Herpes zoster (shingles) treatment should be started promptly, ideally within 72 hours of rash onset. It may still help up to 7 days, especially if new blisters are appearing or there is severe disease. Antivirals shorten the rash and acute pain. Dermatology 2-Volume Set, p. 1697.
Usual oral antiviral options for uncomplicated shingles in adults
A clinician should choose and prescribe one, with dose adjustment needed for kidney disease:
- Valacyclovir: 1 g by mouth three times daily for 7 days
- Famciclovir: 500 mg by mouth three times daily for 7 days
- Acyclovir: 800 mg by mouth five times daily for 7 days
The CDC lists these as preferred initial antivirals and advises early treatment. See the
CDC clinical overview.
Pain and skin care
- Paracetamol (acetaminophen) or ibuprofen if safe for you.
- A doctor may prescribe stronger pain medicines or nerve-pain medicines if pain is severe or persists.
- Cool wet compresses, calamine lotion, and colloidal oatmeal baths can ease itch and discomfort. See CDC self-care guidance.
- Keep the rash clean, dry, and covered. Do not pick blisters.
Get urgent, same-day medical assessment if:
- Rash or pain is on the eye, forehead, nose, or eyelid, or you have eye redness, blurred vision, or light sensitivity.
- Rash is in or around the ear, with facial weakness, hearing loss, vertigo, or severe headache.
- You are pregnant, immunocompromised, have cancer/HIV, take immune-suppressing medicines, or the rash is widespread.
- You have fever, confusion, weakness, difficulty urinating, or severe uncontrolled pain.
Avoid spreading VZV: Cover the rash and avoid direct contact with pregnant people without chickenpox immunity, newborns, and people with weak immune systems until all lesions have crusted. Shingles can transmit chickenpox, not shingles, to someone who lacks immunity.
After recovery, ask about Shingrix vaccination. It is generally recommended for adults aged 50+ and for immunocompromised adults aged 19+. It is not given during the acute episode.