Here is a complete, easy-to-remember breakdown of antihypertensive drugs using mnemonics:
The Master Mnemonic: ABCD
The quickest framework - covers the 4 first-line classes:
| Letter | Class | Suffix trick |
|---|
| A | ACE inhibitors / ARBs | end in -pril or -sartan |
| B | Beta-blockers | end in -lol |
| C | Calcium channel blockers | end in -dipine (mostly) |
| D | Diuretics | "water pills" |
Modern guidelines (Comprehensive Clinical Nephrology, 7th Ed.) confirm these 5 classes (ACE-i, ARBs, CCBs, diuretics, beta-blockers) as the backbone of antihypertensive therapy.
CLASS-BY-CLASS MNEMONICS
1. ACE Inhibitors - "Future PaRCEL TechniQue"
Fosinopril, Perindopril, Ramipril, Captopril, Enalapril, Lisinopril, Trandolapril, Quinapril
Suffix trick: ALL end in -pril (think: "ACE = A Prize = -pril")
Side effects mnemonic - CAPTOPRIL:
- Cough (dry, persistent)
- Angioedema
- Potassium increase (hyperkalemia)
- Teratogenic (avoid in pregnancy)
- Orthostatic hypotension
- Proteinuria reduction
- Rash
- Inhibits ACE enzyme
- Lowers BP
2. ARBs - "CO-VITaL"
Candesartan, Olmesartan, Valsartan, Irbesartan, Telmisartan, Losartan
Suffix trick: ALL end in -sartan (think: "sart-AN = Angiotensin kicker")
3. Beta-Blockers - "MAP" (selective) + "LaCa" (mixed)
- Metoprolol, Atenolol, Propranolol (beta-1 selective/non-selective)
- Labetalol, Carvedilol (alpha + beta blockers)
Suffix trick: ALL end in -lol (LOL = slows the heart down laughing!)
4. Calcium Channel Blockers - "kNiFe-N-BALL" (dihydropyridines)
Nifedipine, Felodipine, Nitrendipine, Benidipine, Amlodipine, Lacidipine, Lercanidipine
Plus 2 non-dihydropyridines (heart rate-lowering):
- Verapamil (phenylalkylamine)
- Diltiazem (benzothiazepine)
Trick: "Very Difficult" = Verapamil + Diltiazem (these also slow HR)
Suffix trick: Dihydropyridines end in -dipine
5. Diuretics
| Sub-class | Mnemonic | Drugs |
|---|
| Thiazides | CHIN | Chlorthalidone, Hydrochlorothiazide, Indapamide, (+ more) |
| Loop | Better Future | Bumetanide, Furosemide (+ torsemide, ethacrynic acid) |
| K+-sparing | SEA | Spironolactone, Eplerenone, Amiloride |
6. Vasodilators - "MDH" (arteriolar) + Nitroprusside
Minoxidil, Diazoxide, Hydralazine + Nitroprusside (arterio+venodilator)
7. Alpha Blockers - all end in -osin
Prazosin, Terazosin, Doxazosin (remember: PTD = "Press The Down" for BP)
8. Central Sympatholytics
Clonidine, Methyldopa (remember: "Calm Mom" = these were used safely in pregnancy - especially methyldopa)
BONUS: Drugs Safe in Pregnancy - "LAMB"
Labetalol, Amlodipine, Methyldopa, Beta-blockers (some) - used when ACE-i/ARBs are contraindicated
QUICK SUFFIX CHEATSHEET
| Suffix | Class |
|---|
| -pril | ACE inhibitor |
| -sartan | ARB |
| -lol | Beta-blocker |
| -dipine | Dihydropyridine CCB |
| -osin | Alpha-1 blocker |
| -olone / -erone | K+-sparing diuretic |
The suffix trick alone can get you through 80% of MCQs - if you see a drug name ending in -lol, it's a beta-blocker; -pril means ACE inhibitor; and so on. No memorization of individual names needed!