Your message was short, so I'm assuming you mean acute, uncomplicated loose stool in an adult. If it's for a child, an older adult, or someone who is pregnant or immunocompromised, tell me, because the advice changes.
What to do
1. Replace fluids. This matters most. Mild cases may need only fluid replacement. Use an oral rehydration solution (ORS) or an iso-osmolar sugar-electrolyte drink, and sip regularly through the day. Dehydration is the main cause of harm in diarrhea. (Harrison's Principles of Internal Medicine 22E, Acute Diarrhea, Treatment)
2. Keep eating. Eat normal, bland food as tolerated. Avoid alcohol, caffeine, and very fatty or very sugary foods for a few days.
3. Don't test or take antibiotics. Most acute diarrhea is mild and self-limited. It doesn't justify stool tests or drug treatment. More than 90% of acute cases are infectious, often viral. (Harrison's 22E)
4. Loperamide is optional. It's reasonable for symptom control if the diarrhea is moderate, not bloody, and without fever. (Harrison's 22E) Avoid it if you have fever or blood in the stool. Use caution if you take other drugs that can affect heart rhythm. The usual adult dose is 4 mg first, then 2 mg after each loose stool, with a maximum of 16 mg a day. That dosing is from my own knowledge, not the textbook, so check the product label.
5. Check your medications. Laxatives, antacids (magnesium types), colchicine, and antibiotics can all cause diarrhea. It usually stops when you stop the drug. (The Washington Manual of Medical Therapeutics, Acute diarrhea)
When to get evaluated
Harrison's lists these triggers for stool studies and medical review:
- Profuse diarrhea with dehydration, such as dizziness, very dark urine, or inability to keep fluids down
- Visible blood in the stool
- Fever of 38.5°C (101°F) or higher
- No improvement after 48 hours
- Recent antibiotic use, which raises the question of C. difficile
- Severe abdominal pain in someone over 50
- Age 70 or older, or a weakened immune system
- A known outbreak, such as a restaurant, cruise ship, or household cluster
Diarrhea lasting more than 4 weeks is chronic and needs a proper workup. Most chronic causes are not infectious. (Harrison's 22E)
Notes
- Bismuth subsalicylate (Pepto-Bismol) can reduce vomiting and diarrhea. Avoid it if you are immunocompromised or have kidney impairment. (Harrison's 22E)
- Travel-related diarrhea is the main setting where antibiotics are used, and then only in selected cases.
- Wash your hands well and avoid preparing food for others while you're symptomatic.
Recent evidence check: A quick PubMed search for the last 2 years found nothing that contradicts the above. The reviews it returned were about children (probiotics,
PMID 40739406; antibiotics,
PMID 39641317).
If it's a child, or you have any red-flag features, send me the details and I'll adjust.