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Active Management of the Third Stage of Labour (AMTSL)
Definition and Context
The third stage of labour spans from delivery of the infant to delivery of the placenta. It normally completes within 5-30 minutes. Beyond 18 minutes the risk of postpartum haemorrhage (PPH) increases, and by 30 minutes it is up to six times more likely than at normal completion.
Active management is the deliberate, protocol-driven approach to this stage, and is strongly preferred over expectant (physiological) management because it:
- Decreases duration of the third stage
- Reduces maternal blood loss
- Reduces the incidence and severity of PPH
- Reduces the need for blood transfusion
- Reduces the need for additional uterotonics
A 2025
systematic review (PMID 40340625) and a 2026
evidence summary (PMID 42422824) both confirm AMTSL as the global standard for PPH prevention.
The Three Components of AMTSL
1. Uterotonic Agent Administration
The uterotonic is given with or immediately after delivery of the anterior shoulder (before placental separation).
First-line: Oxytocin
- 20-40 units in 1 litre of IV fluid (isotonic), given over 8 hours
- Alternatively: 10 units IM
- Promotes uterine contraction, reduces atony, and hastens placental separation
- Preferred because it is effective, predictable, and well-tolerated
Important: Oxytocin should NOT be given as an IV bolus before placental delivery as this can trap placental fragments or mask an undetected twin.
Second-line uterotonics (if atony/bleeding persists after oxytocin):
| Drug | Dose/Route | Notes |
|---|
| Methylergonovine (methyergonovine) | 2 mg IM | Normotensive patients only - contraindicated in hypertension |
| Carboprost (15-methyl PGF₂α) | 250 μg IM | For refractory atony |
| Misoprostol (PGE₁) | Oral/sublingual | Useful where IV access not available |
| Dinoprostone (PGE₂) | Rectal/vaginal | |
A 2025
meta-analysis comparing misoprostol vs oxytocin (PMID 40357798) found oxytocin remains superior for PPH prevention in hospital settings; misoprostol is an acceptable alternative where oxytocin is unavailable.
2. Controlled Cord Traction (CCT) - Brandt-Andrews Manoeuvre
Expression of placenta: the suprapubic hand stabilises the uterus upward and posteriorly while gentle traction is applied to the cord. The uterus must NOT be pushed down into the birth canal.
Signs of placental separation (wait for these before applying traction):
- Uterus becomes firmer and rises in the abdomen
- Umbilical cord lengthens 5-10 cm
- Sudden gush of blood from the vagina
Technique:
- Place one hand (guard hand) suprapubically on the lower uterine segment to stabilise and guard against uterine inversion
- Apply firm upward counter-pressure to hold the uterus in place
- Apply firm but gentle downward and backward traction on the clamped cord in the axis of the birth canal
- As the placenta descends to the perineum, lift the cord upward to deliver the placenta through the introitus
- Have the mother bear down gently - usually sufficient to expel the placenta
- Rotate the placenta gently as it emerges to help peel off membranes; use ring forceps to retrieve any adherent membranes
Warning: Avoid overaggressive traction - this may detach the cord from the placenta, cause haemorrhage, or precipitate uterine inversion.
3. Uterine Massage
- Begin immediately after placental delivery
- Place one hand on the uterine fundus transabdominally
- Massage firmly until the uterus is well contracted and hard
- Continue for at least 1 hour post-delivery with periodic re-checks
- Breastfeeding at this stage can be initiated to promote natural oxytocin release and uterine contraction
Cord Clamping and Cutting
- Clamp the cord with a plastic clamp 3-4 cm from the umbilicus; place a curved Kocher clamp 3-5 cm distally
- Cut between the clamps
- Release the clamp on the placental side and collect 7-10 mL of cord blood - verify 3 vessels (2 arteries + 1 vein); a 2-vessel cord occurs in 1:500 deliveries and is associated with fetal anomalies
- Allowing cord blood to drain actively shortens the third stage
- If cord blood gases are needed: apply two additional clamps 10-20 cm distally, cut again, collect arterial and venous samples in heparinised syringes on ice
Normal vs. Prolonged Third Stage
| Timepoint | Clinical significance |
|---|
| <5 minutes | Usual placental separation |
| Up to 30 minutes | Acceptable; monitor closely |
| >18 minutes | PPH risk begins to rise |
| >30 minutes | PPH risk up to 6x baseline; act |
If Placenta Not Delivered in 30 Minutes
The placenta may be trapped by a contracted cervical ring (especially if cord lengthening and blood gush already occurred but placenta hasn't passed through cervix).
Brandt Manoeuvre: Apply firm suprapubic pressure to hold uterus in place, then apply firm traction on cord.
If still undelivered - proceed to manual removal of placenta (required in ~3% of vaginal deliveries).
Manual Removal of the Placenta
Indications:
- Placenta not delivered within 30 minutes
- Significant haemorrhage with non-contracting uterus
Technique:
- Change gloves; enter vagina with dominant hand, palpating for lacerations
- Find the cervix; enter the uterus
- Using 2-3 fingers (then whole hand if needed), find the cleavage plane between placenta and uterine wall
- Gently develop this plane circumferentially to separate the placenta
- Grasp placenta with dominant hand; slowly withdraw hand with placenta
- If cleavage plane cannot be developed - suspect placenta accreta/increta/percreta; surgical consultation required
After manual removal: Always examine placenta for completeness; if a lobe is missing, re-enter to retrieve fragments. Administer IV oxytocin and perform uterine massage.
Placenta Examination
Every placenta must be examined after delivery:
- Completeness - missing lobule or membrane suggests retained products
- Cord vessel count - 2 arteries + 1 vein is normal; single umbilical artery = fetal anomaly risk
- Cord insertion - velamentous or marginal insertion noted
- Accessory lobes (succenturiate lobe)
- Clots on uterine surface - may indicate placental abruption
- Overall size/shape abnormalities
The "4 Ts" - Causes of PPH to Monitor For
Even with AMTSL, PPH can still occur. The four causes are:
| Cause | Frequency | Examples |
|---|
| Tone (uterine atony) | ~80% | Overdistended uterus (twins, polyhydramnios), prolonged labour, grand multiparity |
| Trauma | ~20% | Cervical, vaginal, perineal lacerations; uterine rupture; uterine inversion |
| Tissue | ~10% | Retained placenta/membranes; placenta accreta spectrum |
| Thrombin (coagulopathy) | <1% | DIC, pre-existing bleeding disorders |
PPH definition (ACOG): Cumulative blood loss ≥1000 mL with signs/symptoms of hypovolemia within 24 hours of delivery.
Three preventive strategies for PPH:
- AMTSL
- Spontaneous placental separation during caesarean delivery
- Prolonged postpartum oxytocin infusion
Complications Specific to AMTSL
| Complication | Notes |
|---|
| Nausea and vomiting | Side effect of uterotonics (especially ergometrine); acceptable trade-off |
| Uterine inversion | Risk with overaggressive cord traction; treat with uterine relaxants (MgSO₄/β-mimetics) then manual replacement |
| Retained products | If placenta incomplete; risk of endometritis and secondary PPH |
| Maternal hypertension | Contraindication to ergometrine/methylergonovine |
Fourth Stage of Labour
Monitoring continues for 1 hour after placental delivery (the "fourth stage"):
- Periodic uterine fundal massage and palpation for tone
- Inspect cervix and vaginal fornices for lacerations
- Repair episiotomy/lacerations
- Continue oxytocin infusion to maintain contraction
- Monitor for signs of PPH (bleeding, hypotension, tachycardia)
- Encourage breastfeeding
Sources: Pfenninger and Fowler's Procedures for Primary Care, 3rd ed.; Swanson's Family Medicine Review; Rosen's Emergency Medicine; Textbook of Family Medicine, 9th ed.; Creasy & Resnik's Maternal-Fetal Medicine