One health program short note

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One Health Program - Short Note

Definition

One Health is an integrated, multisectoral, transdisciplinary approach that recognizes the health of humans, animals, plants, and the environment as closely linked and interdependent. It aims to sustainably balance and optimize health outcomes across all these domains simultaneously.
The formal OHHLEP (One Health High-Level Expert Panel) definition:
"An integrated, unifying approach that aims to sustainably balance and optimize the health of people, animals and ecosystems, mobilizing multiple sectors, disciplines and communities at varying levels of society."

Historical Background

MilestoneDetail
1800sRudolf Virchow coined "zoonosis"; noted animal-human disease linkage
1964Calvin Schwabe proposed "One Medicine" - unified human and veterinary medicine
2004Manhattan Principles formalized the concept at the Wildlife Conservation Society
2008WHO, FAO, OIE formally endorsed "One World - One Health"
2022Quadripartite (FAO, UNEP, WHO, WOAH) signed cooperation agreement; launched One Health Joint Plan of Action 2022-2026

The Quadripartite (Four Pillars of Governance)

The four international organizations leading One Health globally:
  1. WHO - human health policies, public health outcomes
  2. FAO - food safety, agriculture, animal-human-environment food links
  3. WOAH (formerly OIE) - animal health, welfare, zoonosis prevention
  4. UNEP - environmental health, ecosystem integrity, pollution

Why One Health is Needed

  • About 60-75% of emerging infectious diseases are zoonotic (animal origin)
  • 75% of new pathogens affecting humans originate in animals
  • Antimicrobial resistance (AMR) spreads across humans, animals, and environment - cannot be addressed in isolation
  • Climate change alters disease vectors (malaria, dengue, Lyme disease range expansion)
  • Biodiversity loss and habitat destruction bring wildlife into closer human contact, increasing spillover events
  • Global examples: HIV, Ebola, SARS, COVID-19, avian influenza H5N1, mpox, Nipah virus

Key Domains / Pillars of One Health

1. Zoonotic Disease Prevention and Control

  • Surveillance at human-animal-environment interfaces
  • Joint outbreak response (e.g., avian flu, rabies, Nipah)
  • Cross-sector reporting systems

2. Antimicrobial Resistance (AMR)

  • AMR is a prime One Health issue - antibiotics used in livestock affect human pathogens
  • National Action Plans (NAPs) address AMR across all three sectors together

3. Food Safety and Food Systems

  • Contamination of food supply can originate from animal husbandry, environmental pollutants, or processing
  • FAO-led surveillance linking farm-to-fork

4. Environmental and Ecosystem Health

  • Deforestation, land-use change, and biodiversity loss as risk factors
  • Watershed management, pollution control

5. Vector-Borne Diseases

  • Climate change shifts ranges of mosquitoes, ticks, sandflies
  • Requires environmental monitoring alongside clinical surveillance

6. Biosafety and Biosecurity

  • Preventing accidental or deliberate release of pathogens
  • Lab standards across veterinary and human medicine labs

One Health Joint Plan of Action (OH JPA) 2022-2026

Launched by the Quadripartite, this plan has six action tracks:
TrackFocus Area
1One Health capacity building
2Zoonotic epidemic and pandemic prevention
3Endemic zoonotic disease control
4Food safety
5AMR containment
6Environment, climate and ecosystems

Implementation at Different Levels

Global level: Quadripartite coordination, joint surveillance frameworks, global AMR action plans
National level: Multisectoral National Action Plans; joint ministries of health, agriculture, and environment; National One Health Frameworks (e.g., USA's NOHF-Zoonoses 2025-2029)
Local level: Community-based surveillance, One Health teams at district level, integrated outbreak investigation

One Health in India

  • India has adopted One Health through the National One Health Mission
  • Coordinates the Ministry of Health, Ministry of Agriculture (Animal Husbandry), and Ministry of Environment & Forests
  • Strengthened post-COVID-19 pandemic response
  • Addresses rabies, avian influenza, Nipah, brucellosis, anthrax at the human-animal interface
  • Park's Preventive & Social Medicine emphasizes the Multipurpose Worker Scheme which integrates "one health worker" male and female at sub-centre level to cover a population of 5,000

Benefits of One Health Approach

  1. Prevents pandemics - early detection at animal-human interfaces
  2. Cost-effective - addressing disease at source is cheaper than managing outbreaks
  3. Accelerates research - shared biomedical databases, joint field investigations
  4. Improves food safety - reduces foodborne illness burden
  5. Controls AMR - reduces unnecessary antibiotic use across all sectors
  6. Promotes equity - communities most dependent on livestock/wildlife benefit most

Challenges

  • Siloed governance structures (separate health, agriculture, environment ministries)
  • Funding gaps and coordination failures
  • Weak veterinary and environmental surveillance infrastructure in low-income countries
  • Data sharing barriers between sectors
  • Political will and intersectoral trust

Key Examples of One Health in Practice

DiseaseOne Health Response
RabiesDog vaccination + human post-exposure prophylaxis + wildlife monitoring
Avian Influenza (H5N1/H7N9)Poultry surveillance + human case detection + environmental sampling
COVID-19Animal reservoir tracing + human pandemic response + ecosystem monitoring
AMRAntibiotic stewardship in hospitals + livestock + water systems
Nipah virusFruit bat surveillance + spillover prevention + human contact tracing
BrucellosisLivestock vaccination + occupational exposure control + food pasteurization

Summary

One Health is not merely a concept - it is an operational framework that demands structural integration of public health, veterinary medicine, environmental science, and policy. In an era of climate change, accelerating biodiversity loss, and pandemic threats, it represents the most scientifically sound and cost-efficient approach to global health security. The Quadripartite's OH JPA 2022-2026 gives it a concrete global roadmap, while national frameworks translate it into actionable policy.
Key phrase to remember: "The health of humans, animals, plants, and the environment is one and inseparable."

Sources: WHO/FAO/WOAH/UNEP One Health Joint Plan of Action 2022-2026; Pitt SJ & Gunn A, "The One Health Concept," Br J Biomed Sci, 2024 [PMID: 38434675]; Park's Textbook of Preventive & Social Medicine; U.S. National One Health Framework 2025-2029

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Here is your One Health infographic. It covers:
  • Central Venn diagram - the three overlapping domains: Human Health, Animal Health, and Environment & Ecosystem, with "One Health" at the intersection
  • Six action pillars - Zoonotic Disease Control, AMR, Food Safety, Climate & Ecosystems, Vector-Borne Diseases, and Biosafety
  • Key stakeholders - the Quadripartite (WHO, FAO, WOAH, UNEP) plus national and community-level actors
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One Health antimicrobial resistance zoonosis drug therapy antibiotic

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MDR TB BPaLM KDTripathi

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Here's what was built - 16 slides expanded from your original 13, with a dark navy + red accent design theme:
SlideTopicKD Tripathi Content Added
1Title SlideStyled with all presenter names
2MDR-TB DefinitionCh.46 resistance mechanisms, mutation types
3EpidemiologyRisk factors, India NTEP burden stats
4BPaLM OverviewFull drug class, dose, MOA summary for all 4 drugs
5Mechanisms of ActionDetailed target-based breakdown (ATP synthase, nitric oxide, ribosome, DNA gyrase)
6Bedaquiline Deep DivePK, dosing, ADRs, drug interactions, KD Tripathi quotes
7Linezolid & PretomanidIndividual PK, ADRs, monitoring, clinical notes
8Moxifloxacin DetailMOA dual inhibition, PK, interactions, KD Tripathi classification
9Regimen DurationPhase-by-phase timeline, WHO 2022 guidelines
10Target PopulationInclusion/exclusion criteria, special populations
11ADR ProfileAll 4 drugs side-by-side with monitoring row
12Advantages vs. LimitationsTrial data (ZeNix, TB-PRACTECAL, Nix-TB)
13Monitoring Parameters6-category monitoring cards (ECG, LFTs, CBC, vision, sputum, adherence)
14Status in IndiaNTEP roll-out, free access, KD Tripathi Group A-C drug classification
15Drug ClassificationFull WHO Group A/B/C table per KD Tripathi Chapter 46
16Conclusions7-point summary with presenter credits
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