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Interpret
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Reading File
Finding Sources
Finding Sources
Reading File
Here is the full interpretation of this histopathology report:
Histopathology Report - Interpretation
Patient Details
- Patient: Shafeeque, 38-year-old Male
- Facility: Pariyaram Medical College, Kannur (Histopathology Lab)
- Sample Collected: 26/06/2026 | Report Date: 04/07/2026
- Reported by: Dr. Togy Thomas Zacharia, Associate Professor
What Was Examined
A colon biopsy - multiple small grey-white tissue fragments (0.6 x 0.4 cm) preserved in formalin saline.
Microscopic Findings (Plain Language)
| Finding | What It Means |
|---|---|
| Cryptitis | Neutrophils (infection-fighting white cells) have invaded the glands (crypts) of the colon lining - the hallmark sign of active mucosal inflammation |
| Crypt destructions | The colon's glandular architecture is being damaged and destroyed by ongoing inflammation |
| Epithelium showing ulceration | The surface lining of the colon is broken down, forming ulcers |
| Lamina propria - marked inflammation | The connective tissue layer beneath the surface lining is heavily infiltrated with inflammatory cells |
| Mixed chronic inflammation with activity | Both long-standing (chronic: lymphocytes, plasma cells) AND acute (neutrophils) inflammatory cells are present simultaneously - this "activity" component indicates the disease is currently flaring |
Impression (Diagnosis)
Biopsy colon - Ulcerations with activity, showing cryptitis and crypt destructions
This histological pattern is classic for active Inflammatory Bowel Disease (IBD), most consistent with Ulcerative Colitis (UC) in an active/flaring phase. The combination of cryptitis, crypt destruction, ulceration, and mixed chronic inflammation with activity is the textbook hallmark of UC.
As described in Yamada's Textbook of Gastroenterology: "Neutrophils, the hallmark of active disease, are located within crypt epithelium (cryptitis) and crypt lumina (crypt abscesses)... crypt architectural distortion and increased mucosal chronic inflammation are the two characteristic histological findings" of ulcerative colitis.
What This Means Clinically
- Active IBD/Ulcerative Colitis - the biopsy confirms ongoing mucosal injury with active inflammation. This is not just quiescent/remission IBD.
- "With activity" is an important phrase - it tells the treating doctor the disease is currently flaring and needs active medical management.
- The report does not mention features of Crohn's disease (granulomas, transmural inflammation, skip lesions), nor does it suggest malignancy.
What the Patient/Doctor Should Do Next
- Gastroenterology consultation is needed to correlate with clinical symptoms (bleeding, diarrhea, urgency) and colonoscopy findings.
- Treatment for active UC typically involves aminosalicylates (5-ASA/mesalazine) as first-line, with steroids for moderate-severe flares, and possible escalation to immunomodulators or biologics if refractory.
- Follow-up colonoscopy and biopsies will be needed to monitor treatment response.
- Long-standing colitis increases colorectal cancer surveillance requirements.
Note: This interpretation is for informational purposes. The patient should discuss this report and all treatment decisions with their treating gastroenterologist.
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