vascular enhancement; however, the non-contrast image (B) confirms the pre-existing high density characteristic of calcification rather than contrast-filled lumen. This distinction is critical for radiologists to avoid misdiagnosing a congenital vascular shunt.

This set of diagnostic images features longitudinal two-dimensional (2D) and color Doppler echocardiography of the ductus arteriosus (DA) in neonates. Panels A-C illustrate the 'PDA-closure group,' demonstrating the progressive stages of spontaneous closure. (A) shows a thin, hypoechoic, uneven intima with a patent lumen (D1) and wide transcatheter flow (W1) within 24 hours of birth. (B) displays intimal thickening and lumen occlusion by 48-72 hours. (C) shows the final formation of the hyperechoic ligamentum arteriosum with total cessation of flow at 26 days. Panels D-F depict the 'PDA-open group,' where the intima remains thinner and the lumen (D1-D3) stays more patent over time despite some contraction. Color Doppler confirms persistent shunting (blue and red flow signals) across the DA in the open group, while showing diminishing flow in the closure group. The series highlights the pathophysiology of neonatal DA remodeling, specifically the role of intimal cushions and contraction in transition from a patent ductus arteriosus to an anatomical ligament.

This set of diagnostic images features longitudinal two-dimensional (2D) and color Doppler echocardiography of the ductus arteriosus (DA) in neonates. Panels A-C illustrate the 'PDA-closure group,' demonstrating the progressive stages of spontaneous closure. (A) shows a thin, hypoechoic, uneven intima with a patent lumen (D1) and wide transcatheter flow (W1) within 24 hours of birth. (B) displays intimal thickening and lumen occlusion by 48-72 hours. (C) shows the final formation of the hyperechoic ligamentum arteriosum with total cessation of flow at 26 days. Panels D-F depict the 'PDA-open group,' where the intima remains thinner and the lumen (D1-D3) stays more patent over time despite some contraction. Color Doppler confirms persistent shunting (blue and red flow signals) across the DA in the open group, while showing diminishing flow in the closure group. The series highlights the pathophysiology of neonatal DA remodeling, specifically the role of intimal cushions and contraction in transition from a patent ductus arteriosus to an anatomical ligament.

A clinical photograph of a cadaveric dissection focused on the superior mediastinum, specifically demonstrating the relationship between major cardiovascular and neurovascular structures. The aortic arch is positioned superiorly, with the pulmonary artery (PUL ART) located inferior to it. Connecting these two vessels is the ligamentum arteriosum (LIG), a fibrous remnant of the ductus arteriosus, shown as a short, taut band. The left vagus nerve descends vertically, crossing the lateral aspect of the aortic arch. The left recurrent laryngeal nerve (RLN) is clearly visible branching from the vagus nerve and looping medially and superiorly beneath the aortic arch, just posterior to the ligamentum arteriosum. A metal surgical probe is used to retract the vagus nerve for better visualization of the RLN's origin. This anatomical illustration highlights the clinical importance of the RLN's course, particularly in thoracic surgery or cases of aortic pathology where the nerve may be compressed or injured, leading to vocal cord paralysis.

A clinical photograph of a cadaveric dissection focused on the superior mediastinum, specifically demonstrating the relationship between major cardiovascular and neurovascular structures. The aortic arch is positioned superiorly, with the pulmonary artery (PUL ART) located inferior to it. Connecting these two vessels is the ligamentum arteriosum (LIG), a fibrous remnant of the ductus arteriosus, shown as a short, taut band. The left vagus nerve descends vertically, crossing the lateral aspect of the aortic arch. The left recurrent laryngeal nerve (RLN) is clearly visible branching from the vagus nerve and looping medially and superiorly beneath the aortic arch, just posterior to the ligamentum arteriosum. A metal surgical probe is used to retract the vagus nerve for better visualization of the RLN's origin. This anatomical illustration highlights the clinical importance of the RLN's course, particularly in thoracic surgery or cases of aortic pathology where the nerve may be compressed or injured, leading to vocal cord paralysis.

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Here is a thorough overview of the ligamentum arteriosum, synthesized from multiple authoritative textbooks.

Ligamentum Arteriosum

What It Is

The ligamentum arteriosum is a short, thick fibrous cord in the superior mediastinum that connects the root of the left pulmonary artery to the undersurface of the aortic arch (just distal to the origin of the left subclavian artery). It is the postnatal remnant of the ductus arteriosus, the fetal vascular shunt that allowed blood to bypass the high-resistance pulmonary circulation during intrauterine life.
  • Gray's Anatomy for Students, p. 258
  • Fischer's Mastery of Surgery, 8th ed., p. 2512

Embryological Origin

During fetal development, the ductus arteriosus (derived from the left 6th pharyngeal arch artery) shunts deoxygenated blood from the pulmonary trunk directly into the descending aorta, bypassing the collapsed, fluid-filled fetal lungs.
At birth:
  • Functional closure occurs within the first few days as rising arterial oxygen tension causes smooth muscle contraction of the ductus wall.
  • Anatomical closure (fibrous obliteration into the ligamentum arteriosum) is normally complete by the 12th postnatal week.
  • The Developing Human: Clinically Oriented Embryology, p. 879-880
The mechanism of closure involves a rise in PaO₂ after the first breath, which triggers vasoconstriction of the ductus smooth muscle. There is also evidence that failure of TGF-β induction after birth may underlie persistent patency (patent ductus arteriosus, or PDA).

Adult Anatomy

Diagram of the aortic arch and superior mediastinum showing the ligamentum arteriosum connecting the left pulmonary artery to the aortic arch, with labeled nerves and vessels
Aortic arch anatomy from Gray's Anatomy for Students: the ligamentum arteriosum connects the left pulmonary artery to the undersurface of the aortic arch, just to the right of the left recurrent laryngeal nerve's loop.
Key relationships in the adult:
StructureRelationship
Aortic archSuperior attachment of the ligament
Left pulmonary arteryInferior attachment
Left recurrent laryngeal nerveLoops around the aortic arch just to the right of the ligamentum arteriosum
Left vagus nerveDescends anterior to the aortic arch, gives off the recurrent laryngeal at the level of the ligament

Clinical Significance

1. Landmark for the Left Recurrent Laryngeal Nerve

The left recurrent laryngeal nerve (branch of the vagus) loops around the aortic arch immediately posterior to the ligamentum arteriosum. This makes it vulnerable to injury in thoracic surgery near this region and also explains why aortic arch aneurysms can cause hoarseness (recurrent laryngeal nerve palsy).
  • Fischer's Mastery of Surgery, p. 2512-2513

2. Aortic Trauma - Fixed Point

The aorta has three points of firm fixation: the aortic valve ring, the ligamentum arteriosum, and the diaphragmatic hiatus. In high-speed deceleration injuries (road traffic accidents), the aorta is most susceptible to traumatic rupture at these fixed points - classically just distal to the left subclavian artery at the level of the ligamentum arteriosum.
  • Gray's Anatomy for Students, p. 258

3. Division of the Ligament in Surgery

In thoracic aortic surgery (e.g., repair of coarctation or aneurysms of the aortic arch), division of the ligamentum arteriosum may be necessary to facilitate exposure, clamping, and anastomosis of the distal arch and left subclavian artery.
  • Fischer's Mastery of Surgery, p. 2059

4. Aortic Aneurysms - Anatomical Dividing Line

Thoracic aortic aneurysms (TAAs) are classified as proximal or distal relative to the ligamentum arteriosum. Proximal TAAs (ascending aorta and proximal arch) are not strongly linked to atherosclerotic risk factors, while distal ones are. This distinction guides surgical and endovascular management.
  • Fuster and Hurst's The Heart, 15th ed., p. 3116

5. Patent Ductus Arteriosus (PDA) - Failure to Close

When the ductus arteriosus fails to close postnatally, it remains as a PDA - a left-to-right shunt (aorta → pulmonary trunk) that causes pulmonary overcirculation and volume overload of the left heart. PDA is:
  • 2-3x more common in females
  • Associated with maternal rubella infection in early pregnancy
  • Common in prematurity (<28 weeks), high-altitude birth, and hypoxia
  • Treated medically with indomethacin (COX inhibitor, reduces prostaglandin E2 which normally keeps the ductus open) or surgical/catheter-based ligation
  • The Developing Human: Clinically Oriented Embryology, p. 880

6. Vascular Rings

In cases of abnormal aortic arch development (e.g., right aortic arch with aberrant left subclavian artery), the position of the ductus arteriosus / ligamentum arteriosum determines whether a complete vascular ring forms around the trachea and esophagus, potentially causing stridor and dysphagia.
  • Grainger & Allison's Diagnostic Radiology

7. Calcified Ligamentum Arteriosum on CT

A calcified ligamentum arteriosum can appear on CT as a small focal hyperdense structure in the aortopulmonary window, near the tracheal bifurcation. It is a benign incidental finding but must be distinguished from a small PDA or a mediastinal mass.
CT scan showing calcified ligamentum arteriosum as a focal hyperdensity in the aortopulmonary window
Axial CT: calcified ligamentum arteriosum (arrows) at the aortopulmonary window, confirmed as calcification (not PDA) on the non-contrast image.

Summary Table

FeatureDetail
What it isFibrous remnant of the ductus arteriosus
LocationSuperior mediastinum
ConnectsLeft pulmonary artery → undersurface of aortic arch
Functional closureFirst few days of life
Anatomical closureBy 12th postnatal week
Key nerve nearbyLeft recurrent laryngeal nerve loops just to its right
Trauma significanceFixed point of aorta; rupture site in deceleration injury
Failure to closePatent ductus arteriosus (PDA)

Vocal cords

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vocal cords larynx anatomy diagram true false vocal folds

This clinical image is a frame from a video laryngoscopy showing a post-treatment view of a normal larynx in a pediatric patient. The true vocal cords (vocal folds) are clearly visualized, appearing as symmetrical, smooth, pearly-white bands that form a V-shape. The surrounding supraglottic structures, including the epiglottis, arytenoids, and false vocal cords, appear healthy with smooth, moist, pink mucosa and no evidence of edema or inflammation. The glottic opening is patent, and the vallecula and pyriform sinuses are clear of masses or lesions. This image demonstrates the resolution of a previously documented laryngeal B-cell lymphoma following chemotherapy and surgical intervention, serving as a baseline for normal laryngeal anatomy during follow-up endoscopic assessment.

This clinical image is a frame from a video laryngoscopy showing a post-treatment view of a normal larynx in a pediatric patient. The true vocal cords (vocal folds) are clearly visualized, appearing as symmetrical, smooth, pearly-white bands that form a V-shape. The surrounding supraglottic structures, including the epiglottis, arytenoids, and false vocal cords, appear healthy with smooth, moist, pink mucosa and no evidence of edema or inflammation. The glottic opening is patent, and the vallecula and pyriform sinuses are clear of masses or lesions. This image demonstrates the resolution of a previously documented laryngeal B-cell lymphoma following chemotherapy and surgical intervention, serving as a baseline for normal laryngeal anatomy during follow-up endoscopic assessment.

An endoscopic view of a normal human larynx, representing a baseline for clinical comparison with various voicing disorders. The diagnostic image displays the true vocal folds (vocal cords) as smooth, whitish-pink, and symmetrical structures. They are positioned in a V-shaped configuration, creating a clear triangular glottic opening that indicates the larynx is in a state of abduction (opening for respiration). The surrounding laryngeal mucosa and vestibular folds (false vocal folds) appear healthy, pink, and free of visible lesions, nodules, cysts, or inflammation. Key landmarks visible include the posterior commissure at the base of the 'V' and the surrounding subglottic space appearing dark in the background. This clinical photograph serves as an educational reference for normal laryngeal anatomy in the context of otolaryngology and speech-language pathology.

An endoscopic view of a normal human larynx, representing a baseline for clinical comparison with various voicing disorders. The diagnostic image displays the true vocal folds (vocal cords) as smooth, whitish-pink, and symmetrical structures. They are positioned in a V-shaped configuration, creating a clear triangular glottic opening that indicates the larynx is in a state of abduction (opening for respiration). The surrounding laryngeal mucosa and vestibular folds (false vocal folds) appear healthy, pink, and free of visible lesions, nodules, cysts, or inflammation. Key landmarks visible include the posterior commissure at the base of the 'V' and the surrounding subglottic space appearing dark in the background. This clinical photograph serves as an educational reference for normal laryngeal anatomy in the context of otolaryngology and speech-language pathology.

Two circular panels show a diagnostic endoscopy of the human larynx, specifically a postoperative view following surgical repair of laryngeal trauma. The clinical photographs depict the internal laryngeal anatomy, including the epiglottis, false vocal folds, and true vocal cords. The mucosal surfaces appear pinkish-red and healthy, with no visible signs of acute inflammation, significant granulation tissue, or ulceration. The true vocal folds are centrally positioned and form a dark triangular glottic opening, suggesting patency of the airway. The left panel shows the larynx in a more open (abducted) state, while the right panel shows a slightly different phase of mobilization or viewing angle. The anatomical structures, including the arytenoids and surrounding vestibular folds, appear symmetrical and well-defined. This endoscopic evaluation is used to assess postoperative healing, laryngeal lumen patency, and vocal cord mobility after complex laryngeal reconstruction, such as thyroid and cricoid cartilage fracture repair.

Two circular panels show a diagnostic endoscopy of the human larynx, specifically a postoperative view following surgical repair of laryngeal trauma. The clinical photographs depict the internal laryngeal anatomy, including the epiglottis, false vocal folds, and true vocal cords. The mucosal surfaces appear pinkish-red and healthy, with no visible signs of acute inflammation, significant granulation tissue, or ulceration. The true vocal folds are centrally positioned and form a dark triangular glottic opening, suggesting patency of the airway. The left panel shows the larynx in a more open (abducted) state, while the right panel shows a slightly different phase of mobilization or viewing angle. The anatomical structures, including the arytenoids and surrounding vestibular folds, appear symmetrical and well-defined. This endoscopic evaluation is used to assess postoperative healing, laryngeal lumen patency, and vocal cord mobility after complex laryngeal reconstruction, such as thyroid and cricoid cartilage fracture repair.

This endoscopic clinical photograph depicts the internal anatomy of the human larynx as captured via electronic video laryngoscopy. The visual focuses on the glottis during inspiration, showing the true vocal cords in an abducted position, forming a V-shaped aperture that reveals the subglottic space. The vocal cords exhibit a normal pearly-white to pale-pink mucosal color with a smooth surface, free of visible nodules, polyps, or leukoplakia. Surrounding supraglottic structures, including the aryepiglottic folds and the ventricular zone (false vocal cords), appear symmetrical with healthy pink mucosa. There is no evidence of edema, erythema, or residual tumor mass in this 9-month postoperative view. The image serves as a representative example of a healthy laryngeal recovery following the surgical resection of an extramedullary plasmacytoma (EMP), demonstrating restored anatomical integrity and no signs of clinical recurrence.

This endoscopic clinical photograph depicts the internal anatomy of the human larynx as captured via electronic video laryngoscopy. The visual focuses on the glottis during inspiration, showing the true vocal cords in an abducted position, forming a V-shaped aperture that reveals the subglottic space. The vocal cords exhibit a normal pearly-white to pale-pink mucosal color with a smooth surface, free of visible nodules, polyps, or leukoplakia. Surrounding supraglottic structures, including the aryepiglottic folds and the ventricular zone (false vocal cords), appear symmetrical with healthy pink mucosa. There is no evidence of edema, erythema, or residual tumor mass in this 9-month postoperative view. The image serves as a representative example of a healthy laryngeal recovery following the surgical resection of an extramedullary plasmacytoma (EMP), demonstrating restored anatomical integrity and no signs of clinical recurrence.

This clinical photograph displays an endoscopic view of the human larynx, specifically a fiberoptic nasoendoscopy. The image highlights the glottis and surrounding supraglottic structures. Centrally, the true vocal folds (vocal cords) appear as bright, pearly-white, crescent-shaped bands. The edges of the folds are smooth and symmetrical, framing the dark, patent rima glottidis (airway opening). Above the vocal folds, the vestibular folds (false vocal cords) and the laryngeal vestibule are visible, exhibiting a healthy, reddish-pink mucosal lining with normal vascularity. The epiglottis is partially visible at the top of the frame. Small droplets of clear mucus are scattered across the mucosal surface, which is a normal finding. This image serves as an educational example of normal post-traumatic recovery, demonstrating preserved laryngeal anatomy and unobstructed airway patency following a penetrating neck injury.

This clinical photograph displays an endoscopic view of the human larynx, specifically a fiberoptic nasoendoscopy. The image highlights the glottis and surrounding supraglottic structures. Centrally, the true vocal folds (vocal cords) appear as bright, pearly-white, crescent-shaped bands. The edges of the folds are smooth and symmetrical, framing the dark, patent rima glottidis (airway opening). Above the vocal folds, the vestibular folds (false vocal cords) and the laryngeal vestibule are visible, exhibiting a healthy, reddish-pink mucosal lining with normal vascularity. The epiglottis is partially visible at the top of the frame. Small droplets of clear mucus are scattered across the mucosal surface, which is a normal finding. This image serves as an educational example of normal post-traumatic recovery, demonstrating preserved laryngeal anatomy and unobstructed airway patency following a penetrating neck injury.

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Vocal Cords (Vocal Folds)

Overview

The vocal cords - more accurately termed vocal folds - are paired mucosal structures within the larynx that serve three main functions: phonation, airway protection (during swallowing), and regulation of respiration. There are two pairs: the true vocal folds (responsible for sound production) below, and the vestibular folds (false vocal cords) above.

Anatomy of the Larynx and Vocal Fold Position

The larynx sits at the entrance to the trachea in the anterior neck (C3-C6). The vocal folds are suspended between the thyroid cartilage anteriorly and the arytenoid cartilages posteriorly.
  • The space between the true vocal folds is the rima glottidis (glottic opening)
  • The area above is the supraglottis; below is the subglottis
The anterior 3/5 of each vocal fold is the membranous part; the posterior 2/5 (from the vocal process to the arytenoid face) is the cartilaginous part.
  • Scott-Brown's Otorhinolaryngology, Vol. 1, p. 2466-2470

Endoscopic view - normal larynx:

Endoscopic view of normal larynx showing true vocal cords as pearly-white symmetrical bands forming a V-shaped glottic opening
Flexible laryngoscopy: true vocal folds in abducted (inspiratory) position - pearly-white, smooth, symmetrical.

Microarchitecture - The Layered Structure

The true vocal fold has a unique layered "body-cover" structure that is essential for the mucosal wave of phonation. Loss of this architecture (e.g., vocal fold scar) dramatically degrades voice quality.
Cross-section diagram of vocal fold layers showing epithelium, superficial/intermediate/deep lamina propria, vocalis muscle, and conus elasticus
Layers of the membranous vocal fold (KJ Lee's Essential Otolaryngology, Fig. 50-1)
LayerCompositionNotes
EpitheliumStratified squamous (~50 µm thick)Transitions to pseudocolumnar toward the ventricle and subglottis
Superficial lamina propriaLoose areolar tissue (Reinke's space)Gelatin-like; allows mucosal wave during phonation
Intermediate lamina propriaElastic fibresTogether with deep layer forms the vocal ligament
Deep lamina propriaCollagen fibres (denser)
Vocalis muscle (TAv)Medial portion of thyroarytenoidForms the bulk of the vocal fold body; controls length, tension, stiffness
Conus elasticusElastic membraneUnderlies and supports the fold
The vocal ligament = intermediate + deep layers of the lamina propria (readily identified histologically and microsurgically).
  • Scott-Brown's, p. 2441-2448; KJ Lee's Essential Otolaryngology, p. 1180
Reinke's space (superficial lamina propria) is clinically important - fluid accumulation here causes Reinke's edema (polypoid degeneration), typically from chronic smoking and voice abuse.

Macula Flava

At both the anterior and posterior ends of the membranous vocal fold, a cushion of elastic fibres (macula flava) protects the fold ends from repetitive mechanical trauma during vibration.
  • Scott-Brown's, p. 2462

Intrinsic Laryngeal Muscles

These muscles control vocal fold movement (adduction, abduction, tension):
MuscleOrigin → InsertionActionNerve
Posterior cricoarytenoid (PCA)Posterior cricoid lamina → muscular process of arytenoidAbduction (only abductor)RLN
Lateral cricoarytenoid (LCA)Lateral cricoid arch → muscular processAdduction (primary adductor)RLN
Thyroarytenoid (TA)Anterior thyroid → vocal process + arytenoidAdduction; shortens/thickens foldRLN
- Vocalis (TAv, medial part)Controls tension, length, stiffnessRLN
Interarytenoid (IA)Connects the two arytenoidsCloses posterior glottis; only unpaired muscleRLN (bilateral)
Cricothyroid (CT)Anterior thyroid-cricoidLengthens/tenses fold (raises pitch)External SLN
  • The PCA is the sole abductor - its bilateral paralysis causes life-threatening airway obstruction
  • The LCA is the primary adductor (strongest), but complete glottic closure requires all adductors together
  • Cummings Otolaryngology, p. 1019; KJ Lee's, p. 1021-1068

Innervation

Both nerves are branches of the vagus nerve (CN X):

Superior Laryngeal Nerve (SLN)

  • Internal branch (sensory): pierces the thyrohyoid membrane; carries sensation from the supraglottic and glottic larynx
  • External branch (motor): supplies the cricothyroid muscle → controls pitch

Recurrent Laryngeal Nerve (RLN)

  • Motor nucleus: nucleus ambiguus
  • Supplies all intrinsic laryngeal muscles except cricothyroid (ipsilateral)
  • The interarytenoid muscle receives bilateral innervation
  • Carries sensory fibres from the subglottis and trachea to nucleus solitarius
  • Left RLN: loops around the ligamentum arteriosum (arch of aorta), ascends in the tracheoesophageal groove - hence its vulnerability in thoracic and thyroid disease
  • Right RLN: loops around the right subclavian artery, shorter course
  • Both enter the larynx near the cricothyroid joint
  • A non-recurrent RLN occurs with anomalous retroesophageal subclavian artery
Recent evidence shows that both motor and sensory fibres arise from both SLN and RLN via Galen's anastomosis (SLN internal to RLN) and the human communicating nerve.
  • KJ Lee's Essential Otolaryngology, p. 1163-1213

Phonation - How the Vocal Folds Produce Sound

The myoelastic-aerodynamic theory explains vocal fold vibration:
  1. Adductors close the glottis
  2. Subglottic air pressure builds until it forces the folds apart
  3. The Bernoulli effect and tissue elasticity snap the folds back together
  4. This cycle repeats ~100-300 times/second (fundamental frequency)
The mucosal wave (ripple across the vocal fold surface) depends on the loose Reinke's space allowing the cover (epithelium + superficial LP) to slide over the stiffer body (vocal ligament + vocalis).
Pitch is controlled by:
  • Cricothyroid muscle (lengthens/tenses fold → higher pitch)
  • Vocalis muscle (shortens/thickens fold → lower pitch)
Loudness is controlled by subglottic pressure.
  • Cummings Otolaryngology, p. 2203-2216

Respiratory Role

The PCA is also a respiratory muscle - it begins contracting with each inspiration (before the diaphragm), dilating the glottis to reduce airway resistance. During increased respiratory demand, PCA activity increases proportionally with diaphragmatic effort.
  • Cummings Otolaryngology, p. 2266-2268

Clinical Conditions

Vocal Cord Paralysis

  • Unilateral: usually presents as hoarseness/dysphonia, breathy voice; rarely dyspnea
  • Bilateral: presents with biphasic stridor, respiratory distress, and a near-normal voice
  • Common causes: thyroid surgery (most common for bilateral), lung/mediastinal malignancy (left RLN), neck surgery, aortic arch aneurysm, skull base tumors, idiopathic (viral)
  • Treated with vocal cord medialization (injection laryngoplasty with CMC, gel foam, calcium hydroxyapatite for temporary; fat or Teflon for permanent), medialization thyroplasty, or arytenoid adduction
  • KJ Lee's, p. 6141-7178; Textbook of Family Medicine 9e

Reinke's Edema

Fluid accumulation in the superficial lamina propria (Reinke's space), causing bilateral polypoid vocal folds and a characteristically low-pitched, rough voice. Strongly associated with smoking.

Vocal Cord Nodules

Bilateral symmetric lesions at the junction of the anterior 1/3 and posterior 2/3 of the membranous fold (maximum vibration amplitude point). Caused by voice abuse/misuse. Treated with voice therapy ± microsurgery.

Anterior Commissure Involvement in Laryngeal Cancer

The anterior commissure (Broyle's ligament) connects directly to the thyroid cartilage perichondrium and to the subglottis. Glottic tumors involving the anterior commissure readily spread to the subglottis and through the cartilage - a key staging consideration.
  • Scott-Brown's, p. 2483-2487

Summary

FeatureTrue Vocal FoldVestibular Fold (False Cord)
PositionInferiorSuperior
RolePhonation, airway protectionNo phonation role; protects true cords
ColorPearly-whitePinkish-red
EpitheliumStratified squamousRespiratory (pseudostratified columnar)
Key muscleVocalis (thyroarytenoid)None
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