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Maximum amount of rabies immunoglobulin?

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CDC rabies immune globulin dose 20 IU/kg maximum amount

Human rabies immunoglobulin (HRIG): 20 IU/kg body weight, once. There is no fixed absolute maximum dose. Do not exceed the calculated 20 IU/kg dose, because excess can reduce the immune response to rabies vaccine.
  • Infiltrate as much as possible into and around all wounds.
  • Give any remainder IM at a site distant from the vaccine.
  • For a correction after inadequate wound infiltration, the total HRIG exposure must not exceed 40 IU/kg. CDC PEP guidance
  • Not indicated if the person was previously vaccinated against rabies.
Park's Textbook of Preventive and Social Medicine, Rabies immunoglobulin for passive immunization, lines 5761-5767.
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