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pancreatic neuroendocrine tumors diagnosis treatment

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pancreatic neuroendocrine tumors 2024 2025 latest guidelines treatment advances

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pancreatic neuroendocrine tumor PRRT sunitinib everolimus surgery

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pancreatic neuroendocrine tumor treatment guidelines 2024 2025

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PanNEN Comprehensive 2025

Presentation · PPTX


What's included (50 slides across 12 sections):
#SectionSlides
1Introduction & Epidemiology1–6
2Pathogenesis & Molecular Genetics (2025 proteogenomic data)7–9
3WHO 2022 Grading + G3 NET vs NEC distinction10–12
4Insulinoma – Whipple's triad, 72-hr fast, imaging, surgery13–16
5Gastrinoma & ZES – secretin test, gastrinoma triangle, management17–20
6Glucagonoma – 4 D's, NME rash21–22
7VIPoma, Somatostatinoma & rare functional tumours23–25
8Non-functional PanNETs – incidentaloma, active surveillance26–28
9MEN-1 syndrome, genetics, surveillance29–31
10Imaging (CT/MRI/EUS/DOTATATE PET) & biomarkers32–35
11Treatment – Surgery, SSAs, Everolimus, Sunitinib, Cabozantinib (FDA approved March 2025), PRRT (NETTER-1/2), chemo, NCCN 2025 algorithm, liver mets36–45
12Prognosis tables, key trials, exam pearls46–50
Latest evidence incorporated:
  • CABINET trial (NEJM, Feb 2025) - Cabozantinib HR 0.47 in PanNETs, FDA approved March 2025
  • NETTER-2 (Lancet, Jun 2024) - First-line Lu-177 DOTATATE in G2/G3 PanNETs
  • ENETS 2023 guidance papers for functional and non-functional PanNETs
  • NCCN 2025 G3 NET dedicated algorithm
  • Ji et al. Cancer Cell 2025 - proteogenomic subtypes
Design: Navy/teal/amber palette, clutter-free layouts, section dividers, data tables, card grids, and dark evidence slides.

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The file is confirmed valid - 50 slides, all readable, 911 KB. The presentation is ready to download:

PanNEN Comprehensive 2025

Presentation · PPTX


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