Anatomy of the Female Reproductive System
The system has two parts. The external genitalia (vulva) and the internal genitalia (vagina, cervix, uterus, fallopian tubes, ovaries) are separated by the hymen (Thieme Atlas, General Anatomy and Musculoskeletal System, p. 252).
1. External genitalia (vulva)
- Mons pubis is the fatty tissue over the pubic symphysis. The pudendal cleft divides its lower part into the labia majora.
- Labia majora are pigmented skin folds containing smooth muscle, sebaceous, sweat and scent glands. They join at the anterior and posterior commissures.
- Labia minora fuse anteriorly to form the clitoral hood (prepuce) and posteriorly to form the vestibule.
- Clitoris has a glans, with the vestibular bulbs lying beneath the superficial perineal structures.
- Vestibule contains the urethral meatus and the vaginal introitus, which is outlined by the hymenal ring. Hart's line marks its outer border. Its anterior boundary is the clitoral frenulum and its posterior boundary is the posterior fourchette.
- Bartholin glands open at the fossa navicularis, posterolateral to the introitus. They are homologues of the male bulbourethral glands.
- Skene glands lie beside the urethral meatus. They are homologues of the prostate.
- Both glands provide lubrication.
- Perineum: a line between the ischial tuberosities divides it into an anterior urogenital triangle and a posterior anal triangle.
(Sabiston Textbook of Surgery, Ch. 120, p. 2783)
2. Internal genitalia
Vagina
- It is a flattened fibromuscular tube.
- Its layers, from inside out, are stratified squamous mucosa, lamina propria, muscularis and areolar connective tissue.
- Development: the lower part comes from the urogenital sinus. The upper part comes from the Müllerian ducts.
- Blood supply: the vaginal artery (from the internal iliac), with anastomoses from the uterine, internal pudendal, inferior vesical and middle hemorrhoidal arteries.
- Nerve supply: S2-S4, ending in the pudendal nerve. Sensation is concentrated in the distal vagina and is sparse in the upper part.
Cervix
- It is about 3 cm long, with a central canal (the os) connecting the vagina to the uterine cavity.
- The ectocervix has squamous epithelium and the endocervix has mucus-secreting columnar epithelium. The junction is the transition zone, where cervical intraepithelial neoplasia (CIN) arises.
- Blood supply: descending branches of the uterine artery run at the 3 and 9 o'clock positions. Azygos arteries run anteriorly and posteriorly in the midline.
- Innervation: parasympathetic (S2-S4), mostly in the endocervix.
Uterus
- It is an intraperitoneal muscular organ lying behind the bladder and in front of the rectum. The nonpregnant uterus weighs 40-80 g.
- Parts: fundus, corpus (body), isthmus and cervix.
- Wall layers: serosa (perimetrium), myometrium (smooth muscle in three layers) and endometrium.
- Supports and ligaments:
- The broad ligament is a peritoneal fold.
- The round ligament runs from the cornu through the inguinal canal to the labia majora.
- The cardinal (transverse cervical) ligaments support the cervix and carry the uterine arteries.
- The uterosacral ligaments run from the posterior cervix to S3.
- Blood supply: uterine arteries (from the internal iliac) and ovarian arteries (from the aorta).
- Innervation: sympathetic via the hypogastric and ovarian plexuses, and parasympathetic S2-S4. Visceral afferents travel at T11-T12.
Fallopian tubes (uterine tubes)
They are 10-14 cm long and have four parts:
| Part | Features |
|---|
| Interstitial (intramural) | 1-2 cm, within the myometrium |
| Isthmus | About 4 cm, narrow, most muscular |
| Ampulla | 4-6 cm, wider, the usual site of fertilization |
| Infundibulum | Funnel-shaped, with fimbriae that surround the ostium |
- The mucosa has ciliated columnar, secretory and peg cells.
- Blood supply: ovarian and uterine arteries via the mesosalpinx.
Ovaries
- They are paired, oval and about 2-3 cm in diameter. They lie intraperitoneally in the ovarian fossa, between the internal and external iliac arteries. The ureter lies close behind.
- Attachments:
- The mesovarium attaches to the posterior broad ligament.
- The suspensory (infundibulopelvic) ligament carries the ovarian vessels.
- The ovarian (uteroovarian) ligament runs to the uterine tubal angle.
- Microscopic structure: the tunica albuginea is covered by a cuboidal surface epithelium. The cortex holds follicles at various stages and the corpus luteum. The medulla holds vessels, nerves and hilar cells.
- A newborn has about 500,000 to 1-2 million primordial follicles, many of which are lost by puberty. The oocytes are arrested in prophase of meiosis.
- Blood supply: the ovarian artery from the aorta, which anastomoses with the uterine artery.
- Clinical note: 80-90% of ovarian cancers arise from the surface epithelium.
(Sabiston Textbook of Surgery, Ch. 120, pp. 2783-2785; Color Atlas of Human Anatomy Vol. 2, pp. 444-445)
3. Key clinical points
- Uterine artery and ureter: the ureter passes beneath the uterine artery in the cardinal ligament, so it is at risk in hysterectomy.
- The ovarian vessels in the infundibulopelvic ligament must be ligated in oophorectomy, and the ureter lies close by.
- Müllerian fusion failure causes uterine and tubal anomalies. Transverse vaginal septae can present at menarche.
- The ampulla is the commonest site of tubal ectopic pregnancy. This comes from standard teaching, not the pages I read.
Recent literature check
A PubMed search of systematic reviews from the last 2 years found nothing that changes this standard anatomy. The results were on posterior cloaca anomalies (PMID 38216143), menopause and vaginal tissue mechanics (PMID 37542707), and cosmetic procedures (PMID 39529074).
I can go deeper on one area if you want, such as pelvic floor and fascial supports, pelvic blood and nerve supply, or embryology.