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Pulmonary embolism with latest guidelines

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"pulmonary embolism" AND "guidelines"

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PMID: 41712677

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PMID: 41712898

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2026 AHA ACC pulmonary embolism guideline key recommendations clinical categories

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2026 AHA ACC PE guideline clinical categories massive submassive low-intermediate PERT anticoagulation thrombolysis

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2026 AHA ACC PE guideline five clinical categories A B C D E definitions hemodynamics biomarkers

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2026 AHA ACC PE guideline category D E PERT recommendation thrombolysis catheter directed therapy ECMO DOACs

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Key highlights from the 2026 AHA/ACC guideline (the first dedicated US PE guideline, published February 2026):
  1. New 5-category system (A–E) replaces "massive/submassive/low-risk" — more granular, prognosis-driven classification
  2. DOACs are now formally Class I (recommended over VKAs) — first explicit endorsement in a US guideline
  3. PERT activation upgraded to Class I for categories C–E
  4. CDT and mechanical thrombectomy given Class 2a recommendations for Category D (intermediate-high)
  5. Outpatient treatment explicitly endorsed for Category B (low-severity)
  6. VA-ECMO recognized as a bridging strategy in refractory Category E
Ask if you'd like a deeper dive into any section — diagnosis algorithms, DOAC dosing, catheter-based therapies, or CTEPH management.
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