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Preoperative Evaluation and Airway Management in TMJ Ankylosis
Background
Temporomandibular joint (TMJ) ankylosis is the fusion of the mandibular condyle to the glenoid fossa, resulting in restricted or absent mouth opening. It can be bony (true ankylosis) or fibrous (false ankylosis). A patient with only 5 mm of mouth opening presents one of the most challenging airway scenarios in anaesthetic practice - it is effectively a "known difficult airway" with high likelihood of impossible direct laryngoscopy and potentially impossible mask ventilation.
Part 1: Preoperative Evaluation
History
Airway-specific history:
- Duration and progression of mouth opening restriction
- Previous anaesthetic records - any previous intubation attempts, technique used, grade of laryngoscopy, complications. This is the single most important document.
- Prior surgeries or radiation to the head and neck (radiation causes fibrosis and further TMJ ankylosis, distorts tissue planes)
- Symptoms of obstructive sleep apnea (OSA) - chronic reduced mouth opening and micrognathia (especially in childhood-onset cases) predispose to OSA
- Stridor, positional breathing difficulty, snoring - suggest concurrent airway compromise
- History of neck pain, cervical spine disease, or instability (limits head positioning for laryngoscopy)
Cause of ankylosis:
- Traumatic - condylar fracture, particularly common in children after unrecognised condylar injury
- Infective/inflammatory - otitis media (in children), suppurative arthritis, rheumatoid arthritis, ankylosing spondylitis
- Post-radiation fibrosis
- Congenital/syndromic - Pierre Robin sequence, Treacher Collins syndrome, Goldenhar syndrome (these patients have additional craniofacial anomalies compounding airway difficulty)
- Neonatal forceps injury
Systemic history:
- Rheumatoid arthritis or ankylosing spondylitis: also affect cervical spine (atlanto-axial instability, limited neck extension) and arytenoid joints (cricoarytenoid arthritis - may cause fixed vocal cord, narrowed glottis)
- Nutritional status and general fitness (prolonged ankylosis in children leads to micrognathia, mandibular hypoplasia, and malocclusion)
- Aspiration history - chronic reduced oral intake, silent aspiration with recurrent chest infections
Important distinction: Is the restricted mouth opening due to:
- Pain (acute trauma, infection) - may improve with analgesia and muscle relaxation under GA
- Trismus (muscle spasm from infection, trauma) - usually overcomes with muscle relaxation under GA
- True mechanical ankylosis - will NOT improve with GA or muscle relaxation; airway must be secured before induction
"If a patient cannot open their mouth during the preoperative evaluation, one must ascertain if the restriction to mouth opening results from pain, trismus, mechanical problem, or some combination of the three." - Barash's Clinical Anaesthesia
In true bony TMJ ankylosis, the restriction is purely mechanical - relaxing the patient or inducing anaesthesia will make no difference to mouth opening.
Physical Examination
Head and neck examination:
| Parameter | What to Assess | Clinical Relevance |
|---|
| Mouth opening | Measured inter-incisal distance | <20 mm = severe restriction; 5 mm = cannot accommodate any laryngoscope blade |
| Mallampati class | Assess with maximum mouth opening | Near-impossible to assess at 5mm; document what is visible |
| Mandibular morphology | Micrognathia, retrognathia, mandibular hypoplasia | Common in long-standing childhood ankylosis; reduces oropharyngeal space |
| Neck range of motion | Flexion/extension/rotation | Neck extension <35° predicts difficult laryngoscopy |
| Sternomental distance | Head extended, mouth closed | <12.5 cm predicts difficult laryngoscopy |
| Thyromental distance | Chin to thyroid notch | <7 cm predicts difficult laryngoscopy |
| Tracheal position | Midline or deviated | Midline trachea vital for nasal fiberoptic approach |
| Neck veins, thyroid | Any masses displacing airway | Compound the difficulty |
| Dental state | Missing, carious, or crowded teeth | Affects nasal tube path and risk of dental injury |
| Nasal patency | Right vs. left naris | Larger naris for nasal approach; deviated septum may obstruct |
| Facial profile | Profile view - microgenia, bird face deformity | Indicator of mandibular hypoplasia from long-standing childhood ankylosis |
Signs of airway obstruction:
- Stridor (inspiratory = supraglottic, biphasic = glottic/subglottic)
- Chest retraction, accessory muscle use
- Agitation, restlessness (hypoxia)
- Abnormal voice, dysphonia
Investigations
Imaging:
- Orthopantomogram (OPG/panoramic X-ray): Assessment of condylar morphology, bony ankylosis vs. fibrous, extent of joint involvement
- CT scan of TMJ/face/neck (with 3D reconstruction): Gold standard. Defines:
- Nature and extent of ankylosis (unilateral vs. bilateral, fibrous vs. bony, extent of bony mass)
- Mandibular hypoplasia, micrognathia
- Relationship of bony mass to adjacent structures (middle cranial fossa, skull base)
- Airway dimensions (oropharyngeal, hypopharyngeal, tracheal calibre)
- Vascular anatomy of the neck (important if tracheostomy may be needed)
- MRI: Soft tissue detail - articular disc, surrounding muscles; particularly useful in fibrous ankylosis
- Cervical spine X-ray or CT: Especially if there is rheumatoid arthritis, ankylosing spondylitis, or a history suggesting instability (atlantoaxial subluxation)
- Lateral skull and chest X-ray: Chest for aspiration pneumonia, OSA-related changes
Sleep study (polysomnography): If OSA is clinically suspected (particularly in children with micrognathia from childhood-onset ankylosis)
Pulmonary function tests: If concurrent respiratory compromise or severe OSA
Routine labs: CBC, coagulation profile, blood group and crossmatch (surgery may involve significant blood loss); metabolic panel
Airway endoscopy (awake flexible nasendoscopy): Should be performed preoperatively if feasible - assesses:
- Nasal passages for polyps, deviation, obstruction
- Pharyngeal anatomy and dimensions
- Glottic appearance - vocal cord movement, subglottic/glottic narrowing
- Confirms fiberoptic nasal intubation is likely to be feasible
Anaesthetic Risk Stratification
This patient with 5 mm mouth opening should be classified as anticipated extremely difficult airway, with high probability of:
- Failed direct laryngoscopy (impossible to insert blade)
- Failed video laryngoscopy (cannot insert blade despite improved view)
- Potentially difficult mask ventilation (micrognathia, abnormal facial profile)
- Potentially difficult SGA placement (supraglottic airway devices need some mouth opening; most require ≥20 mm)
- Risk of "cannot intubate, cannot oxygenate" (CICO) scenario
The fundamental principle: secure the airway before inducing general anaesthesia.
Part 2: Methods of Airway Management for 5 mm Mouth Opening
The primary technique of choice is awake nasal fiberoptic intubation (FOI). All other methods should be planned as back-up and the team informed.
Preparation Before Any Technique
Multidisciplinary team:
- Senior/experienced anaesthesiologist
- ENT/maxillofacial surgeon scrubbed and available (for emergency surgical airway)
- Experienced anaesthesia nurse/assistant
- Neck prepped and draped for surgical airway at all times
Equipment at the bedside:
- Flexible fiberoptic bronchoscope (video-capable preferred)
- Video laryngoscopes of various types
- Supraglottic airways (LMA, intubating LMA)
- Jet ventilation equipment / transtracheal jet ventilator
- Emergency surgical airway kit (cricothyrotomy, percutaneous or surgical tracheostomy)
- Nasal and oral airways of various sizes
- Endotracheal tubes (assorted sizes including microlaryngoscopy tubes; typically 6.0-7.0 for nasal approach in adults)
- Exhaled CO₂ detector
1. Awake Nasal Fiberoptic Intubation (FOI) - TECHNIQUE OF CHOICE
Rationale: With only 5 mm of mouth opening, oral laryngoscopy and oral intubation are impossible. The nasal route bypasses the oral obstruction, and fiberoptic guidance navigates the anatomy safely under direct vision while the patient remains awake and breathing. This preserves muscle tone, maintains airway patency, and allows verification of tube position.
Step-by-step:
Psychological preparation:
- Detailed pre-procedure explanation; patient cooperation is key to success
- Patient should understand each step and their role (keeping still, breathing, clearing secretions on request)
Pharmacological preparation:
- Antisialagogue: Glycopyrrolate 0.2 mg IV, given 30 minutes before - reduces secretions, improves fiberoptic visibility. Preferred over atropine as it does not cross the blood-brain barrier and causes less tachycardia.
- Sedation (carefully titrated, minimal):
- IV midazolam (1-2 mg titrated) - anxiolysis while maintaining cooperation
- Dexmedetomidine infusion - excellent for awake intubation; provides sedation without respiratory depression, cooperative patient
- Remifentanil infusion (caution - respiratory depression)
- Ketamine (low dose) - preserves airway tone and respiratory drive
- No sedation in patients with already compromised airway
- Supplemental oxygen via nasal cannula throughout (high flow; can use HFNO during procedure)
Topical/regional anaesthesia - key to patient comfort and success:
The airway must be anaesthetised from nares to trachea:
| Level | Agent and Method |
|---|
| Nasal mucosa | 4% cocaine (or 4% lidocaine + 0.25% phenylephrine) on cotton-tipped applicators. Applied to both nares. Provides vasoconstriction (reduces bleeding) and anaesthesia. Alternatively 2% lidocaine-soaked ribbon gauze |
| Oropharynx | 10% lidocaine spray; or 4% lidocaine atomized and inhaled; or 2% lignocaine gargle and spit |
| Glossopharyngeal nerve block | Bilateral injection of 2 mL 2% lidocaine at the base of the palatoglossal arch (anterior tonsillar pillar) - blocks lingual/pharyngeal sensation. Particularly valuable with near-zero mouth opening: may require a narrow-gauge needle approach through the limited aperture |
| Superior laryngeal nerve (SLN) block | 3 mL of 2% lidocaine injected 1 cm below the greater cornu of the hyoid bone bilaterally, where the internal SLN branch penetrates the thyrohyoid membrane. Anaesthetizes epiglottis, aryepiglottic folds, and supraglottic larynx |
| Transtracheal block | Identify the cricothyroid membrane (CTM). After confirming intratracheal position by aspiration of air, inject 4 mL of 4% lidocaine at end expiration - cough distributes the agent throughout the trachea and subglottis |
| Alternatively | Nebulize 4-5 mL of 4% lidocaine via facemask for 10-15 minutes |
Maximum safe lidocaine dose for topical application: 4-9 mg/kg; monitor total dose carefully.
Procedure (nasal fiberoptic intubation):
- Patient sitting or semi-recumbent (head of bed 45°). Oxygen via nasal cannula.
- Select the larger naris. Vasoconstrict with oxymetazoline or cocaine.
- Lubricate a well-sized endotracheal tube (size 6.0-7.0 cuffed for adults; Ring-Adair-Elwyn (RAE) nasal tube or reinforced tube is used for oral surgery cases).
- Load the ETT onto the fiberoptic bronchoscope (scope passes through the ETT lumen, ETT rides on scope).
- Advance the bronchoscope along the nasal floor toward the occiput (not upward), past the inferior turbinate.
- Navigate through the nasopharynx, identify the epiglottis and glottis.
- Pass the scope through the vocal cords into the trachea - confirm by visualizing tracheal rings and carina.
- Advance the ETT over the scope into the trachea, then withdraw the scope.
- Confirm placement with CO₂ capnography, bilateral auscultation, and chest expansion.
- Only after the airway is confirmed secured - induce general anaesthesia.
Keys to success (from Cummings Otolaryngology):
- Expert bronchoscopist
- Functioning, high-quality videobronchoscope
- Meticulous airway preparation (topical anaesthesia)
- Adequate but not excessive sedation
- Patient cooperation
- Overall complication rate is 16.8% without bronchoscopic guidance vs. 8.3% with
"Awake FOI is often an ideal procedure for producing an airway of adequate size and dealing with other medical conditions that make visualization of the glottis difficult, such as marked obesity, a supraglottic/glottic mass, supraglottic/glottic edema, or trismus." - Cummings Otolaryngology
2. Awake Video Laryngoscopy
Considerations:
- Requires some mouth opening; most video laryngoscopes (GlideScope, C-MAC, McGrath) require at least 15-20 mm
- With only 5 mm mouth opening, standard video laryngoscopes cannot be inserted
- Some narrow-profile blades (e.g., C-MAC Pocket Monitor with size 3 blade) may pass through smaller apertures, but 5 mm is generally prohibitive
- May be used as an adjunct after surgical treatment increases mouth opening, or combined with the retrograde technique
3. Retrograde Intubation
A well-described technique for severe mouth opening restriction:
Technique:
- Identify and puncture the cricothyroid membrane with an 18-gauge needle, angled cephalad
- Confirm intratracheal position by aspiration of air
- Pass a J-tipped guidewire (or epidural catheter) through the needle, directed upward (cephalad) into the pharynx
- Retrieve the wire from the nose or mouth using Magill forceps or blind digital retrieval
- Pass the ETT over the wire (wire exits through the distal end or side port of the ETT) and advance into the trachea
- Hold the wire taut at the CTM entry point and advance ETT until resistance is felt at the CTM - indicating the tube is in the correct position
- Release the wire and advance the ETT further; confirm position
Combined retrograde + fiberoptic technique (Miller's Anesthesia):
- The retrieved guidewire is threaded through the suction/working channel of the fiberoptic scope (distal to proximal)
- The FOB follows the wire as a guide, maintaining visualization throughout
- This allows the ETT to negotiate the vocal cord angle under direct vision
- Eliminates the blind advancement problem and reduces dislodgement risk
Advantages: Does not require any mouth opening; confirms tracheal entry at the CTM level; guidewire provides a roadmap through the airway.
Limitations: Technically demanding; requires landmark palpability at CTM; risk of bleeding; cannot be used if CTM is impalpable or overlain by pathology.
4. Blind Nasotracheal Intubation (BNTI)
Principle: An ETT is passed through the nose and advanced blindly by listening to breath sounds transmitted through the tube, advancing at peak inspiration.
Technique:
- Patient positioned with head in neutral or slight extension ("sniffing")
- Lubricate and pass ETT along nasal floor, angling toward occiput
- As tube approaches glottis, maximum airflow is heard through the tube
- Advance swiftly at the start of inspiration; rotate medially 15-30° to enter trachea
- Depth: 28 cm at nares in men, 26 cm in women
- Confirm with CO₂, auscultation, fogging
Use in TMJ ankylosis: Largely superseded by fiberoptic techniques but useful when fiberoptic equipment is unavailable or the glottis cannot be visualised (e.g., blood, secretions obscuring the view). Requires a spontaneously breathing patient.
Limitations: Complication rate high with inexperienced operators; risk of epistaxis, oesophageal intubation, nasal trauma; success requires active respiration; cannot be used in apnoeic patients or when bleeding is significant.
5. Awake Surgical Tracheostomy Under Local Anaesthesia
Indication: When all non-surgical techniques have failed or are contraindicated, or in cases where:
- The anatomy is so distorted that fiberoptic access is impossible
- Severe bleeding/secretions obscure fiberoptic view
- Patient cannot cooperate with awake intubation
- Concurrent severe subglottic or glottic pathology precludes translaryngeal intubation
- In cases where surgery will be near the larynx or will displace the airway
Technique: Standard surgical tracheostomy performed with infiltration of local anaesthetic (lidocaine + epinephrine) in a sitting or semi-recumbent patient who is awake and breathing. Sedation can be cautiously added once the trachea is opened and the tube is partially inserted.
This is the definitive backup technique - it guarantees an airway regardless of the oral/pharyngeal anatomy.
6. Emergency Surgical Airway - Cricothyrotomy / Transtracheal Jet Ventilation (TTJV)
Reserved for CICO (Cannot Intubate, Cannot Oxygenate):
Needle cricothyrotomy + TTJV:
- 14-gauge cannula through CTM; connect to high-pressure oxygen source
- Provides oxygenation for 30-45 minutes (CO₂ accumulates)
- Bridging technique to definitive surgical airway
Surgical cricothyrotomy:
- Horizontal incision through CTM, dilation, insertion of cuffed tube (size 5-6)
- Rapid access; preferred over emergency tracheostomy
- Definitive technique; can be maintained until surgical tracheostomy is performed
Decision Algorithm for 5 mm Mouth Opening
Patient with 5 mm mouth opening (TMJ ankylosis) scheduled for surgery
|
Preoperative assessment + MDT planning
|
Is airway palpable/accessible?
/ \
YES NO
| |
AWAKE NASAL FIBEROPTIC Consider awake tracheostomy
INTUBATION (1st choice) under local anaesthesia
|
Successful? → Induce GA → Surgery
|
Failed (secretions/distorted anatomy)
|
RETROGRADE INTUBATION (± combined FOB)
|
Failed?
|
AWAKE SURGICAL TRACHEOSTOMY UNDER LOCAL
|
CICO emergency → Needle cricothyrotomy + TTJV
→ Surgical cricothyrotomy
Special Considerations in TMJ Ankylosis Surgery
-
Intraoperative airway access: The surgeon will be working in and around the mandible and TMJ area. A nasal RAE tube or reinforced (armoured) nasotracheal tube is preferred to keep the oral cavity clear for the surgeon and to reduce accidental extubation during jaw manipulation.
-
Post-operative airway: After surgical release of ankylosis, the mouth opening may initially increase dramatically but post-operative oedema can reduce it again acutely. Plan for:
- Keep intubated until oedema subsides
- Extubation should be planned (ideally over an airway exchange catheter)
- Post-operative tracheostomy may be appropriate in complex cases
-
Steroids and dexamethasone: Reduce oedema and improve post-operative airway
-
Obstructive sleep apnea co-management: If confirmed, plan CPAP post-operatively
-
Children with childhood-onset ankylosis: Mandibular growth arrest from ankylosis produces progressively worsening micrognathia. The difficulty compounds with age. These children may require distraction osteogenesis at the same sitting, further complicating anaesthetic planning.
-
Paediatric considerations (Cummings): Flexible fiberoptic bronchoscopes of appropriate paediatric size (2.5-3.5 mm outer diameter) are required; nasal RAE tubes sized age-appropriately; have LMA as ventilation rescue device.
Summary Table
| Technique | Mouth Opening Required | Primary Use in TMJ Ankylosis | Key Limitation |
|---|
| Awake nasal FOI | None | First choice | Requires equipment + expertise |
| Retrograde intubation | None | Second choice | Technically demanding |
| BNTI (blind nasal) | None | Backup when FOI unavailable | High complication rate, blind |
| Awake video laryngoscopy | ≥15-20 mm | Not useful at 5 mm | Cannot insert blade |
| Direct laryngoscopy | ≥35 mm | Contraindicated | Impossible at 5 mm |
| Awake tracheostomy (LA) | None | If all else fails; severe cases | Invasive, scar, complications |
| Needle/surgical cricothyrotomy | None | Emergency CICO rescue | Last resort only |
The golden rule in TMJ ankylosis: never remove the patient's ability to breathe spontaneously until the airway is secured. Awake nasal fiberoptic intubation, performed by an expert with a well-prepared patient and appropriately anaesthetised airway, is the technique of choice.
Sources: Morgan & Mikhail's Clinical Anaesthesiology 7e, Cummings Otolaryngology Head and Neck Surgery, Barash's Clinical Anaesthesia 9e, Miller's Anaesthesia 10e, Tintinalli's Emergency Medicine, Miller's Anaesthesia (retrograde intubation)