Maximum dose of injection lobet
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labetalol injection maximum dose IV bolus infusion
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Injection Labetalol (Lobet) - Dosing Summary
Lobet is the brand name for labetalol hydrochloride injection (5 mg/mL), a combined alpha-1 and beta-blocker used for hypertensive emergencies.
IV Bolus (Intermittent)
| Parameter | Dose |
|---|---|
| Initial dose | 20 mg IV over 2 minutes |
| Repeat doses | 40-80 mg IV every 10 minutes as needed |
| Maximum cumulative bolus dose | 300 mg |
Some protocols start as low as 10-20 mg for the first bolus; additional doses of 40-80 mg are given at 10-minute intervals.
IV Infusion (Continuous)
| Parameter | Dose |
|---|---|
| Starting rate | 0.5-2 mg/min (titrate to BP) |
| Maximum infusion rate | Up to 10 mg/min in some protocols |
| Maximum total 24-hour dose | 300 mg (bolus + infusion combined) |
- Typical preparation: 200 mg in 100 mL (2 mg/mL concentration)
- Infusion is titrated based on supine blood pressure response
Special Populations
- Pregnancy (hypertensive emergencies): 20 mg IV bolus; repeat 40-80 mg every 10 min; max 80 mg per bolus episode (some obstetric guidelines); overall max still 300 mg/24h
- Controlled hypotension during anesthesia: 10-30 mg IV initially, then 5-10 mg increments as needed
- Pediatrics/weight-based: 0.3-1.0 mg/kg/dose (max 80 mg per dose)
Key Points
- Always administer IV bolus slowly over 2 minutes - rapid injection causes severe hypotension
- Keep the patient supine during and for up to 3 hours after IV administration (risk of orthostatic hypotension)
- Monitor BP and HR every 15-30 minutes
- Onset of action: within 5 minutes of IV injection; peak effect at ~15 minutes
Sources: Tintinalli's Emergency Medicine; StatPearls (NCBI); LHSC Critical Care Protocol; KEMH Clinical Guideline
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