I now have rich textbook content for a completely new set of 20 MCQs. Here they are:
20 NEW MCQs on Eye Disorders
BSc Nursing - 4th Semester (Set 2)
Q1. Keratitis is best defined as:
- A) Inflammation of the conjunctiva
- B) Inflammation of the corneal stroma
- C) Opacity of the lens
- D) Detachment of the retina
Answer: B
Keratitis is inflammation of the corneal stroma, and can be caused by spread of pathogens from a corneal ulcer. - Goldman-Cecil Medicine
Q2. The most common gram-negative pathogen causing keratitis, especially in contact lens wearers, is:
- A) Neisseria gonorrhoeae
- B) Staphylococcus aureus
- C) Pseudomonas aeruginosa
- D) Haemophilus influenzae
Answer: C
Pseudomonas aeruginosa causes a particularly virulent keratitis and is the most common gram-negative pathogen, especially in contact lens wearers. - Goldman-Cecil Medicine
Q3. Herpes simplex virus causes a characteristic corneal ulceration pattern called:
- A) Geographic ulcer only
- B) Dendritic keratitis - a thin, linear, branching epithelial ulceration with club-shaped terminal bulbs
- C) Ring-shaped stromal infiltrate
- D) Circular central ulcer
Answer: B
Dendritic keratitis is a thin, linear, branching epithelial ulceration with club-shaped terminal bulbs at the end of each branch. - Wills Eye Manual
Q4. Herpes Zoster Ophthalmicus (HZO) involves which nerve?
- A) Facial nerve (CN VII)
- B) Optic nerve (CN II)
- C) Ophthalmic division of the trigeminal nerve (CN V1)
- D) Oculomotor nerve (CN III)
Answer: C
Herpes zoster ophthalmicus is viral reactivation within the trigeminal nerve ganglion, along the ophthalmic division. - Rosen's Emergency Medicine
Q5. The Hutchinson sign in Herpes Zoster Ophthalmicus refers to:
- A) Elevated IOP with cupped optic disc
- B) Vesicles on the tip or side of the nose indicating likely eye involvement
- C) Dendritic ulcer on the cornea
- D) Unilateral proptosis
Answer: B
The Hutchinson sign is a vesicle on the side and tip of the nose; when present, uveitis or eye involvement is most likely. - Rosen's Emergency Medicine / Harrison's Principles
Q6. Acanthamoeba keratitis is strongly associated with:
- A) Systemic immunosuppression
- B) Wearing of contact lenses, especially with fresh water exposure
- C) Prolonged use of topical steroids
- D) Vitamin A deficiency
Answer: B
The wearing of contact lenses is a major risk factor for Acanthamoeba keratitis; a history of swimming or using fresh water to cleanse contact lenses is often elicited. - Goldman-Cecil Medicine
Q7. Cytomegalovirus (CMV) retinitis is classically described as having which appearance on fundoscopy?
- A) "Sea fan" neovascularization
- B) "Pizza pie retinitis" or "hemorrhagic cottage cheese" appearance
- C) "Cherry red spot" at the macula
- D) "Salt and pepper" pigmentation
Answer: B
CMV retinitis shows a characteristic intense, wedge-shaped reaction in the retina, with considerable exudates and hemorrhages - giving the terms "pizza pie retinitis" and "hemorrhagic cottage cheese retinitis". - Goldman-Cecil Medicine
Q8. Nonproliferative diabetic retinopathy is characterized by changes confined to:
- A) The vitreous humor
- B) The choroid
- C) Beneath the internal limiting membrane of the retina
- D) The lens and ciliary body
Answer: C
Nonproliferative diabetic retinopathy includes a spectrum of changes resulting from structural and functional abnormalities of retinal vessels confined beneath the internal limiting membrane. - Robbins Pathologic Basis of Disease
Q9. In diabetic retinopathy, which growth factor is primarily responsible for pathological retinal neovascularization?
- A) TGF-beta
- B) PDGF
- C) VEGF (Vascular Endothelial Growth Factor)
- D) EGF
Answer: C
Retinal neovascularization is attributable to hypoxia-induced expression of VEGF in the retina. - Robbins Pathologic Basis of Disease
Q10. Proliferative diabetic retinopathy is defined by the appearance of:
- A) Microaneurysms alone
- B) Macular edema
- C) New vessels (neovascularization) sprouting on the optic disc (NVD) or retinal surface (NVE)
- D) Hard exudates in the outer plexiform layer
Answer: C
Proliferative diabetic retinopathy is defined by the appearance of new vessels sprouting on the surface of the optic nerve head or the retina's surface. - Robbins Pathologic Basis of Disease
Q11. Neovascular glaucoma in diabetic patients occurs because:
- A) Optic nerve ischemia directly damages the trabecular meshwork
- B) VEGF-driven neovascular iris membrane contracts, forming synechiae that occlude aqueous outflow
- C) Vitreous hemorrhage raises IOP
- D) Lens swelling obstructs the pupil
Answer: B
Contraction of the neovascular iris membrane leads to adhesions between the iris and trabecular meshwork, occluding aqueous outflow and elevating IOP (neovascular glaucoma). - Robbins Pathologic Basis of Disease
Q12. The treatment for proliferative diabetic retinopathy to ablate nonperfused retina is:
- A) Oral corticosteroids
- B) Intravitreal antibiotics
- C) Laser photocoagulation
- D) Keratoplasty
Answer: C
Ablating the nonperfused retina by laser photocoagulation is the treatment for proliferative diabetic retinopathy. - Robbins Pathologic Basis of Disease
Q13. Wet (exudative) age-related macular degeneration (AMD) is treated with:
- A) Topical beta-blocker drops
- B) Anti-VEGF agents (e.g., ranibizumab, bevacizumab)
- C) Systemic antibiotics
- D) Cataract surgery
Answer: B
Anti-VEGF antibodies such as ranibizumab and bevacizumab are used to treat the wet form of age-related macular degeneration. - Bailey and Love's Surgery / Wills Eye Manual
Q14. Uveitis involving the iris is specifically called:
- A) Keratitis
- B) Scleritis
- C) Iritis (anterior uveitis)
- D) Chorioretinitis
Answer: C
Iritis refers to inflammation of the iris and is the most common form of uveitis (anterior uveitis). - Kanski's Clinical Ophthalmology
Q15. Symptoms of anterior uveitis (iritis) include all EXCEPT:
- A) Eye pain and photophobia
- B) Blurred vision
- C) Mucopurulent discharge with lid crusting
- D) Conjunctival injection
Answer: C
Mucopurulent discharge is a feature of bacterial conjunctivitis, not uveitis. Uveitis presents with pain, photophobia, blurred vision, and redness. - Rosen's Emergency Medicine / Yamada's Gastroenterology
Q16. Treatment of herpes zoster ophthalmicus with uveitis includes:
- A) Topical aminoglycoside drops
- B) Prednisolone acetate 1% drops and atropine 1% drops, alongside systemic antivirals
- C) Oral antifungals
- D) Pilocarpine drops
Answer: B
If uveitis develops in HZO, prednisolone acetate drops 1% four times daily and atropine 1% once or twice daily are used, alongside oral acyclovir or valacyclovir. - Goldman-Cecil Medicine
Q17. Gonococcal keratitis in neonates is characterized by:
- A) Watery discharge and mild redness
- B) Copious tearing and hyperpurulent discharge, with risk of corneal perforation
- C) Dendritic ulcer pattern
- D) Gradual painless vision loss
Answer: B
Corneal infection with N. gonorrhoeae is accompanied by copious tearing and a characteristic hyperpurulent discharge; prompt treatment is essential to prevent corneal perforation. - Goldman-Cecil Medicine
Q18. A common early visual symptom of nonproliferative diabetic retinopathy that causes visual loss is:
- A) Sudden painless loss of all vision
- B) Flashes of light and floaters
- C) Macular edema from leakage of retinal microvasculature
- D) Loss of peripheral fields only
Answer: C
The retinal microcirculation in diabetics may be exceptionally leaky, giving rise to macular edema - a common cause of visual loss in these patients. - Robbins Pathologic Basis of Disease
Q19. A patient with contact lens use develops a ring-shaped stromal corneal infiltrate with severe pain out of proportion to the clinical findings. The likely diagnosis is:
- A) Bacterial conjunctivitis
- B) Acanthamoeba keratitis
- C) Herpetic dendritic keratitis
- D) Pseudomonal conjunctivitis
Answer: B
Acanthamoeba keratitis develops a characteristic stromal ring infiltrate; patients may have pain out of proportion to examination findings. - Goldman-Cecil Medicine
Q20. Which of the following statements about corneal sensation in herpetic keratitis is correct?
- A) Corneal sensation is increased (hyperaesthesia)
- B) Corneal sensation is normal
- C) Corneal sensation is reduced
- D) Corneal sensation is only affected in bacterial keratitis
Answer: C
Corneal sensation is reduced in herpetic keratitis. Inadvertent topical steroid treatment may promote progressive enlargement of the ulcer to a geographical or amoeboid configuration. - Kanski's Clinical Ophthalmology
Topic Summary
| Topic | Questions |
|---|
| Corneal Ulcer / Keratitis (bacterial, viral, Acanthamoeba) | Q1, Q2, Q3, Q6, Q17, Q19, Q20 |
| Herpes Zoster Ophthalmicus | Q4, Q5, Q16 |
| CMV Retinitis | Q7 |
| Diabetic Retinopathy | Q8, Q9, Q10, Q11, Q12, Q18 |
| Age-Related Macular Degeneration | Q13 |
| Uveitis / Iritis | Q14, Q15 |
All questions sourced from Goldman-Cecil Medicine, Robbins Pathologic Basis of Disease, Kanski's Clinical Ophthalmology, Wills Eye Manual, Rosen's Emergency Medicine, and Harrison's Principles of Internal Medicine - fully appropriate for BSc Nursing 4th semester level.