Basic Drug Doses in Children - By Age and Weight

from reportlab.lib.pagesizes import A4
from reportlab.lib import colors
from reportlab.lib.styles import getSampleStyleSheet, ParagraphStyle
from reportlab.lib.units import cm, mm
from reportlab.platypus import (
    SimpleDocTemplate, Paragraph, Spacer, Table, TableStyle,
    HRFlowable, KeepTogether
)
from reportlab.lib.enums import TA_CENTER, TA_LEFT, TA_RIGHT
from reportlab.platypus import PageBreak
from datetime import date

OUTPUT = "/home/daytona/workspace/pediatric-drug-ref/Pediatric_Drug_Quick_Reference.pdf"

# ── Colours ──────────────────────────────────────────────────────────────────
DARK_BLUE   = colors.HexColor("#1a3a5c")
MID_BLUE    = colors.HexColor("#2566a8")
LIGHT_BLUE  = colors.HexColor("#dbeafe")
ACCENT      = colors.HexColor("#e05c2a")
HEADER_BG   = colors.HexColor("#1a3a5c")
ROW_ALT     = colors.HexColor("#f0f6ff")
WHITE       = colors.white
LIGHT_GRAY  = colors.HexColor("#f5f5f5")
WARN_YELLOW = colors.HexColor("#fff3cd")
WARN_BORDER = colors.HexColor("#e6a817")

doc = SimpleDocTemplate(
    OUTPUT,
    pagesize=A4,
    leftMargin=1.5*cm, rightMargin=1.5*cm,
    topMargin=1.8*cm, bottomMargin=1.8*cm,
    title="Pediatric Drug Quick Reference",
    author="Orris Medical Reference | Harriet Lane Handbook 23rd Ed."
)

W = A4[0] - 3*cm  # usable width

styles = getSampleStyleSheet()

# Custom styles
def S(name, **kw):
    base = kw.pop("base", "Normal")
    return ParagraphStyle(name, parent=styles[base], **kw)

title_style   = S("DocTitle", fontSize=22, textColor=WHITE, alignment=TA_CENTER,
                  fontName="Helvetica-Bold", leading=28)
sub_style     = S("DocSub",   fontSize=11, textColor=colors.HexColor("#cce0ff"),
                  alignment=TA_CENTER, fontName="Helvetica", leading=15)
source_style  = S("Source",   fontSize=7.5, textColor=colors.HexColor("#aacbee"),
                  alignment=TA_CENTER, fontName="Helvetica-Oblique")
drug_hdr      = S("DrugHdr",  fontSize=13, textColor=WHITE,
                  fontName="Helvetica-Bold", leading=17, alignment=TA_LEFT)
section_hdr   = S("SectionHdr", fontSize=9, textColor=DARK_BLUE,
                  fontName="Helvetica-Bold", leading=12)
note_style    = S("Note",     fontSize=7.5, textColor=colors.HexColor("#5a3e00"),
                  fontName="Helvetica-Oblique", leading=10)
warn_style    = S("Warn",     fontSize=8, textColor=colors.HexColor("#7a3000"),
                  fontName="Helvetica-Bold", leading=11)
footer_style  = S("Footer",   fontSize=7, textColor=colors.gray,
                  alignment=TA_CENTER, fontName="Helvetica-Oblique")
cell_style    = S("Cell",     fontSize=7.8, fontName="Helvetica", leading=10)
cell_b_style  = S("CellB",    fontSize=7.8, fontName="Helvetica-Bold", leading=10)
cell_hdr      = S("CellHdr",  fontSize=8, fontName="Helvetica-Bold",
                  textColor=WHITE, leading=10)

# ── Helper: table style ───────────────────────────────────────────────────────
def drug_table_style(nrows, ncols, alt_start=1):
    s = TableStyle([
        # Header row
        ('BACKGROUND',  (0,0), (-1,0), MID_BLUE),
        ('TEXTCOLOR',   (0,0), (-1,0), WHITE),
        ('FONTNAME',    (0,0), (-1,0), 'Helvetica-Bold'),
        ('FONTSIZE',    (0,0), (-1,0), 8),
        ('ALIGN',       (0,0), (-1,0), 'CENTER'),
        ('VALIGN',      (0,0), (-1,-1), 'MIDDLE'),
        ('ROWBACKGROUND',(0, 0), (-1, 0), MID_BLUE),
        ('GRID',        (0,0), (-1,-1), 0.3, colors.HexColor("#b0c8e8")),
        ('TOPPADDING',  (0,0), (-1,-1), 3),
        ('BOTTOMPADDING',(0,0), (-1,-1), 3),
        ('LEFTPADDING', (0,0), (-1,-1), 5),
        ('RIGHTPADDING',(0,0), (-1,-1), 5),
    ])
    # Alternating rows
    for r in range(alt_start, nrows):
        if r % 2 == 0:
            s.add('BACKGROUND', (0,r), (-1,r), ROW_ALT)
        else:
            s.add('BACKGROUND', (0,r), (-1,r), WHITE)
    return s

def drug_block(name, brand, indication, table_data, col_widths, notes=None, warn=None):
    """Returns a list of flowables for one drug block."""
    items = []

    # Drug header bar
    hdr_tbl = Table(
        [[Paragraph(f"  {name}", drug_hdr),
          Paragraph(f"{brand}", S("BrandRight", fontSize=9, textColor=colors.HexColor("#cce0ff"),
                                   fontName="Helvetica-Oblique", alignment=TA_RIGHT))]],
        colWidths=[W*0.6, W*0.4]
    )
    hdr_tbl.setStyle(TableStyle([
        ('BACKGROUND', (0,0), (-1,-1), DARK_BLUE),
        ('VALIGN',     (0,0), (-1,-1), 'MIDDLE'),
        ('TOPPADDING', (0,0), (-1,-1), 6),
        ('BOTTOMPADDING', (0,0), (-1,-1), 6),
        ('LEFTPADDING', (0,0), (-1,-1), 4),
        ('RIGHTPADDING', (0,0), (-1,-1), 8),
    ]))
    items.append(hdr_tbl)

    # Indication tag
    ind_tbl = Table(
        [[Paragraph(f"  Uses: {indication}", S("IndTag", fontSize=8,
                    textColor=WHITE, fontName="Helvetica",
                    leading=11))]],
        colWidths=[W]
    )
    ind_tbl.setStyle(TableStyle([
        ('BACKGROUND', (0,0), (-1,-1), MID_BLUE),
        ('TOPPADDING', (0,0), (-1,-1), 3),
        ('BOTTOMPADDING', (0,0), (-1,-1), 3),
        ('LEFTPADDING', (0,0), (-1,-1), 6),
    ]))
    items.append(ind_tbl)

    # Dose table
    formatted = []
    for i, row in enumerate(table_data):
        if i == 0:
            formatted.append([Paragraph(str(c), cell_hdr) for c in row])
        else:
            formatted.append([Paragraph(str(c), cell_style) for c in row])
    t = Table(formatted, colWidths=col_widths, repeatRows=1)
    t.setStyle(drug_table_style(len(formatted), len(col_widths)))
    items.append(t)

    # Notes
    if notes:
        nt = Table(
            [[Paragraph(f"Note: {notes}", note_style)]],
            colWidths=[W]
        )
        nt.setStyle(TableStyle([
            ('BACKGROUND', (0,0), (-1,-1), LIGHT_GRAY),
            ('TOPPADDING', (0,0), (-1,-1), 3),
            ('BOTTOMPADDING', (0,0), (-1,-1), 3),
            ('LEFTPADDING', (0,0), (-1,-1), 6),
            ('GRID', (0,0), (-1,-1), 0.3, colors.HexColor("#cccccc")),
        ]))
        items.append(nt)

    if warn:
        wt = Table(
            [[Paragraph(f"⚠  {warn}", warn_style)]],
            colWidths=[W]
        )
        wt.setStyle(TableStyle([
            ('BACKGROUND', (0,0), (-1,-1), WARN_YELLOW),
            ('TOPPADDING', (0,0), (-1,-1), 3),
            ('BOTTOMPADDING', (0,0), (-1,-1), 3),
            ('LEFTPADDING', (0,0), (-1,-1), 6),
            ('BOX', (0,0), (-1,-1), 0.8, WARN_BORDER),
        ]))
        items.append(wt)

    items.append(Spacer(1, 6))
    return KeepTogether(items)

# ══════════════════════════════════════════════════════════════════════════════
# Build story
# ══════════════════════════════════════════════════════════════════════════════
story = []

# ── COVER HEADER ─────────────────────────────────────────────────────────────
cover = Table(
    [[Paragraph("PEDIATRIC DRUG", title_style)],
     [Paragraph("QUICK REFERENCE GUIDE", title_style)],
     [Spacer(1, 4)],
     [Paragraph("Common Drug Doses by Age & Weight · Including mL Volumes", sub_style)],
     [Spacer(1, 3)],
     [Paragraph(f"Based on Harriet Lane Handbook, 23rd Edition (Johns Hopkins) · Generated {date.today().strftime('%B %d, %Y')}", source_style)],
    ],
    colWidths=[W]
)
cover.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), DARK_BLUE),
    ('TOPPADDING',    (0,0), (-1,-1), 6),
    ('BOTTOMPADDING', (0,0), (-1,-1), 6),
    ('LEFTPADDING',   (0,0), (-1,-1), 10),
    ('RIGHTPADDING',  (0,0), (-1,-1), 10),
]))
story.append(cover)
story.append(Spacer(1, 8))

# Important warning box
imp = Table([[Paragraph(
    "⚠  IMPORTANT: Always dose by WEIGHT (kg) when possible. Verify doses before prescribing. "
    "Do not exceed stated maximum doses. Adjust for renal/hepatic impairment. "
    "mL volumes shown assume the STANDARD concentration listed for each drug.",
    warn_style)]], colWidths=[W])
imp.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), WARN_YELLOW),
    ('BOX', (0,0), (-1,-1), 1, WARN_BORDER),
    ('TOPPADDING', (0,0), (-1,-1), 5),
    ('BOTTOMPADDING', (0,0), (-1,-1), 5),
    ('LEFTPADDING', (0,0), (-1,-1), 8),
]))
story.append(imp)
story.append(Spacer(1, 10))

# ══════════════════════════════════════════════════════════════════════════════
# 1. ACETAMINOPHEN (Paracetamol)
# ══════════════════════════════════════════════════════════════════════════════
# Suspension: 120 mg/5 mL (paeds) and 250 mg/5 mL (older)
# Dose: 15 mg/kg/dose Q4-6hr

para_data = [
    ["Weight (kg)", "Age", "Dose (mg)", "Volume\n120mg/5mL susp.", "Volume\n250mg/5mL susp.", "Frequency", "Max/24hr"],
    ["2.7–5",   "0–3 mo",   "40",   "1.7 mL",  "—",      "Q4–6 hr", "5 doses"],
    ["5.1–7.7", "4–11 mo",  "80",   "3.3 mL",  "—",      "Q4–6 hr", "5 doses"],
    ["7.8–10.5","1–2 yr",   "120",  "5.0 mL",  "2.4 mL", "Q4–6 hr", "5 doses"],
    ["10.6–15.9","2–3 yr",  "160",  "6.7 mL",  "3.2 mL", "Q4–6 hr", "5 doses"],
    ["16–21.4", "4–5 yr",   "240",  "10 mL",   "4.8 mL", "Q4–6 hr", "5 doses"],
    ["21.5–26.8","6–8 yr",  "325",  "13.5 mL", "6.5 mL", "Q4–6 hr", "5 doses"],
    ["26.9–32.3","9–10 yr", "400",  "—",       "8.0 mL", "Q4–6 hr", "5 doses"],
    ["32.4–43.2","11 yr",   "500",  "—",       "10 mL",  "Q4–6 hr", "5 doses"],
    ["≥44",     "≥12 yr/Adult","500–650","—",  "10–13 mL","Q4–6 hr","4 g/day"],
]
cw = [W*0.11, W*0.10, W*0.10, W*0.155, W*0.155, W*0.12, W*0.12]
story.append(drug_block(
    "ACETAMINOPHEN (PARACETAMOL)",
    "Tylenol · Panadol · Calpol · FeverAll",
    "Fever · Mild-Moderate Pain",
    para_data, cw,
    notes="10–15 mg/kg/dose PO/PR. Suspension 120 mg/5 mL (infant) or 250 mg/5 mL (older child). "
          "Max 75 mg/kg/24hr or 4 g/24hr. Do NOT exceed 5 doses in 24 hours.",
    warn="OVERDOSE RISK: Paracetamol is the leading cause of acute liver failure. Check ALL sources of paracetamol before dosing."
))

# ══════════════════════════════════════════════════════════════════════════════
# 2. IBUPROFEN
# ══════════════════════════════════════════════════════════════════════════════
# Suspension: 100 mg/5 mL (standard OTC)
ibup_data = [
    ["Weight (kg)", "Age", "Dose (mg)\n5–10 mg/kg", "Volume\n100mg/5mL susp.", "Frequency", "Max/24hr"],
    ["< 6 mo",  "< 6 mo",     "NOT RECOMMENDED",   "—",       "—",       "—"],
    ["7–9",     "6–12 mo",    "50–75 mg",          "2.5–3.75 mL","Q6–8 hr","2.4 g"],
    ["9–12",    "1–2 yr",     "75–100 mg",         "3.75–5 mL",  "Q6–8 hr","2.4 g"],
    ["12–16",   "2–4 yr",     "100–150 mg",        "5–7.5 mL",   "Q6–8 hr","2.4 g"],
    ["16–21",   "4–6 yr",     "150–200 mg",        "7.5–10 mL",  "Q6–8 hr","2.4 g"],
    ["21–27",   "6–9 yr",     "200–250 mg",        "10–12.5 mL", "Q6–8 hr","2.4 g"],
    ["27–32",   "9–11 yr",    "250–300 mg",        "12.5–15 mL", "Q6–8 hr","2.4 g"],
    ["32–40",   "11–13 yr",   "300–400 mg",        "15–20 mL",   "Q6–8 hr","2.4 g"],
    ["≥40",     "≥12 yr/Adult","400 mg",           "20 mL",      "Q6–8 hr","3.2 g"],
]
cw2 = [W*0.11, W*0.11, W*0.175, W*0.185, W*0.115, W*0.115]
story.append(drug_block(
    "IBUPROFEN",
    "Motrin · Advil · Children's Advil · Nurofen",
    "Fever · Pain · Inflammation",
    ibup_data, cw2,
    notes="5–10 mg/kg/dose Q6–8hr PO. Standard suspension: 100 mg/5 mL. "
          "Max 40 mg/kg/24hr or 2400 mg/24hr (antipyretic). Give with food to reduce GI upset.",
    warn="NOT for infants <6 months. Avoid in dehydration, renal impairment, GI disease, or asthma sensitive to NSAIDs."
))

story.append(PageBreak())

# ══════════════════════════════════════════════════════════════════════════════
# 3. AMOXICILLIN
# ══════════════════════════════════════════════════════════════════════════════
# Suspension: 125 mg/5 mL (standard) or 250 mg/5 mL
amox_data = [
    ["Age / Weight", "Indication", "Dose", "Frequency", "Volume\n125mg/5mL", "Volume\n250mg/5mL"],
    ["Neonate/≤3 mo",   "General",               "20–30 mg/kg/24hr",  "÷ Q12hr",   "—",                "—"],
    ["Child (std dose)","Mild–mod infections",    "25–50 mg/kg/24hr",  "÷ Q8–12hr", "Per weight",       "Per weight"],
    ["Child (high dose)","AOM, CAP, sinusitis\n(resistant organisms)", "80–90 mg/kg/24hr","÷ Q8–12hr","Per weight","Per weight"],
    ["Child",           "Pharyngitis (GAS)",      "50 mg/kg/24hr",     "÷ Q12hr\n× 10 days","Per weight","Per weight"],
    ["10 kg example",   "Standard dose",          "250–500 mg/day",    "125–250 mg Q12hr","5–10 mL Q12hr","2.5–5 mL Q12hr"],
    ["15 kg example",   "High dose",              "1200–1350 mg/day",  "400–450 mg Q8hr", "16–18 mL Q8hr","8–9 mL Q8hr"],
    ["20 kg example",   "High dose",              "1600–1800 mg/day",  "530–600 mg Q8hr", "21–24 mL Q8hr","10.6–12 mL Q8hr"],
    ["Adult",           "Mild/moderate",          "250–500 mg/dose",   "Q8hr PO",   "—",                "—"],
    ["Adult",           "Severe",                 "500–875 mg/dose",   "Q8–12hr PO","—",                "—"],
]
cw3 = [W*0.14, W*0.19, W*0.15, W*0.12, W*0.175, W*0.175]
story.append(drug_block(
    "AMOXICILLIN",
    "Amoxil · Trimox · Generics",
    "Ear / Throat / Chest / Urinary infections",
    amox_data, cw3,
    notes="Suspension available as 125 mg/5 mL or 250 mg/5 mL. "
          "High-dose (80–90 mg/kg/day) recommended for AOM, CAP, sinusitis. Max 3 g/24hr.",
))

# ══════════════════════════════════════════════════════════════════════════════
# 4. AMOXICILLIN-CLAVULANIC ACID
# ══════════════════════════════════════════════════════════════════════════════
amoxclav_data = [
    ["Age / Weight", "Indication", "Dose (amox component)", "Frequency", "Volume\n125/31.25 mg/5mL", "Volume\n200/28.5 mg/5mL"],
    ["Infant 1–<3 mo",   "General",          "30 mg/kg/24hr",     "÷ Q12hr",  "6 mL/kg/day",   "—"],
    ["Child <40 kg\n(std)", "Mild–mod",      "25–45 mg/kg/24hr",  "÷ Q12hr",  "5–9 mL/kg/day", "3.1–5.6 mL/kg/day"],
    ["Child <40 kg\n(high)", "CAP, orbital cellulitis, severe", "90 mg/kg/24hr","÷ Q8–12hr","18 mL/kg/day","11.25 mL/kg/day"],
    ["10 kg (std)",      "Mild–mod",         "250–400 mg/day",    "Q12hr",    "~5–8 mL Q12hr", "~3–5 mL Q12hr"],
    ["15 kg (high)",     "Severe/CAP",       "1350 mg/day",       "Q8hr",     "~9 mL Q8hr",    "~5.6 mL Q8hr"],
    ["≥40 kg / Adult",   "Mild–mod",         "250–500 mg",        "Q8hr PO",  "—",             "—"],
    ["≥40 kg / Adult",   "Severe",           "875 mg",            "Q12hr PO", "—",             "—"],
]
cw4 = [W*0.14, W*0.18, W*0.17, W*0.11, W*0.195, W*0.175]
story.append(drug_block(
    "AMOXICILLIN-CLAVULANATE",
    "Augmentin · Augmentin ES-600",
    "AOM · Sinusitis · Animal bites · Lower respiratory infections",
    amoxclav_data, cw4,
    notes="Doses based on amoxicillin component. Available as 125/31.25 mg/5 mL or 200/28.5 mg/5 mL suspension. "
          "Use ES-600 formulation for high-dose regimens. Max 3 g amoxicillin/24hr.",
    warn="Avoid in penicillin allergy. Diarrhea is common — counsel parents."
))

story.append(PageBreak())

# ══════════════════════════════════════════════════════════════════════════════
# 5. CETIRIZINE
# ══════════════════════════════════════════════════════════════════════════════
# Syrup: 5 mg/5 mL
cet_data = [
    ["Age", "Dose", "Frequency", "Volume (5mg/5mL syrup)", "Max/24hr"],
    ["6–12 months",     "2.5 mg",   "Once daily",       "2.5 mL",       "2.5 mg"],
    ["12–23 months",    "2.5 mg",   "Once daily\n(max Q12hr if needed)", "2.5 mL", "5 mg"],
    ["2–5 years",       "2.5 mg",   "Once daily\n(max 5 mg/day)",        "2.5 mL", "5 mg"],
    ["≥6 years",        "5–10 mg",  "Once daily",       "5–10 mL",      "10 mg"],
    ["Adult",           "10 mg",    "Once daily",       "10 mL",        "10 mg"],
]
cw5 = [W*0.18, W*0.13, W*0.22, W*0.26, W*0.15]
story.append(drug_block(
    "CETIRIZINE",
    "Zyrtec · Reactine",
    "Allergic rhinitis · Urticaria · Allergic reactions",
    cet_data, cw5,
    notes="Less sedating antihistamine. Syrup: 5 mg/5 mL. Reduce dose in hepatic impairment.",
))

# ══════════════════════════════════════════════════════════════════════════════
# 6. CHLORPHENIRAMINE
# ══════════════════════════════════════════════════════════════════════════════
# Syrup: 2 mg/5 mL
chlor_data = [
    ["Age", "Dose", "Frequency", "Volume (2mg/5mL syrup)", "Max/24hr"],
    ["2–6 years",       "1 mg",    "Q4–6 hr",  "2.5 mL",     "6 mg"],
    ["6–12 years",      "2 mg",    "Q4–6 hr",  "5 mL",       "12 mg"],
    ["≥12 years/Adult", "4 mg",    "Q4–6 hr",  "10 mL",      "24 mg"],
]
cw6 = [W*0.22, W*0.14, W*0.17, W*0.27, W*0.18]
story.append(drug_block(
    "CHLORPHENIRAMINE",
    "Chlor-Trimeton · Piriton · Generics",
    "Allergic rhinitis · Urticaria · Anaphylaxis (adjunct)",
    chlor_data, cw6,
    notes="First-generation antihistamine. Syrup: 2 mg/5 mL. Causes sedation. NOT for infants <2 years.",
    warn="Avoid in children <2 years — risk of paradoxical excitability and respiratory depression."
))

# ══════════════════════════════════════════════════════════════════════════════
# 7. SALBUTAMOL (Albuterol) - Nebulization
# ══════════════════════════════════════════════════════════════════════════════
# Nebuliser solution: 2.5 mg/2.5 mL unit dose or 5 mg/mL
salb_data = [
    ["Weight (kg)", "Age", "Nebuliser dose", "Volume (5mg/mL neb solution + NS)", "MDI puffs (100mcg/puff)", "Frequency"],
    ["<10",   "<2 yr",    "1.25 mg",  "0.25 mL + 2 mL NS",  "1–2 puffs via spacer",  "Q4–6 hr"],
    ["10–20", "2–6 yr",   "2.5 mg",   "0.5 mL + 2 mL NS",   "2–4 puffs via spacer",  "Q4–6 hr"],
    ["20–30", "6–10 yr",  "2.5 mg",   "0.5 mL + 2 mL NS",   "4–6 puffs via spacer",  "Q4–6 hr"],
    [">30",   ">10 yr",   "5 mg",     "1 mL + 2 mL NS",      "4–8 puffs via spacer",  "Q4–6 hr"],
    ["Acute severe", "Any","2.5–5 mg","0.5–1 mL + 2 mL NS",  "As directed",           "Q20 min × 3 then reassess"],
]
cw7 = [W*0.10, W*0.09, W*0.14, W*0.22, W*0.21, W*0.21]
story.append(drug_block(
    "SALBUTAMOL (ALBUTEROL)",
    "Ventolin · Proventil · AccuNeb",
    "Acute asthma / Bronchospasm / Wheeze",
    salb_data, cw7,
    notes="Nebulizer solution: 5 mg/mL. Always dilute to 2.5–3 mL total with NS. MDI: use with spacer in all children. "
          "Continuous nebulization may be used in severe acute asthma (ICU setting).",
    warn="Monitor heart rate — tachycardia and tremor are common. Hypokalaemia with high doses."
))

story.append(PageBreak())

# ══════════════════════════════════════════════════════════════════════════════
# 8. PREDNISOLONE / PREDNISONE
# ══════════════════════════════════════════════════════════════════════════════
pred_data = [
    ["Indication", "Dose", "Duration", "Notes"],
    ["Acute asthma / croup",  "1–2 mg/kg/day",   "3–5 days",   "Max 40–60 mg/day"],
    ["Nephrotic syndrome (induction)", "2 mg/kg/day", "4–6 wk",  "Max 80 mg/day; specialist guidance"],
    ["Severe allergic reaction", "1–2 mg/kg/day", "3–5 days",   "Max 60 mg/day"],
    ["Anti-inflammatory",     "0.5–1 mg/kg/day", "As needed",   "Taper if >7 days"],
    ["Immunosuppressive",     "1–2 mg/kg/day",   "Varies",      "Specialist supervision required"],
]
# mL reference for syrup 5 mg/mL
pred_data2 = [
    ["Weight (kg)", "Dose (1 mg/kg)", "Volume\n5mg/5mL syrup (1mg/kg)", "Volume\n5mg/mL sol (1mg/kg)"],
    ["5 kg",   "5 mg",   "5 mL",    "1 mL"],
    ["10 kg",  "10 mg",  "10 mL",   "2 mL"],
    ["15 kg",  "15 mg",  "15 mL",   "3 mL"],
    ["20 kg",  "20 mg",  "20 mL",   "4 mL"],
    ["30 kg",  "30 mg",  "30 mL",   "6 mL"],
    ["≥40 kg", "40 mg (max)", "—",  "8 mL (use tabs)"],
]
cwpred = [W*0.24, W*0.18, W*0.24, W*0.34]
cwpred2 = [W*0.17, W*0.2, W*0.31, W*0.32]
story.append(drug_block(
    "PREDNISOLONE / PREDNISONE",
    "Deltacortril · Prelone · Pediapred",
    "Asthma · Croup · Allergic reactions · Nephrotic syndrome",
    pred_data, cwpred,
    notes="Syrup: 5 mg/5 mL. Soluble: 5 mg/mL. Give with food. If >7 day course, taper dose gradually."
))
t2 = Table(
    [[Paragraph("mL Volume Reference (1 mg/kg dose, Prednisolone 5 mg/5 mL syrup / 5 mg/mL solution)", section_hdr)]],
    colWidths=[W]
)
t2.setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), LIGHT_BLUE),
    ('TOPPADDING', (0,0), (-1,-1), 3),
    ('BOTTOMPADDING', (0,0), (-1,-1), 3),
    ('LEFTPADDING', (0,0), (-1,-1), 6),
]))
story.append(t2)
formatted2 = []
for i, row in enumerate(pred_data2):
    if i == 0:
        formatted2.append([Paragraph(str(c), cell_hdr) for c in row])
    else:
        formatted2.append([Paragraph(str(c), cell_style) for c in row])
t3 = Table(formatted2, colWidths=cwpred2, repeatRows=1)
t3.setStyle(drug_table_style(len(formatted2), 4))
story.append(t3)
story.append(Spacer(1, 8))

# ══════════════════════════════════════════════════════════════════════════════
# 9. ORS (Oral Rehydration Solution)
# ══════════════════════════════════════════════════════════════════════════════
ors_data = [
    ["Severity", "Age / Weight", "Volume of ORS", "Method", "Duration"],
    ["Mild dehydration\n(3–5%)", "All ages", "50 mL/kg", "Sips every 5 min", "Over 4 hours"],
    ["Moderate dehydration\n(5–10%)", "All ages", "100 mL/kg", "Frequent small sips", "Over 4 hours"],
    ["Maintenance\n(ongoing losses)", "Infant", "10 mL/kg per stool\nor 2 mL/kg per vomit", "After each loss", "Ongoing"],
    ["Maintenance", "Child >1 yr", "100–200 mL per stool", "After each loss", "Ongoing"],
    ["Severe dehydration\n(>10%)", "Any", "IV FLUIDS — not ORS alone", "Urgent IV access", "Immediate"],
]
cwors = [W*0.17, W*0.14, W*0.22, W*0.22, W*0.18]
story.append(drug_block(
    "ORAL REHYDRATION SOLUTION (ORS)",
    "ORS · Pedialyte · Dioralyte",
    "Diarrhoea · Vomiting · Dehydration",
    ors_data, cwors,
    notes="WHO-ORS: 75 mmol/L Na, 75 mmol/L glucose, 245 mOsm/L. Do not use plain water, juices, or sports drinks.",
    warn="Severe dehydration (>10%, shock) requires immediate IV fluid resuscitation — ORS alone is insufficient."
))

story.append(PageBreak())

# ══════════════════════════════════════════════════════════════════════════════
# 10. DIAZEPAM - Febrile/Acute Seizures
# ══════════════════════════════════════════════════════════════════════════════
diaz_data = [
    ["Route", "Age / Weight", "Dose", "Volume / Notes", "Max dose"],
    ["Rectal (Diastat)", "< 5 yr",    "0.5 mg/kg",  "Rectal gel, round to 2.5 mg", "5 mg"],
    ["Rectal (Diastat)", "5–12 yr",   "0.3 mg/kg",  "Rectal gel, round to 5 mg",   "10 mg"],
    ["IV / IO",          "Neonate",   "0.1–0.3 mg/kg IV", "5 mg/mL solution; give slowly over 2–3 min", "2 mg"],
    ["IV / IO",          "Infant/Child", "0.1–0.3 mg/kg IV", "Dilute to 1 mg/mL; give over 2 min", "5 mg (<5yr)\n10 mg (>5yr)"],
    ["IV / IO",          "Adolescent/Adult", "5–10 mg IV", "Give slowly; may repeat Q5 min", "30 mg"],
    ["Intranasal (off-label)", "All ages", "0.5 mg/kg IN", "Use IV formulation intranasally", "20 mg"],
]
cwdiaz = [W*0.13, W*0.17, W*0.16, W*0.30, W*0.17]
story.append(drug_block(
    "DIAZEPAM",
    "Valium · Diastat · Stesolid",
    "Febrile seizures · Status epilepticus",
    diaz_data, cwdiaz,
    notes="IV formulation: 5 mg/mL. Rectal gel: 2.5 mg, 5 mg, 10 mg unit doses. "
          "Lorazepam (0.1 mg/kg IV) preferred in hospital setting for status epilepticus.",
    warn="RESPIRATORY DEPRESSION RISK. Have bag-mask ventilation immediately available. Do not give fast IV push."
))

# ══════════════════════════════════════════════════════════════════════════════
# 11. PAEDIATRIC FLUID RESUSCITATION (Bonus)
# ══════════════════════════════════════════════════════════════════════════════
fluid_data = [
    ["Indication", "Fluid", "Volume", "Rate", "Notes"],
    ["Septic shock / hypovolaemia", "0.9% NaCl or Ringers Lactate", "10–20 mL/kg bolus", "As fast as possible (over 5–15 min)", "Reassess after each bolus; max 40–60 mL/kg in first hour"],
    ["Maintenance (Holliday-Segar)", "0.9% NaCl + 5% Dextrose", "100 mL/kg/day (first 10 kg)", "4 mL/kg/hr (0–10 kg)", "Add 50 mL/kg/day for 10–20 kg; 20 mL/kg/day for >20 kg"],
    ["Maintenance", "—", "1000 mL + 50 mL/kg for each kg 10–20 kg", "—", "e.g. 20 kg child: 1500 mL/day = 62.5 mL/hr"],
    ["DKA", "0.9% NaCl", "10 mL/kg over 1hr, then deficit over 48hr", "Slow", "Avoid aggressive fluid — risk of cerebral oedema"],
]
cwfl = [W*0.18, W*0.18, W*0.20, W*0.20, W*0.24]
story.append(drug_block(
    "PAEDIATRIC IV FLUID GUIDE",
    "Emergency & Maintenance Fluids",
    "Shock · Dehydration · Maintenance",
    fluid_data, cwfl,
    notes="Holliday-Segar formula: 4 mL/kg/hr for first 10 kg + 2 mL/kg/hr for 10–20 kg + 1 mL/kg/hr for >20 kg.",
    warn="CAUTION in DKA, cardiac disease, hyponatraemia — seek senior/specialist guidance before fluid type and rate."
))

story.append(PageBreak())

# ══════════════════════════════════════════════════════════════════════════════
# QUICK SUMMARY TABLE
# ══════════════════════════════════════════════════════════════════════════════
story.append(Table([[Paragraph("  QUICK SUMMARY — Common Paediatric Doses at a Glance", drug_hdr)]],
    colWidths=[W]))
story[-1].setStyle(TableStyle([
    ('BACKGROUND', (0,0), (-1,-1), DARK_BLUE),
    ('TOPPADDING', (0,0), (-1,-1), 7),
    ('BOTTOMPADDING', (0,0), (-1,-1), 7),
    ('LEFTPADDING', (0,0), (-1,-1), 6),
]))
story.append(Spacer(1, 4))

summary_data = [
    ["Drug", "Dose (per kg)", "Formulation", "Usual mL/dose (10 kg child)", "Frequency", "Max/dose"],
    ["Paracetamol", "10–15 mg/kg", "120 mg/5 mL syrup", "4.2–6.3 mL", "Q4–6 hr", "1 g"],
    ["Ibuprofen", "5–10 mg/kg", "100 mg/5 mL susp", "2.5–5 mL", "Q6–8 hr", "400 mg"],
    ["Amoxicillin (std)", "25–50 mg/kg/day", "125 mg/5 mL susp", "10–20 mL/day ÷ Q8–12hr", "Q8–12 hr", "—"],
    ["Amoxicillin (high)", "80–90 mg/kg/day", "250 mg/5 mL susp", "16–18 mL/day ÷ Q8hr", "Q8 hr", "3 g/day"],
    ["Amox-Clav (std)", "25–45 mg/kg/day", "125/31.25 mg/5 mL", "10–18 mL/day ÷ Q12hr", "Q12 hr", "—"],
    ["Amox-Clav (high)", "90 mg/kg/day", "ES-600", "Per label", "Q8–12 hr", "3 g/day"],
    ["Cetirizine", "—", "5 mg/5 mL syrup", "2.5–5 mL", "Once daily", "10 mg"],
    ["Chlorpheniramine", "0.35 mg/kg/day", "2 mg/5 mL syrup", "4.4 mL/day ÷ Q6hr", "Q4–6 hr", "24 mg/day"],
    ["Prednisolone", "1–2 mg/kg/day", "5 mg/5 mL syrup", "10–20 mL/day", "Once–BID", "60 mg/day"],
    ["Salbutamol (neb)", "—", "5 mg/mL neb solution", "0.5 mL + 2 mL NS", "Q4–6 hr", "5 mg/neb"],
    ["Diazepam (rectal)", "0.3–0.5 mg/kg", "2.5/5/10 mg rectal gel", "Rectal gel unit dose", "Once; repeat × 1", "10 mg"],
]
cws = [W*0.15, W*0.12, W*0.16, W*0.21, W*0.12, W*0.12]
formatted_s = []
for i, row in enumerate(summary_data):
    if i == 0:
        formatted_s.append([Paragraph(str(c), cell_hdr) for c in row])
    else:
        formatted_s.append([Paragraph(str(c), cell_style) for c in row])

ts = Table(formatted_s, colWidths=cws, repeatRows=1)
ts.setStyle(drug_table_style(len(formatted_s), len(cws)))
story.append(ts)
story.append(Spacer(1, 10))

# ── FOOTER ───────────────────────────────────────────────────────────────────
story.append(HRFlowable(width=W, thickness=0.5, color=MID_BLUE))
story.append(Spacer(1, 4))
story.append(Paragraph(
    "Source: Harriet Lane Handbook 23rd Ed. (Johns Hopkins Hospital) | "
    "Doses shown for standard concentrations — verify formulation before administering | "
    "This reference is a clinical aid only — clinical judgement and local formulary always take precedence.",
    footer_style
))

# ── BUILD ─────────────────────────────────────────────────────────────────────
doc.build(story)
print(f"PDF generated: {OUTPUT}")