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Tests for Ovarian Reserve - Simply Explained

Ovarian reserve just means: how many eggs does a woman still have left? As women age, the number of eggs in their ovaries goes down. These tests help doctors figure out that number.

The Tests

1. FSH (Day 3)
  • FSH = Follicle Stimulating Hormone - a signal from the brain telling the ovaries to grow eggs
  • Normally, a healthy ovary responds easily, so the brain doesn't need to shout loudly
  • If the ovaries are running low on eggs, the brain has to send a stronger signal = higher FSH
  • High FSH = fewer eggs / ovaries struggling
2. E2 (Estrogen)
  • Estrogen is made by the ovaries
  • If the ovaries are failing, they produce less estrogen
  • Low estrogen = ovarian failure
3. Anti-Mullerian Hormone (AMH)
  • Made directly by the small follicles (egg sacs) in the ovary
  • More follicles = more AMH
  • Fewer follicles = less AMH
  • Low AMH = fewer eggs remaining
  • AMH is considered the BEST test for ovarian reserve because it stays fairly stable throughout the month (doesn't vary much with the cycle) - so you can test it on any day
4. Antral Follicle Count (AFC)
  • Done via ultrasound - the doctor literally counts the tiny follicles visible in the ovaries
  • Fewer follicles seen = lower ovarian reserve

Important Extra Points

Inhibin B - NOT a test for ovarian reserve. Instead, it's used as a marker for a specific ovarian tumor called a granulosa cell tumor. Don't confuse it with the others.
STRAW Staging - This is a system that maps out the stages of a woman's reproductive life, like chapters in a book:
  1. Early reproductive age
  2. Reproductive age (peak fertility)
  3. Late reproductive age (fertility declining)
  4. Early menopausal transition (cycles becoming irregular)
  5. Late menopausal transition (very irregular)
  6. Menopause (periods have stopped)
It helps doctors tell a woman exactly where she is in her reproductive timeline.

Quick Summary Table

TestWhat happens in ovarian failureBest for?
FSHGoes UPCommon screening
Estrogen (E2)Goes DOWNSupporting test
AMHGoes DOWNBest overall test
Antral Follicle CountGoes DOWNUltrasound-based count
The key idea: when the ovaries have fewer eggs, AMH, E2, and AFC all drop, while FSH rises (the brain tries harder to stimulate failing ovaries).
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