Library Note: Apurba Sastry ki Essentials of Medical Microbiology directly available nahi thi, lekin yahan jo content diya gaya hai wo Goldman-Cecil Medicine, Robbins Pathology, aur Medical Microbiology 9e se liya gaya hai - ye sab Apurba Sastry ke curriculum ke equivalent standard references hain. Concepts exactly waise hi hain.

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MI 3.1 - Infective Endocarditis:

• Causative organisms setting-wise (S. viridans, S. aureus, HACEK, Enterococcus, culture-negative)
• Pathogenesis flowchart - NBTE se vegetation formation tak step-by-step
• Acute vs Subacute IE comparison table
• Clinical features - FROM JANE mnemonic (Osler vs Janeway distinction ke saath)
• Modified Duke Criteria - major/minor criteria clearly
• Treatment - organism-specific antibiotics + surgical indications + prophylaxis

MI 3.2 - Rheumatic Fever & S. pyogenes:

• S. pyogenes - basic properties, virulence factors (M protein central role)
• Diseases - suppurative vs non-suppurative (key: RF only after pharyngitis, NOT skin)
• Molecular mimicry - RF ka core pathogenic mechanism
• Pathogenesis flowchart - pharyngitis se pancarditis tak
• Aschoff bodies - pathognomonic histological lesion
• Jones Criteria (2015 revision) - CASES mnemonic ke saath, low-risk vs high-risk population differences
• Lab diagnosis - Centor score, RAT, ASO vs Anti-DNase B
• Treatment + Secondary prophylaxis - duration table ke saath