Painful swelling needs a cause before choosing a tablet. For a healthy 25-year-old with a minor sprain or injury:
- Paracetamol (acetaminophen): 500 mg to 1,000 mg every 6-8 hours as needed. Do not exceed 3,000 mg in 24 hours without clinician advice, and avoid if significant liver disease or heavy alcohol use.
- Ibuprofen: 200-400 mg with food every 6-8 hours if suitable. Avoid it if there is stomach ulcer/bleeding, kidney disease, uncontrolled high blood pressure, asthma triggered by NSAIDs, blood thinner use, or dehydration. Do not combine with other anti-inflammatory pain tablets such as diclofenac or naproxen.
For a fresh limb injury, rest, elevate it, and use an ice pack wrapped in cloth for up to 20 minutes every 2-3 hours. NHS guidance also lists paracetamol or ibuprofen as options for pain and swelling after a minor injury.
NHS knee-pain advice
Get urgent medical assessment today if swelling is one-sided in the calf/leg without a clear injury, or there is redness/warmth, fever, severe pain, inability to bear weight, deformity, numbness, chest pain, or shortness of breath. These can indicate infection, fracture, or a blood clot, not something to self-treat with painkillers.
Tell me where the swelling is, when it began, and whether there was an injury, redness, fever, or calf pain.