Can create a presentation on topic drugs for treatment of mycosis of skin and its derivatives from KD tripathi
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Finding Sources
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antifungal drugs mechanism ergosterol synthesis pathway
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tinea pedis dermatophyte skin infection clinical
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onychomycosis nail fungal infection treatment
Running Command
ls -la /home/daytona/workspace/ 2>/dev/null || echo "workspace does not exist"
Running Command
mkdir -p /home/daytona/workspace/antifungal-pptx && echo "done"
Writing File
~/antifungal-pptx/create_pptx.js
const pptxgen = require("pptxgenjs");
const { execSync } = require("child_process");
// Fetch images as base64
function fetchImages(urls) {
try {
const result = execSync(
`node /home/daytona/skills/shared/scripts/fetch_images.js ${urls.map(u => `"${u}"`).join(" ")}`,
{ timeout: 30000 }
).toString();
return JSON.parse(result);
} catch (e) {
console.error("Image fetch error:", e.message);
return urls.map(() => ({ base64: null, error: e.message }));
}
}
const imageUrls = [
"https://cdn.orris.care/cdss_images/585cc05c46e0821032775915a73cb2a9fb4fd3168d8f218856fdf10051f34e13.png", // ergosterol pathway
"https://cdn.orris.care/cdss_images/pmc_clinical_VQA_9cba238b28ddb695bf76b8ea05f85765cda3dfd04d149f32c7dd0a713338bfdd.jpg", // amphotericin B MOA
"https://cdn.orris.care/cdss_images/DermNetNZ_1760031388440_a7240925-8188-4fe2-bc0c-19fa2cd962ff.jpg", // tinea pedis
"https://cdn.orris.care/cdss_images/DermNetNZ_1760031790129_8f43eb0d-b9dd-4b5b-a800-4d57732cbb7b.jpg", // onychomycosis
];
console.log("Fetching images...");
const imgs = fetchImages(imageUrls);
console.log("Images fetched:", imgs.map((i, idx) => `[${idx}]: ${i.error ? 'FAIL:'+i.error : 'OK'}`).join(", "));
// Color scheme - deep teal/medical dark blue
const C = {
bg: "0D2137", // deep navy bg
accent1: "1ABC9C", // teal
accent2: "E74C3C", // red for warnings
white: "FFFFFF",
offwhite: "ECF0F1",
yellow: "F1C40F",
lightblue: "5DADE2",
darkCard: "13293D",
midCard: "1A3A52",
pill: "16A085",
};
let pres = new pptxgen();
pres.layout = "LAYOUT_16x9";
pres.author = "KD Tripathi Pharmacology";
pres.title = "Drugs for Treatment of Mycosis of Skin & Its Derivatives";
// ─────────────────────────────────────────────
// SLIDE 1 – TITLE
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
// Full dark background
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
// Teal accent bar left
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 0.12, h: 5.625, fill: { color: C.accent1 }, line: { color: C.accent1 } });
// Top accent strip
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.accent1 }, line: { color: C.accent1 } });
// Bottom strip
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 5.45, w: 10, h: 0.18, fill: { color: C.accent1 }, line: { color: C.accent1 } });
// Main title
s.addText("DRUGS FOR TREATMENT OF", {
x: 0.4, y: 0.9, w: 9.2, h: 0.7,
fontSize: 28, bold: true, color: C.accent1,
fontFace: "Calibri", align: "center", charSpacing: 4
});
s.addText("MYCOSIS OF SKIN", {
x: 0.4, y: 1.55, w: 9.2, h: 1.0,
fontSize: 52, bold: true, color: C.white,
fontFace: "Calibri", align: "center"
});
s.addText("& ITS DERIVATIVES", {
x: 0.4, y: 2.5, w: 9.2, h: 0.65,
fontSize: 30, bold: false, color: C.lightblue,
fontFace: "Calibri", align: "center", charSpacing: 2
});
// Divider line
s.addShape(pres.shapes.RECTANGLE, { x: 2.5, y: 3.28, w: 5, h: 0.04, fill: { color: C.accent1 }, line: { color: C.accent1 } });
// Subtitle
s.addText("Hair · Nails · Skin Folds", {
x: 0.4, y: 3.42, w: 9.2, h: 0.45,
fontSize: 18, bold: false, color: C.offwhite,
fontFace: "Calibri", align: "center", italic: true
});
// Source tag
s.addText("Based on KD Tripathi — Essentials of Medical Pharmacology", {
x: 0.4, y: 4.1, w: 9.2, h: 0.35,
fontSize: 13, color: "7FB3C8", fontFace: "Calibri", align: "center"
});
// Drug class pills row
const pills = ["Polyenes", "Azoles", "Allylamines", "Griseofulvin", "Others"];
pills.forEach((p, i) => {
const x = 0.5 + i * 1.8;
s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x, y: 4.65, w: 1.6, h: 0.38, fill: { color: C.pill }, line: { color: C.pill }, rectRadius: 0.08 });
s.addText(p, { x, y: 4.65, w: 1.6, h: 0.38, fontSize: 11, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
});
}
// ─────────────────────────────────────────────
// SLIDE 2 – OVERVIEW / CLASSIFICATION
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.accent1 }, line: { color: C.accent1 } });
// Slide title
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("CLASSIFICATION OF ANTIFUNGAL DRUGS FOR SKIN MYCOSES", {
x: 0.3, y: 0.1, w: 9.4, h: 0.71,
fontSize: 18, bold: true, color: C.accent1, fontFace: "Calibri", align: "left", valign: "middle"
});
// Intro text
s.addText("Mycosis of skin and its derivatives (hair & nails) includes dermatophytoses (tinea), cutaneous candidiasis, and pityriasis versicolor. Treatment is classified into topical and systemic agents.", {
x: 0.3, y: 0.97, w: 9.4, h: 0.55,
fontSize: 12, color: C.offwhite, fontFace: "Calibri", italic: false
});
// Two columns of classification boxes
const leftClasses = [
{ title: "TOPICAL AGENTS", color: C.pill, items: ["Azoles: Clotrimazole, Miconazole, Ketoconazole", "Allylamines: Terbinafine, Naftifine", "Polyenes: Nystatin, Amphotericin B", "Ciclopirox olamine", "Tolnaftate, Whitfield's ointment"] },
];
const rightClasses = [
{ title: "SYSTEMIC AGENTS", color: "E67E22", items: ["Griseofulvin (dermatophytes)", "Terbinafine oral (dermatophytes, nails)", "Itraconazole (broad spectrum)", "Fluconazole (Candida, dermatophytes)", "Amphotericin B (severe systemic)"] },
];
// Left box
s.addShape(pres.shapes.RECTANGLE, { x: 0.3, y: 1.62, w: 4.4, h: 3.5, fill: { color: C.darkCard }, line: { color: C.pill }, lineSize: 2 });
s.addShape(pres.shapes.RECTANGLE, { x: 0.3, y: 1.62, w: 4.4, h: 0.42, fill: { color: C.pill }, line: { color: C.pill } });
s.addText("TOPICAL AGENTS", { x: 0.32, y: 1.63, w: 4.36, h: 0.4, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
const topItems = [
"Azoles: Clotrimazole, Miconazole,\n Ketoconazole (1-2% cream/gel)",
"Allylamines: Terbinafine 1%,\n Naftifine, Butenafine",
"Polyenes: Nystatin (Candida only),\n Amphotericin B lotion",
"Ciclopirox olamine 1% (broad)",
"Tolnaftate 1%\nWhitfield's ointment (keratolytic)"
];
topItems.forEach((item, i) => {
s.addShape(pres.shapes.RECTANGLE, { x: 0.35, y: 2.12 + i * 0.56, w: 4.3, h: 0.5, fill: { color: i % 2 === 0 ? C.midCard : C.darkCard }, line: { color: C.midCard } });
s.addText([
{ text: "▸ ", options: { color: C.accent1, bold: true } },
{ text: item, options: { color: C.offwhite } }
], { x: 0.42, y: 2.12 + i * 0.56, w: 4.16, h: 0.5, fontSize: 10.5, fontFace: "Calibri", valign: "middle" });
});
// Right box
s.addShape(pres.shapes.RECTANGLE, { x: 5.3, y: 1.62, w: 4.4, h: 3.5, fill: { color: C.darkCard }, line: { color: "E67E22" }, lineSize: 2 });
s.addShape(pres.shapes.RECTANGLE, { x: 5.3, y: 1.62, w: 4.4, h: 0.42, fill: { color: "E67E22" }, line: { color: "E67E22" } });
s.addText("SYSTEMIC AGENTS", { x: 5.32, y: 1.63, w: 4.36, h: 0.4, fontSize: 13, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
const sysItems = [
"Griseofulvin\n (dermatophytes, DOC in children)",
"Terbinafine oral\n (dermatophytes, onychomycosis)",
"Itraconazole\n (dermatophytes, Candida, tinea)",
"Fluconazole\n (Candida, tinea capitis)",
"Amphotericin B IV\n (severe/invasive infections)"
];
sysItems.forEach((item, i) => {
s.addShape(pres.shapes.RECTANGLE, { x: 5.35, y: 2.12 + i * 0.56, w: 4.3, h: 0.5, fill: { color: i % 2 === 0 ? C.midCard : C.darkCard }, line: { color: C.midCard } });
s.addText([
{ text: "▸ ", options: { color: C.yellow, bold: true } },
{ text: item, options: { color: C.offwhite } }
], { x: 5.42, y: 2.12 + i * 0.56, w: 4.16, h: 0.5, fontSize: 10.5, fontFace: "Calibri", valign: "middle" });
});
}
// ─────────────────────────────────────────────
// SLIDE 3 – GRISEOFULVIN
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.yellow }, line: { color: C.yellow } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("GRISEOFULVIN", {
x: 0.3, y: 0.1, w: 7, h: 0.71,
fontSize: 24, bold: true, color: C.yellow, fontFace: "Calibri", align: "left", valign: "middle"
});
s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.5, y: 0.17, w: 2.1, h: 0.45, fill: { color: "C0392B" }, line: { color: "C0392B" }, rectRadius: 0.08 });
s.addText("Fungistatic", { x: 7.5, y: 0.17, w: 2.1, h: 0.45, fontSize: 12, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
const sections = [
{
title: "SOURCE & CHEMISTRY",
color: "8E44AD",
text: "Isolated from Penicillium griseofulvum. Practically insoluble in water.\nMicrosize & ultramicrosize formulations available."
},
{
title: "MECHANISM OF ACTION",
color: C.accent1,
text: "Inhibits microtubule function → disrupts mitotic spindle assembly → fungistatic effect.\nBinds to tubulin → prevents cell division in fungi.\nDeposits in keratin precursor cells; active drug in new keratin is toxic to dermatophytes."
},
{
title: "SPECTRUM",
color: C.lightblue,
text: "ONLY dermatophytes: Trichophyton, Microsporum, Epidermophyton spp.\nNOT active against: Candida, Pityrosporum, non-dermatophyte molds."
},
{
title: "INDICATIONS",
color: "27AE60",
text: "DOC for tinea capitis in children (scalp ringworm)\nTinea corporis, tinea pedis, tinea unguium (nails — long course)\nResistant tinea not responding to topical agents."
},
{
title: "PHARMACOKINETICS",
color: "E67E22",
text: "Oral — absorption enhanced by fatty meal. Deposited in keratinizing cells.\nMetabolized by liver (CYP450). Induces hepatic enzymes.\nDuration: skin 2–4 wks; nails 6–12 months."
},
{
title: "ADVERSE EFFECTS & INTERACTIONS",
color: C.accent2,
text: "Headache, GI disturbances, photosensitivity, urticaria.\nHepatotoxicity (rare). Teratogenic — avoid in pregnancy.\nDrug interactions: reduces efficacy of warfarin, OCPs (enzyme inducer)."
}
];
sections.forEach((sec, i) => {
const col = i < 3 ? 0 : 1;
const row = i % 3;
const x = col === 0 ? 0.2 : 5.1;
const y = 1.02 + row * 1.48;
s.addShape(pres.shapes.RECTANGLE, { x, y, w: 4.7, h: 1.38, fill: { color: C.darkCard }, line: { color: sec.color }, lineSize: 1.5 });
s.addShape(pres.shapes.RECTANGLE, { x, y, w: 4.7, h: 0.3, fill: { color: sec.color }, line: { color: sec.color } });
s.addText(sec.title, { x: x + 0.08, y: y + 0.01, w: 4.54, h: 0.28, fontSize: 10, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
s.addText(sec.text, { x: x + 0.1, y: y + 0.33, w: 4.5, h: 1.0, fontSize: 10, color: C.offwhite, fontFace: "Calibri", valign: "top" });
});
}
// ─────────────────────────────────────────────
// SLIDE 4 – AZOLE ANTIFUNGALS
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.lightblue }, line: { color: C.lightblue } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("AZOLE ANTIFUNGALS", {
x: 0.3, y: 0.1, w: 7, h: 0.71,
fontSize: 24, bold: true, color: C.lightblue, fontFace: "Calibri", align: "left", valign: "middle"
});
s.addText("Imidazoles · Triazoles", { x: 6.8, y: 0.25, w: 2.9, h: 0.4, fontSize: 13, color: C.offwhite, fontFace: "Calibri", italic: true, align: "center" });
// MOA box (full width)
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 0.95, w: 9.6, h: 0.75, fill: { color: C.midCard }, line: { color: C.lightblue }, lineSize: 1.5 });
s.addText([
{ text: "MECHANISM: ", options: { bold: true, color: C.lightblue } },
{ text: "Inhibit fungal CYP450 enzyme 14α-demethylase → block conversion of lanosterol → ergosterol → ergosterol depletion → altered membrane permeability → fungistatic (fungicidal at high conc.)", options: { color: C.offwhite } }
], { x: 0.35, y: 0.97, w: 9.3, h: 0.71, fontSize: 11.5, fontFace: "Calibri", valign: "middle" });
// Ergosterol image if available
const ergoImg = imgs[0];
if (ergoImg && ergoImg.base64) {
s.addImage({ data: ergoImg.base64, x: 6.3, y: 1.82, w: 3.5, h: 2.2 });
s.addText("Ergosterol synthesis pathway\n(Dermatology 5e)", { x: 6.3, y: 3.98, w: 3.5, h: 0.38, fontSize: 8, color: "7FB3C8", fontFace: "Calibri", align: "center", italic: true });
}
const azoles = [
{ name: "Clotrimazole", type: "Imidazole", use: "Topical — tinea, cutaneous candidiasis", note: "1% cream, powder, lotion, pessary" },
{ name: "Miconazole", type: "Imidazole", use: "Topical skin & nail infections, Candida", note: "2% cream/powder; nail lacquer" },
{ name: "Ketoconazole", type: "Imidazole", use: "Topical: tinea versicolor, seborrheic dermatitis\nOral: restricted (hepatotoxicity risk)", note: "2% shampoo/cream" },
{ name: "Fluconazole", type: "Triazole", use: "Systemic Candida; off-label dermatophytes", note: "Weekly dose for tinea; nail 150mg/wk x 6m" },
{ name: "Itraconazole", type: "Triazole", use: "Onychomycosis, tinea capitis, versicolor", note: "Pulse therapy: 200mg BD x 1wk/month" },
];
azoles.forEach((az, i) => {
const y = 1.82 + i * 0.68;
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y, w: 5.9, h: 0.62, fill: { color: i % 2 === 0 ? C.darkCard : C.midCard }, line: { color: C.midCard } });
s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 0.25, y: y + 0.07, w: 1.4, h: 0.28, fill: { color: C.lightblue }, line: { color: C.lightblue }, rectRadius: 0.05 });
s.addText(az.name, { x: 0.25, y: y + 0.07, w: 1.4, h: 0.28, fontSize: 10, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 1.72, y: y + 0.07, w: 1.1, h: 0.24, fill: { color: C.darkCard }, line: { color: C.lightblue }, rectRadius: 0.04 });
s.addText(az.type, { x: 1.72, y: y + 0.07, w: 1.1, h: 0.24, fontSize: 9, color: C.lightblue, fontFace: "Calibri", align: "center", valign: "middle" });
s.addText(az.use, { x: 2.9, y: y + 0.04, w: 3.1, h: 0.3, fontSize: 9.5, color: C.offwhite, fontFace: "Calibri", valign: "top" });
s.addText(az.note, { x: 2.9, y: y + 0.33, w: 3.1, h: 0.25, fontSize: 8.5, color: "7FB3C8", fontFace: "Calibri", italic: true });
});
}
// ─────────────────────────────────────────────
// SLIDE 5 – ALLYLAMINES
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.accent1 }, line: { color: C.accent1 } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("ALLYLAMINES & BENZYLAMINES", { x: 0.3, y: 0.1, w: 8, h: 0.71, fontSize: 24, bold: true, color: C.accent1, fontFace: "Calibri", align: "left", valign: "middle" });
s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.7, y: 0.17, w: 1.95, h: 0.45, fill: { color: C.accent1 }, line: { color: C.accent1 }, rectRadius: 0.08 });
s.addText("Fungicidal", { x: 7.7, y: 0.17, w: 1.95, h: 0.45, fontSize: 12, bold: true, color: C.bg, fontFace: "Calibri", align: "center", valign: "middle" });
// MOA
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 0.95, w: 9.6, h: 0.65, fill: { color: C.midCard }, line: { color: C.accent1 }, lineSize: 1.5 });
s.addText([
{ text: "MECHANISM: ", options: { bold: true, color: C.accent1 } },
{ text: "Inhibit squalene epoxidase → squalene accumulates (toxic) + ergosterol depleted → fungicidal effect. More selective than azoles (no human CYP450 inhibition).", options: { color: C.offwhite } }
], { x: 0.35, y: 0.97, w: 9.3, h: 0.61, fontSize: 11.5, fontFace: "Calibri", valign: "middle" });
// Terbinafine large card
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.72, w: 5.85, h: 3.5, fill: { color: C.darkCard }, line: { color: C.accent1 }, lineSize: 2 });
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.72, w: 5.85, h: 0.38, fill: { color: C.accent1 }, line: { color: C.accent1 } });
s.addText("TERBINAFINE (Allylamine)", { x: 0.25, y: 1.73, w: 5.75, h: 0.36, fontSize: 13, bold: true, color: C.bg, fontFace: "Calibri", valign: "middle" });
const terbRows = [
["Spectrum", "Dermatophytes (T. rubrum, T. mentagrophytes, Epidermophyton). Limited Candida activity."],
["Forms", "1% topical cream (tinea corporis, pedis, cruris); Oral 250 mg tablets (onychomycosis, severe tinea)"],
["Indications", "Tinea pedis, tinea corporis, tinea cruris (topical). Onychomycosis, tinea capitis (oral). Drug of choice for dermatophyte nail infections."],
["Dosing", "Tinea pedis: 1 wk topical. Onychomycosis: 250mg/day oral — 6 wks (fingernails), 12 wks (toenails).\nMycologic cure: ~70% toenails, 80% fingernails."],
["Adverse FX", "Oral: GI disturbances, taste/smell disturbances, hepatotoxicity (rare), Stevens-Johnson syndrome.\nTopical: mild irritation. Accumulates in skin/nails/fat."],
];
terbRows.forEach((row, i) => {
const y = 2.18 + i * 0.58;
s.addShape(pres.shapes.RECTANGLE, { x: 0.25, y, w: 1.35, h: 0.52, fill: { color: C.pill }, line: { color: C.pill } });
s.addText(row[0], { x: 0.25, y, w: 1.35, h: 0.52, fontSize: 10, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
s.addText(row[1], { x: 1.66, y: y + 0.03, w: 4.3, h: 0.5, fontSize: 9.5, color: C.offwhite, fontFace: "Calibri", valign: "top" });
});
// Right - Naftifine & Others
s.addShape(pres.shapes.RECTANGLE, { x: 6.25, y: 1.72, w: 3.55, h: 1.65, fill: { color: C.darkCard }, line: { color: "16A085" }, lineSize: 1.5 });
s.addShape(pres.shapes.RECTANGLE, { x: 6.25, y: 1.72, w: 3.55, h: 0.35, fill: { color: "16A085" }, line: { color: "16A085" } });
s.addText("NAFTIFINE", { x: 6.3, y: 1.73, w: 3.45, h: 0.33, fontSize: 12, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
s.addText("Allylamine • Topical only (1% cream/gel)\nSpectrum: dermatophytes, some Candida\nUse: tinea corporis, pedis, cruris\nAdvantage: anti-inflammatory effect\nFrequency: once daily (gel) or twice daily (cream)", {
x: 6.3, y: 2.1, w: 3.45, h: 1.22, fontSize: 10, color: C.offwhite, fontFace: "Calibri"
});
s.addShape(pres.shapes.RECTANGLE, { x: 6.25, y: 3.5, w: 3.55, h: 1.7, fill: { color: C.darkCard }, line: { color: "F39C12" }, lineSize: 1.5 });
s.addShape(pres.shapes.RECTANGLE, { x: 6.25, y: 3.5, w: 3.55, h: 0.35, fill: { color: "F39C12" }, line: { color: "F39C12" } });
s.addText("BUTENAFINE (Benzylamine)", { x: 6.3, y: 3.51, w: 3.45, h: 0.33, fontSize: 11, bold: true, color: C.bg, fontFace: "Calibri", valign: "middle" });
s.addText("Topical 1% cream\nSpectrum: dermatophytes (fungicidal)\nUse: tinea pedis, corporis, cruris\nNote: longer post-antifungal effect than\nterbinafine cream", {
x: 6.3, y: 3.88, w: 3.45, h: 1.25, fontSize: 10, color: C.offwhite, fontFace: "Calibri"
});
}
// ─────────────────────────────────────────────
// SLIDE 6 – POLYENES (Nystatin & Amphotericin B)
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: "9B59B6" }, line: { color: "9B59B6" } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("POLYENE ANTIFUNGALS", { x: 0.3, y: 0.1, w: 7.5, h: 0.71, fontSize: 24, bold: true, color: "9B59B6", fontFace: "Calibri", align: "left", valign: "middle" });
s.addShape(pres.shapes.ROUNDED_RECTANGLE, { x: 7.6, y: 0.17, w: 2.05, h: 0.45, fill: { color: "9B59B6" }, line: { color: "9B59B6" }, rectRadius: 0.08 });
s.addText("Fungicidal", { x: 7.6, y: 0.17, w: 2.05, h: 0.45, fontSize: 12, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
// MOA + image
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 0.95, w: 9.6, h: 0.65, fill: { color: C.midCard }, line: { color: "9B59B6" }, lineSize: 1.5 });
s.addText([
{ text: "MECHANISM: ", options: { bold: true, color: "9B59B6" } },
{ text: "Bind ergosterol in fungal cell membrane → form transmembrane pores → leakage of K⁺, Mg²⁺, amino acids, sugars → cell death. Selectivity based on higher affinity for ergosterol vs. cholesterol.", options: { color: C.offwhite } }
], { x: 0.35, y: 0.97, w: 9.3, h: 0.61, fontSize: 11.5, fontFace: "Calibri", valign: "middle" });
// Nystatin card
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.72, w: 4.5, h: 3.5, fill: { color: C.darkCard }, line: { color: "27AE60" }, lineSize: 2 });
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.72, w: 4.5, h: 0.38, fill: { color: "27AE60" }, line: { color: "27AE60" } });
s.addText("NYSTATIN", { x: 0.25, y: 1.73, w: 4.4, h: 0.36, fontSize: 14, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
const nysRows = [
["Source", "Streptomyces noursei — polyene macrolide"],
["Spectrum", "Candida spp. (skin, mucosal). NOT active against dermatophytes."],
["Topical Use", "Cutaneous candidiasis, candidal intertrigo, diaper dermatitis, perianal candidiasis, vaginal candidiasis (pessaries)"],
["Oral Use", "Oral/GI candidiasis (not absorbed — local effect).\nOropharyngeal thrush: oral suspension 100,000 U/mL"],
["Adverse FX", "Topical: minimal irritation.\nOral: nausea, GI upset. Not used IV (too toxic)."],
];
nysRows.forEach((row, i) => {
const y = 2.18 + i * 0.58;
s.addShape(pres.shapes.RECTANGLE, { x: 0.25, y, w: 1.1, h: 0.52, fill: { color: "27AE60" }, line: { color: "27AE60" } });
s.addText(row[0], { x: 0.25, y, w: 1.1, h: 0.52, fontSize: 10, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
s.addText(row[1], { x: 1.42, y: y + 0.03, w: 3.2, h: 0.5, fontSize: 9.5, color: C.offwhite, fontFace: "Calibri", valign: "top" });
});
// AmB image + card
const ambImg = imgs[1];
if (ambImg && ambImg.base64) {
s.addImage({ data: ambImg.base64, x: 4.9, y: 1.72, w: 2.5, h: 1.95 });
s.addText("Amphotericin B pore mechanism", { x: 4.9, y: 3.65, w: 2.5, h: 0.25, fontSize: 7.5, color: "7FB3C8", fontFace: "Calibri", align: "center", italic: true });
}
s.addShape(pres.shapes.RECTANGLE, { x: 4.9, y: 3.95, w: 4.9, h: 1.27, fill: { color: C.darkCard }, line: { color: "9B59B6" }, lineSize: 1.5 });
s.addShape(pres.shapes.RECTANGLE, { x: 4.9, y: 3.95, w: 4.9, h: 0.3, fill: { color: "9B59B6" }, line: { color: "9B59B6" } });
s.addText("AMPHOTERICIN B — TOPICAL", { x: 4.95, y: 3.96, w: 4.8, h: 0.28, fontSize: 11, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
s.addText("3% cream/lotion — cutaneous candidiasis, mucocutaneous candidiasis\nNOT effective for dermatophyte skin infections\nIV formulation reserved for severe/systemic fungal infections\nNephrotoxic IV: pre-hydration required; liposomal form safer", {
x: 4.97, y: 4.28, w: 4.8, h: 0.92, fontSize: 9.5, color: C.offwhite, fontFace: "Calibri"
});
}
// ─────────────────────────────────────────────
// SLIDE 7 – OTHER TOPICAL AGENTS
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: "E67E22" }, line: { color: "E67E22" } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("OTHER TOPICAL ANTIFUNGAL AGENTS", { x: 0.3, y: 0.1, w: 9.4, h: 0.71, fontSize: 22, bold: true, color: "E67E22", fontFace: "Calibri", align: "left", valign: "middle" });
const agents = [
{
name: "CICLOPIROX OLAMINE", color: "E67E22",
text: "Hydroxypyridinone class (unique MOA)\nMechanism: Chelates metal ions → inhibits fungal enzymes\nSpectrum: Broadest topical — dermatophytes, Candida, Malassezia, bacteria\nForms: 1% cream/lotion (tinea), 8% nail lacquer (onychomycosis)\nIndications: Tinea corporis, pedis, cruris, versicolor, onychomycosis, seborrheic dermatitis"
},
{
name: "TOLNAFTATE 1%", color: C.lightblue,
text: "Mechanism: Inhibits squalene epoxidase (like allylamines)\nSpectrum: Dermatophytes ONLY — no activity vs Candida\nForms: Cream, powder, solution, spray\nUse: Tinea pedis, corporis, cruris (mild-moderate)\nMost useful as prophylaxis in tinea pedis"
},
{
name: "WHITFIELD'S OINTMENT", color: C.accent1,
text: "Keratolytic combination: Benzoic acid 6% + Salicylic acid 3%\nMechanism: Keratolytic (removes infected keratin) + mild antifungal\nUse: Tinea pedis, tinea corporis (moccasin-type)\nBenefits: Cheap, widely available; reduces hyperkeratotic lesions\nLimitations: Staining, irritation; less effective than modern agents"
},
{
name: "UNDECYLENIC ACID & ZINC", color: "8E44AD",
text: "Mechanism: Fatty acid — interferes with fungal cell growth\nForms: Cream, powder, spray (OTC)\nUse: Tinea pedis, tinea cruris (mild)\nLess potent than azoles or allylamines; often in OTC foot preparations"
},
{
name: "SELENIUM SULFIDE 2.5%", color: "C0392B",
text: "Mechanism: Cytostatic — reduces Malassezia overgrowth\nUse: Pityriasis versicolor (tinea versicolor), seborrheic dermatitis\nForms: 2.5% lotion/shampoo; applied for 10 min then rinsed\nNote: Apply weekly for 4 weeks. Avoid on inflamed/broken skin."
},
{
name: "EFINACONAZOLE 10% & TAVABOROLE 5%", color: "16A085",
text: "Newer topical agents approved for onychomycosis\nEfinaconazole: triazole antifungal nail solution\nTavaborole: oxaborole — boron-based, excellent nail penetration\nBoth applied daily × 48 weeks; can be used over nail polish\nCure rate 6–18% — adjunct to oral therapy for mild nail disease"
},
];
agents.forEach((ag, i) => {
const col = i % 2;
const row = Math.floor(i / 2);
const x = col === 0 ? 0.2 : 5.15;
const y = 0.97 + row * 1.56;
s.addShape(pres.shapes.RECTANGLE, { x, y, w: 4.7, h: 1.46, fill: { color: C.darkCard }, line: { color: ag.color }, lineSize: 1.5 });
s.addShape(pres.shapes.RECTANGLE, { x, y, w: 4.7, h: 0.3, fill: { color: ag.color }, line: { color: ag.color } });
s.addText(ag.name, { x: x + 0.08, y: y + 0.01, w: 4.54, h: 0.28, fontSize: 9.5, bold: true, color: C.white, fontFace: "Calibri", valign: "middle" });
s.addText(ag.text, { x: x + 0.1, y: y + 0.33, w: 4.5, h: 1.1, fontSize: 9, color: C.offwhite, fontFace: "Calibri", valign: "top" });
});
}
// ─────────────────────────────────────────────
// SLIDE 8 – DISEASE-SPECIFIC TREATMENT (with clinical images)
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.accent2 }, line: { color: C.accent2 } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("DISEASE-SPECIFIC TREATMENT APPROACH", { x: 0.3, y: 0.1, w: 9.4, h: 0.71, fontSize: 20, bold: true, color: C.accent2, fontFace: "Calibri", align: "left", valign: "middle" });
const diseases = [
{ name: "Tinea Pedis\n(Athlete's Foot)", first: "Terbinafine 1% cream × 1–2 wks\nClotrimazole/Miconazole 2–4 wks", second: "Terbinafine oral 250mg/day × 2 wks\nItraconazole 100mg/day × 4 wks" },
{ name: "Tinea Corporis\n(Ringworm)", first: "Any topical azole or allylamine × 2–4 wks\nExtend 1 wk beyond healing", second: "Griseofulvin 500mg/day × 4–6 wks\nTerbinafine oral × 1–2 wks" },
{ name: "Tinea Cruris\n(Jock Itch)", first: "Terbinafine cream × 1 wk\nClotrimazole/Miconazole × 2 wks\nKeep area dry", second: "Griseofulvin or Terbinafine oral\n× 2–4 wks" },
{ name: "Tinea Capitis\n(Scalp Ringworm)", first: "Topical alone INSUFFICIENT\nKetoconazole 2% shampoo (adjunct)", second: "Griseofulvin 15–20mg/kg/day × 6–8 wks (DOC)\nTerbinafine (Trichophyton)\nItraconazole (Microsporum)" },
{ name: "Tinea Versicolor\n(Malassezia)", first: "Selenium sulfide 2.5% × 2–4 wks\nKetoconazole 2% shampoo\nClotrimazole/Miconazole cream", second: "Itraconazole 200mg/day × 5–7 days\nFluconazole 300mg single dose\nItraconazole 200mg once/month (prophylaxis)" },
{ name: "Cutaneous\nCandidiasis", first: "Nystatin cream (any Candida)\nClotrimazole/Miconazole cream\nCiclopirox olamine", second: "Fluconazole 150mg/week × 4–6 wks\n(severe or resistant)" },
];
// Add clinical images in a strip at top right area
const tinPedisImg = imgs[2];
if (tinPedisImg && tinPedisImg.base64) {
s.addImage({ data: tinPedisImg.base64, x: 8.2, y: 0.97, w: 1.6, h: 1.3, rounding: false });
s.addText("Tinea pedis", { x: 8.2, y: 2.27, w: 1.6, h: 0.2, fontSize: 7, color: "7FB3C8", fontFace: "Calibri", align: "center", italic: true });
}
const onychImg = imgs[3];
if (onychImg && onychImg.base64) {
s.addImage({ data: onychImg.base64, x: 8.2, y: 2.55, w: 1.6, h: 1.3 });
s.addText("Onychomycosis", { x: 8.2, y: 3.85, w: 1.6, h: 0.2, fontSize: 7, color: "7FB3C8", fontFace: "Calibri", align: "center", italic: true });
}
diseases.forEach((d, i) => {
const y = 0.97 + i * 0.77;
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y, w: 7.8, h: 0.71, fill: { color: i % 2 === 0 ? C.darkCard : C.midCard }, line: { color: C.midCard } });
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y, w: 1.75, h: 0.71, fill: { color: "C0392B" }, line: { color: "C0392B" } });
s.addText(d.name, { x: 0.22, y, w: 1.71, h: 0.71, fontSize: 9.5, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
s.addShape(pres.shapes.RECTANGLE, { x: 1.97, y, w: 0.55, h: 0.31, fill: { color: C.pill }, line: { color: C.pill } });
s.addText("1st", { x: 1.97, y, w: 0.55, h: 0.31, fontSize: 8, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
s.addText(d.first, { x: 2.55, y: y + 0.03, w: 5.3, h: 0.3, fontSize: 8.5, color: C.offwhite, fontFace: "Calibri" });
s.addShape(pres.shapes.RECTANGLE, { x: 1.97, y: y + 0.35, w: 0.55, h: 0.28, fill: { color: "E67E22" }, line: { color: "E67E22" } });
s.addText("2nd", { x: 1.97, y: y + 0.35, w: 0.55, h: 0.28, fontSize: 8, bold: true, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
s.addText(d.second, { x: 2.55, y: y + 0.37, w: 5.3, h: 0.3, fontSize: 8.5, color: "7FB3C8", fontFace: "Calibri" });
});
}
// ─────────────────────────────────────────────
// SLIDE 9 – ONYCHOMYCOSIS (Nail Infections)
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: "F39C12" }, line: { color: "F39C12" } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("ONYCHOMYCOSIS — TREATMENT OF NAIL FUNGAL INFECTIONS", { x: 0.3, y: 0.1, w: 9.4, h: 0.71, fontSize: 18, bold: true, color: "F39C12", fontFace: "Calibri", align: "left", valign: "middle" });
// Key note
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 0.95, w: 9.6, h: 0.58, fill: { color: C.midCard }, line: { color: "F39C12" }, lineSize: 1.5 });
s.addText("Onychomycosis (tinea unguium) is the most common nail disorder. Caused by T. rubrum (>90%). Nail infections are difficult to cure — poor antifungal penetration into nail + slow nail turnover require prolonged therapy with high recurrence rates.", {
x: 0.35, y: 0.97, w: 9.3, h: 0.54, fontSize: 11, color: C.offwhite, fontFace: "Calibri", valign: "middle"
});
// Oral drugs comparison table
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 1.62, w: 9.6, h: 0.35, fill: { color: "F39C12" }, line: { color: "F39C12" } });
["DRUG", "DOSE", "FINGERNAILS", "TOENAILS", "CURE RATE", "NOTES"].forEach((h, i) => {
const widths = [1.6, 2.0, 1.4, 1.4, 1.2, 2.0];
const x = 0.2 + widths.slice(0, i).reduce((a, b) => a + b, 0);
s.addText(h, { x, y: 1.63, w: widths[i], h: 0.33, fontSize: 10, bold: true, color: C.bg, fontFace: "Calibri", align: "center", valign: "middle" });
});
const rows = [
["Terbinafine 250mg", "250 mg/day\ncontinuous", "6 weeks", "12 weeks", "~80% fingers\n~70% toes", "DOC; fungicidal; superior mycologic cure"],
["Itraconazole\n(continuous)", "200 mg/day", "6 weeks", "12 weeks", "~70%", "Pulse or continuous; check for drug interactions"],
["Itraconazole\n(pulse)", "200 mg BD\n1 wk/month", "2 pulses", "3 pulses", "~60–70%", "Better patient compliance; cheaper"],
["Fluconazole", "150–300 mg\nonce/week", "6 months", "9–12 months", "~50%", "Off-label; useful when other drugs not tolerated"],
];
rows.forEach((row, ri) => {
const widths = [1.6, 2.0, 1.4, 1.4, 1.2, 2.0];
const y = 2.05 + ri * 0.66;
const bg = ri % 2 === 0 ? C.darkCard : C.midCard;
row.forEach((cell, ci) => {
const x = 0.2 + widths.slice(0, ci).reduce((a, b) => a + b, 0);
s.addShape(pres.shapes.RECTANGLE, { x, y, w: widths[ci], h: 0.6, fill: { color: bg }, line: { color: "F39C12", transparency: 70 } });
s.addText(cell, { x: x + 0.05, y, w: widths[ci] - 0.1, h: 0.6, fontSize: ci === 0 ? 10 : 9, bold: ci === 0, color: ci === 0 ? "F39C12" : C.offwhite, fontFace: "Calibri", align: "center", valign: "middle" });
});
});
// Topical section
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y: 4.75, w: 9.6, h: 0.6, fill: { color: C.darkCard }, line: { color: C.lightblue }, lineSize: 1.5 });
s.addText([
{ text: "TOPICAL: ", options: { bold: true, color: C.lightblue } },
{ text: "Ciclopirox 8% nail lacquer (48 wks) — mild disease. Efinaconazole 10% solution (48 wks). Tavaborole 5% solution (48 wks). Amorolfine 5% nail lacquer (6–12 months). All have low cure rates (~6–18%) — suitable only for mild superficial disease.", options: { color: C.offwhite } }
], { x: 0.35, y: 4.77, w: 9.3, h: 0.56, fontSize: 10.5, fontFace: "Calibri", valign: "middle" });
}
// ─────────────────────────────────────────────
// SLIDE 10 – SUMMARY / KEY POINTS
// ─────────────────────────────────────────────
{
let s = pres.addSlide();
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 5.625, fill: { color: C.bg }, line: { color: C.bg } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0, w: 10, h: 0.08, fill: { color: C.accent1 }, line: { color: C.accent1 } });
s.addShape(pres.shapes.RECTANGLE, { x: 0, y: 0.08, w: 10, h: 0.75, fill: { color: C.midCard }, line: { color: C.midCard } });
s.addText("KEY CLINICAL POINTS & SUMMARY", { x: 0.3, y: 0.1, w: 9.4, h: 0.71, fontSize: 22, bold: true, color: C.accent1, fontFace: "Calibri", align: "left", valign: "middle" });
const keyPoints = [
{ icon: "◈", color: C.accent1, text: "Griseofulvin: DOC for tinea capitis in children; only active against dermatophytes; fungistatic; needs long therapy (6–8 wks scalp, 6–12 months nails); enzyme inducer." },
{ icon: "◈", color: C.lightblue, text: "Azoles (topical): First choice for most superficial dermatophyte and Candida skin infections. Ketoconazole oral — avoid due to hepatotoxicity." },
{ icon: "◈", color: C.accent1, text: "Terbinafine: Fungicidal allylamine — superior to griseofulvin and azoles for onychomycosis and most adult dermatophytoses. DOC for nail infections." },
{ icon: "◈", color: "F39C12", text: "Nystatin: Only for Candida infections. NOT for dermatophytes. Topical & oral (not absorbed) forms available." },
{ icon: "◈", color: "9B59B6", text: "Polyenes bind ergosterol (pore formation). Azoles inhibit ergosterol synthesis (14α-demethylase). Allylamines inhibit squalene epoxidase. Griseofulvin inhibits microtubules." },
{ icon: "◈", color: C.accent2, text: "Tinea capitis requires systemic therapy — topical alone insufficient. Tinea versicolor: selenium sulfide 2.5% or itraconazole. Recurrence common." },
{ icon: "◈", color: "27AE60", text: "Onychomycosis: Terbinafine oral (12 wks toenails, 6 wks fingernails) — highest cure rate. Itraconazole pulse therapy equally effective, better compliance." },
];
keyPoints.forEach((kp, i) => {
const y = 0.97 + i * 0.65;
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y, w: 9.6, h: 0.6, fill: { color: i % 2 === 0 ? C.darkCard : C.midCard }, line: { color: C.midCard } });
s.addShape(pres.shapes.RECTANGLE, { x: 0.2, y, w: 0.35, h: 0.6, fill: { color: kp.color }, line: { color: kp.color } });
s.addText(kp.icon, { x: 0.2, y, w: 0.35, h: 0.6, fontSize: 14, color: C.white, fontFace: "Calibri", align: "center", valign: "middle" });
s.addText(kp.text, { x: 0.62, y: y + 0.05, w: 9.1, h: 0.52, fontSize: 10.5, color: C.offwhite, fontFace: "Calibri", valign: "top" });
});
}
// Save
const outPath = "/home/daytona/workspace/antifungal-pptx/Antifungal_Skin_Mycosis_KDTripathi.pptx";
pres.writeFile({ fileName: outPath }).then(() => {
console.log("SUCCESS: " + outPath);
}).catch(e => {
console.error("FAILED:", e);
});
Running Command
cd /home/daytona/workspace/antifungal-pptx && node create_pptx.js 2>&1
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