Orris

Advance researches in ent field

Reading File
“Advanced research in ENT” is broad. Which area do you want to focus on?
  1. Otology and neurotology
  2. Rhinology and skull-base surgery
  3. Head and neck oncology
  4. Laryngology, airway, and voice
  5. Sleep medicine and pediatric ENT

Find recent ENT research papers by subspecialty

Reading File
Reading File
Searching PubMed

otology AND hearing loss

Searching PubMed

rhinology AND chronic rhinosinusitis

Searching PubMed

head neck cancer

Searching PubMed

laryngology AND voice

Searching PubMed

pediatric otolaryngology OR sleep apnea

Searching the Web

site:pubmed.ncbi.nlm.nih.gov 2025 otolaryngology research recent otology rhinology head neck laryngology pediatric

Searching PubMed

cochlear implant hearing loss

Searching PubMed

chronic rhinosinusitis biologics

Searching PubMed

oropharyngeal cancer immunotherapy

Searching PubMed

vocal fold paralysis treatment

Searching PubMed

pediatric obstructive sleep apnea adenotonsillectomy

Recent ENT literature by subspecialty

Selection is focused on 2024-2026 papers with a clear subspecialty focus. Most of the highly relevant recent hits are reviews or evidence syntheses, useful for rapidly mapping active research areas.

1. Otology and neurotology

  • Cochlear implantation in genetically characterized sensorineural hearing loss: Fehrmann et al. (2025), Cochlear Implantation Outcomes in Genotyped Subjects with Sensorineural Hearing Loss, JARO. Observational outcomes research relevant to precision counseling and genotype-informed implantation. PMID: 40268851
  • Cochlear implants for asymmetric hearing loss in older adults: Smith et al. (2025), Hearing Benefits of Cochlear Implantation in Older Adults With Asymmetric Hearing Loss, Otology & Neurotology. PMID: 40075242
  • Hearing preservation after residual hearing loss in cochlear implant users: Thompson et al. (2024), Variables Affecting Cochlear Implant Performance After Loss of Residual Hearing, The Laryngoscope. PMID: 37767794
  • Infant vestibular screening: Yang et al. (2025), Clinical Consensus on Vestibular Infant Screening. A Delphi consensus addressing screening targets, timing, and cVEMP protocol standardization. PMID: 41276659
Research directions: genetic stratification of cochlear implantation outcomes, expansion of adult CI candidacy, hearing preservation, and early vestibular assessment.

2. Rhinology and anterior skull base

  • Systematic review . Tier 1: Monos et al. (2024), Predicting Adherence to Topical Medications in Chronic Rhinologic Disease, Otolaryngology-Head and Neck Surgery. Relevant to a major determinant of medical and postoperative CRS outcomes. PMID: 38822756
  • Systematic review . Tier 1: Huang et al. (2025), Bibliometric Analysis of Biologic Treatments for Chronic Rhinosinusitis, Frontiers in Medicine. Maps the expanding biologics literature in CRSwNP. PMID: 40861204
  • Review . Tier 7: Jin et al. (2025), Biological Therapy in Chronic Rhinosinusitis With Nasal Polyps, Expert Review of Clinical Immunology. PMID: 39862235
  • Review . Tier 7: Boyd and Khanwalkar (2024), Biologics in Chronic Rhinosinusitis: Current and Emerging, Immunology and Allergy Clinics of North America. PMID: 39389716
Research directions: selection and sequencing of biologics, biomarkers for treatment response, topical-therapy adherence, and disease-control measures beyond polyp score.

3. Head and neck oncology

  • Systematic review . Tier 1: Shen and He (2026), Advancements in Immunotherapy for Oropharyngeal Cancer: Current Landscape and Future Prospects. Focuses on checkpoint inhibitors, HPV-related disease, and cancer-vaccine approaches. PMID: 40827652
  • Translational research: Cha et al. (2024), Single-Cell Analysis Reveals Cellular and Molecular Factors Counteracting HPV-Positive Oropharyngeal Cancer Immunotherapy Outcomes, Journal for ImmunoTherapy of Cancer. PMID: 38857913
  • Review . Tier 7: Razavian (2025), Advances in Systemic and Immunotherapies for Human Papillomavirus-Mediated Oropharyngeal Cancers, Cancer Journal. PMID: 40459978
  • Broad clinical review: Dunn, Ho, and Pfister (2026), Head and Neck Cancer: A Review, JAMA. PMID: 41396597
Research directions: predictive immune biomarkers, de-escalation in HPV-associated oropharyngeal carcinoma, personalized systemic therapy, and tumor-microenvironment profiling.

4. Laryngology, voice, and airway

  • Review . Tier 7: Szalenko-Tőkés et al. (2025), Injection Laryngoplasty for the Treatment of Unilateral Vocal Fold Paralysis. Covers contemporary injectable approaches and outcome considerations. PMID: 40581924
  • Practice-pattern research: Yam et al. (2026), Prevalence of Objective Voice Measurement Use in Laryngology Practices in the United States, Journal of Voice. PMID: 37980207
  • Clinical review: Hartley and Hartley (2025), Management of Bilateral Vocal Fold Paralysis in Children, Current Opinion in Otolaryngology & Head and Neck Surgery. PMID: 40836783
  • Pediatric review: Kiessling and Sidell (2026), Pediatric Vocal Fold Paralysis, Otolaryngologic Clinics of North America. PMID: 42014211
Research directions: objective and patient-reported voice metrics, timing and durability of injection laryngoplasty, pediatric airway reconstruction, and nerve-reinnervation strategies.

5. Pediatric ENT and sleep surgery

  • Review . Tier 7: Lele et al. (2025), An Overview of Management Strategies for Pediatric Obstructive Sleep Apnea Following Adenotonsillectomy. Addresses persistent OSA after first-line surgery. PMID: 40338224
  • Perioperative review: Penberthy and Dalesio (2025), Perioperative Management of Pediatric Patients With Obstructive Sleep Apnea Syndrome Presenting for Adenotonsillectomy. PMID: 40241421
  • Review . Tier 7: Jaensch et al. (2024), Adenotonsillectomy for Obstructive Sleep Apnea in Children, Otolaryngologic Clinics of North America. PMID: 38575485
  • Pediatric airway case research: Endoscopic Aryepiglottic Z-Plasty for Pediatric Post-Supraglottoplasty Supraglottic Stenosis (2025). A report of a mucosa-sparing approach to a complex postoperative airway complication. PMID: 40948443
Research directions: persistent OSA phenotyping after adenotonsillectomy, obesity-associated surgical outcomes, perioperative risk stratification, DISE-guided surgery, and complex endoscopic airway reconstruction.

Cross-cutting emerging themes

  1. Precision ENT: use of genomics, single-cell profiling, and biomarkers to predict treatment response.
  2. Biologics and immunotherapy: especially CRSwNP and HPV-associated head and neck cancer.
  3. Outcome measurement: stronger interest in validated patient-reported outcomes and objective voice, hearing, and sleep metrics.
  4. Minimally invasive intervention: endoscopic airway techniques, advances in cochlear implantation, and tailored surgical decision-making.
  5. Equity and implementation: adherence, access to biologics and implants, and variation in practice are receiving greater attention.
These citations are a current reading shortlist, not a systematic review. For journal-club use, prioritize the systematic reviews and the single-cell HPV-positive oropharyngeal cancer paper, then narrow by the clinical question.
This is a shared conversation. Sign in to Orris to start your own chat.