You are a medical pharmacology expert. Search the medical textbook library for comprehensive information on Antitubercular drugs, Rifampicin, DOTS, MDR TB, and XDR TB. Use query_library_db to search for relevant sections. Here are the SQL queries to use: 1. First find relevant TB pharmacology sections: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'antitubercular drugs tuberculosis' ORDER BY rank LIMIT 10 ``` 2. Search for DOTS and MDR TB: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'DOTS MDR tuberculosis' ORDER BY rank LIMIT 10 ``` 3. Search for Rifampicin specifically: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'rifampicin rifampin' ORDER BY rank LIMIT 10 ``` After finding the file paths and line numbers, use read_file to read the actual content. Read 150 lines at a time using offset and limit parameters. Please extract and return ALL of the following in detail (this is for 2nd year MBBS pharmacology, KD Tripathi style): 1. **Antitubercular Drugs Classification** - First line (HRZE + S), Second line drugs, third line 2. **MOA of each drug** - Isoniazid, Rifampicin, Pyrazinamide, Ethambutol, Streptomycin, and second-line drugs 3. **Adverse effects of each drug** - detailed 4. **Precautions/Contraindications** for each 5. **Chemoprophylaxis indications** - who gets it, which drug, duration 6. **DOTS (Directly Observed Treatment Short Course)** - complete description including Category I, II, III regimens, phases (intensive + continuation), drug doses 7. **MDR TB definition and treatment** - drugs used, regimens 8. **XDR TB definition and drugs** - list all drugs 9. **Rifampicin** - antimicrobial spectrum, pharmacokinetics (absorption, distribution, metabolism, excretion), drug interactions, adverse effects in detail, precautions, other therapeutic uses 10. **Failure of drug treatment of TB** - causes Return all information in a very detailed, structured format suitable for MBBS exams.

You are a medical pharmacology expert. Search the medical textbook library for comprehensive information on Leprosy treatment and Antimalarial drugs including Artemisinin/ACT. Use query_library_db to search for relevant sections: 1. Search for leprosy treatment: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'leprosy treatment multibacillary' ORDER BY rank LIMIT 10 ``` 2. Search for antimalarial drugs: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'antimalarial drugs malaria treatment' ORDER BY rank LIMIT 10 ``` 3. Search for Artemisinin ACT: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'artemisinin ACT combination therapy' ORDER BY rank LIMIT 10 ``` 4. Search for Chloroquine: ```sql SELECT title, book_title, '/textbooks/' || block_file_path AS file_path, line_number, para_line_ranges, para_count FROM headings_fts WHERE headings_fts MATCH 'chloroquine malaria' ORDER BY rank LIMIT 10 ``` After finding file paths and line numbers, use read_file to read actual content (150 lines at a time with offset/limit). Please extract and return ALL of the following in detail (2nd year MBBS pharmacology, KD Tripathi style): **LEPROSY:** 1. **Multibacillary Leprosy treatment** - WHO MDT regimen in detail: drugs, doses, duration 2. **Paucibacillary Leprosy treatment** - for comparison 3. **Rifampicin in Leprosy** - MOA, role, dose **ANTIMALARIAL DRUGS:** 1. **Classification** of antimalarials - by chemical class and by stage of action 2. **Terms used** to describe antimalarial action in relation to life cycle of P. vivax - tissue schizonticide, blood schizonticide, gametocide, etc. with specific drugs for each 3. **Chloroquine** - MOA in detail, therapeutic uses (malaria + other), adverse effects (acute + chronic), precautions, contraindications, pharmacokinetics 4. **Artemisinin derivatives** - MOA, uses, adverse effects, precautions, examples (artesunate, artemether, dihydroartemisinin) 5. **ACT (Artemisinin-based Combination Therapy)** - rationale/indications, advantages over other antimalarials, complete regimens (at least 3 different ACT regimens for uncomplicated P. falciparum) 6. **Uncomplicated P. falciparum malaria** - list all various ACT regimens currently used 7. **Justification for combining two drugs in ACT** - pharmacological rationale 8. **Quinine** - MOA, uses, adverse effects (cinchonism), precautions 9. **Primaquine** - MOA, uses (radical cure, gametocide), adverse effects (G6PD deficiency), precautions 10. **Mefloquine, Lumefantrine, Piperaquine** - brief details 11. **P. vivax malaria treatment** - radical cure regimen Return all information in very detailed, structured format suitable for MBBS long answer questions.