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Raised right-ventricular pressure or volume load causes RVH, for example:
- Pulmonary hypertension or chronic lung disease (cor pulmonale)
- Pulmonary embolism, especially acute right-heart strain
- Congenital heart disease, such as atrial septal defect
- Pulmonary valve or pulmonary artery obstruction
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The increased pressure/volume stretches, enlarges, or remodels the right ventricle and may affect its conduction tissue, including the right bundle branch. This can delay right-ventricular activation and produce RBBB.
RBBB itself is an electrical conduction delay. It changes the ECG pattern but does not make the right-ventricular muscle hypertrophy. It can also occur in an otherwise structurally normal heart. Harrison's notes that RBBB may occur without structural heart disease, but may also accompany congenital and acquired cardiac disease.
RBBB overview similarly notes that chronically raised right-sided pressure, such as in cor pulmonale, can stretch the right bundle branch.