Amikacin dose
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amikacin injection prescribing information dosage renal impairment FDA
Amikacin injection (IV/IM) dosing must be individualized by age, actual/adjusted body weight, infection, renal function, dialysis status, and drug-level monitoring.
Common conventional dosing for adults and children with normal renal function:
- 15 mg/kg/day, divided as:
- 7.5 mg/kg every 12 hours, or
- 5 mg/kg every 8 hours
- Usual maximum: 1.5 g/day. DailyMed prescribing information
Uncomplicated UTI: 250 mg every 12 hours may be used in selected patients.
Newborns: label dosing is 10 mg/kg loading, then 7.5 mg/kg every 12 hours, but neonatal schedules vary substantially by gestational age and postnatal age.
Renal impairment: do not use the normal schedule unchanged. The dose and/or interval must be adjusted using creatinine clearance and amikacin serum concentrations. Amikacin can cause serious kidney injury and irreversible hearing/vestibular toxicity, especially with high levels or prolonged treatment.
Please provide:
- Age and weight
- Indication/culture
- Serum creatinine or creatinine clearance/eGFR
- IV or IM, and whether on dialysis
Then I can help check an appropriate regimen, but a prescriber or clinical pharmacist should authorize the final dose.
INJ pantaprozole pediatric dose
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pantoprazole pediatric dosing
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pantoprazole sodium intravenous pediatric dosage prescribing information DailyMed
Pantoprazole injection, pediatric IV dose for GERD/erosive esophagitis:
| Child’s weight | Dose |
|---|---|
| ≤40 kg | 20 mg IV once daily |
| >40 kg | 40 mg IV once daily |
- Give as slow IV injection over at least 2 minutes or IV infusion over 15 minutes.
- Use only until oral treatment is possible, then switch to oral PPI. IV therapy is generally short-term, up to 7-10 days depending on the product label and local protocol.
- Use in infants and for upper GI bleeding/stress-ulcer prophylaxis is commonly protocol-directed or off-label. Do not apply an adult GI-bleed bolus/infusion regimen without a pediatric specialist's order.
The current US labeling notes that pediatric IV-use information is product-specific and that effectiveness for upper GI bleeding has not been established in children. See the DailyMed IV pantoprazole label.
Please state the child’s age, weight, indication, and whether it is for GI bleeding, and I can help verify the ordered dose.
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