A 22 hour-old, 3kg term male neonate was brought to the special care baby unit (SCBU) of a teaching hospital, with yellowness of the body noticed at the 15th hour of life. He was delivered via elective cesarean section. Pregnancy was booked and uneventful. Mother’s prenatal tests were said to be normal. The mother’s blood type was O rhesus D antigen positive while father was blood type B rhesus D antigen positive. There was a positive family history of neonatal jaundice in all 3 siblings within the first week of life. Physical examination of the index case revealed temperature of 37.2oC and generalized jaundice (Kramer 5). He was not pale nor dehydrated. No dysmorphic features were appreciated. Admitting serum bilirubin (SB) was total SB (TSB) of 25mg/dl, baby’s blood group was B positive. The baby immediately commenced intensive phototherapy and had double volume EBT with a compatible blood within 5hrs of admission. Three additional exchange transfusions with supplemental blood transfusions were performed over the next three days due to persistently high unconjugated hyperbilirubinemia and pallor. Additionally, fever was noted. Given the refractory severe NNJ despite treatment, the presence of fever, and the family history of G6PD deficiency, a differential diagnosis of ABO incompatibility with superimposed sepsis and G6PD deficiency was entertained. This is a case for my seminar. Draft an effective introduction and conclusion. Yellow baby picture has been attached. The audience should get hooked. Make it impactful, concise, perfect. Like a strong clinician.