Shock and there pathophysiology condition symptoms diagnosis and treatment
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types of shock classification pathophysiology diagram
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This is a comprehensive review of shock synthesized from five major medical textbooks. Here's a quick navigation guide to the content above:
What's covered:
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Definition — failure of circulation to meet cellular metabolic needs; mortality >20%
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Classification (6 types)
- Hypovolemic, Cardiogenic, Distributive/Septic, Obstructive, Neurogenic, Anaphylactic
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Pathophysiology (4 levels)
- Cellular/mitochondrial: aerobic → anaerobic → lactate → ATP depletion
- Neuroendocrine compensation: baroreceptors, RAAS, catecholamines, ADH
- Three progressive stages: Compensated → Progressive → Irreversible
- Septic shock: TLR/NF-κB activation → cytokine storm → DIC → organ failure
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The vicious cycle diagram from Guyton & Hall showing how decreased cardiac output feeds back on itself
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Symptoms — including the ATLS hemorrhagic shock classification (Class I–IV)
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Diagnosis — Rosen's empirical criteria; lactate and base deficit as key biomarkers
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Treatment — type-specific protocols including balanced resuscitation for hemorrhage, 1-hour antibiotics for sepsis, emergency procedures for obstructive shock
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Organ complications — ATN, ARDS, DIC, centrilobular necrosis, bacterial translocation
Hirsutism, virilization and endometriosis according to bereks and Novak gyncelogy book
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