ls -la /home/daytona/workspace/ 2>/dev/null | head -20; mkdir -p /home/daytona/w…

~/ens-histology-ppt/build.js

const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");

const pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.title = "Enteric Nervous System Histology";
pres.author = "Medical Education";

// ─── DESIGN TOKENS ───────────────────────────────────────────
const C = {
  darkBg:   "0D1B2A",   // deep navy
  midBg:    "1B3A5C",   // medium navy
  accent1:  "00B4D8",   // teal/cyan
  accent2:  "90E0EF",   // light cyan
  gold:     "F4A261",   // warm amber
  white:    "FFFFFF",
  lightGray:"D9E8F5",
  bodyText: "E0F0FF",
  darkText: "0D1B2A",
};

// helper: slide background
function darkSlide(pres) {
  const s = pres.addSlide();
  s.background = { color: C.darkBg };
  return s;
}
function midSlide(pres) {
  const s = pres.addSlide();
  s.background = { color: C.midBg };
  return s;
}

// helper: section tag pill
function addTag(slide, label, x, y) {
  slide.addShape(pres.ShapeType.roundRect, {
    x, y, w: 2.5, h: 0.32, fill: { color: C.accent1 }, line: { color: C.accent1 }, rectRadius: 0.08
  });
  slide.addText(label, { x, y, w: 2.5, h: 0.32, fontSize: 10, bold: true, color: C.darkText, align: "center", valign: "middle", margin: 0 });
}

// helper: horizontal divider line
function hline(slide, x, y, w) {
  slide.addShape(pres.ShapeType.line, { x, y, w, h: 0, line: { color: C.accent1, width: 1.5 } });
}

// ─── FETCH IMAGES ─────────────────────────────────────────────
const imgUrls = [
  "https://cdn.orris.care/cdss_images/7f071bdc91c1650b8541acfc52cbb091dc9a03abe77845e4d8ba61741457be98.png",
  "https://cdn.orris.care/cdss_images/f66bdb540f1db9aee2c3aaeb84edf23447038ed307056e424e2f806cfa1f33ff.png",
  "https://cdn.orris.care/cdss_images/450af6ec01e18f5f5cc90dab381f978c5d17db4926d867862fa988cb4ff34668.png",
];
const imgs = JSON.parse(
  execSync(`node /home/daytona/skills/shared/scripts/fetch_images.js "${imgUrls[0]}" "${imgUrls[1]}" "${imgUrls[2]}"`).toString()
);
const imgNeural = imgs[0].base64;   // neural control diagram (Guyton)
const imgPlexus = imgs[1].base64;   // enteric plexuses cross section (Yamada)
const imgAuerbach = imgs[2].base64; // historic wholemount drawing

// ════════════════════════════════════════════════════════════
// SLIDE 1 — TITLE
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  // large accent bar left
  s.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 0.18, h: 5.625, fill: { color: C.accent1 }, line: { color: C.accent1 } });
  // top accent rect
  s.addShape(pres.ShapeType.rect, { x: 0.18, y: 0, w: 9.82, h: 0.12, fill: { color: C.accent1 }, line: { color: C.accent1 } });

  s.addText("Enteric Nervous System", {
    x: 0.5, y: 0.6, w: 9.0, h: 1.1,
    fontSize: 40, bold: true, color: C.white, fontFace: "Calibri",
  });
  s.addText("Histology of the Auerbach (Myenteric) &\nMeissner (Submucosal) Plexuses", {
    x: 0.5, y: 1.75, w: 9.0, h: 1.1,
    fontSize: 22, bold: false, color: C.accent2, fontFace: "Calibri",
  });
  hline(s, 0.5, 3.0, 5.5);
  s.addText("Division of Histology  |  Gastrointestinal Neuroscience", {
    x: 0.5, y: 3.15, w: 8.0, h: 0.45,
    fontSize: 13, color: C.lightGray, italic: true,
  });
  s.addText("Sources: Guyton & Hall  •  Yamada's Gastroenterology  •  Ganong's Physiology", {
    x: 0.5, y: 4.9, w: 9.0, h: 0.4,
    fontSize: 10, color: C.accent1, italic: true,
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 2 — INTRODUCTION
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "INTRODUCTION", 0.4, 0.2);
  s.addText("What is the Enteric Nervous System?", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 28, bold: true, color: C.white,
  });
  hline(s, 0.4, 1.45, 9.2);

  const bullets = [
    "The ENS lies entirely within the wall of the digestive tract — from the esophagus to the anus.",
    "Contains >100 million neurons, surpassing the neuron count of the entire spinal cord.",
    "Functions independently of the CNS and is therefore called the \"mini-brain\" of the gut.",
    "Composed of sensory neurons, interneurons, and motor neurons — a complete nervous system in the gut wall.",
    "Regulates motility, secretion, absorption, and local blood flow.",
    "Extrinsic sympathetic and parasympathetic inputs modulate but do not dictate ENS activity.",
  ];
  const bulletItems = bullets.map((b, i) => ({
    text: b,
    options: { bullet: { code: "2022" }, color: i === 0 ? C.accent2 : C.bodyText, breakLine: i < bullets.length - 1 },
  }));
  s.addText(bulletItems, {
    x: 0.5, y: 1.6, w: 5.8, h: 3.7,
    fontSize: 13.5, fontFace: "Calibri", valign: "top",
  });
  // right image
  s.addImage({ data: imgNeural, x: 6.5, y: 1.4, w: 3.3, h: 3.8, sizing: { type: "contain", w: 3.3, h: 3.8 } });
  s.addText("Fig: Neural control of gut wall\n(Guyton & Hall, Fig. 63.4)", {
    x: 6.5, y: 5.1, w: 3.3, h: 0.4, fontSize: 8.5, color: C.accent1, italic: true, align: "center",
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 3 — MAIN DIVISIONS OF THE NERVOUS SYSTEM
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "MAIN DIVISIONS", 0.4, 0.2);
  s.addText("The Nervous System: Where Does the ENS Fit?", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 26, bold: true, color: C.white,
  });
  hline(s, 0.4, 1.45, 9.2);

  // Three boxes: CNS | PNS | ENS
  const boxes = [
    { label: "Central Nervous System (CNS)", color: C.midBg, pts: ["Brain", "Spinal cord", "Processes and integrates information"] },
    { label: "Peripheral Nervous System (PNS)", color: "163E6F", pts: ["Somatic NS — voluntary control", "Autonomic NS — involuntary", "  · Sympathetic (fight-or-flight)", "  · Parasympathetic (rest-and-digest)"] },
    { label: "Enteric Nervous System (ENS)", color: "0A3D5C", pts: ["3rd division of the ANS", "Intrinsic gut wall network", "400–600 million neurons", "Two main plexuses: Auerbach & Meissner"] },
  ];
  boxes.forEach((box, i) => {
    const x = 0.25 + i * 3.25;
    s.addShape(pres.ShapeType.roundRect, {
      x, y: 1.65, w: 3.0, h: 3.6,
      fill: { color: box.color }, line: { color: C.accent1, width: 1.5 }, rectRadius: 0.1,
    });
    s.addText(box.label, {
      x: x + 0.1, y: 1.75, w: 2.8, h: 0.65,
      fontSize: 13, bold: true, color: C.gold, align: "center",
    });
    const pts = box.pts.map((p, j) => ({
      text: p,
      options: { bullet: { code: "25B8" }, color: C.bodyText, breakLine: j < box.pts.length - 1 },
    }));
    s.addText(pts, { x: x + 0.12, y: 2.5, w: 2.76, h: 2.6, fontSize: 12, valign: "top" });
  });

  s.addText("The ENS is uniquely capable of autonomous function — it can direct full gut reflexes without any input from the brain or spinal cord.", {
    x: 0.4, y: 5.15, w: 9.2, h: 0.38,
    fontSize: 11, color: C.accent2, italic: true, align: "center",
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 4 — MAJOR PARTS: OVERVIEW OF THE TWO PLEXUSES
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "MAJOR PARTS", 0.4, 0.2);
  s.addText("Two Ganglionated Plexuses of the ENS", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 26, bold: true, color: C.white,
  });
  hline(s, 0.4, 1.45, 9.2);

  // Left text panels
  s.addShape(pres.ShapeType.roundRect, { x: 0.3, y: 1.6, w: 4.5, h: 1.65, fill: { color: C.midBg }, line: { color: C.gold, width: 1.5 }, rectRadius: 0.1 });
  s.addText("Myenteric Plexus (Auerbach)", { x: 0.4, y: 1.65, w: 4.3, h: 0.45, fontSize: 14, bold: true, color: C.gold });
  s.addText("Between the longitudinal and circular muscle layers\nLinear chain of interconnecting neurons along entire GI tract\nPrimary role: controls GI motility", {
    x: 0.4, y: 2.1, w: 4.3, h: 1.0, fontSize: 11.5, color: C.bodyText, valign: "top",
  });

  s.addShape(pres.ShapeType.roundRect, { x: 0.3, y: 3.4, w: 4.5, h: 1.65, fill: { color: C.midBg }, line: { color: C.accent1, width: 1.5 }, rectRadius: 0.1 });
  s.addText("Submucosal Plexus (Meissner)", { x: 0.4, y: 3.45, w: 4.3, h: 0.45, fontSize: 14, bold: true, color: C.accent1 });
  s.addText("Between circular muscle and luminal mucosa (submucosa)\nThree interconnected layers (outer = Henle / Schabadasch plexus)\nPrimary role: secretion, absorption, local blood flow", {
    x: 0.4, y: 3.9, w: 4.3, h: 1.0, fontSize: 11.5, color: C.bodyText, valign: "top",
  });

  // Right: cross-section diagram
  s.addImage({ data: imgPlexus, x: 5.1, y: 1.5, w: 4.7, h: 3.85, sizing: { type: "contain", w: 4.7, h: 3.85 } });
  s.addText("Fig: Enteric plexuses in (a) wholemount and (b) transverse section\n(Yamada's Gastroenterology, Fig. 12.2)", {
    x: 5.1, y: 5.25, w: 4.7, h: 0.35, fontSize: 8.5, color: C.accent1, italic: true, align: "center",
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 5 — AUERBACH (MYENTERIC) PLEXUS: HISTOLOGY
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "AUERBACH PLEXUS", 0.4, 0.2);
  s.addText("Myenteric (Auerbach) Plexus — Histology", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 26, bold: true, color: C.gold,
  });
  hline(s, 0.4, 1.45, 9.2);

  const pts = [
    ["Location", "Between longitudinal and circular smooth muscle layers"],
    ["Extent", "Runs the entire length of the GI tract (esophagus to anus)"],
    ["Structure", "Linear chain of ganglia connected by internodal strands; secondary & tertiary plexus components"],
    ["Neurons", "Multipolar neurons with large pale nuclei; glial (enteric glia) cells present"],
    ["Staining", "H&E: ganglia visible as clusters of neurons; silver stains highlight nerve networks"],
    ["Historical note", "First drawn by Leopold Auerbach (1871), published in Henle's Textbook of Histology"],
    ["Function", "Controls tonic contraction, rhythmic contraction rate, peristaltic wave velocity"],
    ["Key NTs", "Excitatory: ACh, Substance P, Glutamate — Inhibitory: VIP, NO, ATP"],
  ];
  pts.forEach(([label, val], i) => {
    const y = 1.6 + i * 0.47;
    s.addShape(pres.ShapeType.rect, { x: 0.35, y, w: 2.2, h: 0.4, fill: { color: "163E6F" }, line: { color: C.accent1 } });
    s.addText(label, { x: 0.35, y, w: 2.2, h: 0.4, fontSize: 11, bold: true, color: C.gold, align: "center", valign: "middle", margin: 0 });
    s.addText(val, { x: 2.6, y: y + 0.03, w: 7.1, h: 0.4, fontSize: 11, color: C.bodyText, valign: "middle" });
  });

  // small Auerbach drawing inset bottom right
  s.addImage({ data: imgAuerbach, x: 7.8, y: 1.5, w: 1.9, h: 3.6, sizing: { type: "contain", w: 1.9, h: 3.6 } });
  s.addText("Auerbach's 1871\nwholemount drawing", {
    x: 7.8, y: 5.1, w: 1.9, h: 0.4, fontSize: 7.5, color: C.accent1, italic: true, align: "center",
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 6 — MEISSNER (SUBMUCOSAL) PLEXUS: HISTOLOGY
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "MEISSNER PLEXUS", 0.4, 0.2);
  s.addText("Submucosal (Meissner) Plexus — Histology", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 26, bold: true, color: C.accent1,
  });
  hline(s, 0.4, 1.45, 9.2);

  // Two column layout
  const left = [
    ["Location", "In the submucosa, between the circular muscle and the mucosa"],
    ["Layers", "3 interconnected layers:\n• Outer (Henle / Schabadasch plexus)\n• Inner Meissner plexus\n• Mucous (mucosal plexus)"],
    ["Neurons", "Smaller ganglia than myenteric; neurons with round nuclei; fewer cells per ganglion"],
    ["Staining", "H&E: small discrete ganglia in submucosa; immunohistochemistry: VIP, NPY, ACh neurons"],
    ["Function", "Senses luminal environment; regulates secretion, absorption, mucosal blood flow"],
  ];
  const right = [
    ["Sensory inputs", "Epithelial mechanoreceptors & chemoreceptors feed into this plexus"],
    ["Targets", "Mucosal secretory cells, enterocytes, GI neuroendocrine cells, submucosal arterioles"],
    ["Key NTs", "ACh (secretomotor), VIP, NPY, Substance P, CGRP"],
    ["Connection", "Receives projections from myenteric plexus; directly modulates submucosal arteriolar tone"],
    ["Clinical link", "Hirschsprung disease: absent ganglia in both plexuses of rectosigmoid segment"],
  ];

  const addTableCol = (items, xStart) => {
    items.forEach(([label, val], i) => {
      const y = 1.6 + i * 0.73;
      s.addShape(pres.ShapeType.rect, { x: xStart, y, w: 1.8, h: 0.62, fill: { color: "0A3D5C" }, line: { color: C.accent2 } });
      s.addText(label, { x: xStart, y, w: 1.8, h: 0.62, fontSize: 10, bold: true, color: C.accent2, align: "center", valign: "middle", margin: 2 });
      s.addText(val, { x: xStart + 1.85, y: y + 0.02, w: 2.8, h: 0.65, fontSize: 10, color: C.bodyText, valign: "top" });
    });
  };
  addTableCol(left, 0.3);
  addTableCol(right, 5.1);

  // vertical separator
  s.addShape(pres.ShapeType.line, { x: 4.85, y: 1.55, w: 0, h: 3.8, line: { color: C.accent1, width: 0.8 } });
}

// ════════════════════════════════════════════════════════════
// SLIDE 7 — COMPARISON TABLE
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "MAJOR PARTS", 0.4, 0.2);
  s.addText("Auerbach vs. Meissner: Side-by-Side Comparison", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 24, bold: true, color: C.white,
  });
  hline(s, 0.4, 1.45, 9.2);

  const headers = ["Feature", "Myenteric (Auerbach)", "Submucosal (Meissner)"];
  const rows = [
    ["Location", "Between longitudinal & circular muscle", "Between circular muscle & mucosa (submucosa)"],
    ["Ganglion size", "Larger ganglia, dense network", "Smaller ganglia, 3 sub-layers"],
    ["Primary function", "Motility & peristalsis", "Secretion, absorption, blood flow"],
    ["Neuron types", "Motor (excitatory & inhibitory), interneurons", "Sensory, secretomotor, vasomotor"],
    ["Key NTs", "ACh, SubP, VIP, NO, ATP", "ACh, VIP, NPY, SubP, CGRP"],
    ["Stimulation effect", "Increased tone & contraction rate", "Modulates mucosal secretion & blood flow"],
    ["Extrinsic input", "Para- & sympathetic fibers synapse here", "Receives vagal preganglionic fibres"],
  ];

  const colW = [2.3, 3.4, 3.4];
  const rowH = 0.52;
  const startX = 0.35;
  let startY = 1.6;

  // header row
  headers.forEach((h, ci) => {
    const x = startX + colW.slice(0, ci).reduce((a, b) => a + b, 0);
    s.addShape(pres.ShapeType.rect, { x, y: startY, w: colW[ci], h: 0.45, fill: { color: C.accent1 }, line: { color: C.accent1 } });
    s.addText(h, { x, y: startY, w: colW[ci], h: 0.45, fontSize: 12, bold: true, color: C.darkText, align: "center", valign: "middle", margin: 0 });
  });

  rows.forEach((row, ri) => {
    const y = startY + 0.45 + ri * rowH;
    const bg = ri % 2 === 0 ? "163E6F" : "0D2740";
    row.forEach((cell, ci) => {
      const x = startX + colW.slice(0, ci).reduce((a, b) => a + b, 0);
      s.addShape(pres.ShapeType.rect, { x, y, w: colW[ci], h: rowH, fill: { color: bg }, line: { color: C.midBg } });
      s.addText(cell, {
        x: x + 0.05, y, w: colW[ci] - 0.1, h: rowH,
        fontSize: ci === 0 ? 11 : 10.5,
        bold: ci === 0, color: ci === 0 ? C.gold : C.bodyText,
        align: ci === 0 ? "center" : "left", valign: "middle", margin: 2,
      });
    });
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 8 — HOW THE SIGNAL TRAVELS (part 1: sensory → integration)
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "SIGNAL PATHWAY", 0.4, 0.2);
  s.addText("How the Signal Travels — Sensory Input & Integration", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 24, bold: true, color: C.white,
  });
  hline(s, 0.4, 1.45, 9.2);

  // Step boxes with arrows
  const steps = [
    { n: "1", title: "STIMULUS", text: "Mechanical stretch, chemical contents, osmotic change, or thermal stimuli detected in gut lumen / wall", color: "14213D" },
    { n: "2", title: "SENSORY NEURONS (IPANs)", text: "Intrinsic Primary Afferent Neurons in mucosa fire; signals enter Meissner plexus and myenteric plexus", color: "163E6F" },
    { n: "3", title: "INTERNEURONS", text: "Ascending & descending interneurons integrate signals within the plexuses; coordinate oral vs. anal responses", color: "0A3D5C" },
    { n: "4", title: "CNS FEEDBACK LOOPS", text: "Some afferent signals travel via vagus nerve to brain stem and via spinal cord to prevertebral ganglia for higher-level modulation", color: "0D2A3A" },
  ];

  steps.forEach((st, i) => {
    const y = 1.6 + i * 0.9;
    s.addShape(pres.ShapeType.roundRect, {
      x: 0.3, y, w: 9.3, h: 0.77,
      fill: { color: st.color }, line: { color: C.accent1, width: 1 }, rectRadius: 0.08,
    });
    s.addShape(pres.ShapeType.ellipse, {
      x: 0.35, y: y + 0.12, w: 0.5, h: 0.5,
      fill: { color: C.accent1 }, line: { color: C.accent1 },
    });
    s.addText(st.n, { x: 0.35, y: y + 0.12, w: 0.5, h: 0.5, fontSize: 14, bold: true, color: C.darkText, align: "center", valign: "middle", margin: 0 });
    s.addText(st.title, { x: 0.95, y: y + 0.03, w: 2.3, h: 0.38, fontSize: 11, bold: true, color: C.gold, valign: "middle" });
    s.addText(st.text, { x: 0.95, y: y + 0.36, w: 8.5, h: 0.38, fontSize: 10.5, color: C.bodyText, valign: "middle" });
    if (i < steps.length - 1) {
      s.addShape(pres.ShapeType.line, { x: 4.8, y: y + 0.77, w: 0, h: 0.13, line: { color: C.accent1, width: 1.5 } });
    }
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 9 — HOW THE SIGNAL TRAVELS (part 2: motor output)
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  addTag(s, "SIGNAL PATHWAY", 0.4, 0.2);
  s.addText("How the Signal Travels — Motor Output & Peristaltic Reflex", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 23, bold: true, color: C.white,
  });
  hline(s, 0.4, 1.45, 9.2);

  // Left: peristaltic reflex description
  const leftContent = [
    { h: "Peristaltic Reflex (Law of the Intestine)", b: "Oral (upstream) stimulation → ascending excitation via ACh/SubP → circular muscle contracts\nAnal (downstream) → descending inhibition via VIP/NO → circular muscle relaxes\nResult: bolus propulsion through the gut" },
    { h: "Myenteric Plexus Motor Output", b: "Excitatory motor neurons (ACh, Substance P, Glutamate): increase tone and contraction intensity\nInhibitory motor neurons (VIP, NO, ATP): relax sphincters (pyloric, ileocecal) to permit passage" },
    { h: "Submucosal Plexus Secretomotor Output", b: "Integrates sensory input → triggers secretion from mucosal glands\nControls villous infolding and local blood flow via submucosal arterioles" },
    { h: "Extrinsic Modulation", b: "Parasympathetic (vagus/pelvic): enhances motility and secretion via ACh at nicotinic receptors on ENS ganglia\nSympathetic (prevertebral ganglia): inhibits motility, reduces secretion, constricts blood vessels via NE" },
  ];

  leftContent.forEach((item, i) => {
    const y = 1.6 + i * 0.97;
    s.addShape(pres.ShapeType.roundRect, {
      x: 0.3, y, w: 6.1, h: 0.88,
      fill: { color: i % 2 === 0 ? "163E6F" : "0A3D5C" },
      line: { color: i % 2 === 0 ? C.gold : C.accent1, width: 1 },
      rectRadius: 0.08,
    });
    s.addText(item.h, { x: 0.4, y: y + 0.03, w: 5.9, h: 0.35, fontSize: 11.5, bold: true, color: i % 2 === 0 ? C.gold : C.accent2 });
    s.addText(item.b, { x: 0.4, y: y + 0.36, w: 5.9, h: 0.5, fontSize: 9.5, color: C.bodyText, valign: "top" });
  });

  // Right: neurotransmitter legend box
  s.addShape(pres.ShapeType.roundRect, {
    x: 6.65, y: 1.55, w: 3.1, h: 3.9,
    fill: { color: "14213D" }, line: { color: C.accent2, width: 1.5 }, rectRadius: 0.1,
  });
  s.addText("KEY NEUROTRANSMITTERS", {
    x: 6.75, y: 1.6, w: 2.9, h: 0.4, fontSize: 11, bold: true, color: C.accent2, align: "center",
  });
  hline(s, 6.75, 2.05, 2.9);
  const nts = [
    ["ACh", "Excitatory — motility & secretion"],
    ["SubP", "Excitatory — ascending contraction"],
    ["VIP", "Inhibitory — relaxation, vasodilation"],
    ["NO", "Inhibitory — sphincter relaxation"],
    ["ATP", "Inhibitory — smooth muscle"],
    ["NPY", "Vasomotor, inhibitory"],
    ["5-HT", "Sensory signalling trigger"],
    ["NE", "Sympathetic inhibition"],
  ];
  nts.forEach(([nt, desc], i) => {
    const y = 2.15 + i * 0.41;
    s.addText(nt, { x: 6.75, y, w: 0.75, h: 0.37, fontSize: 10, bold: true, color: C.gold });
    s.addText(desc, { x: 7.52, y, w: 2.13, h: 0.37, fontSize: 9, color: C.bodyText });
  });
}

// ════════════════════════════════════════════════════════════
// SLIDE 10 — SUMMARY & CLINICAL SIGNIFICANCE
// ════════════════════════════════════════════════════════════
{
  const s = darkSlide(pres);
  // accent bar
  s.addShape(pres.ShapeType.rect, { x: 0, y: 0, w: 10, h: 0.12, fill: { color: C.accent1 }, line: { color: C.accent1 } });
  s.addShape(pres.ShapeType.rect, { x: 0, y: 5.505, w: 10, h: 0.12, fill: { color: C.accent1 }, line: { color: C.accent1 } });

  addTag(s, "SUMMARY", 0.4, 0.22);
  s.addText("Summary & Clinical Significance", {
    x: 0.4, y: 0.65, w: 9.2, h: 0.75,
    fontSize: 26, bold: true, color: C.white,
  });
  hline(s, 0.4, 1.45, 9.2);

  // Summary 4 boxes
  const sumBoxes = [
    {
      title: "ENS Structure", color: "14213D", border: C.gold,
      pts: ["Two ganglionated plexuses: Auerbach (myenteric) & Meissner (submucosal)", "400–600 million neurons; complete mini-nervous system", "Both intrinsic + extrinsic inputs"],
    },
    {
      title: "Auerbach Plexus", color: "0D2A3A", border: C.gold,
      pts: ["Between longitudinal & circular muscle", "Controls motility, peristalsis, sphincter tone", "Excitatory NTs: ACh, SubP; Inhibitory: VIP, NO, ATP"],
    },
    {
      title: "Meissner Plexus", color: "0A3D5C", border: C.accent1,
      pts: ["In submucosa; 3 sublayers", "Controls secretion, absorption, mucosal blood flow", "Receives sensory epithelial input"],
    },
    {
      title: "Clinical Relevance", color: "163E6F", border: C.accent2,
      pts: ["Hirschsprung disease: absent ganglia → megacolon", "IBS & IBD: ENS-immune dysregulation", "Drug targets: prokinetics (metoclopramide), antiemetics"],
    },
  ];
  sumBoxes.forEach((box, i) => {
    const x = 0.25 + (i % 2) * 4.85;
    const y = 1.6 + Math.floor(i / 2) * 1.8;
    s.addShape(pres.ShapeType.roundRect, {
      x, y, w: 4.6, h: 1.65,
      fill: { color: box.color }, line: { color: box.border, width: 1.5 }, rectRadius: 0.1,
    });
    s.addText(box.title, { x: x + 0.1, y: y + 0.05, w: 4.4, h: 0.38, fontSize: 13, bold: true, color: box.border });
    const pts = box.pts.map((p, j) => ({
      text: p,
      options: { bullet: { code: "2022" }, color: C.bodyText, breakLine: j < box.pts.length - 1 },
    }));
    s.addText(pts, { x: x + 0.1, y: y + 0.46, w: 4.4, h: 1.1, fontSize: 10.5, valign: "top" });
  });

  s.addText("Sources: Guyton & Hall Medical Physiology  •  Yamada's Textbook of Gastroenterology  •  Ganong's Physiology  •  Localization in Clinical Neurology", {
    x: 0.3, y: 5.2, w: 9.4, h: 0.28,
    fontSize: 8.5, color: C.accent1, italic: true, align: "center",
  });
}

// ─── WRITE FILE ───────────────────────────────────────────────
pres.writeFile({ fileName: "/home/daytona/workspace/ens-histology-ppt/ENS_Histology_Auerbach_Meissner.pptx" })
  .then(() => console.log("DONE: /home/daytona/workspace/ens-histology-ppt/ENS_Histology_Auerbach_Meissner.pptx"))
  .catch(e => { console.error(e); process.exit(1); });

cd /home/daytona/workspace/ens-histology-ppt && node build.js 2>&1

cd /home/daytona/workspace/ens-histology-ppt && \ wget -q "https://cdn.orris.car…

~/ens-histology-ppt/build.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ens-histology-ppt/build.js'

~/ens-histology-ppt/build.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ens-histology-ppt/build.js'

~/ens-histology-ppt/build.js

Successfully replaced 1 instance(s) of the string in '/home/daytona/workspace/ens-histology-ppt/build.js'